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No. 薬物名(臨床試験情報から抽出) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1Any other approved Antiepileptic Drug----1件: 144
2Cannabidiol1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬18件: 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
3Cannabidiol (CBD)1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬7件: 6, 13, 140, 144, 145, 156, 158
4Cannabidiol Oral Solution1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬4件: 140, 144, 145, 193
5Carisbamate1件: Carisbamate1件: D06573 --1件: 144
6CBD----13件: 2, 6, 8, 13, 36, 46, 51, 140, 144, 145, 156, 158, 206
7CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144
8Clemizole1件: Clemizole---2件: 140, 144
9Clemizole HCl1件: Clemizole---1件: 144
10Clobazam1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 140, 144
11Clobazam High Dose1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
12Clobazam Low Dose1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
13Clobazam Medium Dose1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
14Clobazam PhEur1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
15Clobazam Tablets1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
16Clobazam Tablets 10mg1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
17Clobazam Tablets 20mg1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
18Clobazam Tablets 5mg1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
19E2007----2件: 6, 144
20E2080----1件: 144
21Epidiolex1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144
22Epidiolex 100 mg/mL Oral Solution1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144
23Ezogabine1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬2件: 2, 144
24EZOGABINE (US ONLY)1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
25Ezogabine/retigabine1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
26Fenfluramina1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144
27Fenfluramina Cloridrato1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144
28FENFLURAMINE1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬4件: 140, 144, 145, 149
29Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬1件: 144
30FENFLURAMINE HYDROCHLORIDE1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144
31FENFLURAMINE HYDROCHLORIDE (colorless)1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144
32Fycompa1件: Perampanel1件: D08964 4件: GRIA1,
GRIA2,
GRIA3,
GRIA4 💬
16件: Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬2件: 2, 144
33GW582892----1件: 144
34GWP42003-P----5件: 140, 144, 145, 156, 158
35GWP42003-P 20 mg/kg/day Dose----2件: 140, 144
36Inovelon1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
37Investigators Choice of Approved AED----1件: 144
38Investigators choice of approved AEDs----1件: 144
39Lamictal1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
40Lamotrigine1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬5件: 13, 34, 38, 114, 144
41LP352----2件: 140, 144
42MIC----2件: 140, 144
43PEG----15件: 6, 13, 41, 46, 60, 65, 78, 96, 97, 140, 144, 240, 246, 299, 337
44Perampanel1件: Perampanel1件: D08964 4件: GRIA1,
GRIA2,
GRIA3,
GRIA4 💬
16件: Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬3件: 2, 6, 144
45Placebo----28件: 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
46Potiga1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
47RETIGABINE1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬2件: 2, 144
48RETIGABINE/EZOGABINE1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
49RUFINAMIDE1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
50Rufinamide (E2080)1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
51Rufinamide oral suspension1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
52Sodio valproato----1件: 144
53SOTICLESTAT1件: Soticlestat1件: D11590 1件: CYP46A1 💬1件: Primary bile acid biosynthesis 💬2件: 140, 144
54TAK-935----2件: 140, 144
55Topimarate----1件: 144
56Topimarato----1件: 144
57TOPIRAMATE1件: Topiramate1件: D00537 36件: CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
53件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 6, 97, 140, 144, 156, 193
58Turmeric1件: Turmeric---4件: 140, 144, 158, 299
59ZX008----2件: 140, 144
60ZX008 (Fenfluramine Hydrochloride)1件: Fenfluramine1件: D07945 5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬
10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144
61ZX008 0.2 or 0.8 mg/kg/day----1件: 144
62ZX008 0.2 to 0.8 mg/kg/day----2件: 140, 144