Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CHRM1 8件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton, Alzheimer disease, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine 1件: 254
2 CHRM2 6件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton D00270 Chlorpromazine 1件: 254
3 CHRM3 11件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine 1件: 254
4 CHRM4 3件: Neuroactive ligand-receptor interaction, Cholinergic synapse, Regulation of actin cytoskeleton D00270 Chlorpromazine 1件: 254
5 CHRM5 6件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Regulation of actin cytoskeleton, Alzheimer disease, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine 1件: 254
6 ADRA2A 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction D00270 Chlorpromazine 1件: 254
7 ADRA2B 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction D00270 Chlorpromazine 1件: 254
8 ADRA2C 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction D00270 Chlorpromazine 1件: 254
9 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00270 Chlorpromazine 1件: 254
10 ALAS1 4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors D10003 Hemin 1件: 254
11 ALAS1 4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors D11702 Givosiran 1件: 254
12 ALAS2 4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors D10003 Hemin 1件: 254
13 HMOX1 10件: Porphyrin metabolism, Metabolic pathways, HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis D05922 Stannsoporfin 1件: 254
14 HMOX2 3件: Porphyrin metabolism, Metabolic pathways, Mineral absorption D05922 Stannsoporfin 1件: 254
15 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
16 HRH2 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion D00295 Cimetidine 2件: 2, 254
17 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
18 HTR2B 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
19 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
20 MC1R 2件: Neuroactive ligand-receptor interaction, Melanogenesis D10511 Afamelanotide 3件: 159, 161, 254