149. 片側痙攣・片麻痺・てんかん症候群 Hemiconvulsion hemiplegia epilepsy syndrome Clinical trials / Disease details
臨床試験数 : 25 / 薬物数 : 35 - (DrugBank : 13) / 標的遺伝子数 : 16 - 標的パスウェイ数 : 22
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05615987 (ClinicalTrials.gov) | December 1, 2022 | 2/11/2022 | Comparison of Botulinum Toxin Injection Techniques in Spasticity | Comparison of the Efficacy of 2 Different Botulinum Toxin Injection Techniques in Gastrocnemius Muscle Spasticity in Hemiplegic Patients: A Randomized Double-blind Controlled Study. | Spastic Hemiplegia | Drug: Onabotulinumtoxina for Injection | Konya Beyhekim Training and Research Hospital | NULL | Not yet recruiting | 18 Years | 90 Years | All | 60 | Phase 4 | Turkey |
| 2 | NCT05260125 (ClinicalTrials.gov) | March 15, 2022 | 18/2/2022 | Comparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke Patients | Comparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke Patients With Hemiplegic Shoulder Pain. | Hemiplegia;Stroke | Drug: Ultrasound-guided Suprascapular Nerve Block;Drug: Anatomical Landmark-guided Suprascapular Nerve Block | Abant Izzet Baysal University | NULL | Recruiting | 25 Years | 75 Years | All | 50 | Phase 4 | Turkey |
| 3 | ChiCTR2000040083 | 2021-01-01 | 2020-11-20 | Effect of Taiji Cloud Hand Visual Feedback Training on Balance Function of Stroke Patients with Subacute Hemiplegia | Effect of Taiji Cloud Hand Visual Feedback Training on Balance Function of Stroke Patients with Subacute Hemiplegia | Stroke | Experimental group:Summative Visual Feedback Taiji Cloud Hand Training;Control Group:Summative Visual Feedback Standing Balance Training; | Shanghai Baoshan district Renhe hospital | NULL | Pending | 40 | 70 | Both | Experimental group:45;Control Group:45; | China | |
| 4 | JPRN-UMIN000042549 | 2020/12/01 | 25/11/2020 | Effect of neuromuscular electrical stimulation therapy on anticipatory postural adjustments in patients with stroke hemiplegia | Effect of neuromuscular electrical stimulation therapy on anticipatory postural adjustments in patients with stroke hemiplegia - Effect of neuromuscular electrical stimulation therapy on anticipatory postural adjustments in patients with stroke hemiplegia | Post-Stroke Hemiplegic Patients | In addition to standard physiotherapy (flexibility increase, muscle strengthening, balance exercise, walking exercise), center of gravity movement exercise and step exercise using IVES (tibialis anterior muscle, soleus muscle stimulation) are performed for 2 groups of subjects. One session is 20 minutes, 3 times a week for a total of 2 weeks. | Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University | NULL | Pending | 45years-old | 85years-old | Male and Female | 20 | Not selected | Japan |
| 5 | NCT04630873 (ClinicalTrials.gov) | November 20, 2020 | 31/10/2020 | Low or High Botox Dilution for the Hemiplegic Gait? | Different Dilutions and Efficacy of Botulin Toxin in the Correction of the Hemiplegic Gait | Post Stroke Spastic Hemiplegia | Drug: Botulinum toxin;Diagnostic Test: gait analysis | University of Ioannina | NULL | Recruiting | 18 Years | N/A | All | 20 | Phase 1 | Greece |
| 6 | JPRN-JapicCTI-194958 | 01/10/2019 | 18/09/2019 | A pharmacokinetic, safety, and tolerability study of padsevonil in CYP2C19 genotyped healthy male Japanese study participants. | An Open-Label, Parallel Group, Single-Center Study to Investigate the Pharmacokinetic, Safety, and Tolerability Profiles of Padsevonil in CYP2C19 Genotyped Healthy Male Japanese Study Participants | Epilepsy and epilepsy syndrome | Intervention name : padsevonil INN of the intervention : padsevonil Dosage And administration of the intervention : Oral administration Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 20 | 55 | Male | 39 | Phase 1 | Japan |
| 7 | JPRN-JapicCTI-194633 | 05/6/2019 | 15/02/2019 | A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled Study of T-817MA in Post-stroke Patients Undergoing Rehabilitation for Upper Limb Hemiplegia | A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled Study of T-817MA in Post-stroke Patients Undergoing Rehabilitation for Upper Limb Hemiplegia | Patients with upper limb hemiplegia after cerebral infarction or cerebral hemorrhage (other than subarachnoid hemorrhage) | Intervention name : T-817MA INN of the intervention : Edonerpic Dosage And administration of the intervention : Oral Multiple Dose Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | FUJIFILM Toyama Chemical Co., Ltd | NULL | complete | 20 | 84 | BOTH | 65 | Phase 2 | Japan |
| 8 | JPRN-jRCTs042190020 | 03/05/2019 | 22/04/2019 | The Effectiveness of BEAR for hemiplegic patients | The Effectiveness of Balance Exercise Assist Robot for convalescent patients with hemiplegia after stroke - EBEARCPHAS | Stroke | Using Balance Exercise Assist Robot | Otaka Yohei | NULL | Recruiting | >= 20age old | < 90age old | Both | 60 | N/A | Japan |
| 9 | JPRN-JapicCTI-184137 | 04/1/2019 | 03/10/2018 | A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam as Replaement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age with Partial Seizures With or Without Secondary Generalization | A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam as Replaement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age with Partial Seizures With or Without Secondary Generalization | Epilepsy and epilepsy syndrome | Intervention name : brivaracetam INN of the intervention : brivaracetam Dosage And administration of the intervention : Intravenous (iv) injection Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 16 | BOTH | 10 | Phase 3 | Japan | |
| 10 | JPRN-UMIN000035315 | 2018/12/19 | 19/12/2018 | Verification of effectiveness of sitting training equipment using virtual reality for patients with stroke hemiplegia | Verification of effectiveness of sitting training equipment using virtual reality for patients with stroke hemiplegia - Verification of effectiveness of sitting training equipment using virtual reality for patients with stroke hemiplegia | stroke | Virtual reality by viewing spatial gradient | Waseda University | NULL | Pending | 20years-old | 80years-old | Male and Female | 10 | Not selected | Japan |
| 11 | NCT03857607 (ClinicalTrials.gov) | September 1, 2018 | 26/2/2019 | Natural History Study of ATP1A3-related Disease | Natural History of ATP1A3-related Disease: a Deep Phenotyping-genotyping Project | ATP1A3-related Disease;Alternating Hemiplegia of Childhood;Rapid Onset Dystonia Parkinsonism;CAPOS | Genetic: Whole exome sequencing | Institute of Child Health | Great Ormond Street Hospital for Children NHS Foundation Trust;University College, London | Recruiting | 6 Months | 60 Years | All | 100 | United Kingdom | |
| 12 | NCT03860662 (ClinicalTrials.gov) | May 26, 2018 | 8/2/2019 | The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex | Doctor, Physical Medicine and Rehabilitation | Stroke Sequelae;Spastic Hemiplegia | Diagnostic Test: Nociceptor flexor reflex;Drug: Botox;Drug: Baclofen | Mustafa Kemal University | NULL | Completed | 18 Years | 60 Years | All | 29 | Phase 4 | Turkey |
| 13 | JPRN-JapicCTI-173615 | 22/8/2017 | 15/06/2017 | A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam Subjects (>=16 to 80 Years of Age) With Partial Seizures With or Without Secondary Generalization | A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam Subjects (>=16 to 80 Years of Age) With Partial Seizures With or Without Secondary Generalization | Epilepsy and epilepsy syndrome | Intervention name : ucb 34714 INN of the intervention : Brivaracetam Dosage And administration of the intervention : Oral administration Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | recruiting | 16 | 80 | BOTH | 444 | Phase 3 | Japan, Asia except Japan |
| 14 | JPRN-JapicCTI-173687 | 05/8/2017 | 21/08/2017 | An Open-Label, Multicenter, Follow-up Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization | An Open-Label, Multicenter, Follow-up Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization | Epilepsy and epilepsy syndrome | Intervention name : brivaracetam INN of the intervention : brivaracetam Dosage And administration of the intervention : Oral administration Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | recruiting | 16 | BOTH | 214 | Phase 3 | Japan, Asia except Japan | |
| 15 | JPRN-JapicCTI-153104 | 18/3/2016 | 22/12/2015 | AN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | AN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | Epilepsy and epilepsy syndrome | Intervention name : SPM927 INN of the intervention : Lacosamide Dosage And administration of the intervention : oral administration Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 4 | BOTH | 239 | Phase 3 | Japan, Asia except Japan, North America, Europe, Oceania | |
| 16 | JPRN-JapicCTI-153103 | 08/12/2015 | 22/12/2015 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY | Epilepsy and epilepsy syndrome | Intervention name : SPM927 INN of the intervention : Lacosamide Dosage And administration of the intervention : oral administration Control intervention name : Placebo INN of the control intervention : - Dosage And administration of the control intervention : - | UCB Japan Co., Ltd. | NULL | complete | 4 | BOTH | 242 | Phase 3 | Japan, Asia except Japan, North America, Europe, Oceania | |
| 17 | NCT02455232 (ClinicalTrials.gov) | May 2015 | 7/5/2015 | Determine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic Patients | Determine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic Patients | Hemiplegia | Procedure: upper limb muscle block;Drug: 4cc of lidocaïne® | Centre d'Investigation Clinique et Technologique 805 | NULL | Completed | 18 Years | 75 Years | All | 20 | N/A | France |
| 18 | NCT02408354 (ClinicalTrials.gov) | April 15, 2015 | 24/3/2015 | Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of Childhood | Etude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant HEMIHEP | Alternating Hemiplegia of Childhood | Drug: Triheptanoin;Drug: Placebo | Institut National de la Santé Et de la Recherche Médicale, France | NULL | Completed | 15 Years | N/A | All | 10 | Phase 2 | France |
| 19 | ChiCTR-ICR-15007022 | 2014-05-01 | 2015-09-06 | A research of biomechanic stimulation and healing of hemiplegia gait | A research of biomechanic stimulation and healing of hemiplegia gait | stroke | botulinum toxin A type group:inject botulinum toxin A type;conventional treatment A group :conventional treatment;Dynamic electrical stimulation treatment group:Dynamic electrical stimulation;conventional treatment B group :conventional treatment;blank control group:null;validation group :botulinum toxin A type ; | Nanjing Sports Institude | NULL | Recruiting | 40 | 70 | Both | botulinum toxin A type group:30;conventional treatment A group :30;Dynamic electrical stimulation treatment group:30;conventional treatment B group :30;blank control group:30;validation group :30; | China | |
| 20 | NCT01623622 (ClinicalTrials.gov) | July 2012 | 18/6/2012 | Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke | A Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After Stroke | Severe Upper Limb Hemiplegia | Drug: HC-58;Drug: Placebo | Asahi Kasei Pharma Corporation | NULL | Completed | 20 Years | N/A | All | 270 | Phase 2 | Japan |
| 21 | EUCTR2009-015620-29-BE (EUCTR) | 08/03/2010 | 09/02/2010 | The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance. | The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance. | The main objective of this study is to investigate the effect of Botulinum toxin A to improve the Upper Limb dysfunction in Hemiplegic Cerebral Palsy Children and in particular, its impact on Upper limb activity performance and how this might be translate in bimanual activities. MedDRA version: 12.0;Level: LLT;Classification code 10019475;Term: Hemiplegic infantile cerebral palsy | Trade Name: BOTOX Product Name: BOTOX Product Code: 9060X Other descriptive name: BOTULINUM TOXIN TYPE A | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 30 | Belgium | ||||
| 22 | NCT00931164 (ClinicalTrials.gov) | August 2009 | 30/6/2009 | Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO) | Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial) | Alternating Hemiplegia of Childhood | Drug: Sodium Oxybate | University of Utah | Alternating Hemiplegia of Childhood Foundation;Jazz Pharmaceuticals | Completed | 6 Months | 25 Years | All | 6 | Phase 1/Phase 2 | United States |
| 23 | NCT00632528 (ClinicalTrials.gov) | March 2008 | 28/2/2008 | MEOPA to Improve Physical Therapy Results After Multilevel Surgery | Evaluation of the Efficacy of MEOPA Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. | Cerebral Palsy;Spastic Diplegia;Quadriplegia;Hemiplegia | Drug: MEOPA;Drug: Medicinal air | Assistance Publique - Hôpitaux de Paris | NULL | Completed | 6 Years | 20 Years | All | 64 | Phase 3 | France |
| 24 | NCT00276185 (ClinicalTrials.gov) | December 2005 | 12/1/2006 | HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke | Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke | Hemiplegia | Drug: Time delay treatment of botulinum toxin | University Hospital, Clermont-Ferrand | J. Rebeyrol Hospital in Limoges;Rennes University Hospital;Center of Physical Medicine and Rehabilitation (Notre Dame de Lourdes Center in Rennes);Saint Jacques Hospital in Nantes;Centre Hospitalier Universitaire de Saint Etienne;Centre Régional de Département de médecine physique et réadaptation CHU-C3RF in Angers;Centre Hospitalier Universitaire de Besancon | Recruiting | 18 Years | N/A | Both | 180 | Phase 3 | France |
| 25 | EUCTR2011-004114-42-BE (EUCTR) | 06/04/2021 | Fenfluramine as anti-epilepticum in a difficult to treat epilepsy syndrome. | Fenfluramine as anti-epilepticum in Dravet syndrome. | Fenfluramine is an amphetamine which was in the past used as anorexigan. Their are a few publications of effectivness of this medication in epilepsy.We want to investigate was is the exact place of fenfluramine in the treatment of a therapy resitant epilepsy named Dravet syndrome. MedDRA version: 21.0;Level: PT;Classification code 10015037;Term: Epilepsy;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Product Name: fenfluramine INN or Proposed INN: FENFLURAMINE | University Hospital Antwerp | NULL | NA | Female: yes Male: yes | 50 | Phase 3 | Belgium |