DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト）

A　B　C　D　E　F　G　H　 I 　J　K　L　M　N　O　P　Q　R　S　T　U　V　W　X　Y　Z　other

62 / 275 pathways found* Show info (disease name, etc.) on mouse-over.

No.	KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related	KEGG GENES *	KEGG DRUG *	DrugBank	指定難病告示番号 *
1	Adherens junction 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
2	Alcoholism 2 genes, 4 drugs (DrugBank) and 5 diseases shown	2件: DRD1, DRD2	D00633	Dopamine	3件: 6, 7, 74
			D07870
		1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
			D00784	Ropinirole	3件: 6, 74, 309
			D08489
3	Amphetamine addiction 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: DRD1	D00633	Dopamine	3件: 6, 7, 74
			D07870
4	Bladder cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
5	Breast cancer 4 genes, 2 drugs (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		2件: ESR1, ESR2	D00962	Clomifene	1件: 74
			D07726
6	Calcium signaling pathway 4 genes, 2 drugs (DrugBank) and 5 diseases shown	2件: DRD1, DRD5	D00633	Dopamine	3件: 6, 7, 74
			D07870
		2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
7	cAMP signaling pathway 6 genes, 5 drugs (DrugBank) and 6 diseases shown	3件: DRD1, DRD2, DRD5	D00633	Dopamine	3件: 6, 7, 74
			D07870
		1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
			D00784	Ropinirole	3件: 6, 74, 309
			D08489
		3件: SSTR1, SSTR2, SSTR5	D10147	Pasireotide	3件: 67, 74, 75
8	Central carbon metabolism in cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
9	Choline metabolism in cancer 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
10	Cocaine addiction 2 genes, 4 drugs (DrugBank) and 5 diseases shown	2件: DRD1, DRD2	D00633	Dopamine	3件: 6, 7, 74
			D07870
		1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
			D00784	Ropinirole	3件: 6, 74, 309
			D08489
11	Colorectal cancer 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
12	Cushing syndrome 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
13	Cytokine-cytokine receptor interaction 2 genes, 3 drugs (DrugBank) and 19 diseases shown	1件: GHR	D02691	Somatotropin	18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299
		1件: PRL	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
14	Dopaminergic synapse 5 genes, 4 drugs (DrugBank) and 5 diseases shown	5件: DRD1, DRD2, DRD3, DRD4, DRD5	D00633	Dopamine	3件: 6, 7, 74
			D07870
		1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
		3件: DRD2, DRD3, DRD4	D00784	Ropinirole	3件: 6, 74, 309
			D08489
15	EGFR tyrosine kinase inhibitor resistance 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
16	Endocrine and other factor-regulated calcium reabsorption 1 gene, 1 drug (DrugBank) and 1 disease shown	1件: ESR1	D00962	Clomifene	1件: 74
			D07726
17	Endocrine resistance 4 genes, 2 drugs (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		2件: ESR1, ESR2	D00962	Clomifene	1件: 74
			D07726
18	Endocytosis 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
19	Endometrial cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
20	Epithelial cell signaling in Helicobacter pylori infection 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
21	ErbB signaling pathway 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
22	Estrogen signaling pathway 3 genes, 2 drugs (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		2件: ESR1, ESR2	D00962	Clomifene	1件: 74
			D07726
23	Focal adhesion 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
24	FoxO signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
25	Gap junction 3 genes, 5 drugs (DrugBank) and 6 diseases shown	2件: DRD1, DRD2	D00633	Dopamine	3件: 6, 7, 74
			D07870
		1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
			D00784	Ropinirole	3件: 6, 74, 309
			D08489
		1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
26	Gastric acid secretion 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: SSTR2	D10147	Pasireotide	3件: 67, 74, 75
27	Gastric cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
28	Glioma 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
29	GnRH secretion 1 gene, 1 drug (DrugBank) and 1 disease shown	1件: ESR2	D00962	Clomifene	1件: 74
			D07726
30	GnRH signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
31	Growth hormone synthesis, secretion and action 5 genes, 2 drugs (DrugBank) and 19 diseases shown	1件: GHR	D02691	Somatotropin	18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299
		4件: SSTR1, SSTR2, SSTR3, SSTR5	D10147	Pasireotide	3件: 67, 74, 75
32	Hepatitis C 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
33	Hepatocellular carcinoma 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
34	HIF-1 signaling pathway 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
35	Human cytomegalovirus infection 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
36	Human papillomavirus infection 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
37	JAK-STAT signaling pathway 3 genes, 4 drugs (DrugBank) and 20 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		1件: GHR	D02691	Somatotropin	18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299
		1件: PRL	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
38	MAPK signaling pathway 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
39	Melanoma 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
40	MicroRNAs in cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
41	Morphine addiction 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: DRD1	D00633	Dopamine	3件: 6, 7, 74
			D07870
42	Neuroactive ligand-receptor interaction 12 genes, 7 drugs (DrugBank) and 36 diseases shown	5件: DRD1, DRD2, DRD3, DRD4, DRD5	D00633	Dopamine	3件: 6, 7, 74
			D07870
		3件: DRD2, DRD3, DRD4	D00784	Ropinirole	3件: 6, 74, 309
			D08489
		2件: DRD2, PRL	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
		1件: GHR	D02691	Somatotropin	18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299
		1件: NR3C1	D00292	Dexamethasone	20件: 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299
			D00975
			D01510
			D01615
			D01632
			D01948
			D02174
			D02591
			D02592
		4件: SSTR1, SSTR2, SSTR3, SSTR5	D10147	Pasireotide	3件: 67, 74, 75
43	Non-small cell lung cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
44	Oxytocin signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
45	Pancreatic cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
46	Parathyroid hormone synthesis, secretion and action 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
47	Parkinson disease 2 genes, 4 drugs (DrugBank) and 5 diseases shown	2件: DRD1, DRD2	D00633	Dopamine	3件: 6, 7, 74
			D07870
		1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
			D00784	Ropinirole	3件: 6, 74, 309
			D08489
48	Pathways in cancer 4 genes, 2 drugs (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		2件: ESR1, ESR2	D00962	Clomifene	1件: 74
			D07726
49	PD-L1 expression and PD-1 checkpoint pathway in cancer 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
50	Phospholipase D signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
51	PI3K-Akt signaling pathway 4 genes, 4 drugs (DrugBank) and 20 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		1件: GHR	D02691	Somatotropin	18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299
		1件: PRL	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
52	Platinum drug resistance 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
53	Prolactin signaling pathway 3 genes, 3 drugs (DrugBank) and 3 diseases shown	2件: ESR1, ESR2	D00962	Clomifene	1件: 74
			D07726
		1件: PRL	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
54	Prostate cancer 2 genes, 1 drug (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
55	Proteoglycans in cancer 3 genes, 2 drugs (DrugBank) and 3 diseases shown	2件: EGFR, ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108
		1件: ESR1	D00962	Clomifene	1件: 74
			D07726
56	Rap1 signaling pathway 2 genes, 5 drugs (DrugBank) and 6 diseases shown	1件: DRD2	D00780	Bromocriptine	2件: 6, 74
			D03165
			D00987	Cabergoline	3件: 6, 74, 75
			D00633	Dopamine	3件: 6, 7, 74
			D07870
			D00784	Ropinirole	3件: 6, 74, 309
			D08489
		1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
57	Ras signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
58	Regulation of actin cytoskeleton 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
59	Relaxin signaling pathway 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
60	Shigellosis 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: EGFR	D04024	Lapatinib	3件: 34, 74, 75
			D08108
61	Thyroid hormone signaling pathway 1 gene, 1 drug (DrugBank) and 1 disease shown	1件: ESR1	D00962	Clomifene	1件: 74
			D07726
62	Tight junction 1 gene, 1 drug (DrugBank) and 3 diseases shown	1件: ERBB2	D04024	Lapatinib	3件: 34, 74, 75
			D08108

先頭へ