Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1100 mg ELX (VX-445) / 50 mg TEZ / 75 mg IVA FDC----1件: 299 💬
2100 mg ELX /50 mg TEZ /75 mg IVA FDC----1件: 299 💬
3100 mg ELX/50 mg TEZ /75 mg IVA FDC----1件: 299 💬
4100 mg ELX/50 mg TEZ/75 mg IVA fixed dose combination----1件: 299 💬
5100 mg TEZ/150 mg IVA FDC----1件: 299 💬
6100 mg VX-445 /50 mg TEZ/75 mg IVA FDC----1件: 299 💬
7100 mg VX-445/50 mg TEZ /75 mg IVA FDC----1件: 299 💬
8100-mg ELX (VX-445) / 50-mg TEZ / 75-mg IVA FDC----1件: 299 💬
9100-mg ELX (VX-455) / 50-mg TEZ / 75-mg IVA FDC----1件: 299 💬
10100-mg ELX / 50-mg TEZ / 75 -mg IVA FDC----1件: 299 💬
11100-mg VX-445 / 50-mg TEZ / 75- mg IVA FDC----1件: 299 💬
12100-mg VX-445 / 50-mg TEZ / 75-mg IVA FDC----1件: 299 💬
13100-mg VX-445/50-mg TEZ/75-mg IVA FDC----1件: 299 💬
14100g ELX / 50mg TEZ / 75mg IVA----1件: 299 💬
15100mg ELX/50mg TEZ /75mg IVA----1件: 299 💬
16100mg VX-445/50mg TEZ /75mg IVA FDC----1件: 299 💬
17150-mg IVACAFTOR1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
18150mg IVACAFTOR1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
1950 mg ELX/25 mg TEZ/37.5 mg IVA----1件: 299 💬
2050 mg ELX/25 mg TEZ/37.5 mg IVA fixed dose combination----1件: 299 💬
2175-mg IVACAFTOR1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
2280mg ELX / 40mg TEZ / 60mg IVA----1件: 299 💬
23CF patients with a G551D mutation and treated with Ivacaftor1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
24D-IVA----1件: 299 💬
25Deuterated Ivacaftor1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
26Elexacaftor / Ivacaftor / Tezacaftor3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
27Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
28Elexacaftor-tezacaftor-ivacaftor exposure3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
29Elexacaftor/tezacaftor/ivacaftor3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
30ELX (VX-445)/TEZ (VX-661)/IVA (VX-770)----1件: 299 💬
31ELX/TEZ/IVA----1件: 299 💬
32IVA----1件: 299 💬
33IVA 336----1件: 19 💬
34IVA337----1件: 51 💬
35IVACAFTOR1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
36Ivacaftor (proposed INN)1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
37Ivacaftor 125mg tablet1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
38Ivacaftor 150 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
39Ivacaftor 150 mg or 250 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
40Ivacaftor 25 mg/75 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
41IVACAFTOR 59,5mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
42IVACAFTOR 59.5mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
43Ivacaftor 75 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
44Ivacaftor 75 mg/150 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
45IVACAFTOR 75mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
46Ivacaftor Exposed1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
47Ivacaftor or elexacaftor/tezacaftor/ivacaftor3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
48Ivacaftor+lumacaftor2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
49Ivacaftor/Ataluren2件: Ataluren,
Ivacaftor		2件: Ataluren ,
Ivacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
50Ivacaftor/Kalydeco1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
51Ivacaftor/Trikafta3件: Elexacaftor,
Ivacaftor,
Tezacaftor		3件: Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
52LUM/IVA----1件: 299 💬
53LUM/IVA fixed-dose combination----1件: 299 💬
54Lumacaftor / ivacaftor2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
55Lumacaftor plus Ivacaftor2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
56Lumacaftor Plus Ivacaftor Combination2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
57Lumacaftor, Ivacaftor Drug Combination2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
58Lumacaftor-ivacaftor2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
59Lumacaftor-Ivacaftor treatment2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
60Lumacaftor/Ivacaftor2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
61Lumacaftor/ivacaftor 100mg/125mg tablets2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
62Lumacaftor/ivacaftor 200mg/125mg2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
63Lumacaftor/ivacaftor 200mg/125mg tablets2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
64Lumacaftor/ivacaftor 200mg/83mg tablet2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
65Orkambi: contains lumacaftor and ivacaftor2件: Ivacaftor,
Lumacaftor		2件: Ivacaftor ,
Lumacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
66TEZ/IVA----1件: 299 💬
67Tezacaftor/Ivacaftor2件: Ivacaftor,
Tezacaftor		2件: Ivacaftor ,
Tezacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
68Tezacaftor/Ivacaftor + Ivacaftor2件: Ivacaftor,
Tezacaftor		2件: Ivacaftor ,
Tezacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
69Tezacaftor/Ivacaftor 100mg/150mg2件: Ivacaftor,
Tezacaftor		2件: Ivacaftor ,
Tezacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
70Tezacaftor/Ivacaftor/100mg/150mg2件: Ivacaftor,
Tezacaftor		2件: Ivacaftor ,
Tezacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
71Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor4件: Elexacaftor,
Ivacaftor,
Lumacaftor,
Tezacaftor		4件: Ivacaftor ,
Lumacaftor ,
Tezacaftor ,
Elexacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
72VX-121/TEZ/D-IVA----1件: 299 💬
73VX-445 / TEZ / IVA----1件: 299 💬
74VX-445 / TEZ / IVA FDC----1件: 299 💬
75VX-445 /TEZ/IVA----1件: 299 💬
76VX-445/TEZ/IVA----1件: 299 💬
77VX-659/ TEZ/IVA1件: VX-659---1件: 299 💬
78VX-659/TEZ/IVA1件: VX-659---1件: 299 💬
79VX-659/Tezacaftor/Ivacaftor3件: Ivacaftor,
Tezacaftor,
VX-659		2件: Ivacaftor ,
Tezacaftor 💬		1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
80VX-661 Plus Ivacaftor Combination1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
81VX-661/Ivacaftor1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
82VX-661/ivacaftor (VX-770) 100mg/150 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
83VX-661/ivacaftor 100 mg/ 150 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
84VX-661/ivacaftor 100mg/150 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
85VX-661/ivacaftor 100mg/150mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
86VX-661/ivacaftor 50 mg/ 75 mg1件: Ivacaftor1件: Ivacaftor 💬1件: CFTR 💬8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬1件: 299 💬
87VX-661/VX-770 (TEZ/IVA)----1件: 299 💬