Searched query = "Primary nephrotic syndrome", "Minimal change nephrotic syndrome", "MCNS", "Membranous nephropathy", "Focal segmental glomerulosclerosis", "FSGS", "Membranoproliferative glomerulonephritis", "MPGN"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
|June 2020||7/6/2020||Multitarget Therapy for Idiopathic Membranous Nephropathy||Multitarget Therapy for Idiopathic Membranous Nephropathy||Efficacy||Drug: Prednisone, ciclosporin and mycophenolate mofetil;Drug: Ponticelli Regimen||Beijing Friendship Hospital||NULL||Not yet recruiting||18 Years||70 Years||All||78||Phase 4||China|
|2||JPRN-UMIN000001099||2007/10/01||31/03/2008||Optimal use of ciclosporin in idiopathic membranous nephropathy associated with nephrotic syndrome||idiopathic membranous nephropathy associated with nephrotic syndrome||Steroid group: Immunosuppressive therapy is started by predonisolone 0.8mg/kg/day (max 60mg/day). The dose is decreased by 5mg/day in 2 to 4 weeks after remission. The cases who do not reach remission for 4 weeks, predonisolone is decreased to 0.6mg/kg/day, and ciclosporin (2mg/kg/day) is started once a day. Serum concentration of ciclosporin is measured 2hr after administration, and the dose is adjusted. (The target serum concentration is 800-1000ng/mL.)|
Steroid + ciclosporin group: Immunosupressive therapy is started by predonisolone 0.6mg/kg/day and ciclosporin 2mg/kg/day (once a day). Serum concentration of ciclosporin is measured 2hr after administration, and the dose is adjusted. (The target serum concentration is 800-1000ng/mL.) The dose of predonisolone is decreased by 5mg/day in 2 to 4 weeks after remission. Ciclosporin is continued after remission. (The target C2 is 600-800 ng/mL.) The cases who do not reach remission after 4 weeks, predonisolone is decreased by 5mg/4-8week, and ciclosporin is continued for 6 months. The target C2 is 800-1000ng/mL. At 6 months after, the therapy of non-respnder is not restricted.
|Division of Kidney and Dialysis, Department of Internal Medicine,Hyogo College of Medicine||NULL||16years-old||Not applicable||Male and Female||50||Phase 4||Japan|