6. パーキンソン病 [臨床試験数:2,123,薬物数:2,046(DrugBank:324),標的遺伝子数:183,標的パスウェイ数:198

Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
14 trials found
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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agemax
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PhaseCountries
1ChiCTR20000389372020-11-012020-10-10Clinical study of early diagnosis of Parkinson's disease based on substantia nigra-striatal axis multimodal imagingClinical study of early diagnosis of Parkinson's disease based on substantia nigra-striatal axis multimodal imaging Parkinson's diseaseGold Standard:Clinical diagnosis by experienced movement disorder specialists after 2 years of follow-up.;Index test:Including traditional imaging feature algorithms (SUVR value, total cortical volume, bilateral cortical surface area, cortical thickness, etc.), high-dimensional imaging omics feature algorithms (energy entropy, gray-level co-occurrence matrix, and mutual information, etc.), and brain connection group Learning feature algorithm.;Huashan Hospital, Fudan UniversityNULLRecruiting4580BothTarget condition:105;Difficult condition:0China
2ChiCTR20000378562020-10-012020-09-02Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA) Parkinson's DiseaseGold Standard:DAT-PET and 18F-FDG PET ;Index test:a-synuclein protein misfolding cyclic amplification;Huashan Hospital Affiliated to Fudan UniversityNULLRecruiting5075BothTarget condition:150;Difficult condition:76China
3ChiCTR20000372392020-10-012020-08-27Construction and application of a diagnostic marker for Parkinson's disease based on gut microbiomicsConstruction and application of a diagnostic marker for Parkinson's disease based on gut microbiomics Parkinson's diseaseGold Standard:All patients satisfied the United Kingdom Parkinson's Disease Society Brain Bank criteria;Index test:Microbial gene detection chip;Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNULLRecruiting5580BothTarget condition:500;Difficult condition:600China
4ChiCTR20000361372020-10-012020-08-21Clinical study of 18F-FDG combined with 18F-AV-133 PET/CT imaging in the diagnosis and differentiation of primary Parkinson's diseaseClinical study of 18F-FDG combined with 18F-AV-133 PET/CT imaging in the diagnosis and differentiation of primary Parkinson's disease Parkinson’s diseaseGold Standard:UK Parkinson's disease Society Brain Bank Clinical Diagnosis Criteria;Index test:18F-FDG combined with 18F-AV-133 PET/CT imaging;Renji Hospital (South Court), School of Medicine, Shanghai Jiao Tong UniversityNULLPendingBothTarget condition:50;Difficult condition:0China
5ChiCTR20000360062020-10-012020-08-21The applications of multi- MRI in early diagnosis of Parkinson's Disease based on deep learningThe applications of multi- MRI in early diagnosis of Parkinson's Disease based on deep learning Parkinson's diseaseGold Standard:MDS clinical diagnostic criteria for Parkinson’s disease;Index test:multimodal MRI features in locus coeruleus and substantia nigra;Zhongshan Hospital, Fudan UniversityNULLPending1885BothTarget condition:400;Difficult condition:0China
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
6ChiCTR20000326162020-05-302020-05-04Assistant diagnosis machinery system development based on speech and movement sensitive device for Parkinson's diseaseParkinson's disease, Assistant diagnosis machinery system, speech, movement sensitive device Parkinson's diseaseGold Standard:clinical outcome meet 2015 MDS-probable PD criteria;Index test:Acoustic receptive and analysis device,Wearable movement sensor;Shanghai Jiao Tong University School of Medicine affiliated Shanghai General HospitalNULLPendingBothTarget condition:20;Difficult condition:80China
7NCT03815916December 19, 201918/1/201931P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Parkinson's DiseaseA Phase 2, Pilot Open Label, Sequential Group, Investigator Blinded Study of Magnetic Resonance Spectroscopy (31P-MRS) to Assess the Effects of CNM-Au8 for the Bioenergetic Improvement of Impaired Neuronal Redox State in Parkinson's DiseaseParkinson's DiseaseDrug: Gold NanocrystalsClene NanomedicineUniversity of Texas Southwestern Medical CenterRecruiting30 Years80 YearsAll30Phase 2United States
8ChiCTR19000273062019-11-152019-11-08Application of optical coherence tomography and detection of a-synuclein in tears in the diagnosis of Parkinson's diseaseMorphological changes of retina in patients with Parkinson's disease and the role of a-synuclein in retinal damage Parkinson's diseaseGold Standard:British brain bank Parkinson's disease diagnostic criteria;Index test:Application of optical coherence tomography to observe the retinal structure of the macular area, optic disc area and the expression level of a-synuclein in tears in the diagnosis of Parkinson's disease.;The First Affiliated Hospital of Chengdu Medical CollegeNULLRecruitingBothTarget condition:85;Difficult condition:85China
9ChiCTR18000157572019-04-012018-04-18Value of 131I-MIBG salivary gland imaging in the early diagnosis of Parkinson's diseaseValue of 131I-MIBG salivary gland imaging in the early diagnosis of Parkinson's disease Parkinson's DiseaseGold Standard:PD diagnostic criteria made by MDS in 2016;Index test:reduced uptake in salivery gland and myocardium in I-131-MIBG scintigraphic imaging;Tongji hospital, Tongji UniversityNULLPendingBothTarget condition:30;Difficult condition:30China
10ChiCTR-DDD-160095692017-01-012016-10-24Differential diagnosis of primary Parkinson's disease by 18F-FDG combined with 11C-ß-CFT PET / CT imagingDifferential diagnosis of primary Parkinson's disease by 18F-FDG combined with 11C-ß-CFT PET / CT imaging Parkinson's DiseaseGold Standard:;Index test:;Renji hospital, School of Medicine, Shanghai Jiao Tong UniversityNULLPending2080BothTarget condition:0;Difficult condition:0China
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
11ChiCTR-DOC-160086452016-07-012016-06-15The study of radionuclide imaging and biomarkers in clinical diagnosis and treatment of Parkinson's diseaseThe study of radionuclide imaging and biomarkers in clinical diagnosis and treatment of Parkinson's disease Parkinson DiseaseGold Standard:;Index test:;101th Hospital of PLANULLPending1880BothTarget condition:0;Difficult condition:0NULL
12ChiCTR-DRD-160087782016-07-012016-07-04The study of Parkinson's disease imaging biomarkers based on MR with high resolution and multi modeThe study of Parkinson's disease imaging biomarkers based on MR with high resolution and multi mode Parkinson`s DiseaseGold Standard:;Index test:;Xiangyang Hospital, Hubei University of MedicineNULLRecruitingBothTarget condition:0;Difficult condition:0China
13ChiCTR-DOD-150060972015-03-182015-03-16The diagnostic value of olfactory-evoked potentials in Parkinson'sdiseaseThe diagnostic value of olfactory-evoked potentials in Parkinson'sdisease Parkinson's diseaseGold Standard:;Index test:;Guangdong General Hospital, Guangdong Academy of Medical SciencesNULLRecruiting5080BothTarget condition:0;Difficult condition:0China
14ChiCTR-DDD-170107942014-11-082017-03-05The study on early diagnosis of Parkinson 's disease by transcranial ultrasonographythe study on early diagnosis of Parkinson 's disease by transcranial ultrasonography Parkinson's DiseaseGold Standard:Diagnosis of Parkinson disease needs to meet 3 or more: unilateral onset;resting tremor;progressive course; long term asymmetry, the most obvious symptoms is the onset side; a good response to levodopa (70% ~ 100%); levodopa induced chorea; a reaction of levodopa lasts 5 years or more; clinical course last;Index test:Laboratory apparatus
As shown in Figure 1, The ultrasound equipment, Philips IE33-BOMJH1 color Doppler ultrasonography, Model IE-ELite, with 2-4MHz phased array probe (S5-1 probe) was used for TCS to examine SN in our study.
Transcranial ultrasound study
Ultrasonography through temporal window, alon;
Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union HospitalNULLCompleted3684BothTarget condition:135;Difficult condition:0China