70. 広範脊柱管狭窄症 [臨床試験数:91,薬物数:195(DrugBank:54),標的遺伝子数:60,標的パスウェイ数:85

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
64 trials found
No.TrialIDDate_
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1NCT04483297October 202014/7/2020First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS)First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS) In Subjects With Degenerative Spondylolisthesis and Concomitant Symptomatic Spinal Stenosis Who Are Undergoing Decompression And Single Level Instrumented Posterolateral Lumbar Autograft Fusion SurgeryDegenerative Spondylolisthesis;Spinal StenosisDrug: AK1320 MS;Other: ControlAsahi Kasei Pharma CorporationEmergent Clinical ConsultingRecruiting22 Years80 YearsAll40Phase 1Canada
2NCT04066296September 20203/7/2019Outcomes for Lumbar Decompressions With Use of Liposomal BupivicaineA Double Blinded Randomized Control Trial in Outcomes for Lumbar Decompressions With Use of Liposomal BupivicaineLumbar Spinal StenosisDrug: Liposomal bupivacaineUniversity of Colorado, DenverNULLNot yet recruiting18 YearsN/AAll100Phase 2NULL
3NCT04492774July 1, 202020/7/2020Degenerative Lumbar Stenosis Conservative TreatmentGOLDIC Therapy in Lumbar Degenerative Spinal Stenosis - Randomized Controlled TrialSpinal Stenosis Lumbar;Spinal Canal StenosisCombination Product: Goldic serum;Drug: Steroid injections;Procedure: Manual therapySutherland Medical CenterNULLRecruiting18 YearsN/AAll90Phase 4Poland
4JPRN-jRCTs02120000719/06/202003/06/2020MiroTASEfficacy and Safety of Mirogabalin for the Treatment as Add-On to NSAIDs in patients with Peripheral Neuropathic Pain caused by Lumbar Spinal Stenosis : Multi-institutional, randomized, open, parallel-design and interventional Study Lumber Spiral StenosisComparison in the effect and safety of Mirogabalin add-on therapy to NSAIDs and NSAIDs monotherapy for patients with Lumber Spiral Stenosis and administrated of NSAIDs.
1) NSAIDs monotherapy as a study drug are prescribed in accordance with a package insert and each of their administration and dosage is not changed while a study drug is administrated.
2) Mirogabalin add-on therapy to NSAIDs: NSAIDS as a study drug are prescribed in accordance with a package insert and each of their administration and dosage is not changed while a study drug is administrated. Mirogabalin is prescribed as follows in accordance with renal function of a subject.
Patients with creatinine clearance more than 60mL/min: Mirogabalin is administrated in dose of 5mg twice a day at the first week. At the next week, Mirogabalin is administrated in dose of 10mg twice a day. At week 5(after Visit3), dose of Milogabalin is increased to 15mg twice a day unless there is no problem with the safety. After that, the dose of Mirogabalin is controlled by 10mg twice a day or 15mg twice a day depending on safety findings.
Patients with creatinine clearance 30-60mL/min: Mirogabalin is administrated in dose of 2.5mg twice a day at the first week. At the next week, Mirogabalin is administrated in dose of 5mg twice a day. At week 5(after Visit3), dose of Milogabalin is increased to 7.5mg twice a day unless there is no problem with the safety. After that, the dose of Mirogabalin is controlled by 5mg twice a day or 7.5mg twice a day depending on safety findings.
Also, more than 7 days washout period before enrollment is required for target patients administrated of prohibited drugs.
If the administration of Mirogabalin is discontinued, down-titration is needed in accordance with the insert package.
Nikaido TakuyaDaiichi Sankyo Co., LtdRecruiting>= 20age oldNot applicableBoth300N/AJapan
5EUCTR2019-003590-25-NL15/06/202015/06/2020Epidural analgesia after back surgerya Randomized controlled trial for epidural Analgesia for Pain relief after lumbar Interlaminar Decompressive spine surgery - RAPID - RAPID Lumbar spinal stenosis
MedDRA version: 21.0Level: LLTClassification code 10041595Term: Spinal stenosis lumbarSystem Organ Class: 100000004859;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]
Trade Name: Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml
Product Name: Bupivacaine
Product Code: Sufentanil
NULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
34Phase 4Netherlands
No.TrialIDDate_
enrollment
Date_
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Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
6NCT04401735November 1, 201911/5/2020Effects and Safety of Epidural PDRN vs. PlaceboEffects and Safety of PDRN (Polydeoxyribonucleotide) for Patient With Lumbar Spinal Stenosis Compared With Normal Saline in Randomized Placebo-Controlled Comparative Pilot StudySpinal Stenosis LumbarDrug: Polydeoxyribonucleotides;Drug: Normal salineSeoul National University HospitalNULLRecruiting19 Years80 YearsAll45Phase 4Korea, Republic of
7NCT04611464July 11, 20199/10/2020Misoprostol for Spinal StenosisPain and Functional Outcomes With Misoprostol Treatment for Lumbar Spinal StenosisLumbar Spinal Stenosis;Low Back PainDrug: MisoprostolDallas VA Medical CenterNULLCompleted18 YearsN/AAll23United States
8NCT04042948June 24, 201913/7/2019Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion SurgeryRandomized Controlled Study of Fever Probability, Risk Factors and Preventive Use of Non-steroidal Anti-inflammatory Drugs on Fever After Removal of Drainage Tube After Lumbar FusionLumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar RadiculopathyDrug: TylenolPeking University Third HospitalNULLRecruiting18 YearsN/AAll200N/AChina
9NCT03745040January 26, 20195/11/2018Liposomal Bupivacaine in One-level Instrumented Posterior Spinal FusionDoes Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With InstrumentationLumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Disc Disease;Lumbar SpondylolisthesisDrug: Liposomal bupivacaineAllina Health SystemTwin Cities Spine CenterRecruiting18 YearsN/AAll60Phase 4United States
10NCT04559295November 21, 201831/8/2020Bone Marrow Concentrate (BMC) Injection in Intervertebral DiscsStudy of Bone of Marrow Concentrate (BMC) Injection in Discs, Facets, Sacroiliac Joints, and Epidural Space for Chronic Lower Back Pain With and Without RadiculopathyLow Back Pain;Disc Disease;Disc Degeneration;Arthropathy Vertebrae;Sacral Disorder;Radiculopathy;Spinal StenosisBiological: Bone Marrow ConcentrateStem CuresNULLActive, not recruiting18 Years60 YearsAll80Phase 2/Phase 3United States
No.TrialIDDate_
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11NCT03883022September 3, 201810/3/2019Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine SurgeryVancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine SurgerySpinal Fusion;Spinal Stenosis;SpondylolisthesisDrug: with U-VANCO (vancomycin hydrochloride);Drug: without U-VANCO (vancomycin hydrochloride)Taipei Veterans General Hospital, TaiwanNULLRecruiting20 YearsN/AAll400N/ATaiwan
12NCT03647501August 22, 201821/8/2018Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody CagesLumbar Fusion With 3D-Printed Porous Titanium Interbody Cages - A Single-Blinded Randomized Controlled Trial Evaluating Nexxt Matrixx(TM) Versus PEEK CagesLumbar Degenerative Disc Disease;Lumbar Spinal Stenosis;Lumbar Spondylolisthesis;Lumbar Spinal Deformity;Lumbar SpondylosisDevice: Interbody cage (titanium);Device: Interbody cage (PEEK)Ohio State UniversityNexxt Spine, LLCRecruiting18 YearsN/AAll70N/AUnited States
13NCT03047044July 1, 20185/2/2017The Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' EquipmentThe Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' EquipmentBack Pain;Fusion of Spine, Lumbar Region;Spinal StenosisOther: Optimizing basal infusion (B.I);Other: Conventional PCA modeYonsei UniversityNULLCompleted20 Years70 YearsAll58N/AKorea, Republic of
14NCT03584074July 1, 201829/6/2018Clinical Trial of Pregabalin and COX2 in Spinal StenosisComparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled TrialSpinal Stenosis LumbarDrug: Pregabalin 75mg;Drug: Celebrex 200Mg CapsuleSeoul National University Bundang HospitalNULLUnknown status40 YearsN/AAll60Phase 4NULL
15JPRN-JapicCTI-18386602/2/201815/02/2018Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study)Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study) LSSIntervention name : NS-304
INN of the intervention : Selexipag
Dosage And administration of the intervention : Oral administration
Control intervention name : NS-304 Placebo
INN of the control intervention : -
Dosage And administration of the control intervention : Oral administration
Nippon Shinyaku Co., Ltd.NULLcomplete4079BOTH120Phase 2Japan
No.TrialIDDate_
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16JPRN-UMIN0000308812018/01/1818/01/2018Dietary supplementation in patients following lumbar spine surgery: a randomized controlled trialDietary supplementation in patients following lumbar spine surgery: a randomized controlled trial - Dietary supplementation in patients following lumbar spine surgery lumbar spinal stenosisIntervention group
Twice-daily ingestion of amino acids supplementation for 3 weeks after spinal surgery (100kcal, protein 10g)
Postoperative rehabilitation for 3 weeks
Control group
Twice-daily ingestion of placebo (non amino acids) supplementation for 3 weeks after spinal surgery (100kcal, protein 0g )
Postoperative rehabilitation for 3 weeks
Wakayama Medical UniversityNULLRecruiting50years-old90years-oldMale and Female80Not selectedJapan
17NCT03088306July 1, 201722/2/2017Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery PatientsComparative Effectiveness of Multi-modal Pain Management Versus Standard Intra- and Post-operative Analgesia: Randomized Controlled Clinical Trial to Reduce Post-operative Pain and Opioid Use Among Patients Undergoing Lumbar Spine SurgeryLumbar Spinal Stenosis;Lumbar Spinal Instability;Lumbar Spine DegenerationDrug: Standard analgesia use [Oxygen];Drug: Standard analgesia use [Hydromorphone];Drug: Standard analgesia use [Volatile Anesthesia];Drug: Standard analgesia use [Fentanyl];Drug: Multi-modal pain management [Acetaminophen + Gabapentin];Drug: Multi-modal pain management [Fentanyl];Drug: Multi-modal pain management [Intravenous Ketamine];Drug: Multi-modal pain management [Valium + Gabapentin]Johns Hopkins UniversityNorth American Spine SocietyCompleted18 Years100 YearsAll49Early Phase 1United States
18NCT03011866February 201716/12/2016Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine SurgeriesIntravenous Versus Topical Use of Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS) : A Prospective, Randomized, Double Blind, Head-to-head Comparison StudySpinal Stenosis;Intervertebral Disc DisplacementDrug: Wound topically irrigated with 500mg TXA;Drug: 1mg/kg/hr TXA intravenous infusion till the last suturePeking Union Medical College HospitalNULLNot yet recruiting50 YearsN/AAll176N/ANULL
19EUCTR2016-002887-14-FI31/10/201614/10/2016Dose-response of ketamine in patient controlled analgesia in orthopaedic surgery patientsDose response study of Patient Controlled Analgesia (PCA) of S-ketamine in orthopaedic spine surgery patients - DoseRespKeta Patients who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation
MedDRA version: 19.0Level: LLTClassification code 10041595Term: Spinal stenosis lumbarSystem Organ Class: 100000004859;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11]
Trade Name: Ketanest-S
INN or Proposed INN: KETAMINE
Trade Name: Oxycodone Orion
INN or Proposed INN: OXYCODONE
University of TurkuNULLNot RecruitingFemale: yes
Male: yes
100Phase 1;Phase 4Finland
20NCT02939482October 1, 201615/10/2016A Study Comparison of Clinical Outcome After Different Rate of Infusion in Caudal Epidural Steroid InjectionA Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid InjectionSpinal Stenosis;Lumbosacral Spondylosis;RadiculopathyDrug: Triamcinolone Acetonide and normal saline solutionNavamindradhiraj UniversityNULLCompleted20 YearsN/AAll112N/AThailand
No.TrialIDDate_
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21NCT02902380September 27, 20166/9/2016The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal SurgerySpinal StenosisDrug: dexmedetomidine group;Drug: control groupYonsei UniversityNULLCompleted20 Years70 YearsAll52N/AKorea, Republic of
22EUCTR2015-002694-37-FI01/09/201604/01/2016Dexmedetomidine is a drug that is used mainly for sedation in the intensive care unit. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee.Dexmedetomidine infusion in pain management during low back surgeryDexmedetomidine is an alpha-2-adrenergic agonist that is used mainly for sedation in the intensive care unit. Alpha-2-adrenoceptors agonists have several beneficial actions in a surgical patient. They decrease symphatetic tone, reduce anesthetic and opioid requirements and cause sedation and analgesia. Pain after low back surgery is intense and can become chronic. We need a new drug to manage pain during postoperative period and to prevent chronic pain.DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. Study is single centered, randomized and placebo-controlled study. A total of 60 patients scheduled for low back surgery will be enrolled in this study. Patients eligibility will be assessed by pre-determined inclusion-exclusion-criteria. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. Patients in the dexmedetomidine group receive dexmedetomidine loading dose 1ug/kg for 10 minutes and continuous infusion 1.4 ug/kg/h during surgery and post-anesthesia care unit. Total infusion time will be four hours. Anesthesia is standardized and post-operative pain is treated with patient controlled analgesia made of oxycodone. Questionnaires will be used to assess pain control.Study is scheduled to start as soon as we obtain permission from Finnish Medicines Agency and receive sufficient funding. Low back pain, Discus prolapse, Spinal stenosis;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]Trade Name: Dexmedetomidine
Product Name: Dexdor
INN or Proposed INN: DEXMEDETOMIDINE
Kuopio University hospitalNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
Finland
23NCT02838615July 201625/5/2016Comparison of Transforaminal vs. Parasagittal Interlaminar Epidural InjectionComparison of Lumbar Epidural Steroid Injection: Transforaminal vs. Parasagittal Interlaminar ApproachSpinal StenosisProcedure: epidural steroid (dexamethasone) injectionKeimyung University Dongsan Medical CenterNULLCompletedN/AN/AAll56N/ANULL
24NCT02826889May 24, 20166/7/2016Assessing the Diagnostic Accuracy of Corrected Flow Time (FTc) and Pleth Variability Index (PVI) as Predictors of Fluid Responsiveness in Patients in the Prone Position Using the Jackson TableElective Posterior Lumbar Spinal Fusion for Spinal Stenosis;Spondylolisthesis;Spinal Fractures;Scoliosis or TumorsDevice: Philips Intelivue MP70 monitor;Device: Pleth Variability Index (PVI)Yonsei UniversityNULLCompleted19 Years75 YearsAll58N/AKorea, Republic of
25NCT02700451March 201618/2/2016Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion OutcomesA Randomized Controlled Trial of Post-operative Acetaminophen Versus Nonsteroidal Anti-Inflammatory Drug (NSAID) Use on Lumbar Spinal Fusion OutcomesLumbar Osteoarthritis;Spondylosis;Lumbar Disc Disease;Spinal StenosisDrug: Ketorolac;Drug: Acetaminophen;Drug: PlaceboHospital for Special Surgery, New YorkNULLActive, not recruiting18 Years75 YearsAll300N/AUnited States
No.TrialIDDate_
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26NCT02625194January 1, 201625/11/2015The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided IntubationThe Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided IntubationLumbar Spinal StenosisDrug: OxygenYonsei UniversityNULLCompleted20 Years60 YearsAll36N/AKorea, Republic of
27NCT02444351June 26, 201528/4/2015Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal StenosisSpinal Stenosis With Nocturnal Calf CrampsDrug: botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle;Other: no interventionYonsei UniversityNULLCompleted20 Years80 YearsAll50N/AKorea, Republic of
28EUCTR2014-003252-31-FI15/05/201522/04/2015Dose-response of dexmedetomidine in patient controlled analgesia in orthopaedic surgery patientsDose response study of Patient Controlled Analgesia (PCA) of Dexmedetomidine in orthopaedic spine surgery patients - DoserespDex_2.0 Patients, who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation
MedDRA version: 17.1Level: LLTClassification code 10041595Term: Spinal stenosis lumbarSystem Organ Class: 100000004859;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11]
Trade Name: Dexdor
INN or Proposed INN: deksmedetomidiini
Other descriptive name: DEXMEDETOMIDINE HYDROCHLORIDE
Trade Name: Oxanest
INN or Proposed INN: oksikodoni
Other descriptive name: OXYCODONE HYDROCHLORIDE
University of TurkuNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Finland
29NCT02416804January 201510/4/2015Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal SurgeryPostoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal SurgerySpinal Stenosis;Pain, PostoperativeDrug: Buprenorphine;Drug: TramadolSeoul National University HospitalNULLCompleted20 YearsN/AAll69Phase 4Korea, Republic of
30NCT02093520May 201418/3/2014The MiDAS ENCORE StudyMILD® Percutaneous Image-Guided Lumbar Decompression Versus Epidural Steroid Injections in Patients With Lumbar Spinal Stenosis Exhibiting Neurogenic ClaudicationSpinal Stenosis, Lumbar Region, With Neurogenic ClaudicationProcedure: MILD Procedure;Drug: Epidural Steroid InjectionVertos Medical, Inc.NULLCompleted65 YearsN/AAll302N/AUnited States
No.TrialIDDate_
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31NCT02103543January 201427/3/2014Comparison of the Order of Treatment in Lumbar Spinal StenosisA Randomized Trial in Patients With Lumbar Spinal Stenosis, Comparing the Order of Treatment With Epidural Corticosteroid Injections and Physical TherapyLumbar Spinal StenosisOther: physical therapy;Procedure: lumbar interlaminar epidural steroid injection;Drug: epidural steroid injectionEmory UniversityNULLWithdrawn18 Years65 YearsAll0N/AUnited States
32NCT01934868December 1, 201330/8/2013Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the LegA Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the LegSciatica;Spinal Stenosis of Lumbar Region;Degeneration of Lumbar or Lumbosacral Intervertebral DiscDrug: prolotherapy solution of 20% dextrose;Drug: Epidural Steroid InjectionHadassah Medical OrganizationReuth Rehabilitation HospitalActive, not recruiting18 Years90 YearsAll110Phase 4Israel
33NCT01943435November 20, 20138/9/2013Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)A Comparison of Non-Surgical Treatment Methods for Patients With Lumbar Spinal StenosisLumbar Spinal StenosisDrug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;Procedure: Lumbar epidural injection;Other: Joint Mobilizations (spine, sacroiliac, hip);Other: Individualized exercises: clinical setting;Other: Group Exercise: community settingMichael Schneider, DC, PhDPatient-Centered Outcomes Research InstituteCompleted60 YearsN/AAll259N/AUnited States
34NCT01888536February 201325/6/2013A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal StenosisA Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal StenosisNeurologic Claudication in Patients With Lumbar Spinal StenosisDrug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost)Yungjin Pharm. Co., Ltd.NULLCompleted20 Years75 YearsBoth182Phase 4Korea, Republic of
35ChiCTR-TRC-130036392012-09-132013-09-07The application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal SurgeryThe application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal Surgery Lumbar spinal stenosis and/or lumbar intervertebral disc herniationANI group:ANI guide the administration of remifentanil;control group:remifentanil was adapted by Anaesthesiologist corresponding to clinical experiences ;Peking University Third HospitalNULLCompleted1870BothANI group:30;control group:30;China
No.TrialIDDate_
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36NCT02063035August 201219/12/2013Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal SurgeryTopical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal SurgeryLumbar Spinal Stenosis;Thoracic Spinal StenosisDrug: Tranexamic Acid;Drug: PlaceboMassachusetts General HospitalNULLCompleted18 Years85 YearsAll29Phase 4United States
37NCT02090244August 201216/3/2014Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans?Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi?Spinal StenosisDrug: TeriparatideUniversity Hospital, LinkoepingMedical Research Council of Southeast SwedenCompletedN/AN/AAll34Phase 4Sweden
38EUCTR2011-006152-36-DK10/05/201210/05/2012Does postoperative treatment with parathyroidea hormone Forteo®improve the disability inelderly patients undergoing spinal stabilization fusion surgery comparedwith patients treated with placebo. If that is the case, is there a correlationbetween improvement of disability and solid osseous healing?Postoperative treatment with parathyroidea hormone Forteo® inpatients undergoing posterolateral spinal fusion surgery. A prospektiveand a randomized double-blinded, placebo-controlled study - PTH-U-DESE-STUDY Spinal stenosis
MedDRA version: 14.1Level: LLTClassification code 10041597Term: Spinal stenosis of lumbar regionSystem Organ Class: 10028395 - Musculoskeletal and connective tissue disorders;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]
Trade Name: Forteo
Product Name: Forsteo
Product Code: 0002-8971
INN or Proposed INN: teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34)
Other descriptive name: rhPTH (1-34)
Middelfart RygsektorNULLNot RecruitingFemale: yes
Male: yes
100Phase 2Denmark
39NCT02271191May 201215/10/2014Effect of Nicardipine on Renal Function in Deliberate HypotensionEffect of Nicardipine on Renal Function in Deliberate HypotensionSpinal StenosisDrug: NicardipineYonsei UniversityNULLCompleted20 YearsN/ABoth64Phase 4NULL
40EUCTR2012-000747-26-FI27/04/201202/04/2012Ketamine to reduce postoperative pain in back surgeryAdministration of S-Ketamine during spinal surgery to reduce postoperative pain adult patients undergoing spinal surgery
MedDRA version: 14.1 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
Helsinki Universiy Central HospitalNULLNot Recruiting Female: yes
Male: yes
192 Human pharmacology (Phase 1): no Therapeut1c exploratory (Phase 2): no Therapeut1c conf1rmatory - (Phase 3): no Therapeut1c use (Phase 4): yesFinland
No.TrialIDDate_
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41NCT01522846January 20129/1/2012Heparin Solution and INTEM/HEPTEM AnalysisInfluence by Heparinized Flush Solution of the Radial Artery Catheter: INTEM and HEPTEM Analysis.Brain Tumor;Spinal Stenosis;Cerebral Artery AnuerysmDrug: HeparinSeoul National University Bundang HospitalNULLCompleted20 YearsN/ABoth25N/AKorea, Republic of
42JPRN-UMIN0000065882011/11/0101/11/2011Effect of antiplatelet agent on muscle cramps after surgery of lumbar spinal stenosis in patients with lumbar spinal canal stenosis and peripheral artery disease Lumbar spinal canal stenosisContinuous administration of cilostazolJuntendo UniversityDepartment of Orthopaedic SurgeryNULLRecruitingNot applicableNot applicableMale and Female30Not appl1cableJapan
43NCT01456377July 201112/10/2011The Effectiveness of Oral Corticosteroids in the Treatment of Lumbar StenosisA Prospective Controlled Study Randomized Double Blind Study, Evaluate the Effectiveness of Oral Corticosteroids in the Treatment of Stenosis of Lumbar Canal In Symptomatic PatientsSpinal Stenosis of Lumbar RegionDrug: predinose oral;Drug: placebo groupFederal University of São PauloNULLRecruiting50 Years75 YearsBoth60N/ABrazil
44NCT01238536April 20118/11/2010Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and OlderSpinal Stenosis;Low Back PainProcedure: Epidural steroid with local anesthetic injection;Procedure: Epidural local anesthetic injection;Drug: Epidural steroid injection;Drug: Epidural local anesthetic injectionUniversity of WashingtonKaiser Permanente;University of California, San Francisco;Henry Ford Hospital;Harvard Pilgrim Health Care;Harvard Vanguard Medical Associates;University of Colorado, Denver;Mayo Clinic;Stanford University;Massachusetts General Hospital;Virginia Spine Research Institute;Oregon Health and Science University;Dallas VA Medical CenterCompleted50 YearsN/AAll400Phase 4United States
45NCT01315145March 201111/3/2011MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation StudyMiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation StudyLumbar Spinal StenosisProcedure: Percutaneous Lumbar Decompression;Drug: Epidural Steroid InjectionVertos Medical, Inc.NULLCompleted50 YearsN/AAll138N/AUnited States
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46JPRN-UMIN0000048252011/01/0106/01/2011A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOL Lumbar spinal stenosis15ug/day Limaprost arfadex for 8 weeks
200mg/day Celecoxib for 8 weeks
University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare FederationMito Kyodo HospitalComplete: follow-up complete40years-old85years-oldMale and Female134Phase 3Japan
47NCT01275547January 201111/1/2011The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal MidazolamThe Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery PatientsAnalgesia, Patient-controlled;Spinal StenosisDrug: s-ketamine & midazolam;Drug: Morphine PCAUniversity Hospital, Basel, SwitzerlandNULLCompleted18 YearsN/ABoth22Phase 2/Phase 3Switzerland
48JPRN-UMIN0000053822010/12/0105/04/2011Intraoperative perineural infiltration of ropivacaine for acute postlaminectomy pain lumbar spinal stenosisGeneral anesthesia and NSAIDs.
As a contorol,saline 10ml infiltrate per one interspinal segment.
Generalanesthesia and NSAIDs.
0.2%ropivacaine 10ml infiltrate per one interspinal segment.
General anesthesia and NSAIDs.
From catheter in injury part,administration of 0.2%ropivacaine 6ml/h.
Duration of administration:2 days after the operation.
Higashi Ohmiya general hospitalNULLComplete: follow-up complete20years-old75years-oldMale and Female60Not selectedJapan
49JPRN-UMIN0000059592010/11/0112/07/2011Prospective clinical study of the therapeutic effects of prostaglandin in patients with combined lumbar spinal stenosis and arteriosclerosis obliterans showing intermittent claudication Patients with combined lumbar spinal stenosis and arteriosclerosis obliteransProstaglandin for injection (alprostadil) group: 60 mcg of prostaglandin for injection is intravenously administered once a week or more. This therapy is repeated 10 times or more.
Ripple injection (alprostadil Injection) group: 10 mcg of ripple injection is administered intravenously once a week or more. This treatment is repeated 10 times or more.
Conventional treatment group
Tokai University HospitalDepartment of Orthopaedic SurgeryNULLComplete: follow-up continuing20years-oldNot applicableMale and Female300Not selectedJapan
50NCT03532945October 28, 20102/5/2018A Follow-up Study to Evaluate the Efficacy and Safety of Novomax in Posterior Lumbar Interbody FusionA Long-term Follow-up Study to Evaluate the Efficacy and Safety for the Patients With Bioactive Glass-ceramic Intervertebral Spacer (Novomax) in Posterior Lumbar Interbody Fusion: Comparison With a Titanium CageDegenerative Lumbar Spinal StenosisDevice: Bioactive Glass-Ceramic Spacer;Device: Titanium cageBioAlpha Inc.NULLCompleted30 Years80 YearsAll62N/ANULL
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51NCT01106417June 201016/4/2010Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and FusionPhase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate FixationCervical Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal StenosisBiological: NeoFuse;Device: MasterGraft GranulesMesoblast, Ltd.NULLCompleted18 Years70 YearsAll12Phase 1/Phase 2Australia
52NCT01097486June 201030/3/2010Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical DiscectomyPhase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate FixationCervical Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal StenosisBiological: NeoFuse;Procedure: AllograftMesoblast, Ltd.NULLCompleted18 Years70 YearsAll24Phase 2United States
53NCT01127100May 201019/5/2010Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic PainGabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority TrialNeuropathic Pain;Spinal StenosisDrug: transdermal fentanyl matrix, gabapentinSeoul National University HospitalSeoul National University Bundang Hospital;Asan Medical Center;Inje University;Chonnam National University Hospital;Chung-Ang University Hosptial, Chung-Ang University College of Medicine;Dankook UniversityCompleted20 Years80 YearsBoth108Phase 4Korea, Republic of
54NCT01052324March 201011/1/2010The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic IntubationThe Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic IntubationCervical Disc Herniation;Cervical Spinal Stenosis;Cervical Spine DamageDrug: RemifentanilYonsei UniversityNULLCompleted20 Years65 YearsBoth19Phase 4Korea, Republic of
55NCT00996073September 20099/10/2009Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody FusionA Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With InstrumentationDegenerative Disc Disease;Degenerative Spondylolisthesis;Spinal StenosisBiological: Lumbar Interbody Fusion with Autograft;Biological: Lumbar Interbody Fusion with NeoFuseMesoblast, Ltd.NULLCompleted18 Years70 YearsAll24Phase 2United States
No.TrialIDDate_
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Date_
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Public_titleScientific_titleConditionInterventionPrimary_
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56NCT00995371August 200914/10/2009Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal StenosisComparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal StenosisLumbar Spinal StenosisDevice: MILD® (Minimally Invasive Lumbar Decompression);Drug: Epidural Steroid InjectionCoastal Orthopedics & Sports MedicineVertos Medical, Inc.Completed18 YearsN/AAll38Phase 4United States
57NCT00808665June 200915/12/2008Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine FusionDoes Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled StudySpinal Fusion Acquired;Spinal Stenosis;Lesions of Lumbosacral Intervertebral Disc;Spinal DiseasesDrug: Dexmedetomidine;Drug: 0.9% SalineVanderbilt University Medical CenterNULLCompleted18 Years85 YearsAll68Phase 4United States
58NCT00908375May 200921/5/2009Efficacy of Pregabalin in Patients With Radicular PainEfficacy of Pregabalin in Patients With Radicular PainNeuropathy; Radicular, Lumbar, Lumbosacral;Failed Back Surgery Syndrome;Spinal Stenosis;Herniated DiscDrug: Pregabalin;Drug: Sugar PillNorthwestern UniversityNULLCompleted18 Years64 YearsAll39Phase 4United States
59NCT00810212November 200817/12/2008Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar FusionA Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With Mastergraft Granules in Subjects Undergoing Posterolateral Lumbar Fusion With InstrumentationDegenerative Disc Disease;Degenerative Spondylolisthesis;Spinal StenosisProcedure: PLF with autograft;Biological: PLF with NeoFuseMesoblast, Ltd.NULLWithdrawn18 Years70 YearsAll0Phase 1/Phase 2United States
60NCT00652093March 200811/3/2008Lumbar Stenosis Outcomes Research IILumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over TrialLumbar Spinal StenosisDrug: opana then darvocet then placebo;Drug: opana then placebo then darvocet;Drug: placebo then opana then darvocet;Drug: Placebo then darvocet then opana;Drug: Darvocet then opana then placebo;Drug: Darvocet then placebo then opanaUniversity of RochesterEndo PharmaceuticalsTerminated50 YearsN/AAll24Phase 4United States
No.TrialIDDate_
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61NCT00638443March 200812/3/2008Lumbar Stenosis Outcomes Research (LUSTOR)Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back PainLumbar Spinal StenosisDrug: Pregabalin;Drug: DiphenhydramineUniversity of RochesterPfizerCompleted50 YearsN/AAll29Phase 4United States
62NCT00549913October 200724/10/2007Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF)A Dose-escalation Study to Assess the Feasibility and Safety of 3 Different Doses of NeoFuse When Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion With Instrumentation.Degenerative Disc Disease;Spondylolisthesis;Spinal StenosisBiological: NeoFuse;Procedure: posterolateral spinal fusion with instrumentationMesoblast, Ltd.NULLCompleted18 YearsN/AAll6Phase 1/Phase 2United States
63NCT00370799January 200730/8/2006Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity PainA Randomized, Prospective, Double-Blind Controlled Evaluation of the Effectiveness of Caudal Epidural Injections in Lumbar Disc Herniations, Spinal Stenosis, Discogenic Pain, and Post-Lumbar Laminectomy SyndromeLow Back PainDrug: Caudal epidural injection;Drug: Caudal Epidural Injection with generic Celestone;Drug: Caudal Epidural Injection with Celestone;Drug: Caudal Epidural Injection with DepoMedrolPain Management Center of PaducahNULLCompleted18 YearsN/ABoth240Phase 0United States
64NCT00320619September 200028/4/2006Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine SurgeryAminocaproic Acid and Bleeding in Spinal SurgeryScoliosis;Kyphosis;Lordosis;Spondylitis;Spinal StenosisDrug: Epsilon-Aminocaproic Acid (EACA);Drug: PlaceboNational Heart, Lung, and Blood Institute (NHLBI)NULLCompleted18 YearsN/ABoth182N/AUnited States