70. 広範脊柱管狭窄症 [臨床試験数:91,薬物数:195(DrugBank:54),標的遺伝子数:60,標的パスウェイ数:85

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
6 trials found
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
1NCT04391855
(ClinicalTrials.gov)
May 10, 202013/5/2020Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine SurgeryEffect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine SurgeryAnalgesia;Pain, Postoperative;Spinal Stenosis;Spinal DiseaseDrug: Tramadol with ropivacaine;Drug: Dexmedetomidine with ropivacaine;Drug: Magnesium with ropivacaine;Drug: Ropivacaine plus normal salineAristotle University Of ThessalonikiNULLRecruiting18 Years80 YearsAll78Phase 4Greece
2NCT02902380
(ClinicalTrials.gov)
September 27, 20166/9/2016The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal SurgerySpinal StenosisDrug: dexmedetomidine group;Drug: control groupYonsei UniversityNULLCompleted20 Years70 YearsAll52N/AKorea, Republic of
3EUCTR2015-002694-37-FI
(EUCTR)
01/09/201604/01/2016Dexmedetomidine is a drug that is used mainly for sedation in the intensive care unit. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee.Dexmedetomidine infusion in pain management during low back surgeryDexmedetomidine is an alpha-2-adrenergic agonist that is used mainly for sedation in the intensive care unit. Alpha-2-adrenoceptors agonists have several beneficial actions in a surgical patient. They decrease symphatetic tone, reduce anesthetic and opioid requirements and cause sedation and analgesia. Pain after low back surgery is intense and can become chronic. We need a new drug to manage pain during postoperative period and to prevent chronic pain.DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. Study is single centered, randomized and placebo-controlled study. A total of 60 patients scheduled for low back surgery will be enrolled in this study. Patients eligibility will be assessed by pre-determined inclusion-exclusion-criteria. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. Patients in the dexmedetomidine group receive dexmedetomidine loading dose 1ug/kg for 10 minutes and continuous infusion 1.4 ug/kg/h during surgery and post-anesthesia care unit. Total infusion time will be four hours. Anesthesia is standardized and post-operative pain is treated with patient controlled analgesia made of oxycodone. Questionnaires will be used to assess pain control.Study is scheduled to start as soon as we obtain permission from Finnish Medicines Agency and receive sufficient funding. Low back pain, Discus prolapse, Spinal stenosis;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]Trade Name: Dexmedetomidine
Product Name: Dexdor
INN or Proposed INN: DEXMEDETOMIDINE
Kuopio University hospitalNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
Finland
4EUCTR2014-003252-31-FI
(EUCTR)
15/05/201522/04/2015Dose-response of dexmedetomidine in patient controlled analgesia in orthopaedic surgery patientsDose response study of Patient Controlled Analgesia (PCA) of Dexmedetomidine in orthopaedic spine surgery patients - DoserespDex_2.0 Patients, who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation
MedDRA version: 17.1;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 100000004859;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11]
Trade Name: Dexdor
INN or Proposed INN: deksmedetomidiini
Other descriptive name: DEXMEDETOMIDINE HYDROCHLORIDE
Trade Name: Oxanest
INN or Proposed INN: oksikodoni
Other descriptive name: OXYCODONE HYDROCHLORIDE
University of TurkuNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Finland
5NCT01377623
(ClinicalTrials.gov)
September 20103/1/2011Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal FusionPilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal FusionSpinal Stenosis;InflammationDrug: Dexmedetomidine group;Drug: Placebo groupNew York University School of MedicineHospira, now a wholly owned subsidiary of PfizerTerminated18 YearsN/AAll66N/AUnited States
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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agemax
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gender
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size
PhaseCountries
6NCT00808665
(ClinicalTrials.gov)
June 200915/12/2008Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine FusionDoes Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled StudySpinal Fusion Acquired;Spinal Stenosis;Lesions of Lumbosacral Intervertebral Disc;Spinal DiseasesDrug: Dexmedetomidine;Drug: 0.9% SalineVanderbilt University Medical CenterNULLCompleted18 Years85 YearsAll68Phase 4United States