Calcitriol ( DrugBank: Calcitriol )


9 diseases
告示番号疾患名(ページ内リンク)臨床試験数
18脊髄小脳変性症(多系統萎縮症を除く。)1
37膿疱性乾癬(汎発型)1
46悪性関節リウマチ3
49全身性エリテマトーデス2
66IgA腎症3
96クローン病2
158結節性硬化症1
235副甲状腺機能低下症3
326大理石骨病1

18. 脊髄小脳変性症(多系統萎縮症を除く。)


臨床試験数 : 71 薬物数 : 101 - (DrugBank : 30) / 標的遺伝子数 : 45 - 標的パスウェイ数 : 65
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04801303
(ClinicalTrials.gov)
August 25, 20211/3/2021Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia PatientsPilot Trial About the Effects of Calcitriol's Treatment in the Neurological Function and Frataxin's Level in Friedreich's Ataxia PatientsFriedreich AtaxiaDrug: Calcitriol;Other: Blood analysis for frataxin's level measurement;Diagnostic Test: Blood analysis for hypercalcemia's controlBerta AlemanyInstitut de Recerca Biomèdica de Lleida;Universitat de Lleida;Institut d'Investigació Biomèdica de Girona Dr. Josep TruetaActive, not recruiting16 Years65 YearsAll20Phase 4Spain

37. 膿疱性乾癬(汎発型)


臨床試験数 : 74 薬物数 : 55 - (DrugBank : 20) / 標的遺伝子数 : 20 - 標的パスウェイ数 : 101
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1EUCTR2006-005344-83-DE
(EUCTR)
09/02/200707/11/2006A Randomized, Double-blind, Placebo and Active Treatment-Controlled Study in Psoriatic Patients to Assess the Tolerability, Pharmacokinetics and Efficacy of a Cream Formulation Containing 3% of P32/98A Randomized, Double-blind, Placebo and Active Treatment-Controlled Study in Psoriatic Patients to Assess the Tolerability, Pharmacokinetics and Efficacy of a Cream Formulation Containing 3% of P32/98 Psoriasis is a common inherited autoimmune disease that affects 2-3% of the world-wide population. There are several recognized forms of psoriasis, such as plaque psoriasis, which is also known as psoriasis vulgaris and guttate, inverse, erythrodermic and pustular psoriasis, which can coexist within the same patient. The most common form is the plaque psoriasis.
MedDRA version: 8.1;Level: LLT;Classification code 10037153;Term: Psoriasis
Product Name: P32/98 3%
Product Code: P32/98
Trade Name: Silikis 3µg/g Salbe
INN or Proposed INN: Calcitriol
Probiodrug AGNULLNot RecruitingFemale: yes
Male: yes
Germany

46. 悪性関節リウマチ


臨床試験数 : 4,325 薬物数 : 2,681 - (DrugBank : 417) / 標的遺伝子数 : 185 - 標的パスウェイ数 : 223
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1ChiCTR2100042329
2021-01-192021-01-19Effect of Huangqijishengtang on deficiency of liver and kidney in rheumatoid arthritis and its effect on bone metabolismEffect of Huangqijishengtang on deficiency of liver and kidney in rheumatoid arthritis and its effect on bone metabolism rheumatoid arthritisIntervention group:Huangqijishengtang+Calcitriol Soft Capsules+MTX;Intervention group:Calcitriol Soft Capsules;Intervention group:MTX;Intervention group:Folic Acid;control group:Simulator of Huangqijishengtang;control group:Calcitriol Soft Capsules;control group:MTX;control group:Folic Acid;The Affiliated Hospital of Yunnan University of Traditional Chinese MedicineNULLRecruiting1870BothIntervention group:38;Intervention group:38;Intervention group:38;Intervention group:38;control group:38;control group:38;control group:38;control group:38;China
2ChiCTR-IPR-16009029
2016-11-012016-08-15Clinical Study of the Bone Protection Effect of Biqi Capsule for Treatment of Rheumatoid ArthritisClinical Study of the Bone Protection Effect of Biqi Capsule for Treatment of Rheumatoid Arthritis Rheumatoid arthritisRA:the experimental group:MTX 10-15mg po qw+BiQi Capsule, 1.2g po bid;RA:the control group:MTX 10-15mg po qw+LEF, 10mg, po, bid;OA:The traditional Chinese group:BiQi Capsule, 1.2g po bid+Celecoxib capsules 0.2g po take as needed;OA:The western medicine control group:Calcitriol Soft Capsules 0.25ug, po, bid+Celecoxib capsules 0.2g po take as needed;Guangdong Provincial Hospital of Chinese MedicineNULLPending1865BothRA:the experimental group:60;RA:the control group:60;OA:The traditional Chinese group:60;OA:The western medicine control group:60;China
3NCT00427804
(ClinicalTrials.gov)
January 200725/1/2007Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium AbsorptionTumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium AbsorptionRheumatoid Arthritis;Crohn's DiseaseDrug: calcitriolAtlanta VA Medical CenterEmory UniversityCompleted18 Years50 YearsMale9N/AUnited States

49. 全身性エリテマトーデス


臨床試験数 : 946 薬物数 : 733 - (DrugBank : 186) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 198
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT01863641
(ClinicalTrials.gov)
April 201317/5/2013The Effect of Calcitriol on Progress and Activity of Lupus NephritisThe Effect of Calcitriol on Progress and Activity of Lupus NephritisSystemic Lupus ErythematosusDrug: calcitriol;Drug: placeboGuilan University of Medical SciencesNULLRecruiting18 Years65 YearsBoth50Phase 2Iran, Islamic Republic of
2NCT00508898
(ClinicalTrials.gov)
May 200827/7/2007The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent ProteinuriaThe Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent ProteinuriaSystemic Lupus Erythematosus;Nephritis;ProteinuriaDrug: Calcitriol;Drug: MultivitaminChinese University of Hong KongNULLWithdrawn18 Years65 YearsBoth0Phase 4Hong Kong

66. IgA腎症


臨床試験数 : 255 薬物数 : 261 - (DrugBank : 79) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 137
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT01237028
(ClinicalTrials.gov)
March 20118/11/2010Additive Renoprotective Effects of Oral Calcitriol in IgA Nephropathy Patients Taking Renin-Angiotensin System BlockersAdditive Renoprotective Effects of Oral Calcitriol in IgA Nephropathy Patients Taking Renin-Angiotensin System BlockersIgA NephropathyDrug: CalcitriolYonsei UniversityNULLCompleted20 Years70 YearsBoth168N/AKorea, Republic of
2JPRN-UMIN000002474
2007/01/0101/10/2009Preventive effect of vit K, vit D and, risedronate on 3-dimensional trabecular microstructure in patients with IgA nephropathy on glucocorticoid treatment Glucocorticoid induced osteoporosis in patients with IgA nephropathyMenatetrenone 45mg/day for 6 months
Calcitriol 0.5 microgram/day for 6 months
Risedronate 17.5mg/week for 6 months
Osaka University HospitalDepartment of nephrologyNULLComplete: follow-up complete18years-oldNot applicableMale and Female30Not applicableJapan
3NCT00319761
(ClinicalTrials.gov)
May 200627/4/2006Calcitriol in the Treatment of Immunoglobulin A (IgA) NephropathyThe Safety and Short-Term Efficacy of Calcitriol in the Treatment of Immunoglobulin A NephropathyIGA NephropathyDrug: CalcitriolChinese University of Hong KongNULLCompleted18 Years65 YearsBoth10Phase 4Hong Kong

96. クローン病


臨床試験数 : 2,400 薬物数 : 1,417 - (DrugBank : 267) / 標的遺伝子数 : 168 - 標的パスウェイ数 : 214
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT00427804
(ClinicalTrials.gov)
January 200725/1/2007Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium AbsorptionTumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium AbsorptionRheumatoid Arthritis;Crohn's DiseaseDrug: calcitriolAtlanta VA Medical CenterEmory UniversityCompleted18 Years50 YearsMale9N/AUnited States
2NCT00287170
(ClinicalTrials.gov)
July 20062/2/2006Efficacy Study of Targeted, Local Delivery of Drugs to Treat Crohn's DiseasePilot, Open-Label, Randomized, Parallel Group Study to Evaluate Clinical/ and Immunological Efficacy/Safety of Locally Delivered 6-MP or Calcitriol vs Purinethol in Non-Steroid Dependent Patients With Active CDCrohn's DiseaseDrug: Delayed Release 6MP or Calcitriol vs. PurinetholTeva GTCNULLCompleted18 Years75 YearsBoth15Phase 1/Phase 2Israel

158. 結節性硬化症


臨床試験数 : 108 薬物数 : 67 - (DrugBank : 17) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 118
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT03140449
(ClinicalTrials.gov)
September 5, 201326/4/2017Topical Rapamycin and Calcitriol for Angiofibroma of Tuberous SclerosisStudy of Combination Therapy With Topical Rapamycin and Calcitriol for Cutaneous Lesions of Tuberous Sclerosis: A Double-blind Randomized Controlled TrialFacial AngiofibromaDrug: Rapamycin;Drug: Calcitriol;Drug: Rapamycin-calcitriol combinationNational Taiwan University HospitalNULLCompleted7 Years65 YearsAll52Phase 3NULL

235. 副甲状腺機能低下症


臨床試験数 : 88 薬物数 : 129 - (DrugBank : 25) / 標的遺伝子数 : 4 - 標的パスウェイ数 : 6
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1ChiCTR2100041719
2021-01-042021-01-02A clinical study of efficacy and safety for PTH recombinant plasmid and PTH rhMSC therapy in the patients with hypoparathyroidismA clinical study of efficacy and safety for PTH recombinant plasmid and PTH rhMSC therapy in the patients with hypoparathyroidism hypoparathyroidismPTH naked plasmid-1:PTH naked plasmid 500 µg,/kg,ih+Calcium agent;PTH naked plasmid-2:PTH naked plasmid 300 µg,/kg,ih+Calcium agent;PTH naked plasmid-3:PTH naked plasmid 100 µg,/kg,ih+Calcium agent;PTH-rhMSC-1:PTH-rhMSC 10^6/ kg,ih+Calcium agent;PTH-rhMSC-2:PTH-rhMSC 10^7/ kg,ih+Calcium agent;PTH-rhMSC-3:PTH-rhMSC 10^8/ kg,ih+Calcium agent;Calcium agent therapy control:Calcium +Calcitriol;pcDNA3.1 control:pcDNA3.1 +Calcium agent;uninfected MSC control:uninfected MSC+Calcium agent;Shenzhen Ruipuxun Academy for Stem Cell & Regenerative MedicineNULLRecruiting1865BothPTH naked plasmid-1:50;PTH naked plasmid-2:50;PTH naked plasmid-3:50;PTH-rhMSC-1:50;PTH-rhMSC-2:50;PTH-rhMSC-3:50;Calcium agent therapy control:50;pcDNA3.1 control:50;uninfected MSC control:50;Phase 1-2China
2NCT03249012
(ClinicalTrials.gov)
September 1, 20179/8/2017Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy HypoparathyroidismComparing the Quality of Life Associated With Empiric Calcium Repletion and Parathormone (PTH) Based Calcium Repletion for Post Thyroidectomy HypoparathyroidismHypoparathyroidism Postprocedural;Quality of LifeOther: Empiric use of Calcium Carbonate and Calcitriol;Other: PTH based Calcium Carbonate and Calcitriol repletionCHU de Quebec-Universite LavalNULLRecruiting18 YearsN/AAll120N/ACanada
3NCT00001304
(ClinicalTrials.gov)
October 19913/11/1999Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34HypoparathyroidismDrug: Synthetic Human Parathyroid Hormone 1-34;Drug: Calcitriol & CalciumEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NULLCompleted17 Years69 YearsAll27Phase 2United States

326. 大理石骨病


臨床試験数 : 20 薬物数 : 51 - (DrugBank : 14) / 標的遺伝子数 : 16 - 標的パスウェイ数 : 80
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT00004402
(ClinicalTrials.gov)
November 199918/10/1999Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital OsteopetrosisOsteopetrosisDrug: calcitriol;Drug: interferon gammaFDA Office of Orphan Products DevelopmentMedical University of South CarolinaCompletedN/A10 YearsBoth30Phase 3NULL