Xenon ( DrugBank: Xenon )


4 diseases
告示番号疾患名(ページ内リンク)臨床試験数
22もやもや病1
85特発性間質性肺炎3
228閉塞性細気管支炎2
299嚢胞性線維症8

22. もやもや病


臨床試験数 : 14 薬物数 : 21 - (DrugBank : 14) / 標的遺伝子数 : 28 - 標的パスウェイ数 : 44
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
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Status
Inclusion_
agemin
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agemax
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gender
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size
PhaseCountries
1NCT01419275
(ClinicalTrials.gov)
April 200916/8/2011Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsQuantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsCerebrovascular Accident;Moyamoya DiseaseDrug: Xenon contrast agent;Device: Magnetic Resonance ImagingStanford UniversityNULLCompletedN/AN/AAll126N/AUnited States

85. 特発性間質性肺炎


臨床試験数 : 598 薬物数 : 435 - (DrugBank : 116) / 標的遺伝子数 : 99 - 標的パスウェイ数 : 209
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT05241275
(ClinicalTrials.gov)
March 1, 20223/2/2022Xenon MRI and Progressive ILDXENON ILD: 129Xe MRI to Evaluate aNtifibrotic respOnse and progressioN in ILDIdiopathic Pulmonary Fibrosis;Progressive Pulmonary FibrosisDrug: Hyperpolarized 129 Xenon Gas Comparing Progressive Pulmonary Fibrosis TreatmentDuke UniversityBoehringer IngelheimNot yet recruiting18 YearsN/AAll75Phase 2NULL
2NCT04071769
(ClinicalTrials.gov)
August 3, 20209/8/2019Genentech Xenon MRI Idiopathic Pulmonary FibrosisUsing Xenon MRI to Evaluate the Efficacy of Therapies for Idiopathic Pulmonary FibrosisIdiopathic Pulmonary FibrosisDrug: Hyperpolarized 129 Xenon Gas Comparing Idiopathic Pulmonary Fibrosis (IPF) TreatmentDuke UniversityNULLRecruiting18 YearsN/AAll20Phase 2United States
3NCT02478268
(ClinicalTrials.gov)
May 201516/6/2015Using MRI to Visualize Regional Therapy Response in Idiopathic Pulmonary FibrosisUsing MRI to Visualize Regional Therapy Response in Idiopathic Pulmonary FibrosisIdiopathic Pulmonary FibrosisDrug: Hyperpolarized 129-Xenon gas;Device: MRIBastiaan DriehuysUniversity of Wisconsin, Madison;National Heart, Lung, and Blood Institute (NHLBI)Completed18 YearsN/AAll64Phase 1United States

228. 閉塞性細気管支炎


臨床試験数 : 96 薬物数 : 125 - (DrugBank : 34) / 標的遺伝子数 : 33 - 標的パスウェイ数 : 155
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT03603899
(ClinicalTrials.gov)
August 20204/10/2017Hp129 Xenon Imaging and BOS in Lung TransplantationImaging and Understanding Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplantation With Hyperpolarized 129Xenon MR Lung ImagingBronchiolitis ObliteransDrug: Hp 129XenonChildren's Hospital Medical Center, CincinnatiNULLRecruiting6 YearsN/AAll45Phase 1/Phase 2United States
2NCT04029636
(ClinicalTrials.gov)
August 20197/6/2019Hyperpolarized 129Xe MRI for the Assessment of BOS With Late Onset LONIPCHyperpolarized 129Xe Magnetic Resonance Imaging for the Early Detection of Bronchiolitis Obliterans Syndrome (BOS) and Other Late Onset Non-infectious Pulmonary Complications (LONIPCs) Following Hematopoietic Stem Cell TransplantationBronchiolitis ObliteransOther: Inhaled Hyperpolarized Xenon-129Hamilton Health Sciences CorporationNULLNot yet recruiting18 Years70 YearsAll45Canada

299. 嚢胞性線維症


臨床試験数 : 1,696 薬物数 : 1,644 - (DrugBank : 272) / 標的遺伝子数 : 96 - 標的パスウェイ数 : 170
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04793867
(ClinicalTrials.gov)
February 8, 202123/2/2021Regional Phenotyping of CF and Non-CF BronchiectasisRegional Phenotyping of Cystic Fibrosis Lung Disease and Non-CF BronchiectasisCystic Fibrosis;Non-CF BronchiectasisDiagnostic Test: XenonChildren's Hospital Medical Center, CincinnatiNULLRecruiting5 Years100 YearsAll100United States
2NCT04467957
(ClinicalTrials.gov)
October 1, 202019/6/2020Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic FibrosisNon-contrast Lung Perfusion Mapping Applied for New Insights in Cystic FibrosisCystic FibrosisDrug: Initiation of CFTR Modulator;Drug: Hyperpolarized Xenon 129Children's Hospital Medical Center, CincinnatiNULLNot yet recruiting6 Years21 YearsAll26Phase 4NULL
3NCT03593434
(ClinicalTrials.gov)
July 30, 201828/6/2018Airway Clearance Therapy on Hyperpolarized 129Xenon and MRIThe Effect of Airway Clearance Therapy on Hyperpolarized 129Xenon MRI Compared With Lung Clearance Index and Spirometry in Cystic FibrosisCystic FibrosisDrug: hyperpolarized Xenon gasChildren's Hospital Medical Center, CincinnatiNational Heart, Lung, and Blood Institute (NHLBI)Completed6 Years21 YearsAll20United States
4NCT03482960
(ClinicalTrials.gov)
May 29, 201823/3/2018Comparison of 129Xe MRI With 19F MRI in CF Lung DiseaseComparison of 129Xe MRI With 19F MRI in CF Lung DiseaseCystic FibrosisDrug: Hyperpolarized Xenon gas;Drug: PFPUniversity of North Carolina, Chapel HillCystic Fibrosis FoundationCompleted18 YearsN/AAll11Early Phase 1United States
5NCT02912637
(ClinicalTrials.gov)
October 201613/9/2016Hyperpolarized Xenon Imaging in Patients With Cystic FibrosisHyperpolarised 129Xe MRI for Non-invasive Assessment of Ventilation, Perfusion and the Alveolar Membrane - a Physiological Study in Healthy Volunteers & Cystic Fibrosis PatientsCystic FibrosisOther: Hyperpolarized Xenon MRIPapworth Hospital NHS Foundation TrustUniversity of SheffieldSuspended18 Years70 YearsAll30United Kingdom
6NCT02848560
(ClinicalTrials.gov)
March 201626/7/2016Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRIValidation of MRI as a Sensitive Tool to Longitudinally Monitor CF Lung Disease Progression and Response to CFTR Modulator Therapy in Young Children With CFCystic FibrosisDrug: Hyperpolarized XenonChildren's Hospital Medical Center, CincinnatiNational Heart, Lung, and Blood Institute (NHLBI)Recruiting6 Years12 YearsAll38United States
7NCT02740868
(ClinicalTrials.gov)
August 201519/8/2015Xenon-129 Lung Magnetic Resonance Imaging: Study of Healthy Volunteers and Participants With Pulmonary DiseaseDevelopment of Hyperpolarized Xenon-129 Lung Magnetic Resonance Imaging: Comparative Pilot Study of Healthy Volunteers and Participants With Pulmonary DiseaseCystic Fibrosis;AsthmaDrug: Xenon-129;Device: Magnetic Resonance Imaging;Device: Lung Clearance IndexThe Hospital for Sick ChildrenNULLRecruiting8 YearsN/AAll30Phase 2Canada
8EUCTR2019-003052-36-GB
(EUCTR)
28/02/2020Magnetic Resonance Imaging (MRI) in BronchiectasisTriple Modality Functional Magnetic Resonance Lung Imaging in Cystic Fibrosis and Non-CF Bronchiectasis - MRI in Bronchiectasis Cystic fibrosis (CF) Non-CF Bronchiectasis
MedDRA version: 21.0;Level: PT;Classification code 10006445;Term: Bronchiectasis;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders
MedDRA version: 20.0;Classification code 10011762;Term: Cystic fibrosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]
Trade Name: hyperpolarized xenon-129
Product Name: hyperpolarized xenon-129
The University of NottinghamNULLNA Female: yes
Male: yes
40 Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): noUnited Kingdom