Donepezil    (DrugBank: Donepezil)

9 diseases
告示番号疾患名(ページ内リンク)臨床試験数
5進行性核上性麻痺2
6パーキンソン病23
13多発性硬化症/視神経脊髄炎4
46悪性関節リウマチ1
78下垂体前葉機能低下症1
124皮質下梗塞と白質脳症を伴う常染色体優性脳動脈症7
127前頭側頭葉変性症1
156レット症候群2
206脆弱X症候群2

5. 進行性核上性麻痺 [臨床試験数:82,薬物数:107(DrugBank:36),標的遺伝子数:60,標的パスウェイ数:90
Searched query = "Progressive supranuclear palsy", "PSP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 82 trials found
No.TrialIDDate_
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1EUCTR2006-006166-42-DE17/07/200702/01/2007Exelon bei dementiellem Syndrom bei Patienten mit Progressiver Supranukleärer Parese -offene, prospektive Phase II-Studie -Exelon bei dementiellem Syndrom bei Patienten mit Progressiver Supranukleärer Parese -offene, prospektive Phase II-Studie - Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with hardly any therapeutical option to ameliorate the course of the disease. Results of first trials with physostigmine and donepezil did not point out a definite benefit. In contrast, first clinical observations concerning an effect with rivastigmine in PSP with dementia were promising. This may be due to the fact, that rivastigmine excerts a double action inhibiting both the acetylcholin- and the buturylcholinesterase.Trade Name: Exelon 1,5 mg Hartkapseln
INN or Proposed INN: RIVASTIGMINE
Trade Name: Exelon 3,0 mg Hartkapseln
INN or Proposed INN: RIVASTIGMINE
Trade Name: Exelon 6,0 mg Hartkapseln
INN or Proposed INN: RIVASTIGMINE
University of TuebingenNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Phase 2Germany
2NCT00139373May 200530/8/2005Study of the Distractibility Syndrome in Patients With Progressive Supranuclear PalsyStudy of the Distractibility Syndrome in Patients With Progressive Supranuclear PalsySupranuclear Palsy, ProgressiveDrug: donepezilGroupe Hospitalier Pitie-SalpetriereInstitut National de la Santé Et de la Recherche Médicale, FranceRecruiting30 Years80 YearsBoth16Phase 2France

6. パーキンソン病 [臨床試験数:2,123,薬物数:2,046(DrugBank:324),標的遺伝子数:183,標的パスウェイ数:198
Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
23 / 2,123 trials found
No.TrialIDDate_
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1NCT04117178February 4, 202030/9/2019Monitoring Anti-Dementia Drugs by Serum LevelsMonitoring Anti-Dementia Drugs by Serum Levels: Importance of Serum Levels, Drug-monitoring, Side-effects, Clinical Efficacy and Compliance (Translation of Official Danish Title)Dementia;Dementia With Lewy Bodies;Dementia in Parkinsons Disease;Dementia Alzheimers;Alzheimer DiseaseDrug: Donepezil;Drug: Memantine;Diagnostic Test: Measurement of serum level of anti-dementia drugZealand University HospitalEpilepsihospitalet FiladelfiaRecruiting18 YearsN/AAll110Phase 4Denmark
2NCT03599726July 30, 201829/6/2018Improving Walking Automaticity in Parkinson's Disease: Levodopa or DonepezilImproving Walking Automaticity in Parkinson's Disease: Levodopa or DonepezilParkinson DiseaseDrug: Donepezil;Drug: PlaceboOregon Health and Science UniversityMedical Research Foundation, OregonCompleted50 Years90 YearsAll20Early Phase 1United States
3EUCTR2017-002707-10-DK10/04/201803/11/2017Measurements of drug concentration in the blood for anti-dementia drugs, in order to improve efficacy and reduce side-effectsSerum-monitoring of anti-dementia drugs, and the relevance to side-effects, clinical efficacy and compliance Dementia in Alzheimers Disease, Parkinsons Disease and Dementia with Lewy Bodies
MedDRA version: 20.0Level: PTClassification code 10012271Term: Dementia Alzheimer's typeSystem Organ Class: 10029205 - Nervous system disorders
MedDRA version: 20.0Level: LLTClassification code 10012284Term: Dementia due to Parkinson's diseaseSystem Organ Class: 10029205 - Nervous system disorders
MedDRA version: 20.0Level: PTClassification code 10067889Term: Dementia with Lewy bodiesSystem Organ Class: 10029205 - Nervous system disorders
MedDRA version: 20.0Level: PTClassification code 10075174Term: Mixed dementiaSystem Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Trade Name: Memantin Orion
INN or Proposed INN: MEMANTINE
Product Name: Donepezil Sandoz
Product Code: 25330
INN or Proposed INN: DONEPEZIL
Regional Dementia Research Centre, Dept of NeurologyNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
110Phase 4Denmark
4NCT03011476April 11, 201727/12/2016Effect of Acetylcholinesterase Inhibitors on the Gait of the Patients With Parkinson DiseaseEffect of Acetylcholinesterase Inhibitors on the Gait of the Patients With Parkinson Disease Characterized by Postural Instability and Gait DisturbanceParkinson DiseaseDrug: Donepezil;Drug: PlacebosKyung Hee University HospitalNULLUnknown status40 Years75 YearsAll20Phase 4Korea, Republic of
5NCT02857244November 201625/7/2016A Multidisciplinary Approach to Manage Gait Difficulty in Parkinson PatientsA Multidisciplinary Approach to Manage Gait Difficulty in Parkinson PatientsParkinson's DiseaseDrug: Duloxetine;Drug: Donepezil;Drug: ModafinilUniversity of ChicagoNULLWithdrawn18 Years100 YearsAll0Phase 2United States
No.TrialIDDate_
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6NCT02415062July 201514/3/2015The Efficacy and Safety Study of High Dose Donepezil in Parkinson's Disease With DementiaThe Efficacy of 23mg Versus 10mg of Donepezil in ParkInson's Disease With DementiaParkinson's DiseaseDrug: DonepezilInje UniversityNULLRecruiting50 Years80 YearsBoth150Phase 2Korea, Republic of
7NCT02450786June 201514/5/2015Effect of Donepezil on Cognition in Parkinson's Disease With Mild Cognitive Impairment (PD-MCI)Parkinson's DiseaseDrug: DonepezilYonsei UniversityNULLActive, not recruiting40 YearsN/AAll80Phase 2Korea, Republic of
8NCT02206620July 201429/7/2014Effects of Cholinergic Augmentation on Measures of Balance and GaitEffects of Cholinergic Augmentation on Measures of Balance and GaitParkinson's DiseaseDrug: DonepezilOregon Health and Science UniversityMichael J. Fox Foundation for Parkinson's ResearchCompleted30 YearsN/AAll49Phase 2United States
9NCT02012595October 201326/11/2013[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons Disease[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons DiseaseParkinson's DiseaseOther: [11C]donepezil PETPer BorghammerLundbeck Foundation;Jascha Fonden;Fonden af 2. Juli 1984 til bekæmpelse af Parkinsons SygdomCompleted40 Years80 YearsBoth24N/ADenmark
10JPRN-UMIN0000107522013/05/1717/05/2013A study on usefulness and safety of donepezil for cognitive function and phychological symptoms of patients with Parkinson's disease and Alzheimer type dementia. Parkinson's diseasedonepezilKansai Medical UniversityNULLComplete: follow-up completeNot applicableNot applicableMale and Female50Not selectedJapan
No.TrialIDDate_
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11NCT01877538May 201311/6/2013Study to Investigate the Ability of [11C]Donepezil PET to Image the Parasympathetic Nervous System[11C]Donepezil PET for Imaging the Parasympathetic Nervous System in Healthy AdultsParkinson's DiseaseOther: [11C]donepezil PETPer BorghammerLundbeck FoundationCompleted45 Years75 YearsMale7Denmark
12JPRN-UMIN0000107782013/04/1022/05/2013Delayed start study of donepezil hydrocloride for cognitive decline in Parkinson disease following EDAP-1Delayed start study of donepezil hydrocloride for cognitive decline in Parkinson disease following EDAP-1 - EDAP-2 Parkinson disease5mg donepezil hydroclorideNational Hospital of UtanoNULLComplete: follow-up complete20years-oldNot applicableMale and Female50Not selectedJapan
13JPRN-UMIN0000099582013/03/0801/03/2013Effects of donepezil on the prognosis of Parkinson's disease with severe olfactory dysfunction Parkinson's diseaseDonepezil hydrochloride added to standard therapy
Placebo added to standard therapy
National Hospital Organization, Sendai-Nishitaga HospitalNULLComplete: follow-up complete55years-old75years-oldMale and Female200Not appl1cableJapan
14NCT01014858January 201316/11/2009Multi-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated With Parkinson's DiseaseMulti-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated With Parkinson's DiseaseParkinson's DiseaseDrug: DonepezilNewcastle-upon-Tyne Hospitals NHS TrustUniversity of Newcastle Upon-Tyne;University of Cambridge;University of Manchester;University of Birmingham;Bangor University;London School of Economics and Political Science;University College, London;Lancashire Care NHS Foundation Trust;Newcastle University;King's College LondonTerminated18 YearsN/AAll64Phase 3United Kingdom
15EUCTR2009-015170-35-GB27/01/201221/12/2011Study across 22 UK hospitals investigating if a drug called Donepezil Hydrochloride can help people with an early form of Parkinson's Disease dementia.Multicentre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated with Parkinson's Disease (MUSTARDD-PD) - Donepezil in Early Dementia Associated with Parkinson's Disease Parkinson's disease with mild dementia (PDD);Therapeutic area: Diseases [C] - Nervous System Diseases [C10]The Newcastle upon Tyne Hospitals NHS Foundation TrustNULLNot Recruiting Female: yes
Male: yes
500 Human pharmacology (Phase 1): no Therapeut1c exploratory (Phase 2): no Therapeut1c conf1rmatory - (Phase 3): yes Therapeut1c use (Phase 4): noUnited Kingdom
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
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16NCT01521117December 201112/1/2012The Effect of Donepezil on Gait and Balance in Parkinson's DiseaseA Randomized, Double-blind, Placebo Controlled, Crossover Study to Evaluate the Effect of Donepezil on Gait and Balance in Parkinson's DiseaseParkinson's DiseaseDrug: DonepezilOregon Health and Science UniversityNULLRecruitingN/AN/ABoth12Phase 4United States
17JPRN-UMIN0000054032011/04/0108/04/2011A Multi-center Randomized Placebo-controlled Double-blinded Study for the Efficacy of Donepezil against Psychosis in Parkinson Disease Parkinson disease5mg of donepezil hydrochloride
placebo
Designated Research, National Hospital OrganizationNULLComplete: follow-up complete20years-old80years-oldMale and Female142Phase 3Japan
18JPRN-UMIN0000030802010/01/0130/01/2010Double Blind Study for Effects of Donepezil Hydrochloride on Parkinson's Disease Parkinson's diseaseDonepezil hydrochloride (3mg for 2 weeks, 5mg for 2 weeks)
Placebo
Clinical Research Center, Utano National Hospital, National Hospital OrganizationNULLComplete: follow-up complete40years-old75years-oldMale and Female30Not appl1cableJapan
19NCT00912808October 20052/6/2009Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's DiseaseA Study of Cholinergic Augmentation in Frequently Falling Subjects With Parkinson'sParkinson's DiseaseDrug: Donepezil;Drug: Sugar Pill (placebo)Oregon Health and Science UniversityNULLCompleted21 YearsN/AAll23N/ANULL
20EUCTR2004-003355-39-AT14/09/200408/10/2004A 52-week, multicentre, open label extension study of the safety, tolerability and efficacy of donepezil (Aricept) in Parkinson's disease patients with dementia.A 52-week, multicentre, open label extension study of the safety, tolerability and efficacy of donepezil (Aricept) in Parkinson's disease patients with dementia. Dementia associated with Parkinson's diseaseTrade Name: Aricept 5 mg-Filmtabletten
Product Name: Aricept 5mg-Filmtabletten
Eisai LimitedNULLNot RecruitingFemale: yes
Male: yes
468Austria
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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21NCT01327859March 200330/3/2011Safety, Tolerability, and Efficacy of Donepezil (Aricept) in Parkinson' s Disease (PD) Patients With DementiaA 52-week, Multicentre Open Label Extension Study of the Safety Tolerability and Efficacy of Donepezil (Aricept) in Parkinson's Disease (PD) Patients With DementiaParkinson's Disease;DementiaDrug: Prior Donepezil 5mg;Drug: Prior Donzepezil 10mg;Drug: Prior PlaceboEisai Inc.NULLCompleted40 YearsN/ABoth357Phase 3United Kingdom
22NCT00165815August 200213/9/2005The Efficacy, Tolerability and Safety of Donepezil (Aricept) in Parkinson's Disease Patients With DementiaDementia With Parkinson's DiseaseDrug: ARICEPTEisai LimitedNULLCompleted40 YearsN/ABothPhase 3Germany;Ireland
23NCT00030979February 200215/2/2002Donepezil to Treat Dementia in Parkinson's DiseaseDonepezil for Dementia in Parkinson's Disease: A Randomized, Double Blinded Placebo Controlled Crossover TrialParkinson DiseaseDrug: DonepezilNational Institute of Neurological Disorders and Stroke (NINDS)NULLCompletedN/AN/ABoth28Phase 4United States

13. 多発性硬化症/視神経脊髄炎 [臨床試験数:3,050,薬物数:2,147(DrugBank:348),標的遺伝子数:244,標的パスウェイ数:228
Searched query = "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
4 / 3,050 trials found
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1EUCTR2008-001940-38-IT22/04/200814/04/2008Functional RMN study to evaluate the prompt and middle term effect of the treatment with Donepezil in patients affected by multiple sclerosis and mild impairment of cognitive function. - NDFunctional RMN study to evaluate the prompt and middle term effect of the treatment with Donepezil in patients affected by multiple sclerosis and mild impairment of cognitive function. - ND patients affected by multiple sclerosis
MedDRA version: 9.1Level: LLTClassification code 10063399Term: Relapsing-remitting multiple sclerosis
Trade Name: ARICEPT
INN or Proposed INN: Donepezil
Trade Name: ARICEPT
INN or Proposed INN: Donepezil
OSPEDALE S. RAFFAELENULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Italy
2EUCTR2005-003410-15-SE21/11/200529/09/2005A twelve-month double-blind placebo-controlled cross-over study of the effect ofAricept treatment on cognitive dysfunction in multiple sclerosis. - Aricept in MSA twelve-month double-blind placebo-controlled cross-over study of the effect ofAricept treatment on cognitive dysfunction in multiple sclerosis. - Aricept in MS Multiple sclerosis is a devastating inflammation in the central nervous system and it can often give cognitive dysfunction, affecting memory, mental concentration. Lately it has been shown that the cognitive dysfunction has a big impact on life quality. Immunomodulatory medication can only partially limit the bouts but there is no effective cure at the moment. There is little options to treat the effects on higher functions for the moment.Trade Name: Aricept 5 mg filmdragerade tabletter
Product Name: Aricept 5 mg
INN or Proposed INN: Donepezil
Trade Name: Aricept 10 mg filmdragerade tabletter
Product Name: Aricept 10 mg
INN or Proposed INN: Donepezil
Neurology UnitNULLNot RecruitingFemale: yes
Male: yes
20Sweden
3NCT00315367September 200414/4/2006A fMRI(Functional Magnetic Resonance Imaging) Research Study to Learn More About Multiple Sclerosis and Individuals Potentially Experiencing Memory DifficultiesA Double-Blind, Crossover Trial of Aricept® in Memory-Impaired Patients With Multiple Sclerosis: A Phase IV Demonstration of Functional MRI (fMRI) as a Surrogate Marker of Brain Activity Associated With Improvement in Memory FunctionRelapsing-Remitting Multiple SclerosisDrug: Donepezil HCI (drug)NeurognosticsNULLCompleted18 Years65 YearsBoth26Phase 4United States
4NCT00062972September 199918/6/2003Improving Memory in Patients With Multiple SclerosisInterventions to Improve Memory in Patients With Multiple SclerosisMultiple SclerosisDrug: donepezil;Drug: glucoseEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)U.S. Department of EducationWithdrawn18 Years56 YearsAll0Phase 3United States

46. 悪性関節リウマチ [臨床試験数:4,183,薬物数:2,538(DrugBank:401),標的遺伝子数:183,標的パスウェイ数:219
Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 4,183 trial found
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1NCT02927522September 1, 20185/10/2016Donepezil Attenuate Postoperative Cognitive DysfunctionDonepezil Attenuate Postoperative Cognitive Dysfunction in Aged Patients- A Multi-center, Case Control, Randomized Clinical TrailOsteoarthritis;Femoral Head Necrosis;Rheumatoid ArthritisDrug: Donepezil;Drug: PlaceboRenJi HospitalShanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineRecruiting60 YearsN/AAll550Phase 3China

78. 下垂体前葉機能低下症 [臨床試験数:462,薬物数:346(DrugBank:45),標的遺伝子数:41,標的パスウェイ数:80
Searched query = "Hypopituitarism", "Anterior pituitary hypothyroidism", "Syndrome of abnormal secretion of gonadotropin", "Hyposecretion of gonadotropins", "Adrenocorticotropic hormone deficiency", "ACTH deficiency", "Thyroid-stimulating hormone deficiency", "TSH deficiency", "Growth hormone deficiency", "GH deficiency", "GHD", "CGHD", "AGHD", "Prolactin deficiency", "PRL deficiency"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 462 trial found
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1EUCTR2005-001315-22-AT09/03/200618/01/2006The effect of the cholinesterase inhibitor donepezil on organic and functional deficits related to growth hormone deficiency in old age.The effect of the cholinesterase inhibitor donepezil on organic and functional deficits related to growth hormone deficiency in old age. We plan to study healthy aging subjects.Trade Name: Aricept
Product Name: Aricept
Product Code: Donepezil
Ludwig Boltzmann GesellschaftNULLNot RecruitingFemale: yes
Male: yes
80Austria

124. 皮質下梗塞と白質脳症を伴う常染色体優性脳動脈症 [臨床試験数:11,薬物数:13(DrugBank:4),標的遺伝子数:3,標的パスウェイ数:11
Searched query = "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy", "CADASIL", "Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy", "Autosomal dominant cerebral artery disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
7 / 11 trials found
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Public_titleScientific_titleConditionInterventionPrimary_
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1EUCTR2004-001162-40-IT05/04/200521/09/2005An 18-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment.An 18-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment. Donezepil HCl for treatment of patients with CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infracts and leukoencephalopathy) who have cognitive impairment.
MedDRA version: 6.1Level: PTClassification code 10009843
Trade Name: ARICEPT 5*28 CPR 5 MG
Product Name: NA
Product Code: NA
INN or Proposed INN: Donepezil
EISAI LTD UKNULLNot RecruitingFemale: yes
Male: yes
Finland;United Kingdom;Germany;Spain;Italy;Sweden
2EUCTR2004-001162-40-SE01/04/200503/02/2005An 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASILAn 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASIL Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).CADASIL is a genetic disorder representing a minority of the patients who develop vascular dementia.
MedDRA version: 7.0Level: PTClassification code 10057678
Trade Name: Aricept
Product Name: Aricept
Product Code: E2020
INN or Proposed INN: donepezil hydrochloride
Eisai LtdNULLNot RecruitingFemale: yes
Male: yes
150Finland;United Kingdom;Germany;Spain;Italy;Sweden
3EUCTR2004-001162-40-ES29/03/200520/01/2006An 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASILAn 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASIL Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL is a genetic disorder representing a minority of the patients who develop vascular dementia.
MedDRA version: 7.0 Level: PT Classification code 10057678
Eisai LtdNULLNot Recruiting Female: yes
Male: yes
150 Human pharmacology (Phase 1): Therapeut1c exploratory (Phase 2): yes Therapeut1c conf1rmatory - (Phase 3): Therapeut1c use (Phase 4):Finland;Spain;Germany;Italy;United Kingdom;Sweden
4EUCTR2004-001162-40-FI08/03/200528/12/2004An 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASILAn 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASIL Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).CADASIL is a genetic disorder representing a minority of the patients who develop vascular dementia.
MedDRA version: 7.0Level: PTClassification code 10057678
Trade Name: Aricept
Product Name: Aricept
Product Code: E2020
INN or Proposed INN: donepezil hydrochloride
Eisai LtdNULLNot RecruitingFemale: yes
Male: yes
150Phase 2Finland;Spain;Germany;Italy;United Kingdom;Sweden
5EUCTR2004-001162-40-GB24/02/200523/02/2005An 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASILAn 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASIL Cerebral autosomal dominant arteriopathy with subcortical infracts and leukoencephalopathy (CADASIL). CADASIL is a genetic disorder representing a minority of the patients who develop vascular dementia.
MedDRA version: 7.0 Level: PT Classification code 10057678
Eisai LtdNULLNot Recruiting Female: yes
Male: yes
150 Human pharmacology (Phase 1): Therapeut1c exploratory (Phase 2): yes Therapeut1c conf1rmatory - (Phase 3): Therapeut1c use (Phase 4):Finland;Spain;Germany;Italy;United Kingdom;Sweden
No.TrialIDDate_
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PhaseCountries
6NCT00103948February 200517/2/2005The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive ImpairmentAn 18-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive ImpairmentCognitive ImpairmentDrug: AriceptEisai LimitedNULLCompleted25 Years70 YearsBoth165Phase 2United States;Australia;Spain;Canada;Finland;France;Germany;Italy;Sweden;Switzerland;United Kingdom
7EUCTR2004-001162-40-DE25/01/2005An 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASILAn 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment. - Donepezil HCl in CADASIL Cerebral autosomal dominant arteriopathy with subcortical infracts and leukoencephalopathy (CADASIL).CADASIL is a genetic disorder representing a minority of the patients who develop vascular dementia.
MedDRA version: 7.0Level: PTClassification code 10057678
Trade Name: Aricept
Product Name: Aricept
Product Code: E2020
INN or Proposed INN: donepezil hydrochloride
Eisai LtdNULLNot RecruitingFemale: yes
Male: yes
150Finland;Spain;Germany;Italy;United Kingdom;Sweden

127. 前頭側頭葉変性症 [臨床試験数:74,薬物数:83(DrugBank:28),標的遺伝子数:29,標的パスウェイ数:99
Searched query = "Frontotemporal lobar degeneration", "Frontotemporal dementia", "Semantic dementia"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 74 trial found
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1JPRN-UMIN0000032392008/01/0123/02/2010Influence of donepezil to behavioral and psychological symptoms of frontotemporal dementia Frontotemporal dementiaDiscontinuation of donepezilNational Hospital Organization Kikuchi HospitalNULLComplete: follow-up complete50years-old90years-oldMale and Female25Not selectedJapan

156. レット症候群 [臨床試験数:36,薬物数:49(DrugBank:19),標的遺伝子数:77,標的パスウェイ数:112
Searched query = "Rett syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 36 trials found
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1NCT00069550September 200429/9/2003Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett SyndromePathogenesis of Rett Syndrome: Natural History and TreatmentRett SyndromeDrug: dextromethorphan;Drug: donepezil hydrochlorideEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NULLRecruiting1 Year15 YearsBoth90Phase 3United States
2NCT00004807January 199524/2/2000Study of the Pathogenesis of Rett SyndromeRett SyndromeDrug: dextromethorphan;Drug: topiramate;Drug: DonepezilEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Johns Hopkins UniversityCompletedN/A45 YearsBoth120N/ANULL

206. 脆弱X症候群 [臨床試験数:98,薬物数:73(DrugBank:27),標的遺伝子数:46,標的パスウェイ数:57
Searched query = "Fragile X syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 98 trials found
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1NCT01120626September 20097/5/2010Randomized Controlled Study of Donepezil in Fragile X SyndromeAugmentation of the Cholinergic System in Fragile X Syndrome: A Double-Blind Placebo-Controlled Randomized Study of DonepezilFragile X SyndromeDrug: donepezil;Drug: sugar pillStanford UniversityNational Institute of Mental Health (NIMH);Autism SpeaksCompleted12 Years29 YearsAll45Phase 2United States
2NCT00220584July 200515/9/2005An Open-Label Trial of Donepezil in Fragile X SyndromeAn Open-Label Trial of Donepezil in Fragile X SyndromeFragile X SyndromeDrug: donepezilStanford UniversityNULLCompleted14 YearsN/ABoth10Phase 1United States