Drug（薬物リスト） DrugBank | All Description Patterns💬 Info on mouse-over

No.	薬物名（臨床試験情報から抽出）	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	指定難病告示番号
1	Abatacept (aba) + methotrexate (mtx), double-blind (db)	Abatacept	3件: D00142, D02115, D03203 💬	4件: CD80, CD86, DHFR, DHFR2 💬	17件: Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	1件: 46 💬
2	Abatacept + methotrexate	Abatacept	3件: D00142, D02115, D03203 💬	4件: CD80, CD86, DHFR, DHFR2 💬	17件: Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	1件: 46 💬
3	Abatacept active treatment	Abatacept	1件: D03203 💬	2件: CD80, CD86 💬	12件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	1件: 50 💬
4	Abatacept delayed-onset treatment	Abatacept	1件: D03203 💬	2件: CD80, CD86 💬	12件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	1件: 50 💬
5	Active investigational treatment ent-01	-	-	-	-	1件:  6  💬
6	Active treatment group 7% hypertonic saline	-	-	-	-	1件: 299 💬
7	Adalimumab with methotrexate	Adalimumab	3件: D00142, D02115, D02597 💬	3件: DHFR, DHFR2, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
8	Azathioprine or methotrexate	Azathioprine	4件: D00142, D00238, D02115, D03033 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 96 💬
9	Baseline treatment	-	-	-	-	1件: 13 💬
10	Bdmard treatment	-	-	-	-	1件: 271 💬
11	Behavioral: co-op treatment protocol	-	-	-	-	1件:  6  💬
12	Behavioral: conservative treatment	-	-	-	-	1件: 291 💬
13	Bendamustine	Bendamustine	2件: D07085, D07501 💬	-	-	2件: 28, 61 💬
14	Bendamustine hydrochloride	Bendamustine	2件: D07085, D07501 💬	-	-	1件: 61 💬
15	Bendamustine, rituximab	Bendamustine	3件: D02994, D07085, D07501 💬	1件: MS4A1 💬	1件: Hematopoietic cell lineage	1件: 61 💬
16	Best medical treatment	-	-	-	-	1件:  6  💬
17	Best médical treatment	-	-	-	-	1件:  6  💬
18	Bisphosphonate treatment	-	-	-	-	2件: 113, 299 💬
19	Bms-582949 and methotrexate	BMS-582949	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
20	Botulism toxin treatment	-	-	-	-	1件: 161 💬
21	Break in l-carnitine treatment	Levocarnitine	3件: D02030, D02176, D04713 💬	-	-	1件: 316 💬
22	Busulfan/fludarabine phosphate/tacrolimus/methotrexate/g-csf	Busulfan	8件: D00107, D00142, D00248, D01907, D02115, D03235, D07966, D08556 💬	9件: CSF3R, DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, RRM1 💬	46件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway	1件: 60 💬
23	C-trelin od tab(5mg taltirelin hydrate)	-	-	-	-	1件: 18 💬
24	Certolizumab pegol + methotrexate (mtx)	Certolizumab pegol	3件: D00142, D02115, D03441 💬	3件: DHFR, DHFR2, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
25	Cf patients with a g551d mutation and treated with ivacaftor	Ivacaftor	1件: D09916 💬	1件: CFTR 💬	8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway	1件: 299 💬
26	Classic dmards treatment group	-	-	-	-	1件: 46 💬
27	Clobetasol propionate + methotrexate	Clobetasol	4件: D00142, D01272, D02115, D07715 💬	3件: DHFR, DHFR2, NR3C1 💬	6件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate	1件: 162 💬
28	Clobetasol propionate cream treatment	Clobetasol	2件: D01272, D07715 💬	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction	1件: 162 💬
29	Combination product: active treatment with dual therapy	-	-	-	-	1件:  2  💬
30	Combination product: implantable system for remodulin (treprostinil)	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
31	Combination product: methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
32	Combination product: treprostinil via implanted pump	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
33	Corticosteroid treatment (methylprednisolone or prednisolone)	Methylprednisolone	14件: D00407, D00472, D00751, D00979, D00980, D00981, D00982, D01239, D01998, D02156, D03301, D05000, D05001, D05002 💬	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction	1件: 64 💬
34	Cp-690,550 + methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
35	Current lipid-lowering treatment	-	-	-	-	1件: 79 💬
36	Cutaneous iontophoresis of treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 51 💬
37	Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids	Azathioprine	6件: D00142, D00238, D00287, D02115, D03033, D07760 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 44 💬
38	Cyclosporin, methotrexate (gvhd prophylaxis)	Cyclosporine	3件: D00142, D00184, D02115 💬	7件: DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	37件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway	1件: 326 💬
39	Cytokine-treated veto cells	-	-	-	-	1件: 60 💬
40	Deferiprone treated	Deferiprone	1件: D07416 💬	-	-	1件: 120 💬
41	Detoxifying agents for antineoplastic treatment	-	-	-	-	1件: 299 💬
42	Device: trekking pole (tp).	-	-	-	-	1件: 13 💬
43	Dietanolamina de treprostinilo	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
44	Dmards (methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
45	Dopamine agonist treatment	Dopamine	2件: D00633, D07870 💬	5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬	11件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway	1件: 74 💬
46	Drug treatment	-	-	-	-	4件: 46, 51, 74, 271 💬
47	Early immunosuppressants (azathioprine, methotrexate)	Azathioprine	4件: D00142, D00238, D02115, D03033 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 96 💬
48	Era as specific pah treatment	-	-	-	-	1件: 86 💬
49	Etanercept + methotrexate	Etanercept	3件: D00142, D00742, D02115 💬	4件: DHFR, DHFR2, LTA, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
50	Etanercept , methotrexate	Etanercept	3件: D00142, D00742, D02115 💬	4件: DHFR, DHFR2, LTA, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
51	Etanercept treatment	Etanercept	1件: D00742 💬	2件: LTA, TNF 💬	65件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
52	Etanercept, methotrexate and depomedrone	Etanercept	3件: D00142, D00742, D02115 💬	4件: DHFR, DHFR2, LTA, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
53	Etanercept, methotrexate, prednisolone	Etanercept	11件: D00142, D00472, D00742, D00980, D00981, D00982, D01239, D01998, D02115, D02156, D03301 💬	5件: DHFR, DHFR2, LTA, NR3C1, TNF 💬	70件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 56 💬
54	Eutonic treprostinil solution	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
55	Experimental (non immunosuppressive symptomatic treatment (nist) and rituximab)	Rituximab	1件: D02994 💬	1件: MS4A1 💬	1件: Hematopoietic cell lineage	1件: 222 💬
56	Exposure to one or more disease-modifying drug(s)(dmds) used to treat ms	-	-	-	-	1件: 13 💬
57	Fibrate treatment	-	-	-	-	1件: 160 💬
58	Foliglurax 10 mg (treatment a)	Foliglurax	-	-	-	1件:  6  💬
59	Foliglurax 30 mg (treatment b)	Foliglurax	-	-	-	1件:  6  💬
60	From august 2020 'no additional treatment'	-	-	-	-	1件: 51 💬
61	Genotropin (somatropin) is a growth hormone treatment. it is an exact copy of the natural growth hormone that our bodies make. the main difference is that genotropin is man-made.	Somatotropin	1件: D02691 💬	1件: GHR 💬	5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway	1件: 193 💬
62	Glucocorticoid treatment	-	-	-	-	1件: 41 💬
63	Golimumab treatment optimization.	Golimumab	1件: D04358 💬	1件: TNF 💬	65件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 97 💬
64	Group 1 or orencia treated group	-	-	-	-	1件: 46 💬
65	Guselkumab	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	4件: 37, 41, 96, 97 💬
66	Guselkumab 100 mg	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	1件: 37 💬
67	Guselkumab dose 1	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	2件: 96, 97 💬
68	Guselkumab dose 2	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	2件: 96, 97 💬
69	Guselkumab dose 3	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	1件: 96 💬
70	Guselkumab dose 4	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	1件: 96 💬
71	Guselkumab dose 5	Guselkumab	1件: D10438 💬	1件: IL23A 💬	9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis	1件: 96 💬
72	Hcq/cq and cab combined treatment	-	-	-	-	1件: 74 💬
73	Herbal treatment (sa100)	-	-	-	-	1件: 97 💬
74	Hyperpolarized 129 xenon gas comparing idiopathic pulmonary fibrosis (ipf) treatment	Xenon	2件: D01901, D06339 💬	-	-	1件: 85 💬
75	Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)	Azathioprine	8件: D00142, D00238, D00752, D02115, D03033, D05094, D05095, D05096 💬	4件: DHFR, DHFR2, IMPDH1, IMPDH2 💬	7件: Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism	1件: 49 💬
76	Immunosuppressive treatment	-	-	-	-	1件: 66 💬
77	Immunosuppressive treatment (eg, rituximab)	Rituximab	1件: D02994 💬	1件: MS4A1 💬	1件: Hematopoietic cell lineage	1件: 64 💬
78	In double-blind phase: treatment with tofacitinib	Tofacitinib	1件: D09970 💬	4件: JAK1, JAK2, JAK3, TYK2 💬	35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis	1件: 107 💬
79	In open-label phase: treatment with tofacitinib	Tofacitinib	1件: D09970 💬	4件: JAK1, JAK2, JAK3, TYK2 💬	35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis	1件: 107 💬
80	Infliximab + methotrexate (mtx)	Infliximab	3件: D00142, D02115, D02598 💬	3件: DHFR, DHFR2, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
81	Infliximab, methylprednisolone, methotrexate	Infliximab	9件: D00142, D00407, D00751, D00979, D02115, D02598, D05000, D05001, D05002 💬	4件: DHFR, DHFR2, NR3C1, TNF 💬	70件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
82	Inhaled dry powder treprostinil (liq861)	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
83	Inhaled treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	2件: 84, 86 💬
84	Interferon beta treatment to add-on atorvastatin treatment	Atorvastatin	3件: D00258, D00887, D07474 💬	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis	1件: 13 💬
85	Intrathecal methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 13 💬
86	Intravenous treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
87	Intravenous/subcutaneous treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
88	Iontophoresis of treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 51 💬
89	Iv treatment with igsc, 10%	-	-	-	-	1件: 65 💬
90	L606 (liposomal treprostinil) inhalation solution 51ug	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
91	Lapaquistat acetate and current lipid-lowering treatment	Acetate	-	-	-	1件: 79 💬
92	Liq861 inhaled treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
93	Lumacaftor-ivacaftor treatment	Ivacaftor	2件: D09916, D10134 💬	1件: CFTR 💬	8件: ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway	1件: 299 💬
94	Metformin treatment	Metformin	2件: D00944, D04966 💬	2件: PRKAA1, PRKAA2 💬	19件: AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway	1件: 46 💬
95	Methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	35件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
96	Methotrexate 'lederle' 2,5mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
97	Methotrexate 'lederle' 2.5mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
98	Methotrexate 'lederle' tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
99	Methotrexate (metoject® prefilled pen)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
100	Methotrexate (mtx)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
101	Methotrexate (stable dose)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
102	Methotrexate (tapering dose)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
103	Methotrexate + biologic administration	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
104	Methotrexate + infliximab	Infliximab	3件: D00142, D02115, D02598 💬	3件: DHFR, DHFR2, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
105	Methotrexate + methylprednisolone	Methotrexate	8件: D00142, D00407, D00751, D00979, D02115, D05000, D05001, D05002 💬	3件: DHFR, DHFR2, NR3C1 💬	6件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate	1件: 46 💬
106	Methotrexate + salazopyrine + hydroxychloroquine administration	Hydroxychloroquine	3件: D00142, D02115, D08050 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
107	Methotrexate - amneal	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
108	Methotrexate - dava	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
109	Methotrexate - delay	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
110	Methotrexate - etanercept - prednisolone arm	Etanercept	11件: D00142, D00472, D00742, D00980, D00981, D00982, D01239, D01998, D02115, D02156, D03301 💬	5件: DHFR, DHFR2, LTA, NR3C1, TNF 💬	70件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
111	Methotrexate - immediate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
112	Methotrexate 10 mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
113	Methotrexate 10 mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
114	Methotrexate 2.5 mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 44 💬
115	Methotrexate 2.5 mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
116	Methotrexate 2.5mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
117	Methotrexate 2.5mg tablets bp	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
118	Methotrexate 25 mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 44 💬
119	Methotrexate 50mg/ml solution for injection, pre-filled syringe	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
120	Methotrexate ``lederle`` 2.5mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
121	Methotrexate and folic acid	Folic acid	3件: D00070, D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 49 💬
122	Methotrexate as methotrexate disodium	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
123	Methotrexate bellon	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 97 💬
124	Methotrexate bellon 25mg/ml	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 97 💬
125	Methotrexate capsules	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
126	Methotrexate disodium	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	3件: 46, 96, 97 💬
127	Methotrexate ebewe	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
128	Methotrexate hospira 2,5 mg tablety	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
129	Methotrexate hospira 2.5 mg tablety	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
130	Methotrexate injection	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	2件: 96, 97 💬
131	Methotrexate lachema 5inj. sol	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 50 💬
132	Methotrexate lederle 2.5 mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
133	Methotrexate pfizer 2,5 mg tabletter	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
134	Methotrexate placebo	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
135	Methotrexate plus enbrel or enbrel alone	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
136	Methotrexate plus erb-041 for 12 weeks	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
137	Methotrexate plus sulfasalazine	Methotrexate	3件: D00142, D00448, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
138	Methotrexate pre-filled pen	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
139	Methotrexate prefilled pen	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
140	Methotrexate prefilled syringe	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
141	Methotrexate sodium	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	2件: 46, 256 💬
142	Methotrexate sodium 2.5mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
143	Methotrexate sodium tablets 2.5 mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
144	Methotrexate sodium tablets 2.5mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
145	Methotrexate tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 40 💬
146	Methotrexate tablets 2.5 mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
147	Methotrexate treatment	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	2件: 41, 46 💬
148	Methotrexate wyeth 2,5mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 50 💬
149	Methotrexate wyeth 2,5mg tbl.	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 50 💬
150	Methotrexate ® 2.5mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
151	Methotrexate(mtx)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
152	Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
153	Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
154	Methotrexate(necessary)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
155	Methotrexate*100cpr 2,5mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
156	Methotrexate*10mg/1,33ml 4s	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
157	Methotrexate*15mg/2ml 4sir	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
158	Methotrexate*2,5mg 25cpr	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
159	Methotrexate*20mg/2,66ml 4s	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
160	Methotrexate*25cpr 2,5mg	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
161	Methotrexate*7,5mg/ml 4sir.	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
162	Methotrexate, leucovorin and bms-986142	BMS-986142	5件: D00142, D01211, D02115, D07986, D07987 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
163	Methotrexate,adalimumab	Adalimumab	3件: D00142, D02115, D02597 💬	3件: DHFR, DHFR2, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
164	Methotrexate-lachema	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
165	Methotrexate-sulfasalazine-hydroxychloroquine	Hydroxychloroquine	4件: D00142, D00448, D02115, D08050 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
166	Methotrexate® 2.5 mg tablets	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
167	Mk0812 / duration of treatment: 12 weeks	-	-	-	-	1件: 46 💬
168	Monthly autologous treg cells infusions + 3 times per week interleukin-2 injections	Human interleukin-2	-	-	-	1件:  2  💬
169	Mp-435(dose1) + methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
170	Msc treatment	-	-	-	-	1件: 49 💬
171	Msc treatment 01	-	-	-	-	1件: 96 💬
172	Msc treatment 02	-	-	-	-	1件: 96 💬
173	Mycophenolate mofetil,methotrexate	Methotrexate	6件: D00142, D00752, D02115, D05094, D05095, D05096 💬	4件: DHFR, DHFR2, IMPDH1, IMPDH2 💬	7件: Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism	3件: 42, 43, 45 💬
174	Natalizumab treatment	Natalizumab	1件: D06886 💬	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection	1件: 13 💬
175	Nifurtimox-eflronithine combination treatment (nect)	Nifurtimox	1件: D00833 💬	-	-	1件: 65 💬
176	Nusinersen treatments	Nusinersen	1件: D10881 💬	1件: SMN2 💬	1件: RNA transport	1件:  3  💬
177	Nutrition treat	-	-	-	-	1件: 96 💬
178	Observational study with patients treated with tracleer, ventavis, veletri, opsumit and/or uptravi	-	-	-	-	1件: 86 💬
179	Oc oral solution treatment a	-	-	-	-	1件:  6  💬
180	Oc oral solution treatment b	-	-	-	-	1件:  6  💬
181	Oc oral solution treatment c	-	-	-	-	1件:  6  💬
182	Oc oral solution treatment d	-	-	-	-	1件:  6  💬
183	Only 1 arm: treatment with msc-afp	-	-	-	-	1件: 96 💬
184	Optimized antiparkinsonian treatment	-	-	-	-	1件:  6  💬
185	Oral anticoagulant treatment	-	-	-	-	1件: 86 💬
186	Oral methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
187	Oral treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	2件: 51, 86 💬
188	Oral treprostinil (ut-15c) sustained release tablets	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
189	Other parkinson's disease treatments	-	-	-	-	1件:  6  💬
190	Other: adalimumab treatment	Adalimumab	1件: D02597 💬	1件: TNF 💬	65件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 151 💬
191	Other: best medical treatment	-	-	-	-	1件:  6  💬
192	Other: cd-treat diet	-	-	-	-	1件: 96 💬
193	Other: control wound treatment	-	-	-	-	1件: 36 💬
194	Other: crohn's disease treatment-with-eating diet (cd-treat diet)	-	-	-	-	1件: 96 💬
195	Other: current treatment	-	-	-	-	1件: 46 💬
196	Other: dead sea solar and water treatment	Water	1件: D00001 💬	-	-	1件: 46 💬
197	Other: diet treatment	-	-	-	-	1件: 240 💬
198	Other: group 2 (dmards treated group)	-	-	-	-	1件: 46 💬
199	Other: intensify treatment with the existing drug	-	-	-	-	2件: 96, 97 💬
200	Other: methotrexate therapy	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
201	Other: motor assessments before taking regular pd treatment	-	-	-	-	1件:  6  💬
202	Other: motor assessments on regular pd treatment	-	-	-	-	1件:  6  💬
203	Other: multidisciplinary intensive rehabilitation treatment	-	-	-	-	1件:  6  💬
204	Other: no active treatment	-	-	-	-	1件: 274 💬
205	Other: no anti-inflammatory treatment	-	-	-	-	1件: 271 💬
206	Other: no it treatment	-	-	-	-	1件: 19 💬
207	Other: no treatment	-	-	-	-	2件: 53, 256 💬
208	Other: no treatment arm	-	-	-	-	1件: 13 💬
209	Other: no treatment given	-	-	-	-	1件: 78 💬
210	Other: observation of ocrelizumab as treatment in rrms patients	Ocrelizumab	1件: D05218 💬	1件: MS4A1 💬	1件: Hematopoietic cell lineage	1件: 13 💬
211	Other: on-demand treatment	-	-	-	-	1件: 299 💬
212	Other: other: symptomatic treatment of als	-	-	-	-	1件:  2  💬
213	Other: sle treatment	-	-	-	-	1件: 49 💬
214	Other: standard steroid treatment	-	-	-	-	1件: 113 💬
215	Other: standard treatment	-	-	-	-	1件: 227 💬
216	Other: standard treatment according to the clinical protocols	-	-	-	-	1件: 49 💬
217	Other: usual drug treatment of parkinson's disease	-	-	-	-	1件:  6  💬
218	Ova-treg	-	-	-	-	1件: 96 💬
219	Ovastat 1000 (treosulfan injection)	Treosulfan	1件: D07253 💬	-	-	1件: 65 💬
220	Ovastat 5000 (treosulfan injection)	Treosulfan	1件: D07253 💬	-	-	1件: 65 💬
221	Parenteral remodulin (treprostinil) injection	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
222	Patient treated with dmard	-	-	-	-	1件: 46 💬
223	Pentoxifylline	Pentoxifylline	1件: D00501 💬	-	-	10件: 26, 56, 84, 93, 96, 113, 220, 222, 296, 298 💬
224	Phase 1: methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
225	Pioglitazone and tretinoin	Pioglitazone	3件: D00094, D00945, D08378 💬	4件: PML, PPARG, RARA, RARB 💬	19件: AMPK signaling pathway, Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Huntington disease, Influenza A, Longevity regulating pathway, Non-small cell lung cancer, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis	1件:  2  💬
226	Plasma from healthy young people treatment + riluzole	Riluzole	1件: D00775 💬	14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway	1件:  2  💬
227	Pooled plasma (human), solvent/detergent treated	-	-	-	-	1件: 64 💬
228	Ppi treatment	-	-	-	-	1件: 299 💬
229	Prednisone and ustekinumab treatment	Prednisone	2件: D00473, D09214 💬	4件: IL12A, IL12B, IL23A, NR3C1 💬	27件: African trypanosomiasis, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Malaria, Measles, Neuroactive ligand-receptor interaction, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus	1件: 41 💬
230	Prednisone treatment	Prednisone	1件: D00473 💬	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction	1件: 41 💬
231	Probiotic treatment	-	-	-	-	1件: 294 💬
232	Procedure: in vitro-treated bone marrow transplantation	-	-	-	-	1件: 60 💬
233	Procedure: in vitro-treated peripheral blood stem cell transplantation	-	-	-	-	2件: 60, 65 💬
234	Procedure: surgery treatment	-	-	-	-	1件: 291 💬
235	Procedure: transsphenoidal surgery treatment	-	-	-	-	1件: 74 💬
236	Procedure: treatment according to current standards without knowledge of serum infliximab and anti-infliximab ab status	Infliximab	1件: D02598 💬	1件: TNF 💬	65件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 96 💬
237	Propranolol treatment	Propranolol	2件: D00483, D08443 💬	3件: ADRB1, ADRB2, ADRB3 💬	11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway	1件: 227 💬
238	Rapid dose titration group of subcutaneous treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
239	Regular treatment	-	-	-	-	1件: 97 💬
240	Remodulin (treprostinil sodium)	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
241	Remodulin® (treprostinil) 1 mg/ml solution for infusion	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
242	Remodulin® (treprostinil) 10 mg/ml solution for infusion	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
243	Remodulin® (treprostinil) 2.5 mg/ml solution for infusion	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
244	Remodulin® (treprostinil) 5 mg/ml solution for infusion	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
245	Repository corticotropin injection -treatment extension	Corticotropin	1件: D00146 💬	1件: MC2R 💬	5件: Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway	1件: 84 💬
246	Response to anakinra associated with methotrexate	Anakinra	3件: D00142, D02115, D02934 💬	4件: DHFR, DHFR2, IL1R1, IL1R2 💬	20件: Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer	1件: 46 💬
247	Response to infliximab associated with methotrexate	Infliximab	3件: D00142, D02115, D02598 💬	3件: DHFR, DHFR2, TNF 💬	69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
248	Routine treatment of cd	-	-	-	-	1件: 96 💬
249	Sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group)	Amitriptyline	7件: D00326, D00809, D00823, D01355, D02691, D07448, D08623 💬	4件: GHR, OPRM1, SLC6A2, SLC6A4 💬	9件: Cytokine-cytokine receptor interaction, Estrogen signaling pathway, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Serotonergic synapse, Synaptic vesicle cycle	1件: 78 💬
250	Sc treatment with igsc, 10% with rhuph20 followed by iv/igsc, 10% only (safety)	-	-	-	-	1件: 65 💬
251	Sc treatment with igsc, 10% with rhuph20 followed by sc/igsc, 10% only (safety)	-	-	-	-	1件: 65 💬
252	Simvastatin treatment for 28 days	Simvastatin	1件: D00434 💬	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis	1件: 299 💬
253	Slow dose titration group of subcutaneous treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
254	Stable weekly dose of methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
255	Standard of care treatment	-	-	-	-	2件: 245, 246 💬
256	Standard steroid treatment	-	-	-	-	1件: 85 💬
257	Standard treatment with a conventional drug	-	-	-	-	1件: 13 💬
258	Standrd of care treatment	-	-	-	-	1件: 64 💬
259	Subcutaneous treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
260	Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin)	Aldosterone	3件: D00150, D02014, D10528 💬	3件: AGTR1, AGTR2, NR3C2 💬	17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	1件: 222 💬
261	Symptomatic treatment, steroids, immunosuppressive agents( azathioprine, tacrolimus, mycophenolate mofetil)	Azathioprine	8件: D00107, D00238, D00752, D03033, D05094, D05095, D05096, D08556 💬	7件: IMPDH1, IMPDH2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	35件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Drug metabolism - other enzymes, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway	1件: 11 💬
262	Symptomatic treatment, steroids, immunosuppressive agents, plasma exchange(pe), intravenous immunoglobulin(ivig)	Human immunoglobulin G	-	-	-	1件: 11 💬
263	Systemic non-biological treatments	-	-	-	-	2件: 46, 271 💬
264	Tacrolimus with methotrexate	Methotrexate	4件: D00107, D00142, D02115, D08556 💬	7件: DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	37件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway	1件: 46 💬
265	Tak-715 and methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
266	Tak-783 and methotrexate	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
267	Tasocitinib plus methotrexate	Methotrexate	3件: D00142, D02115, D09970 💬	6件: DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬	40件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis	1件: 46 💬
268	The comprehensive treatment regimen of traditional chinese medicine	-	-	-	-	1件: 222 💬
269	The standard steroid treatment, plasma exchange and rituximab	Rituximab	1件: D02994 💬	1件: MS4A1 💬	1件: Hematopoietic cell lineage	1件: 85 💬
270	Time delay treatment of botulinum toxin	-	-	-	-	1件: 149 💬
271	Tl011, anti cd20, for the treatment of rheumatoid arthritis	-	-	-	-	1件: 46 💬
272	Tocilizumab + methotrexate(mtx)	Methotrexate	3件: D00142, D02115, D02596 💬	3件: DHFR, DHFR2, IL6R 💬	17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor	1件: 46 💬
273	Tocilizumab plus methotrexate	Methotrexate	3件: D00142, D02115, D02596 💬	3件: DHFR, DHFR2, IL6R 💬	17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor	1件: 46 💬
274	Tocilizumab treatment	Tocilizumab	1件: D02596 💬	1件: IL6R 💬	12件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor	1件: 41 💬
275	Tocilizumab+methotrexate(mtx)	Methotrexate	3件: D00142, D02115, D02596 💬	3件: DHFR, DHFR2, IL6R 💬	17件: Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor	1件: 46 💬
276	Tofacitinib with methotrexate	Methotrexate	3件: D00142, D02115, D09970 💬	6件: DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬	40件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis	1件: 46 💬
277	Tofacitinib without methotrexate	Methotrexate	3件: D00142, D02115, D09970 💬	6件: DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬	40件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis	1件: 46 💬
278	Topical pentoxifylline gel (vehicle +ptx)	Pentoxifylline	1件: D00501 💬	-	-	1件: 56 💬
279	Tr004 (treg immunotherapy)	-	-	-	-	1件: 96 💬
280	Traditional treatment of cgd and tb	-	-	-	-	1件: 65 💬
281	Traditional treatments	-	-	-	-	1件: 97 💬
282	Tre	-	-	-	-	1件: 86 💬
283	Treat to target	-	-	-	-	1件: 46 💬
284	Treat with lansoprazole 30 mg bid for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms	Lansoprazole	1件: D00355 💬	2件: ATP4A, ATP4B 💬	4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation	1件: 98 💬
285	Treatment	-	-	-	-	2件: 41, 299 💬
286	Treatment a	-	-	-	-	2件: 34, 46 💬
287	Treatment algorithm a	-	-	-	-	1件: 97 💬
288	Treatment algorithm b	-	-	-	-	1件: 97 💬
289	Treatment algorithm c	-	-	-	-	1件: 97 💬
290	Treatment as usual (tau)	-	-	-	-	1件: 85 💬
291	Treatment b	-	-	-	-	2件: 34, 46 💬
292	Treatment bx1514m	-	-	-	-	1件: 58 💬
293	Treatment c	-	-	-	-	2件: 34, 46 💬
294	Treatment d	-	-	-	-	1件: 34 💬
295	Treatment defined only by active substance	-	-	-	-	1件: 50 💬
296	Treatment i	-	-	-	-	1件: 46 💬
297	Treatment ii	-	-	-	-	1件: 46 💬
298	Treatment iii	-	-	-	-	1件: 46 💬
299	Treatment of mtx	-	-	-	-	1件: 46 💬
300	Treatment of mtx and hcq	-	-	-	-	1件: 46 💬
301	Treatment of mtx and twhf	-	-	-	-	1件: 46 💬
302	Treatment of tcm	-	-	-	-	1件: 46 💬
303	Treatment of twhf	-	-	-	-	1件: 46 💬
304	Treatment phase group 4	-	-	-	-	1件: 113 💬
305	Treatment systemic therapy (prednisone)	Prednisone	1件: D00473 💬	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction	1件: 162 💬
306	Treatment with adalimumab	Adalimumab	1件: D02597 💬	1件: TNF 💬	65件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 96 💬
307	Treatment with azathioprin	-	-	-	-	1件: 95 💬
308	Treatment with mycophenolat mofetil	-	-	-	-	1件: 95 💬
309	Treatment with polyethylene glycol (macrogol 4000)	Polyethylene glycol	1件: D03370 💬	-	-	1件: 299 💬
310	Treatment with systemic therapy (doxycycline)	Doxycycline	5件: D00307, D02129, D03903, D03904, D07876 💬	-	-	1件: 162 💬
311	Treatment with systemic therapy (methotrexate)	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 162 💬
312	Treatment with systemic therapy (prednisone)	Prednisone	1件: D00473 💬	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction	1件: 162 💬
313	Treatment with topical superpotent corticosteroid therapy	-	-	-	-	1件: 162 💬
314	Tregalizumab	Tregalizumab	-	-	-	1件: 46 💬
315	Trehalose	Trehalose	-	-	-	1件: 113 💬
316	Tremfya	-	-	-	-	2件: 37, 97 💬
317	Tremfya®	-	-	-	-	2件: 37, 97 💬
318	Treosulfan	Treosulfan	1件: D07253 💬	-	-	3件: 13, 19, 65 💬
319	Treprosinil diethanolamine	-	-	-	-	1件: 86 💬
320	Treprostin	-	-	-	-	1件: 86 💬
321	Treprostinil	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	6件: 51, 84, 85, 86, 88, 210 💬
322	Treprostinil dietanolamina	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
323	Treprostinil diethanolamine	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	2件: 51, 86 💬
324	Treprostinil diolamine	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
325	Treprostinil inhalation powder	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
326	Treprostinil inhalations	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
327	Treprostinil injectable product	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
328	Treprostinil sodium	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	3件: 51, 86, 88 💬
329	Treprostinil sodium for inhalation	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 85 💬
330	Treprostinil sodium solution for inhalation	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
331	Treprostinil sodium, ut-15	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
332	Treprostinil, ut-15, lrx-15, 15au81, bw a15au, u-62, 840	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
333	Treprostinilo	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
334	Tretinoin	Tretinoin	1件: D00094 💬	3件: PML, RARA, RARB 💬	12件: Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis	2件:  2 , 75 💬
335	Tretinoin and pioglitazone hcl	Pioglitazone	3件: D00094, D00945, D08378 💬	4件: PML, PPARG, RARA, RARB 💬	19件: AMPK signaling pathway, Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Huntington disease, Influenza A, Longevity regulating pathway, Non-small cell lung cancer, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis	1件:  2  💬
336	Trexan	-	-	-	-	2件: 46, 97 💬
337	Trexan inj 25 mg/ml	-	-	-	-	1件: 97 💬
338	Trexan+salazopyrin+oxiklorin+prednisolone	Prednisolone	8件: D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	1件: NR3C1 💬	1件: Neuroactive ligand-receptor interaction	1件: 46 💬
339	Trexan+salazopyrin+oxiklorin+prednisolone + infliximab	Infliximab	9件: D00472, D00980, D00981, D00982, D01239, D01998, D02156, D02598, D03301 💬	2件: NR3C1, TNF 💬	66件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	1件: 46 💬
340	Untreated to atorvastatin treatment	Atorvastatin	3件: D00258, D00887, D07474 💬	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis	1件: 13 💬
341	Urine samples taken to measure methotrexate and its major metabolite 7-oh-methotrexate level	Methotrexate	2件: D00142, D02115 💬	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	1件: 46 💬
342	Usual dopaminergic per os treatment	-	-	-	-	1件:  6  💬
343	Ut-15c (treprostinil diethanolamine)	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
344	Ut-15c sr (treprostinil diethanolamine)	Treprostinil	1件: D06213 💬	1件: PTGIR 💬	3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction	1件: 86 💬
345	Vancomycin pre-treat	Vancomycin	2件: D00212, D00926 💬	-	-	1件: 97 💬
346	Vancomycin pre-treatment	Vancomycin	2件: D00212, D00926 💬	-	-	1件: 97 💬
347	Viral load driven treatment interruption	-	-	-	-	1件: 265 💬

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