DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト）💬 Info on mouse-over

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59 / 286 pathways

No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Adrenergic signaling in cardiomyocytes 💬	5件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
2	Adrenergic signaling in cardiomyocytes 💬	1件: KCNQ1 💬	D09569 💬	Ezogabine	2件: 2 , 144 💬
3	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D00354 💬	Lamotrigine	5件: 13, 34, 38, 114, 144 💬
4	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D05775 💬	Rufinamide	1件: 144 💬
5	Aldosterone synthesis and secretion 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
6	Alzheimer disease 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
7	Amphetamine addiction 💬	6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
8	Amphetamine addiction 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
9	Amyotrophic lateral sclerosis 💬	2件: GRIA1, GRIA2 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
10	Amyotrophic lateral sclerosis 💬	2件: GRIA1, GRIA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
11	Arrhythmogenic right ventricular cardiomyopathy 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
12	Bile secretion 💬	1件: CA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
13	Calcium signaling pathway 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
14	Calcium signaling pathway 💬	3件: HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	3件: 140, 144, 145 💬
15	cAMP signaling pathway 💬	8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
16	cAMP signaling pathway 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
17	Carbohydrate digestion and absorption 💬	1件: CACNA1D 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
18	Cardiac muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
19	Cellular senescence 💬	1件: CACNA1D 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
20	cGMP-PKG signaling pathway 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
21	Cholinergic synapse 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
22	Cholinergic synapse 💬	5件: KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬	D09569 💬	Ezogabine	2件: 2 , 144 💬
23	Circadian entrainment 💬	6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
24	Circadian entrainment 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
25	Circadian entrainment 💬	2件: MTNR1A, MTNR1B 💬	D08170 💬	Melatonin	11件: 6 , 8 , 13, 46, 49, 90, 97, 144, 145, 149, 202 💬
26	Cocaine addiction 💬	1件: GRIA2 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
27	Cocaine addiction 💬	1件: GRIA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
28	Collecting duct acid secretion 💬	1件: CA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
29	Cortisol synthesis and secretion 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
30	Cushing syndrome 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
31	Dilated cardiomyopathy 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
32	Dopaminergic synapse 💬	7件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
33	Dopaminergic synapse 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
34	Dopaminergic synapse 💬	1件: SCN1A 💬	D00354 💬	Lamotrigine	5件: 13, 34, 38, 114, 144 💬
35	Dopaminergic synapse 💬	1件: SCN1A 💬	D05775 💬	Rufinamide	1件: 144 💬
36	GABAergic synapse 💬	20件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
37	GABAergic synapse 💬	16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	2件: 140, 144 💬
38	Gap junction 💬	3件: HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	3件: 140, 144, 145 💬
39	Gastric acid secretion 💬	1件: CA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
40	Gastric acid secretion 💬	1件: KCNQ1 💬	D09569 💬	Ezogabine	2件: 2 , 144 💬
41	Glutamatergic synapse 💬	11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
42	Glutamatergic synapse 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
43	GnRH secretion 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
44	GnRH signaling pathway 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
45	Growth hormone synthesis, secretion and action 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
46	Huntington disease 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
47	Huntington disease 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
48	Hypertrophic cardiomyopathy 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
49	Inflammatory mediator regulation of TRP channels 💬	3件: HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	3件: 140, 144, 145 💬
50	Insulin secretion 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
51	Long-term depression 💬	3件: GRIA1, GRIA2, GRIA3 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
52	Long-term depression 💬	3件: GRIA1, GRIA2, GRIA3 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
53	Long-term potentiation 💬	3件: CACNA1C, GRIA1, GRIA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
54	Long-term potentiation 💬	2件: GRIA1, GRIA2 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
55	MAPK signaling pathway 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
56	Metabolic pathways 💬	2件: CA2, CA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
57	Morphine addiction 💬	16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	2件: 140, 144 💬
58	Morphine addiction 💬	16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
59	Neuroactive ligand-receptor interaction 💬	2件: CNR1, CNR2 💬	D10915 💬	Cannabidiol	19件: 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
60	Neuroactive ligand-receptor interaction 💬	16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	2件: 140, 144 💬
61	Neuroactive ligand-receptor interaction 💬	25件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
62	Neuroactive ligand-receptor interaction 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
63	Neuroactive ligand-receptor interaction 💬	3件: HTR2A, HTR2B, HTR2C 💬	D07945 💬	Fenfluramine	3件: 140, 144, 145 💬
64	Neuroactive ligand-receptor interaction 💬	2件: MTNR1A, MTNR1B 💬	D08170 💬	Melatonin	11件: 6 , 8 , 13, 46, 49, 90, 97, 144, 145, 149, 202 💬
65	Nicotine addiction 💬	16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	2件: 140, 144 💬
66	Nicotine addiction 💬	20件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
67	Nicotine addiction 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
68	Nitrogen metabolism 💬	2件: CA2, CA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
69	Oxytocin signaling pathway 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
70	Pancreatic secretion 💬	1件: CA2 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
71	Pancreatic secretion 💬	1件: KCNQ1 💬	D09569 💬	Ezogabine	2件: 2 , 144 💬
72	Pathways of neurodegeneration - multiple diseases 💬	8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
73	Pathways of neurodegeneration - multiple diseases 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
74	Prion disease 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
75	Protein digestion and absorption 💬	1件: KCNQ1 💬	D09569 💬	Ezogabine	2件: 2 , 144 💬
76	Proximal tubule bicarbonate reclamation 💬	2件: CA2, CA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
77	Rap1 signaling pathway 💬	1件: CNR1 💬	D10915 💬	Cannabidiol	19件: 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
78	Renin secretion 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
79	Retrograde endocannabinoid signaling 💬	24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
80	Retrograde endocannabinoid signaling 💬	1件: CNR1 💬	D10915 💬	Cannabidiol	19件: 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
81	Retrograde endocannabinoid signaling 💬	16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D01253 💬	Clobazam	2件: 140, 144 💬
82	Retrograde endocannabinoid signaling 💬	4件: GRIA1, GRIA2, GRIA3, GRIA4 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
83	Serotonergic synapse 💬	7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
84	Serotonergic synapse 💬	3件: GABRB1, GABRB2, GABRB3 💬	D01253 💬	Clobazam	2件: 140, 144 💬
85	Serotonergic synapse 💬	4件: HTR2A, HTR2B, HTR2C, SLC6A4 💬	D07945 💬	Fenfluramine	3件: 140, 144, 145 💬
86	Spinocerebellar ataxia 💬	3件: GRIA1, GRIA2, GRIA3 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
87	Spinocerebellar ataxia 💬	3件: GRIA1, GRIA2, GRIA3 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
88	Synaptic vesicle cycle 💬	1件: SLC6A4 💬	D07945 💬	Fenfluramine	3件: 140, 144, 145 💬
89	Taste transduction 💬	10件: CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
90	Taste transduction 💬	6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬	D01253 💬	Clobazam	2件: 140, 144 💬
91	Taste transduction 💬	3件: SCN2A, SCN3A, SCN9A 💬	D00354 💬	Lamotrigine	5件: 13, 34, 38, 114, 144 💬
92	Taste transduction 💬	3件: SCN2A, SCN3A, SCN9A 💬	D05775 💬	Rufinamide	1件: 144 💬
93	Thermogenesis 💬	1件: CNR1 💬	D10915 💬	Cannabidiol	19件: 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
94	Tight junction 💬	1件: CACNA1D 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
95	Transcriptional misregulation in cancer 💬	1件: GRIA3 💬	D08964 💬	Perampanel	3件: 2 , 6 , 144 💬
96	Transcriptional misregulation in cancer 💬	1件: GRIA3 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
97	Type II diabetes mellitus 💬	2件: CACNA1C, CACNA1D 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
98	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D00537 💬	Topiramate	5件: 6 , 140, 144, 156, 193 💬
99	Vibrio cholerae infection 💬	1件: KCNQ1 💬	D09569 💬	Ezogabine	2件: 2 , 144 💬

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