1 |
Any other approved antiepileptic drug |
- |
- |
- |
- |
144 [1] 144 💬 |
2 |
Cannabidiol |
Cannabidiol |
[1] D10915 D10915 💬 |
CNR1 [2] CNR1, CNR2 💬 |
Neuroactive ligand-receptor interaction [4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis |
006 [17] 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 226, 271 💬 |
3 |
Cannabidiol (cbd) |
Cannabidiol |
[1] D10915 D10915 💬 |
CNR1 [2] CNR1, CNR2 💬 |
Neuroactive ligand-receptor interaction [4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis |
006 [6] 6 , 140, 144, 145, 156, 158 💬 |
4 |
Cannabidiol oral solution |
Cannabidiol |
[1] D10915 D10915 💬 |
CNR1 [2] CNR1, CNR2 💬 |
Neuroactive ligand-receptor interaction [4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis |
140 [4] 140, 144, 145, 193 💬 |
5 |
Carisbamate |
Carisbamate |
[1] D06573 D06573 💬 |
- |
- |
144 [1] 144 💬 |
6 |
Cbd |
- |
- |
- |
- |
002 [11] 2 , 6 , 8 , 13, 46, 140, 144, 145, 156, 158, 206 💬 |
7 |
Cbd - oral solution, is known as epidiolex, and is the approved name in the usa. |
- |
- |
- |
- |
140 [3] 140, 144, 158 💬 |
8 |
Clobazam |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
140 [2] 140, 144 💬 |
9 |
Clobazam high dose |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
10 |
Clobazam low dose |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
11 |
Clobazam medium dose |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
12 |
Clobazam pheur |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
13 |
Clobazam tablets |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
14 |
Clobazam tablets 10mg |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
15 |
Clobazam tablets 20mg |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
16 |
Clobazam tablets 5mg |
Clobazam |
[1] D01253 D01253 💬 |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
GABAergic synapse [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
144 [1] 144 💬 |
17 |
E2007 |
- |
- |
- |
- |
006 [2] 6 , 144 💬 |
18 |
E2080 |
- |
- |
- |
- |
144 [1] 144 💬 |
19 |
Ezogabine |
Ezogabine |
[1] D09569 D09569 💬 |
KCNQ1 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 |
Adrenergic signaling in cardiomyocytes [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection |
002 [2] 2 , 144 💬 |
20 |
Ezogabine (us only) |
Ezogabine |
[1] D09569 D09569 💬 |
KCNQ1 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 |
Adrenergic signaling in cardiomyocytes [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection |
144 [1] 144 💬 |
21 |
Ezogabine/retigabine |
Ezogabine |
[1] D09569 D09569 💬 |
KCNQ1 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 |
Adrenergic signaling in cardiomyocytes [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection |
144 [1] 144 💬 |
22 |
Fenfluramine |
Fenfluramine |
[1] D07945 D07945 💬 |
HTR2A [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 |
Calcium signaling pathway [6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
140 [3] 140, 144, 145 💬 |
23 |
Fenfluramine hcl, dl-fenfluramine, (±)-fenfluramine |
Fenfluramine |
[1] D07945 D07945 💬 |
HTR2A [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 |
Calcium signaling pathway [6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
144 [1] 144 💬 |
24 |
Fenfluramine hydrochloride |
Fenfluramine |
[1] D07945 D07945 💬 |
HTR2A [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 |
Calcium signaling pathway [6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
140 [2] 140, 144 💬 |
25 |
Fenfluramine hydrochloride (colorless) |
Fenfluramine |
[1] D07945 D07945 💬 |
HTR2A [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 |
Calcium signaling pathway [6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
140 [2] 140, 144 💬 |
26 |
Fycompa |
- |
- |
- |
- |
002 [2] 2 , 144 💬 |
27 |
Gw582892 |
- |
- |
- |
- |
144 [1] 144 💬 |
28 |
Gwp42003-p |
- |
- |
- |
- |
140 [5] 140, 144, 145, 156, 158 💬 |
29 |
Gwp42003-p 20 mg/kg/day dose |
- |
- |
- |
- |
140 [2] 140, 144 💬 |
30 |
Inovelon |
- |
- |
- |
- |
144 [1] 144 💬 |
31 |
Investigators choice of approved aed |
- |
- |
- |
- |
144 [1] 144 💬 |
32 |
Investigators choice of approved aeds |
- |
- |
- |
- |
144 [1] 144 💬 |
33 |
Lamictal |
- |
- |
- |
- |
144 [1] 144 💬 |
34 |
Lamotrigine |
Lamotrigine |
[1] D00354 D00354 💬 |
SCN1A [5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 |
Adrenergic signaling in cardiomyocytes [3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction |
013 [5] 13, 34, 38, 114, 144 💬 |
35 |
Melatonin |
Melatonin |
[1] D08170 D08170 💬 |
MTNR1A [2] MTNR1A, MTNR1B 💬 |
Circadian entrainment [2] Circadian entrainment, Neuroactive ligand-receptor interaction |
006 [11] 6 , 8 , 13, 46, 49, 90, 97, 144, 145, 149, 202 💬 |
36 |
Perampanel |
Perampanel |
[1] D08964 D08964 💬 |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Amphetamine addiction [16] Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway |
002 [3] 2 , 6 , 144 💬 |
37 |
Placebo |
- |
- |
- |
- |
003 [26] 3 , 5 , 6 , 13, 14, 37, 40, 46, 49, 50, 51, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬 |
38 |
Potiga |
- |
- |
- |
- |
144 [1] 144 💬 |
39 |
Procedure: 12-lead ecg |
- |
- |
- |
- |
140 [2] 140, 144 💬 |
40 |
Retigabine |
Ezogabine |
[1] D09569 D09569 💬 |
KCNQ1 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 |
Adrenergic signaling in cardiomyocytes [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection |
002 [2] 2 , 144 💬 |
41 |
Retigabine/ezogabine |
Ezogabine |
[1] D09569 D09569 💬 |
KCNQ1 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 |
Adrenergic signaling in cardiomyocytes [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection |
144 [1] 144 💬 |
42 |
Rufinamide |
Rufinamide |
[1] D05775 D05775 💬 |
SCN1A [5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 |
Adrenergic signaling in cardiomyocytes [3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction |
144 [1] 144 💬 |
43 |
Rufinamide (e2080) |
Rufinamide |
[1] D05775 D05775 💬 |
SCN1A [5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 |
Adrenergic signaling in cardiomyocytes [3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction |
144 [1] 144 💬 |
44 |
Rufinamide oral suspension |
Rufinamide |
[1] D05775 D05775 💬 |
SCN1A [5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 |
Adrenergic signaling in cardiomyocytes [3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction |
144 [1] 144 💬 |
45 |
Sodio valproato |
- |
- |
- |
- |
144 [1] 144 💬 |
46 |
Tak-935 |
- |
- |
- |
- |
140 [2] 140, 144 💬 |
47 |
Topimarate |
- |
- |
- |
- |
144 [1] 144 💬 |
48 |
Topimarato |
- |
- |
- |
- |
144 [1] 144 💬 |
49 |
Topiramate |
Topiramate |
[1] D00537 D00537 💬 |
CA2 [36] CA2, CA4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 |
Adrenergic signaling in cardiomyocytes [52] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
006 [5] 6 , 140, 144, 156, 193 💬 |
50 |
Turmeric |
Turmeric |
- |
- |
- |
140 [4] 140, 144, 158, 299 💬 |
51 |
Zx008 |
- |
- |
- |
- |
140 [2] 140, 144 💬 |
52 |
Zx008 (fenfluramine hydrochloride) |
Fenfluramine |
[1] D07945 D07945 💬 |
HTR2A [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 |
Calcium signaling pathway [6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
140 [2] 140, 144 💬 |
53 |
Zx008 0.2 and 0.8 mg/kg/day |
- |
- |
- |
- |
140 [2] 140, 144 💬 |
54 |
Zx008 0.2 or 0.8 mg/kg/day |
- |
- |
- |
- |
144 [1] 144 💬 |