1 |
Abatacept (aba) + methotrexate (mtx), double-blind (db) |
Abatacept |
[3] D00142 D00142, D02115 D02115, D03203 D03203 💬 |
CD80 [4] CD80, CD86, DHFR, DHFR2 💬 |
Allograft rejection [17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis |
046 [1] 46 💬 |
2 |
Abatacept + methotrexate |
Abatacept |
[3] D00142 D00142, D02115 D02115, D03203 D03203 💬 |
CD80 [4] CD80, CD86, DHFR, DHFR2 💬 |
Allograft rejection [17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis |
046 [1] 46 💬 |
3 |
Abatacept active treatment |
Abatacept |
[1] D03203 D03203 💬 |
CD80 [2] CD80, CD86 💬 |
Allograft rejection [12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis |
050 [1] 50 💬 |
4 |
Abatacept delayed-onset treatment |
Abatacept |
[1] D03203 D03203 💬 |
CD80 [2] CD80, CD86 💬 |
Allograft rejection [12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis |
050 [1] 50 💬 |
5 |
Active investigational treatment ent-01 |
- |
- |
- |
- |
006 [1] 6 💬 |
6 |
Active treatment group 7% hypertonic saline |
- |
- |
- |
- |
299 [1] 299 💬 |
7 |
Adalimumab with methotrexate |
Adalimumab |
[3] D00142 D00142, D02115 D02115, D02597 D02597 💬 |
DHFR [3] DHFR, DHFR2, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
8 |
Azathioprine or methotrexate |
Azathioprine |
[4] D00142 D00142, D00238 D00238, D02115 D02115, D03033 D03033 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
096 [1] 96 💬 |
9 |
Baseline treatment |
- |
- |
- |
- |
013 [1] 13 💬 |
10 |
Bdmard treatment |
- |
- |
- |
- |
271 [1] 271 💬 |
11 |
Behavioral: co-op treatment protocol |
- |
- |
- |
- |
006 [1] 6 💬 |
12 |
Behavioral: conservative treatment |
- |
- |
- |
- |
291 [1] 291 💬 |
13 |
Bendamustine |
Bendamustine |
[2] D07085 D07085, D07501 D07501 💬 |
- |
- |
028 [2] 28, 61 💬 |
14 |
Bendamustine hydrochloride |
Bendamustine |
[2] D07085 D07085, D07501 D07501 💬 |
- |
- |
061 [1] 61 💬 |
15 |
Bendamustine, rituximab |
Bendamustine |
[3] D02994 D02994, D07085 D07085, D07501 D07501 💬 |
MS4A1 [1] MS4A1 💬 |
Hematopoietic cell lineage [1] Hematopoietic cell lineage |
061 [1] 61 💬 |
16 |
Best medical treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
17 |
Best médical treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
18 |
Bisphosphonate treatment |
- |
- |
- |
- |
113 [2] 113, 299 💬 |
19 |
Bms-582949 and methotrexate |
BMS-582949 |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
20 |
Botulism toxin treatment |
- |
- |
- |
- |
161 [1] 161 💬 |
21 |
Break in l-carnitine treatment |
Levocarnitine |
[3] D02030 D02030, D02176 D02176, D04713 D04713 💬 |
- |
- |
316 [1] 316 💬 |
22 |
Busulfan/fludarabine phosphate/tacrolimus/methotrexate/g-csf |
Busulfan |
[8] D00107 D00107, D00142 D00142, D00248 D00248, D01907 D01907, D02115 D02115, D03235 D03235, D07966 D07966, D08556 D08556 💬 |
CSF3R [9] CSF3R, DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, RRM1 💬 |
Alzheimer disease [46] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
060 [1] 60 💬 |
23 |
C-trelin od tab(5mg taltirelin hydrate) |
- |
- |
- |
- |
018 [1] 18 💬 |
24 |
Certolizumab pegol + methotrexate (mtx) |
Certolizumab pegol |
[3] D00142 D00142, D02115 D02115, D03441 D03441 💬 |
DHFR [3] DHFR, DHFR2, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
25 |
Cf patients with a g551d mutation and treated with ivacaftor |
Ivacaftor |
[1] D09916 D09916 💬 |
CFTR [1] CFTR 💬 |
ABC transporters [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway |
299 [1] 299 💬 |
26 |
Classic dmards treatment group |
- |
- |
- |
- |
046 [1] 46 💬 |
27 |
Clobetasol propionate + methotrexate |
Clobetasol |
[4] D00142 D00142, D01272 D01272, D02115 D02115, D07715 D07715 💬 |
DHFR [3] DHFR, DHFR2, NR3C1 💬 |
Antifolate resistance [6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate |
162 [1] 162 💬 |
28 |
Clobetasol propionate cream treatment |
Clobetasol |
[2] D01272 D01272, D07715 D07715 💬 |
NR3C1 [1] NR3C1 💬 |
Neuroactive ligand-receptor interaction [1] Neuroactive ligand-receptor interaction |
162 [1] 162 💬 |
29 |
Combination product: active treatment with dual therapy |
- |
- |
- |
- |
002 [1] 2 💬 |
30 |
Combination product: implantable system for remodulin (treprostinil) |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
31 |
Combination product: methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
32 |
Combination product: treprostinil via implanted pump |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
33 |
Corticosteroid treatment (methylprednisolone or prednisolone) |
Methylprednisolone |
[14] D00407 D00407, D00472 D00472, D00751 D00751, D00979 D00979, D00980 D00980, D00981 D00981, D00982 D00982, D01239 D01239, D01998 D01998, D02156 D02156, D03301 D03301, D05000 D05000, D05001 D05001, D05002 D05002 💬 |
NR3C1 [1] NR3C1 💬 |
Neuroactive ligand-receptor interaction [1] Neuroactive ligand-receptor interaction |
064 [1] 64 💬 |
34 |
Cp-690,550 + methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
35 |
Current lipid-lowering treatment |
- |
- |
- |
- |
079 [1] 79 💬 |
36 |
Cutaneous iontophoresis of treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
051 [1] 51 💬 |
37 |
Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids |
Azathioprine |
[6] D00142 D00142, D00238 D00238, D00287 D00287, D02115 D02115, D03033 D03033, D07760 D07760 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
044 [1] 44 💬 |
38 |
Cyclosporin, methotrexate (gvhd prophylaxis) |
Cyclosporine |
[3] D00142 D00142, D00184 D00184, D02115 D02115 💬 |
DHFR [7] DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Alzheimer disease [37] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
326 [1] 326 💬 |
39 |
Cytokine-treated veto cells |
- |
- |
- |
- |
060 [1] 60 💬 |
40 |
Deferiprone treated |
Deferiprone |
[1] D07416 D07416 💬 |
- |
- |
120 [1] 120 💬 |
41 |
Detoxifying agents for antineoplastic treatment |
- |
- |
- |
- |
299 [1] 299 💬 |
42 |
Device: trekking pole (tp). |
- |
- |
- |
- |
013 [1] 13 💬 |
43 |
Dietanolamina de treprostinilo |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
44 |
Dmards (methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
45 |
Dopamine agonist treatment |
Dopamine |
[2] D00633 D00633, D07870 D07870 💬 |
DRD1 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 |
Alcoholism [11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway |
074 [1] 74 💬 |
46 |
Drug treatment |
- |
- |
- |
- |
046 [4] 46, 51, 74, 271 💬 |
47 |
Early immunosuppressants (azathioprine, methotrexate) |
Azathioprine |
[4] D00142 D00142, D00238 D00238, D02115 D02115, D03033 D03033 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
096 [1] 96 💬 |
48 |
Era as specific pah treatment |
- |
- |
- |
- |
086 [1] 86 💬 |
49 |
Etanercept + methotrexate |
Etanercept |
[3] D00142 D00142, D00742 D00742, D02115 D02115 💬 |
DHFR [4] DHFR, DHFR2, LTA, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
50 |
Etanercept , methotrexate |
Etanercept |
[3] D00142 D00142, D00742 D00742, D02115 D02115 💬 |
DHFR [4] DHFR, DHFR2, LTA, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
51 |
Etanercept treatment |
Etanercept |
[1] D00742 D00742 💬 |
LTA [2] LTA, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
52 |
Etanercept, methotrexate and depomedrone |
Etanercept |
[3] D00142 D00142, D00742 D00742, D02115 D02115 💬 |
DHFR [4] DHFR, DHFR2, LTA, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
53 |
Etanercept, methotrexate, prednisolone |
Etanercept |
[11] D00142 D00142, D00472 D00472, D00742 D00742, D00980 D00980, D00981 D00981, D00982 D00982, D01239 D01239, D01998 D01998, D02115 D02115, D02156 D02156, D03301 D03301 💬 |
DHFR [5] DHFR, DHFR2, LTA, NR3C1, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
056 [1] 56 💬 |
54 |
Eutonic treprostinil solution |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
55 |
Experimental (non immunosuppressive symptomatic treatment (nist) and rituximab) |
Rituximab |
[1] D02994 D02994 💬 |
MS4A1 [1] MS4A1 💬 |
Hematopoietic cell lineage [1] Hematopoietic cell lineage |
222 [1] 222 💬 |
56 |
Exposure to one or more disease-modifying drug(s)(dmds) used to treat ms |
- |
- |
- |
- |
013 [1] 13 💬 |
57 |
Fibrate treatment |
- |
- |
- |
- |
160 [1] 160 💬 |
58 |
Foliglurax 10 mg (treatment a) |
Foliglurax |
- |
- |
- |
006 [1] 6 💬 |
59 |
Foliglurax 30 mg (treatment b) |
Foliglurax |
- |
- |
- |
006 [1] 6 💬 |
60 |
From august 2020 'no additional treatment' |
- |
- |
- |
- |
051 [1] 51 💬 |
61 |
Genotropin (somatropin) is a growth hormone treatment. it is an exact copy of the natural growth hormone that our bodies make. the main difference is that genotropin is man-made. |
Somatotropin |
[1] D02691 D02691 💬 |
GHR [1] GHR 💬 |
Cytokine-cytokine receptor interaction [5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway |
193 [1] 193 💬 |
62 |
Glucocorticoid treatment |
- |
- |
- |
- |
041 [1] 41 💬 |
63 |
Golimumab treatment optimization. |
Golimumab |
[1] D04358 D04358 💬 |
TNF [1] TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
097 [1] 97 💬 |
64 |
Group 1 or orencia treated group |
- |
- |
- |
- |
046 [1] 46 💬 |
65 |
Guselkumab |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
037 [4] 37, 41, 96, 97 💬 |
66 |
Guselkumab 100 mg |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
037 [1] 37 💬 |
67 |
Guselkumab dose 1 |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
096 [2] 96, 97 💬 |
68 |
Guselkumab dose 2 |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
096 [2] 96, 97 💬 |
69 |
Guselkumab dose 3 |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
096 [1] 96 💬 |
70 |
Guselkumab dose 4 |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
096 [1] 96 💬 |
71 |
Guselkumab dose 5 |
Guselkumab |
[1] D10438 D10438 💬 |
IL23A [1] IL23A 💬 |
C-type lectin receptor signaling pathway [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis |
096 [1] 96 💬 |
72 |
Hcq/cq and cab combined treatment |
- |
- |
- |
- |
074 [1] 74 💬 |
73 |
Herbal treatment (sa100) |
- |
- |
- |
- |
097 [1] 97 💬 |
74 |
Hyperpolarized 129 xenon gas comparing idiopathic pulmonary fibrosis (ipf) treatment |
Xenon |
[2] D01901 D01901, D06339 D06339 💬 |
- |
- |
085 [1] 85 💬 |
75 |
Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate) |
Azathioprine |
[8] D00142 D00142, D00238 D00238, D00752 D00752, D02115 D02115, D03033 D03033, D05094 D05094, D05095 D05095, D05096 D05096 💬 |
DHFR [4] DHFR, DHFR2, IMPDH1, IMPDH2 💬 |
Antifolate resistance [7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism |
049 [1] 49 💬 |
76 |
Immunosuppressive treatment |
- |
- |
- |
- |
066 [1] 66 💬 |
77 |
Immunosuppressive treatment (eg, rituximab) |
Rituximab |
[1] D02994 D02994 💬 |
MS4A1 [1] MS4A1 💬 |
Hematopoietic cell lineage [1] Hematopoietic cell lineage |
064 [1] 64 💬 |
78 |
In double-blind phase: treatment with tofacitinib |
Tofacitinib |
[1] D09970 D09970 💬 |
JAK1 [4] JAK1, JAK2, JAK3, TYK2 💬 |
AGE-RAGE signaling pathway in diabetic complications [35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis |
107 [1] 107 💬 |
79 |
In open-label phase: treatment with tofacitinib |
Tofacitinib |
[1] D09970 D09970 💬 |
JAK1 [4] JAK1, JAK2, JAK3, TYK2 💬 |
AGE-RAGE signaling pathway in diabetic complications [35] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis |
107 [1] 107 💬 |
80 |
Infliximab + methotrexate (mtx) |
Infliximab |
[3] D00142 D00142, D02115 D02115, D02598 D02598 💬 |
DHFR [3] DHFR, DHFR2, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
81 |
Infliximab, methylprednisolone, methotrexate |
Infliximab |
[9] D00142 D00142, D00407 D00407, D00751 D00751, D00979 D00979, D02115 D02115, D02598 D02598, D05000 D05000, D05001 D05001, D05002 D05002 💬 |
DHFR [4] DHFR, DHFR2, NR3C1, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
82 |
Inhaled dry powder treprostinil (liq861) |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
83 |
Inhaled treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
084 [2] 84, 86 💬 |
84 |
Interferon beta treatment to add-on atorvastatin treatment |
Atorvastatin |
[3] D00258 D00258, D00887 D00887, D07474 D07474 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
013 [1] 13 💬 |
85 |
Intrathecal methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
013 [1] 13 💬 |
86 |
Intravenous treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
87 |
Intravenous/subcutaneous treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
88 |
Iontophoresis of treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
051 [1] 51 💬 |
89 |
Iv treatment with igsc, 10% |
- |
- |
- |
- |
065 [1] 65 💬 |
90 |
L606 (liposomal treprostinil) inhalation solution 51ug |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
91 |
Lapaquistat acetate and current lipid-lowering treatment |
Acetate |
- |
- |
- |
079 [1] 79 💬 |
92 |
Liq861 inhaled treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
93 |
Lumacaftor-ivacaftor treatment |
Ivacaftor |
[2] D09916 D09916, D10134 D10134 💬 |
CFTR [1] CFTR 💬 |
ABC transporters [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway |
299 [1] 299 💬 |
94 |
Metformin treatment |
Metformin |
[2] D00944 D00944, D04966 D04966 💬 |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
AMPK signaling pathway [19] AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway |
046 [1] 46 💬 |
95 |
Methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
96 |
Methotrexate 'lederle' 2,5mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
97 |
Methotrexate 'lederle' 2.5mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
98 |
Methotrexate 'lederle' tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
99 |
Methotrexate (metoject® prefilled pen) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
100 |
Methotrexate (mtx) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
101 |
Methotrexate (stable dose) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
102 |
Methotrexate (tapering dose) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
103 |
Methotrexate + biologic administration |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
104 |
Methotrexate + infliximab |
Infliximab |
[3] D00142 D00142, D02115 D02115, D02598 D02598 💬 |
DHFR [3] DHFR, DHFR2, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
105 |
Methotrexate + methylprednisolone |
Methotrexate |
[8] D00142 D00142, D00407 D00407, D00751 D00751, D00979 D00979, D02115 D02115, D05000 D05000, D05001 D05001, D05002 D05002 💬 |
DHFR [3] DHFR, DHFR2, NR3C1 💬 |
Antifolate resistance [6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate |
046 [1] 46 💬 |
106 |
Methotrexate + salazopyrine + hydroxychloroquine administration |
Hydroxychloroquine |
[3] D00142 D00142, D02115 D02115, D08050 D08050 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
107 |
Methotrexate - amneal |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
108 |
Methotrexate - dava |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
109 |
Methotrexate - delay |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
110 |
Methotrexate - etanercept - prednisolone arm |
Etanercept |
[11] D00142 D00142, D00472 D00472, D00742 D00742, D00980 D00980, D00981 D00981, D00982 D00982, D01239 D01239, D01998 D01998, D02115 D02115, D02156 D02156, D03301 D03301 💬 |
DHFR [5] DHFR, DHFR2, LTA, NR3C1, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
111 |
Methotrexate - immediate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
112 |
Methotrexate 10 mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
113 |
Methotrexate 10 mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
114 |
Methotrexate 2.5 mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
044 [1] 44 💬 |
115 |
Methotrexate 2.5 mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
116 |
Methotrexate 2.5mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
117 |
Methotrexate 2.5mg tablets bp |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
118 |
Methotrexate 25 mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
044 [1] 44 💬 |
119 |
Methotrexate 50mg/ml solution for injection, pre-filled syringe |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
120 |
Methotrexate ``lederle`` 2.5mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
121 |
Methotrexate and folic acid |
Folic acid |
[3] D00070 D00070, D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
049 [1] 49 💬 |
122 |
Methotrexate as methotrexate disodium |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
123 |
Methotrexate bellon |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
097 [1] 97 💬 |
124 |
Methotrexate bellon 25mg/ml |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
097 [1] 97 💬 |
125 |
Methotrexate capsules |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
126 |
Methotrexate disodium |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [3] 46, 96, 97 💬 |
127 |
Methotrexate ebewe |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
128 |
Methotrexate hospira 2,5 mg tablety |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
129 |
Methotrexate hospira 2.5 mg tablety |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
130 |
Methotrexate injection |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
096 [2] 96, 97 💬 |
131 |
Methotrexate lachema 5inj. sol |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
050 [1] 50 💬 |
132 |
Methotrexate lederle 2.5 mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
133 |
Methotrexate pfizer 2,5 mg tabletter |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
134 |
Methotrexate placebo |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
135 |
Methotrexate plus enbrel or enbrel alone |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
136 |
Methotrexate plus erb-041 for 12 weeks |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
137 |
Methotrexate plus sulfasalazine |
Methotrexate |
[3] D00142 D00142, D00448 D00448, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
138 |
Methotrexate pre-filled pen |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
139 |
Methotrexate prefilled pen |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
140 |
Methotrexate prefilled syringe |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
141 |
Methotrexate sodium |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [2] 46, 256 💬 |
142 |
Methotrexate sodium 2.5mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
143 |
Methotrexate sodium tablets 2.5 mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
144 |
Methotrexate sodium tablets 2.5mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
145 |
Methotrexate tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
040 [1] 40 💬 |
146 |
Methotrexate tablets 2.5 mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
147 |
Methotrexate treatment |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
041 [2] 41, 46 💬 |
148 |
Methotrexate wyeth 2,5mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
050 [1] 50 💬 |
149 |
Methotrexate wyeth 2,5mg tbl. |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
050 [1] 50 💬 |
150 |
Methotrexate ® 2.5mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
151 |
Methotrexate(mtx) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
152 |
Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
153 |
Methotrexate(mtx) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol. |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
154 |
Methotrexate(necessary) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
155 |
Methotrexate*100cpr 2,5mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
156 |
Methotrexate*10mg/1,33ml 4s |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
157 |
Methotrexate*15mg/2ml 4sir |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
158 |
Methotrexate*2,5mg 25cpr |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
159 |
Methotrexate*20mg/2,66ml 4s |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
160 |
Methotrexate*25cpr 2,5mg |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
161 |
Methotrexate*7,5mg/ml 4sir. |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
162 |
Methotrexate, leucovorin and bms-986142 |
BMS-986142 |
[5] D00142 D00142, D01211 D01211, D02115 D02115, D07986 D07986, D07987 D07987 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
163 |
Methotrexate,adalimumab |
Adalimumab |
[3] D00142 D00142, D02115 D02115, D02597 D02597 💬 |
DHFR [3] DHFR, DHFR2, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
164 |
Methotrexate-lachema |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
165 |
Methotrexate-sulfasalazine-hydroxychloroquine |
Hydroxychloroquine |
[4] D00142 D00142, D00448 D00448, D02115 D02115, D08050 D08050 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
166 |
Methotrexate® 2.5 mg tablets |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
167 |
Mk0812 / duration of treatment: 12 weeks |
- |
- |
- |
- |
046 [1] 46 💬 |
168 |
Monthly autologous treg cells infusions + 3 times per week interleukin-2 injections |
Human interleukin-2 |
- |
- |
- |
002 [1] 2 💬 |
169 |
Mp-435(dose1) + methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
170 |
Msc treatment |
- |
- |
- |
- |
049 [1] 49 💬 |
171 |
Msc treatment 01 |
- |
- |
- |
- |
096 [1] 96 💬 |
172 |
Msc treatment 02 |
- |
- |
- |
- |
096 [1] 96 💬 |
173 |
Mycophenolate mofetil,methotrexate |
Methotrexate |
[6] D00142 D00142, D00752 D00752, D02115 D02115, D05094 D05094, D05095 D05095, D05096 D05096 💬 |
DHFR [4] DHFR, DHFR2, IMPDH1, IMPDH2 💬 |
Antifolate resistance [7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism |
042 [3] 42, 43, 45 💬 |
174 |
Natalizumab treatment |
Natalizumab |
[1] D06886 D06886 💬 |
ITGA4 [1] ITGA4 💬 |
Arrhythmogenic right ventricular cardiomyopathy [14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection |
013 [1] 13 💬 |
175 |
Nifurtimox-eflronithine combination treatment (nect) |
Nifurtimox |
[1] D00833 D00833 💬 |
- |
- |
065 [1] 65 💬 |
176 |
Nusinersen treatments |
Nusinersen |
[1] D10881 D10881 💬 |
SMN2 [1] SMN2 💬 |
RNA transport [1] RNA transport |
003 [1] 3 💬 |
177 |
Nutrition treat |
- |
- |
- |
- |
096 [1] 96 💬 |
178 |
Observational study with patients treated with tracleer, ventavis, veletri, opsumit and/or uptravi |
- |
- |
- |
- |
086 [1] 86 💬 |
179 |
Oc oral solution treatment a |
- |
- |
- |
- |
006 [1] 6 💬 |
180 |
Oc oral solution treatment b |
- |
- |
- |
- |
006 [1] 6 💬 |
181 |
Oc oral solution treatment c |
- |
- |
- |
- |
006 [1] 6 💬 |
182 |
Oc oral solution treatment d |
- |
- |
- |
- |
006 [1] 6 💬 |
183 |
Only 1 arm: treatment with msc-afp |
- |
- |
- |
- |
096 [1] 96 💬 |
184 |
Optimized antiparkinsonian treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
185 |
Oral anticoagulant treatment |
- |
- |
- |
- |
086 [1] 86 💬 |
186 |
Oral methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
187 |
Oral treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
051 [2] 51, 86 💬 |
188 |
Oral treprostinil (ut-15c) sustained release tablets |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
189 |
Other parkinson's disease treatments |
- |
- |
- |
- |
006 [1] 6 💬 |
190 |
Other: adalimumab treatment |
Adalimumab |
[1] D02597 D02597 💬 |
TNF [1] TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
151 [1] 151 💬 |
191 |
Other: best medical treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
192 |
Other: cd-treat diet |
- |
- |
- |
- |
096 [1] 96 💬 |
193 |
Other: control wound treatment |
- |
- |
- |
- |
036 [1] 36 💬 |
194 |
Other: crohn's disease treatment-with-eating diet (cd-treat diet) |
- |
- |
- |
- |
096 [1] 96 💬 |
195 |
Other: current treatment |
- |
- |
- |
- |
046 [1] 46 💬 |
196 |
Other: dead sea solar and water treatment |
Water |
[1] D00001 D00001 💬 |
- |
- |
046 [1] 46 💬 |
197 |
Other: diet treatment |
- |
- |
- |
- |
240 [1] 240 💬 |
198 |
Other: group 2 (dmards treated group) |
- |
- |
- |
- |
046 [1] 46 💬 |
199 |
Other: intensify treatment with the existing drug |
- |
- |
- |
- |
096 [2] 96, 97 💬 |
200 |
Other: methotrexate therapy |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
201 |
Other: motor assessments before taking regular pd treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
202 |
Other: motor assessments on regular pd treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
203 |
Other: multidisciplinary intensive rehabilitation treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
204 |
Other: no active treatment |
- |
- |
- |
- |
274 [1] 274 💬 |
205 |
Other: no anti-inflammatory treatment |
- |
- |
- |
- |
271 [1] 271 💬 |
206 |
Other: no it treatment |
- |
- |
- |
- |
019 [1] 19 💬 |
207 |
Other: no treatment |
- |
- |
- |
- |
053 [2] 53, 256 💬 |
208 |
Other: no treatment arm |
- |
- |
- |
- |
013 [1] 13 💬 |
209 |
Other: no treatment given |
- |
- |
- |
- |
078 [1] 78 💬 |
210 |
Other: observation of ocrelizumab as treatment in rrms patients |
Ocrelizumab |
[1] D05218 D05218 💬 |
MS4A1 [1] MS4A1 💬 |
Hematopoietic cell lineage [1] Hematopoietic cell lineage |
013 [1] 13 💬 |
211 |
Other: on-demand treatment |
- |
- |
- |
- |
299 [1] 299 💬 |
212 |
Other: other: symptomatic treatment of als |
- |
- |
- |
- |
002 [1] 2 💬 |
213 |
Other: sle treatment |
- |
- |
- |
- |
049 [1] 49 💬 |
214 |
Other: standard steroid treatment |
- |
- |
- |
- |
113 [1] 113 💬 |
215 |
Other: standard treatment |
- |
- |
- |
- |
227 [1] 227 💬 |
216 |
Other: standard treatment according to the clinical protocols |
- |
- |
- |
- |
049 [1] 49 💬 |
217 |
Other: usual drug treatment of parkinson's disease |
- |
- |
- |
- |
006 [1] 6 💬 |
218 |
Ova-treg |
- |
- |
- |
- |
096 [1] 96 💬 |
219 |
Ovastat 1000 (treosulfan injection) |
Treosulfan |
[1] D07253 D07253 💬 |
- |
- |
065 [1] 65 💬 |
220 |
Ovastat 5000 (treosulfan injection) |
Treosulfan |
[1] D07253 D07253 💬 |
- |
- |
065 [1] 65 💬 |
221 |
Parenteral remodulin (treprostinil) injection |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
222 |
Patient treated with dmard |
- |
- |
- |
- |
046 [1] 46 💬 |
223 |
Pentoxifylline |
Pentoxifylline |
[1] D00501 D00501 💬 |
- |
- |
026 [10] 26, 56, 84, 93, 96, 113, 220, 222, 296, 298 💬 |
224 |
Phase 1: methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
225 |
Pioglitazone and tretinoin |
Pioglitazone |
[3] D00094 D00094, D00945 D00945, D08378 D08378 💬 |
PML [4] PML, PPARG, RARA, RARB 💬 |
AMPK signaling pathway [19] AMPK signaling pathway, Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Huntington disease, Influenza A, Longevity regulating pathway, Non-small cell lung cancer, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis |
002 [1] 2 💬 |
226 |
Plasma from healthy young people treatment + riluzole |
Riluzole |
[1] D00775 D00775 💬 |
GRIA1 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Alcoholism [23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway |
002 [1] 2 💬 |
227 |
Pooled plasma (human), solvent/detergent treated |
- |
- |
- |
- |
064 [1] 64 💬 |
228 |
Ppi treatment |
- |
- |
- |
- |
299 [1] 299 💬 |
229 |
Prednisone and ustekinumab treatment |
Prednisone |
[2] D00473 D00473, D09214 D09214 💬 |
IL12A [4] IL12A, IL12B, IL23A, NR3C1 💬 |
African trypanosomiasis [27] African trypanosomiasis, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Malaria, Measles, Neuroactive ligand-receptor interaction, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus |
041 [1] 41 💬 |
230 |
Prednisone treatment |
Prednisone |
[1] D00473 D00473 💬 |
NR3C1 [1] NR3C1 💬 |
Neuroactive ligand-receptor interaction [1] Neuroactive ligand-receptor interaction |
041 [1] 41 💬 |
231 |
Probiotic treatment |
- |
- |
- |
- |
294 [1] 294 💬 |
232 |
Procedure: in vitro-treated bone marrow transplantation |
- |
- |
- |
- |
060 [1] 60 💬 |
233 |
Procedure: in vitro-treated peripheral blood stem cell transplantation |
- |
- |
- |
- |
060 [2] 60, 65 💬 |
234 |
Procedure: surgery treatment |
- |
- |
- |
- |
291 [1] 291 💬 |
235 |
Procedure: transsphenoidal surgery treatment |
- |
- |
- |
- |
074 [1] 74 💬 |
236 |
Procedure: treatment according to current standards without knowledge of serum infliximab and anti-infliximab ab status |
Infliximab |
[1] D02598 D02598 💬 |
TNF [1] TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
096 [1] 96 💬 |
237 |
Propranolol treatment |
Propranolol |
[2] D00483 D00483, D08443 D08443 💬 |
ADRB1 [3] ADRB1, ADRB2, ADRB3 💬 |
Adrenergic signaling in cardiomyocytes [11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway |
227 [1] 227 💬 |
238 |
Rapid dose titration group of subcutaneous treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
239 |
Regular treatment |
- |
- |
- |
- |
097 [1] 97 💬 |
240 |
Remodulin (treprostinil sodium) |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
241 |
Remodulin® (treprostinil) 1 mg/ml solution for infusion |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
242 |
Remodulin® (treprostinil) 10 mg/ml solution for infusion |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
243 |
Remodulin® (treprostinil) 2.5 mg/ml solution for infusion |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
244 |
Remodulin® (treprostinil) 5 mg/ml solution for infusion |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
245 |
Repository corticotropin injection -treatment extension |
Corticotropin |
[1] D00146 D00146 💬 |
MC2R [1] MC2R 💬 |
Aldosterone synthesis and secretion [5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway |
084 [1] 84 💬 |
246 |
Response to anakinra associated with methotrexate |
Anakinra |
[3] D00142 D00142, D02115 D02115, D02934 D02934 💬 |
DHFR [4] DHFR, DHFR2, IL1R1, IL1R2 💬 |
Amoebiasis [20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer |
046 [1] 46 💬 |
247 |
Response to infliximab associated with methotrexate |
Infliximab |
[3] D00142 D00142, D02115 D02115, D02598 D02598 💬 |
DHFR [3] DHFR, DHFR2, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
248 |
Routine treatment of cd |
- |
- |
- |
- |
096 [1] 96 💬 |
249 |
Sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group) |
Amitriptyline |
[7] D00326 D00326, D00809 D00809, D00823 D00823, D01355 D01355, D02691 D02691, D07448 D07448, D08623 D08623 💬 |
GHR [4] GHR, OPRM1, SLC6A2, SLC6A4 💬 |
Cytokine-cytokine receptor interaction [9] Cytokine-cytokine receptor interaction, Estrogen signaling pathway, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Serotonergic synapse, Synaptic vesicle cycle |
078 [1] 78 💬 |
250 |
Sc treatment with igsc, 10% with rhuph20 followed by iv/igsc, 10% only (safety) |
- |
- |
- |
- |
065 [1] 65 💬 |
251 |
Sc treatment with igsc, 10% with rhuph20 followed by sc/igsc, 10% only (safety) |
- |
- |
- |
- |
065 [1] 65 💬 |
252 |
Simvastatin treatment for 28 days |
Simvastatin |
[1] D00434 D00434 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
299 [1] 299 💬 |
253 |
Slow dose titration group of subcutaneous treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
254 |
Stable weekly dose of methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
255 |
Standard of care treatment |
- |
- |
- |
- |
245 [2] 245, 246 💬 |
256 |
Standard steroid treatment |
- |
- |
- |
- |
085 [1] 85 💬 |
257 |
Standard treatment with a conventional drug |
- |
- |
- |
- |
013 [1] 13 💬 |
258 |
Standrd of care treatment |
- |
- |
- |
- |
064 [1] 64 💬 |
259 |
Subcutaneous treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
260 |
Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin) |
Aldosterone |
[3] D00150 D00150, D02014 D02014, D10528 D10528 💬 |
AGTR1 [3] AGTR1, AGTR2, NR3C2 💬 |
AGE-RAGE signaling pathway in diabetic complications [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway |
222 [1] 222 💬 |
261 |
Symptomatic treatment, steroids, immunosuppressive agents( azathioprine, tacrolimus, mycophenolate mofetil) |
Azathioprine |
[8] D00107 D00107, D00238 D00238, D00752 D00752, D03033 D03033, D05094 D05094, D05095 D05095, D05096 D05096, D08556 D08556 💬 |
IMPDH1 [7] IMPDH1, IMPDH2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Alzheimer disease [35] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Drug metabolism - other enzymes, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
011 [1] 11 💬 |
262 |
Symptomatic treatment, steroids, immunosuppressive agents, plasma exchange(pe), intravenous immunoglobulin(ivig) |
Human immunoglobulin G |
- |
- |
- |
011 [1] 11 💬 |
263 |
Systemic non-biological treatments |
- |
- |
- |
- |
046 [2] 46, 271 💬 |
264 |
Tacrolimus with methotrexate |
Methotrexate |
[4] D00107 D00107, D00142 D00142, D02115 D02115, D08556 D08556 💬 |
DHFR [7] DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Alzheimer disease [37] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
046 [1] 46 💬 |
265 |
Tak-715 and methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
266 |
Tak-783 and methotrexate |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
267 |
Tasocitinib plus methotrexate |
Methotrexate |
[3] D00142 D00142, D02115 D02115, D09970 D09970 💬 |
DHFR [6] DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬 |
AGE-RAGE signaling pathway in diabetic complications [40] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis |
046 [1] 46 💬 |
268 |
The comprehensive treatment regimen of traditional chinese medicine |
- |
- |
- |
- |
222 [1] 222 💬 |
269 |
The standard steroid treatment, plasma exchange and rituximab |
Rituximab |
[1] D02994 D02994 💬 |
MS4A1 [1] MS4A1 💬 |
Hematopoietic cell lineage [1] Hematopoietic cell lineage |
085 [1] 85 💬 |
270 |
Time delay treatment of botulinum toxin |
- |
- |
- |
- |
149 [1] 149 💬 |
271 |
Tl011, anti cd20, for the treatment of rheumatoid arthritis |
- |
- |
- |
- |
046 [1] 46 💬 |
272 |
Tocilizumab + methotrexate(mtx) |
Methotrexate |
[3] D00142 D00142, D02115 D02115, D02596 D02596 💬 |
DHFR [3] DHFR, DHFR2, IL6R 💬 |
Antifolate resistance [17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor |
046 [1] 46 💬 |
273 |
Tocilizumab plus methotrexate |
Methotrexate |
[3] D00142 D00142, D02115 D02115, D02596 D02596 💬 |
DHFR [3] DHFR, DHFR2, IL6R 💬 |
Antifolate resistance [17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor |
046 [1] 46 💬 |
274 |
Tocilizumab treatment |
Tocilizumab |
[1] D02596 D02596 💬 |
IL6R [1] IL6R 💬 |
Coronavirus disease - COVID-19 [12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor |
041 [1] 41 💬 |
275 |
Tocilizumab+methotrexate(mtx) |
Methotrexate |
[3] D00142 D00142, D02115 D02115, D02596 D02596 💬 |
DHFR [3] DHFR, DHFR2, IL6R 💬 |
Antifolate resistance [17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor |
046 [1] 46 💬 |
276 |
Tofacitinib with methotrexate |
Methotrexate |
[3] D00142 D00142, D02115 D02115, D09970 D09970 💬 |
DHFR [6] DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬 |
AGE-RAGE signaling pathway in diabetic complications [40] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis |
046 [1] 46 💬 |
277 |
Tofacitinib without methotrexate |
Methotrexate |
[3] D00142 D00142, D02115 D02115, D09970 D09970 💬 |
DHFR [6] DHFR, DHFR2, JAK1, JAK2, JAK3, TYK2 💬 |
AGE-RAGE signaling pathway in diabetic complications [40] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis |
046 [1] 46 💬 |
278 |
Topical pentoxifylline gel (vehicle +ptx) |
Pentoxifylline |
[1] D00501 D00501 💬 |
- |
- |
056 [1] 56 💬 |
279 |
Tr004 (treg immunotherapy) |
- |
- |
- |
- |
096 [1] 96 💬 |
280 |
Traditional treatment of cgd and tb |
- |
- |
- |
- |
065 [1] 65 💬 |
281 |
Traditional treatments |
- |
- |
- |
- |
097 [1] 97 💬 |
282 |
Tre |
- |
- |
- |
- |
086 [1] 86 💬 |
283 |
Treat to target |
- |
- |
- |
- |
046 [1] 46 💬 |
284 |
Treat with lansoprazole 30 mg bid for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms |
Lansoprazole |
[1] D00355 D00355 💬 |
ATP4A [2] ATP4A, ATP4B 💬 |
Collecting duct acid secretion [4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation |
098 [1] 98 💬 |
285 |
Treatment |
- |
- |
- |
- |
041 [2] 41, 299 💬 |
286 |
Treatment a |
- |
- |
- |
- |
034 [2] 34, 46 💬 |
287 |
Treatment algorithm a |
- |
- |
- |
- |
097 [1] 97 💬 |
288 |
Treatment algorithm b |
- |
- |
- |
- |
097 [1] 97 💬 |
289 |
Treatment algorithm c |
- |
- |
- |
- |
097 [1] 97 💬 |
290 |
Treatment as usual (tau) |
- |
- |
- |
- |
085 [1] 85 💬 |
291 |
Treatment b |
- |
- |
- |
- |
034 [2] 34, 46 💬 |
292 |
Treatment bx1514m |
- |
- |
- |
- |
058 [1] 58 💬 |
293 |
Treatment c |
- |
- |
- |
- |
034 [2] 34, 46 💬 |
294 |
Treatment d |
- |
- |
- |
- |
034 [1] 34 💬 |
295 |
Treatment defined only by active substance |
- |
- |
- |
- |
050 [1] 50 💬 |
296 |
Treatment i |
- |
- |
- |
- |
046 [1] 46 💬 |
297 |
Treatment ii |
- |
- |
- |
- |
046 [1] 46 💬 |
298 |
Treatment iii |
- |
- |
- |
- |
046 [1] 46 💬 |
299 |
Treatment of mtx |
- |
- |
- |
- |
046 [1] 46 💬 |
300 |
Treatment of mtx and hcq |
- |
- |
- |
- |
046 [1] 46 💬 |
301 |
Treatment of mtx and twhf |
- |
- |
- |
- |
046 [1] 46 💬 |
302 |
Treatment of tcm |
- |
- |
- |
- |
046 [1] 46 💬 |
303 |
Treatment of twhf |
- |
- |
- |
- |
046 [1] 46 💬 |
304 |
Treatment phase group 4 |
- |
- |
- |
- |
113 [1] 113 💬 |
305 |
Treatment systemic therapy (prednisone) |
Prednisone |
[1] D00473 D00473 💬 |
NR3C1 [1] NR3C1 💬 |
Neuroactive ligand-receptor interaction [1] Neuroactive ligand-receptor interaction |
162 [1] 162 💬 |
306 |
Treatment with adalimumab |
Adalimumab |
[1] D02597 D02597 💬 |
TNF [1] TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
096 [1] 96 💬 |
307 |
Treatment with azathioprin |
- |
- |
- |
- |
095 [1] 95 💬 |
308 |
Treatment with mycophenolat mofetil |
- |
- |
- |
- |
095 [1] 95 💬 |
309 |
Treatment with polyethylene glycol (macrogol 4000) |
Polyethylene glycol |
[1] D03370 D03370 💬 |
- |
- |
299 [1] 299 💬 |
310 |
Treatment with systemic therapy (doxycycline) |
Doxycycline |
[5] D00307 D00307, D02129 D02129, D03903 D03903, D03904 D03904, D07876 D07876 💬 |
- |
- |
162 [1] 162 💬 |
311 |
Treatment with systemic therapy (methotrexate) |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
162 [1] 162 💬 |
312 |
Treatment with systemic therapy (prednisone) |
Prednisone |
[1] D00473 D00473 💬 |
NR3C1 [1] NR3C1 💬 |
Neuroactive ligand-receptor interaction [1] Neuroactive ligand-receptor interaction |
162 [1] 162 💬 |
313 |
Treatment with topical superpotent corticosteroid therapy |
- |
- |
- |
- |
162 [1] 162 💬 |
314 |
Tregalizumab |
Tregalizumab |
- |
- |
- |
046 [1] 46 💬 |
315 |
Trehalose |
Trehalose |
- |
- |
- |
113 [1] 113 💬 |
316 |
Tremfya |
- |
- |
- |
- |
037 [2] 37, 97 💬 |
317 |
Tremfya® |
- |
- |
- |
- |
037 [2] 37, 97 💬 |
318 |
Treosulfan |
Treosulfan |
[1] D07253 D07253 💬 |
- |
- |
013 [3] 13, 19, 65 💬 |
319 |
Treprosinil diethanolamine |
- |
- |
- |
- |
086 [1] 86 💬 |
320 |
Treprostin |
- |
- |
- |
- |
086 [1] 86 💬 |
321 |
Treprostinil |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
051 [6] 51, 84, 85, 86, 88, 210 💬 |
322 |
Treprostinil dietanolamina |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
323 |
Treprostinil diethanolamine |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
051 [2] 51, 86 💬 |
324 |
Treprostinil diolamine |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
325 |
Treprostinil inhalation powder |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
326 |
Treprostinil inhalations |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
327 |
Treprostinil injectable product |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
328 |
Treprostinil sodium |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
051 [3] 51, 86, 88 💬 |
329 |
Treprostinil sodium for inhalation |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
085 [1] 85 💬 |
330 |
Treprostinil sodium solution for inhalation |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
331 |
Treprostinil sodium, ut-15 |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
332 |
Treprostinil, ut-15, lrx-15, 15au81, bw a15au, u-62, 840 |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
333 |
Treprostinilo |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
334 |
Tretinoin |
Tretinoin |
[1] D00094 D00094 💬 |
PML [3] PML, RARA, RARB 💬 |
Acute myeloid leukemia [12] Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis |
002 [2] 2 , 75 💬 |
335 |
Tretinoin and pioglitazone hcl |
Pioglitazone |
[3] D00094 D00094, D00945 D00945, D08378 D08378 💬 |
PML [4] PML, PPARG, RARA, RARB 💬 |
AMPK signaling pathway [19] AMPK signaling pathway, Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Huntington disease, Influenza A, Longevity regulating pathway, Non-small cell lung cancer, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis |
002 [1] 2 💬 |
336 |
Trexan |
- |
- |
- |
- |
046 [2] 46, 97 💬 |
337 |
Trexan inj 25 mg/ml |
- |
- |
- |
- |
097 [1] 97 💬 |
338 |
Trexan+salazopyrin+oxiklorin+prednisolone |
Prednisolone |
[8] D00472 D00472, D00980 D00980, D00981 D00981, D00982 D00982, D01239 D01239, D01998 D01998, D02156 D02156, D03301 D03301 💬 |
NR3C1 [1] NR3C1 💬 |
Neuroactive ligand-receptor interaction [1] Neuroactive ligand-receptor interaction |
046 [1] 46 💬 |
339 |
Trexan+salazopyrin+oxiklorin+prednisolone + infliximab |
Infliximab |
[9] D00472 D00472, D00980 D00980, D00981 D00981, D00982 D00982, D01239 D01239, D01998 D01998, D02156 D02156, D02598 D02598, D03301 D03301 💬 |
NR3C1 [2] NR3C1, TNF 💬 |
AGE-RAGE signaling pathway in diabetic complications [66] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
046 [1] 46 💬 |
340 |
Untreated to atorvastatin treatment |
Atorvastatin |
[3] D00258 D00258, D00887 D00887, D07474 D07474 💬 |
HMGCR [1] HMGCR 💬 |
AMPK signaling pathway [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
013 [1] 13 💬 |
341 |
Urine samples taken to measure methotrexate and its major metabolite 7-oh-methotrexate level |
Methotrexate |
[2] D00142 D00142, D02115 D02115 💬 |
DHFR [2] DHFR, DHFR2 💬 |
Antifolate resistance [5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
046 [1] 46 💬 |
342 |
Usual dopaminergic per os treatment |
- |
- |
- |
- |
006 [1] 6 💬 |
343 |
Ut-15c (treprostinil diethanolamine) |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
344 |
Ut-15c sr (treprostinil diethanolamine) |
Treprostinil |
[1] D06213 D06213 💬 |
PTGIR [1] PTGIR 💬 |
Neuroactive ligand-receptor interaction [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction |
086 [1] 86 💬 |
345 |
Vancomycin pre-treat |
Vancomycin |
[2] D00212 D00212, D00926 D00926 💬 |
- |
- |
097 [1] 97 💬 |
346 |
Vancomycin pre-treatment |
Vancomycin |
[2] D00212 D00212, D00926 D00926 💬 |
- |
- |
097 [1] 97 💬 |
347 |
Viral load driven treatment interruption |
- |
- |
- |
- |
265 [1] 265 💬 |