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e.g. Sirolimus, Adalimumab

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28 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Albendazole [2] Albendazole; Albendazole (eskazole);  [1] D00134 💬  -  -  [11]  5 ,  6 ,  7 , 28, 51, 67, 86, 96, 97, 114, 127 💬
 2  Amantadine [13] 240mg amantadine hcl er tablets; 320mg amantadine hcl er tablets; Ads-5102 (extended release amantadine hcl); Amantadine; Amantadine 300 mg; Amantadine hcl er; Amantadine hcl extended release; Amantadine hcl extended release capsule; Amantadine hydrochloride; Amantadine hydrochloride (hcl); Amantadine sulfate; Determination of drug effects through amantadine cessation; Pk-merz® 200mg/500ml inj(amantadine) , normal saline 500ml inj;  [2] D00777
D07441 💬		 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 [20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway  [4]  6 ,  8 , 13, 127 💬
 3  Amiodarone [3] Amiodarone; Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhithmias); Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhythmias) plus egcg;  [2] D00636
D02910 💬		 [16] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCND3, KCNJ11, KCNJ12, KCNJ3, KCNJ5, KCNJ8, KCNQ1, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 [31] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy, Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway  [2] 28, 127 💬
 4  Carbonate ion - -  -  -  [12]  2 , 13, 17, 18, 19, 46, 53, 75, 96, 127, 235, 299 💬
 5  Chloride ion - -  -  -  [25]  6 , 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 78, 96, 97, 127, 168, 171, 193, 227, 228, 271, 288, 296, 297, 299 💬
 6  Citalopram [8] 20mg daily citalopram; Bupropion & citalopram; Citalopram; Citalopram 20mg; Escitalopram; Escitalopram oxalate; Escitalopram oxalate antidepressant; Oral escitalopram;  [2] D00822
D07704 💬		 [1] SLC6A4 💬 [2] Serotonergic synapse, Synaptic vesicle cycle  [6]  6 ,  8 , 13, 18, 46, 127 💬
 7  Davunetide [2] Davunetide; Davunetide (al-108, nap);  [1] D09401 💬  -  -  [3]  5 ,  7 , 127 💬
 8  Donepezil [7] Donepezil; Donepezil hci (drug); Donepezil hydrochloride; Donepezil sandoz; Other: [11c]donepezil pet; Pridia (donepezil hydrochloride) 5mg; Prior donepezil 5mg;  [2] D00670
D07869 💬		 [1] ACHE 💬 [2] Cholinergic synapse, Glycerophospholipid metabolism  [9]  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
 9  Ferulic acid [1] Ferulic acid;  -  -  -  [1] 127 💬
 10  Florbetapir (18F) [2] Florbetapir 18f; Florbetapir 18f injection;  [1] D09617 💬  -  -  [2] 13, 127 💬
 11  Flortaucipir [2] Flortaucipir; Flortaucipir f18;  [1] D11210 💬  -  -  [3]  5 ,  7 , 127 💬
 12  Fludeoxyglucose (18F) - -  -  -  [13]  5 ,  6 ,  7 , 13, 34, 41, 46, 53, 84, 85, 96, 127, 300 💬
 13  Flutemetamol [4] Diagnostic test: flutemetamol f18 injection; Flutemetamol; Flutemetamol f18; Vizamyl (flutemetamol(f-18));  -  -  -  [5]  5 ,  6 ,  7 , 17, 127 💬
 14  Flutemetamol (18F) - [1] D10231 💬  -  -  [5]  5 ,  6 ,  7 , 17, 127 💬
 15  Galantamine [2] Galantamine; Galantamine hydrobromide;  [2] D02173
D04292 💬		 [1] ACHE 💬 [2] Cholinergic synapse, Glycerophospholipid metabolism  [2]  6 , 127 💬
 16  Leucine [8] Administration of stable isotope-labelled leucine-; Diagnostic test: serum leucine-rich alpha-2 glycoprotein (lrg) levels; Essential amino acid intake + leucine vs total aa supplement; L-leucine; Leucine; N acetyl l leucine; N-acetyl-l-leucine; Other: 13c6 leucine;  [1] D00030 💬  -  -  [10]  5 ,  6 ,  7 , 19, 96, 97, 127, 283, 284, 299 💬
 17  Lithium carbonate [1] Lithium carbonate;  [1] D00801 💬  -  -  [6]  2 , 13, 17, 18, 19, 127 💬
 18  Memantine [5] Memantine; Memantine (drug); Memantine (ebixa); Memantine hydrochloride; Memantine hydrochloride oral solution;  [2] D04905
D08174 💬		 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 [20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway  [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
 19  Metformin [21] 750 mg metformin and 7.5 g l-citrulline daily p.o.; Glucophage (metformin); L-citrulline and metformin & l-citrulline; Metformin; Metformin (generic); Metformin 500mg; Metformin and metformin & l-citrulline; Metformin hcl; Metformin hydrochloride; Metformin treatment; Metformin/cp-690,550; Metformina; Metformina - 500 30 compresse 500 mg; Metformine; Metformine arrow 500mg; Metformine hcl 500 pch; Metformine sandoz 850 mg filmomhulde tabletten; Other: metformin; Pioglitazone or metformin; Sitagliptin and metformin; [metformina];  [2] D00944
D04966 💬		 [2] PRKAA1, PRKAA2 💬 [19] AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway  [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
 20  Methylene blue [2] Methylene blue; Methylene blue 25mg tablets;  [2] D02312
D10537 💬		  -  -  [2] 97, 127 💬
 21  Methylprednisolone [35] Administration of rituximab and methylprednisolone; Corticosteroid treatment (methylprednisolone or prednisolone); Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Infliximab, methylprednisolone, methotrexate; Interferon-beta-1a (avonex) plus methylprednisolone; Intravenous (i.v.) methylprednisolone 1000 mg, total 9; Intravenous methylprednisolone; Iv methylprednisolone; Iv methylprednisolone (steroids); Megadose oral methylprednisolone; Methotrexate + methylprednisolone; Methylprednisolone; Methylprednisolone (drug); Methylprednisolone (mp); Methylprednisolone (mp) or prednisone (pred); Methylprednisolone (or other glucocorticoid); Methylprednisolone (solu-medrol); Methylprednisolone 1250 mg/24h x3 days; Methylprednisolone acetate; Methylprednisolone bolus iv 15 mg/kg/d for 3 days.; Methylprednisolone hemisuccinate; Methylprednisolone iv; Methylprednisolone mylan générique; Methylprednisolone or budesonide; Methylprednisolone or prednisolone; Methylprednisolone po; Methylprednisolone pulse; Methylprednisolone sodium hemisuccinate; Methylprednisolone sodium succinate; Methylprednisolone(intravenously in the 1st-2nd-3rd month ); Methylprednisolone(intravenously in the 1st-3rd-5th month); Oral 5-asa+/-topical 5-asa+iv corticosteroids / po methylprednisolone; Oral methylprednisolone 625 mg/24h x3 days; Prednisone (and methylprednisolone); Prednisone, methylprednisolone,cyclophosphamides;  [6] D00407
D00751
D00979
D05000
D05001
D05002 💬		 [1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction  [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
 22  Methylthioninium [3] Leuco-methylthioninium bis(hydromethanesulfonate); Methylthioninium; Methylthioninium chloride;  -  -  -  [1] 127 💬
 23  Oxytocin [8] Intranasal oxytocin; Intranasal oxytocin (in-oxt); Oxytocin; Oxytocin (oxt) continuous; Oxytocin 24iu; Oxytocin 48iu; Oxytocin synthetic; Synthetic oxytocin;  [1] D00089 💬 [1] OXTR 💬 [4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway  [5]  6 , 127, 193, 206, 226 💬
 24  Phenothiazine [4] N,n,n',n'-tetramethyl-10h-phenothiazine-3,7-diaminium bis(methanesulfonate); N,n,n?,n?-tetramethyl-10h-phenothiazine-3,7-diaminium bis(methanesulfonate); N,n,n’,n’-tetramethyl-10h-phenothiazine-3,7-diaminium bis(methanesulfonate); Phenothiazine;  [1] D02601 💬  -  -  [1] 127 💬
 25  Pittsburgh Compound B [3] Other: pittsburgh compound b [11c]-pib; Pittsburgh compound b; Pittsburgh compound b (c-11 pib);  -  -  -  [2]  6 , 127 💬
 26  Prednisone [73] 0 mg prednisone; 5 mg prednisone; 5-aminosalicylic acid(5-asa) and/or prednisone; Adalimumab, plus prednisone; Azathioprine/prednisone; Chinese herb prescription granule plus prednisone; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Corticosteroids (prednisone or prednisolone); Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Cyclophosphamide-prednisone-azathioprine; Enalapril valsartan methylprednisone; Glucocorticoid (prednisone or prednisolone); Granulocyte-colony stimulating factor (g-csf) and prednisone; Hormone (prednisone); Hydroxychloroquine + prednisone; Ir prednisone; Leflunomide 20 mg+prednisone 0.5mg/kg/d; Methylprednisolone (mp) or prednisone (pred); Methylprednisone; Mr prednisone; Mycophenolate mofetil plus lower dose of prednisone; Oral prednisone; Oral prednisone 5mg; Other: prednisone; Over encapsulated prednisone; Prednisolone/prednisone; Prednisone; Prednisone (and methylprednisolone); Prednisone + inhibace/cozaar; Prednisone - azathioprine; Prednisone 0,5 mg/kg orally on alternate days; Prednisone 1 mg; Prednisone 15 mg; Prednisone 2 mg; Prednisone 3 mg; Prednisone 4 mg; Prednisone 5 mg; Prednisone 5 mg tablets; Prednisone 7.5 mg; Prednisone acetate; Prednisone acetate tablets; Prednisone alone; Prednisone and belimumab; Prednisone and cyclophosphamide; Prednisone and mycophenolate mofetil; Prednisone and ustekinumab treatment; Prednisone arrow 20mg; Prednisone arrow 5 mg; Prednisone capsules; Prednisone discontinuation; Prednisone in full dose; Prednisone or prednisolone; Prednisone plus cyclophosphamide; Prednisone tablets usp, 1 mg; Prednisone tablets usp, 2.5 mg; Prednisone tablets usp, 5 mg; Prednisone tablets, usp; Prednisone therapy and pharmacokinetic; Prednisone treatment; Prednisone, ciclosporin and mycophenolate mofetil; Prednisone, cyclophosphamide; Prednisone, fk506, mmf; Prednisone, low dose rituximab; Prednisone, methylprednisolone,cyclophosphamides; Prednisone/prednisolone; Procedure: thymectomy plus prednisone; Rayos (delayed-release prednisone); Sotatercept with prednisone boost; Tacrolimus combined with prednisone; Thalidomide, cyclophosphamide and prednisone; Treatment systemic therapy (prednisone); Treatment with systemic therapy (prednisone); Ursodeoxycholic acid+low dose glucocorticoid(prednisone);  [1] D00473 💬 [1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction  [47]  2 ,  6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 93, 95, 96, 97, 113, 127, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
 27  Sirolimus [22] Rapamycin, sirolimus; Sirolimus; Sirolimus (formerly known as rapamycin); Sirolimus (study drug)+ace inhibitor + statin; Sirolimus 0,1% crème; Sirolimus 0.2%; Sirolimus 0.4%; Sirolimus 1mg/ml; Sirolimus 2 mg; Sirolimus 2%; Sirolimus and hydroxychloroquine 200 mg; Sirolimus and hydroxychloroquine 400 mg; Sirolimus ointment; Sirolimus oral liquid product 1mg/ml; Sirolimus oral product; Sirolimus, 2%; Skincerity plus sirolimus/rapamycin; Skinercity plus sirolimus/rapamycin; Tavt-18 (sirolimus); Temsirolimus; Temsirolimus tablets; Topical 0.1% sirolimus;  [1] D00753 💬 [1] MTOR 💬 [50] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway  [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
 28  Tolcapone [1] Tolcapone;  [1] D00786 💬 [1] COMT 💬 [4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism  [3]  6 , 28, 127 💬