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e.g. Sirolimus, Adalimumab

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23 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Acetylsalicylic acid [2] Acetylsalicylic acid; Acetylsalicylic acid at 1st visit,;  [1] D00109 💬 [2] PTGS1, PTGS2 💬 [23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway  [14] 13, 22, 34, 46, 49, 51, 86, 96, 97, 113, 158, 210, 231, 251 💬
 2  Ambrisentan [11] Ambrisentan; Ambrisentan - high dose; Ambrisentan - low dose; Ambrisentan 5 mg; Ambrisentan 5 mg film-coated tablets; Ambrisentan 5mg film-coated tablets [marketed product]; Ambrisentan plus spironolactone; Ambrisentan tablet; Bosentan, ambrisentan; Tadalafil and ambrisentan upfront combination therapy; Volibris® (ambrisentan);  [1] D07077 💬 [1] EDNRA 💬 [7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [7] 51, 84, 85, 86, 88, 210, 211 💬
 3  Arginine [13] Ar401959 l-arginine; Arginine; Etrasimod l-arginine; Growth hormone releasing hormone (ghrh) and arginine; L-arginine; Ng-monomethyl-l-arginine; Ng-monomethyl-l-arginine (drug); Other: ghrh plus arginine test; Other: glucose -potentiated arginine (gpa) stimulation tests; Procedure: arginine and clonidine stimulation testing; Procedure: arginine stimulation test after each limb; Procedure: ghrh/arginine stimulation testing; Vasopressin, arginine;  [1] D02982 💬  -  -  [9] 46, 67, 78, 96, 97, 113, 210, 251, 299 💬
 4  Ascorbic acid [5] 2l polyethylene glycol/ascorbic acid; Ascorbic acid; Ascorbic acid (vitamin c); Ascorbic acid (vitamin c) and alpha-tocopherol (vitamin e); Ascorbic acid vit c;  [1] D00018 💬  -  -  [8] 10, 97, 192, 206, 210, 211, 212, 298 💬
 5  Bosentan [18] Bosentan; Bosentan (tracleer); Bosentan 125 mg; Bosentan 62.5 mg; Bosentan administration; Bosentan and sildenafil; Bosentan group; Bosentan monohidrato; Bosentan monohydrat; Bosentan monohydrate; Bosentan mylan; Bosentan, ambrisentan; Device: nirs after bosentan administration; Device: tcd after bosentan administration; Duo-therapy with sildenafil + bosentan; Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Sildenafil 20mg and bosentan 62.5mg; Sildenafil singly or in association with bosentan;  [2] D01227
D07538 💬		 [2] EDNRA, EDNRB 💬 [9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
 6  Carvedilol [2] Carvedilol; Spironolactone captopril carvedilol;  [2] D00255
D03415 💬		 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 [12] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [5]  6 , 57, 86, 113, 210 💬
 7  Colchicine [5] Colchicine; Colchicine 1 mg oral tablet; Colchicine sprinkle capsules; Diagnostic test: colchicine level measurement; Other: colchicine cessation;  [1] D00570 💬 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 [10] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection  [7]  2 , 42, 46, 56, 93, 210, 266 💬
 8  Cow milk - -  -  -  [2] 98, 210 💬
 9  Digoxin [3] Bms drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin); Digoxin; Montelukast, flurbiprofen, midazolam, digoxin, pravastatin and bms-986142;  [1] D00298 💬 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 [18] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway  [3]  8 , 46, 210 💬
 10  Enalapril [4] Enalapril; Enalapril and other angiotensin converting enzyme inhibitors; Enalapril maleate; Enalapril valsartan methylprednisone;  [2] D00621
D07892 💬		 [1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system  [7] 19, 46, 66, 113, 210, 222, 223 💬
 11  Eplerenone [1] Eplerenone;  [1] D01115 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption  [4] 75, 113, 210, 215 💬
 12  Horse chestnut [2] Aesculus hippocastanum / horse chestnut; Horse chestnut;  -  -  -  [1] 210 💬
 13  Liothyronine [3] Liothyronine; Liothyronine i 131; Liothyronine sodium;  [2] D01011
D08128 💬		 [2] THRA, THRB 💬 [2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway  [4] 13, 78, 210, 212 💬
 14  Liothyronine I-131 - -  -  -  [2] 210, 212 💬
 15  Macitentan [15] Act-064992 (macitentan); Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Fdc macitentan/tadalafil; Macitentan; Macitentan (act-064992); Macitentan 10 mg; Macitentan 10 mg tablet, once daily.; Macitentan 10mg; Macitentan 3 mg; Macitentan 37.5 mg; Macitentan 3mg; Macitentan 75 mg; Macitentan group; Macitentan tablets; Opsumit (macitentan);  [1] D10135 💬 [2] EDNRA, EDNRB 💬 [9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [5] 51, 85, 86, 88, 210 💬
 16  Nitric Oxide [14] Inhaled nitric oxide; Inhaled nitric oxide & inopulse delivery; Inhaled nitric oxide - 30 mcg/kg ibw/hr; Inhaled nitric oxide 5,10,15 mcg/kg ibw/hr; Inhaled nitric oxide 75 mcg/kg ibw/hr; Nitric oxide; Nitric oxide 160 ppm; Nitric oxide for inhalation; Nitric oxide generated by the geno nitrosyl delivery system; Nitric oxide plus oxygen; Nitric oxide supplement; Other: oral nitric oxide testing; Procedure: exhaled nitric oxide; Procedure: exhaled nitric oxide assessment;  [1] D00074 💬  -  -  [8] 46, 85, 86, 98, 210, 251, 294, 299 💬
 17  Rivaroxaban [3] Lmwh/rivaroxaban; Rivaroxaban; Rivaroxaban 20 mg;  [1] D07086 💬 [1] F10 💬 [1] Complement and coagulation cascades  [5] 46, 49, 75, 91, 210 💬
 18  Sildenafil [32] 20 mg sildenafil citrate by mouth; 5% sildenafil cream; Access program - sildenafil citrate, viagra, revatio; Bosentan and sildenafil; Duo-therapy with sildenafil + bosentan; Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); G04be03- sildenafil - sildenafil (citrato); Mono-therapy with sildenafil; Oral sildenafil; Other: standard of care sildenafil; Sildenafil; Sildenafil (50 mg); Sildenafil (acute-1 hour); Sildenafil (as citrate); Sildenafil (revatio); Sildenafil (revatio) 20 mg tid; Sildenafil (subchronic-4 weeks); Sildenafil 20 mg tablets; Sildenafil 20mg; Sildenafil 20mg and bosentan 62.5mg; Sildenafil 40mg oral capsule; Sildenafil and losartan; Sildenafil by injection; Sildenafil citrate; Sildenafil citrate (uk-92,480); Sildenafil filmtabletten; Sildenafil singly or in association with bosentan; Sildenafil therapy; Sildenafilo; Sitaxsentan and sildenafil; Sodium tanshinone iia sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth; Tadalafil and sildenafil;  [2] D02229
D08514 💬		 [1] PDE5A 💬 [3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway  [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
 19  Spironolactone [5] Ambrisentan plus spironolactone; Spironolactone; Spironolactone (drug); Spironolactone and conivaptan; Spironolactone captopril carvedilol;  [1] D00443 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption  [7] 58, 67, 86, 113, 210, 218, 225 💬
 20  Tadalafil [13] Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); Fdc macitentan/tadalafil; Tadalafil; Tadalafil 20 mg; Tadalafil 20 mg film-coated tablets; Tadalafil 40 mg; Tadalafil and ambrisentan upfront combination therapy; Tadalafil and sildenafil; Tadalafil citrate; Tadalafil oral suspension; Tadalafil, placebo; Tadalafil- tablet or oral suspension; Tadalafilo;  [1] D02008 💬 [1] PDE5A 💬 [3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway  [7]  6 , 51, 75, 84, 86, 113, 210 💬
 21  Treprostinil [39] Combination product: implantable system for remodulin (treprostinil); Combination product: treprostinil via implanted pump; Cutaneous iontophoresis of treprostinil; Dietanolamina de treprostinilo; Eutonic treprostinil solution; Hypotonictreprostinil solution; Inhaled dry powder treprostinil (liq861); Inhaled treprostinil; Intravenous treprostinil; Intravenous/subcutaneous treprostinil; Iontophoresis of treprostinil; L606 (liposomal treprostinil) inhalation solution 51ug; Liq861 inhaled treprostinil; Oral treprostinil; Oral treprostinil (ut-15c) sustained release tablets; Parenteral remodulin (treprostinil) injection; Rapid dose titration group of subcutaneous treprostinil; Remodulin (treprostinil sodium); Remodulin® (treprostinil) 1 mg/ml solution for infusion; Remodulin® (treprostinil) 10 mg/ml solution for infusion; Remodulin® (treprostinil) 2.5 mg/ml solution for infusion; Remodulin® (treprostinil) 5 mg/ml solution for infusion; Slow dose titration group of subcutaneous treprostinil; Subcutaneous treprostinil; Treprostinil; Treprostinil dietanolamina; Treprostinil diethanolamine; Treprostinil diolamine; Treprostinil inhalation powder; Treprostinil inhalations; Treprostinil injectable product; Treprostinil sodium; Treprostinil sodium for inhalation; Treprostinil sodium solution for inhalation; Treprostinil sodium, ut-15; Treprostinil, ut-15, lrx-15, 15au81, bw a15au, u-62, 840; Treprostinilo; Ut-15c (treprostinil diethanolamine); Ut-15c sr (treprostinil diethanolamine);  [1] D06213 💬 [1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction  [6] 51, 84, 85, 86, 88, 210 💬
 22  Udenafil [1] Udenafil;  [1] D10027 💬 [1] PDE5A 💬 [3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway  [2] 86, 210 💬
 23  Vasopressin [2] Vasopressin; Vasopressin, arginine;  [1] D00101 💬 [3] AVPR1A, AVPR1B, AVPR2 💬 [5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption  [1] 210 💬