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e.g. Sirolimus, Adalimumab

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17 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Acetate [98] 11c-acetate; 2-(2-(2-amino-9h-purin-9-yl)ethyl)-1,3-propanediol diacetate ester; 20mg/0.5ml glatiramer acetate; 40 mg glatiramer acetate; 90 mg hydrocortisone acetate suppository with sephure suppository applicator; Abiraterone acetate; Acetate; Bazedoxifene acetate; Betamethasone sodium phosphate/betamethasone acetate (celestone® soluspan®), 30 mg im once a day for four days; Caspofungin acetate; Combination product: twice daily 90 mg hydrocortisone acetate suppository administered with sephure applicator; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortisone acetate; Cosyntropin acetate; Cyclophosphamide/glatiramer acetate; Delmitide acetate; Depot leuprolide acetate 3.75 mg; Desmopressin acetate; Desmopressin acetate trihydrate; Device: cellulose acetate with petrolatum; Dichloroacetate; Dichloroacetate sodium; Dirucotide acetate; Edratide acetate; Etiprednol dicloacetate; Experimental glatiramer acetate; Flecainide acetate; Glatiramer acetate; Glatiramer acetate (copaxone®); Glatiramer acetate (db); Glatiramer acetate (ga); Glatiramer acetate (ga) 40 mg; Glatiramer acetate (gtr); Glatiramer acetate (ol); Glatiramer acetate 150mg enteric coated tablets; Glatiramer acetate 150mg enteric-coated (gastro-resistant) tablets; Glatiramer acetate 20 mg; Glatiramer acetate 20 mg, with mitoxantrone; Glatiramer acetate 20 mg/0.5 ml; Glatiramer acetate 40 mg; Glatiramer acetate [ga]; Glatiramer acetate injection with oral cetirizine hydrochloride; Glatiramer acetate with minocycline; Glatiramer acetate, (copaxone®); Glatiramer acetate, ifn-beta 1a (im), ifn-beta 1a (subcutaneous), and ifn-beta 1b; Glatiramer acetate, n-acetylcysteine; Gonadorelin acetate and triptorelin acetate; Human interferon beta-1a and glatiramer acetate; Hydrocortisone acetate; Hydrocortisone sodium acetate; L-lysyl-d-prolyl-l-threonine acetate; L-lysyl-d-prolyl-lthreonine acetate, lyophilisate; Lanreotide acetate; Lapaquistat acetate and current lipid-lowering treatment; Leuprolide acetate (la); Leuprolide acetate 11.25 mg; Leuprolide acetate 3 month depot; Leuprolide acetate 30 mg; Leuprolide acetate 45 mg; Leuprolide acetate depot; Leuprorelin acetate; Leuprorelin acetate 3.75mg injection; Loestrin (norethindrone acetate and ethinyl estradiol); Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 µg ethinyl estradiol); Luphere depot 3.75mg(leuprolide acetate 3.75mg); Lupron (leuprolide acetate); Macimorelin acetate; Megestrol acetate; Megestrol acetate tablet; Methylprednisolone acetate; Nomegestrol acetate; Octreotide acetate; Oxaloacetate (oaa); Phosphate and betamethasone acetate, 2 ml.; Plovamer acetate; Plovamer acetate 0.5 milligram (mg); Plovamer acetate 10 mg; Plovamer acetate 20 mg; Plovamer acetate 3 mg; Prednisolone acetate; Prednisone acetate; Prednisone acetate tablets; Procedure: warm compress prior to injection of glatiramer acetate; Sodium acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]- phenyl]-acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate; Sotrastaurin (inn) acetate; Tetracosactide acetate; Tetracosactide hexaacetate; Tocopherol acetate; Tocopheryl acetate; Triptorelin acetate and gonadorelin acetate; Ulipristal acetate; Zinc acetate; Zinc acetate (20mg/d); Zinc acetate dihydrate; Zuretinol acetate; [n-trans-3-hexenoyl] human growth hormone releasing factor (1-44) acetate;  -  -  -  [43]  1 ,  2 ,  6 , 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299 💬
 2  Acetazolamide [2] Acetazolamide; Acetazolamide sandoz 250;  [2] D00218
D01196 💬		 [13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬 [7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation  [7] 13, 86, 90, 115, 155, 225, 230 💬
 3  Amiloride [6] Amiloride; Amiloride hcl; Amiloride hydrochloride; Amiloride hydrochloride, 2 h2o; Amiloride solution for inhalation; Hydrochlorothiazide/amiloride;  [2] D00649
D07447 💬		 [3] SCNN1A, SCNN1B, SCNN1G 💬 [2] Aldosterone-regulated sodium reabsorption, Taste transduction  [3] 13, 225, 299 💬
 4  Atorvastatin [9] Atorvastatin; Atorvastatin 10mg; Atorvastatin 20mg; Atorvastatin calcium; Atorvastatin tablet 20 mg; Interferon beta treatment to add-on atorvastatin treatment; Interferon beta-1b/atorvastatin group; Lisinopril, losartan, and atorvastatin; Untreated to atorvastatin treatment;  [3] D00258
D00887
D07474 💬		 [1] HMGCR 💬 [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis  [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
 5  Chlorothiazide [3] Chlorothiazide; Hydrochlorothiazide; Hydrochlorothiazide/amiloride;  [2] D00519
D03471 💬		  -  -  [1] 225 💬
 6  Desmopressin [9] Ddavp (desmopressin); Desmopressin; Desmopressin acetat; Desmopressin acetate; Desmopressin acetate trihydrate; Desmopressin intranasal; Desmopressin oral melt; Desmopressine; Desmopressine nasal spray 10 mg/ml, flacon 60 doses;  [2] D00291
D02235 💬		 [2] AVPR2, F8 💬 [4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption  [6]  6 , 64, 72, 75, 225, 288 💬
 7  Fluconazole [1] Fluconazole;  [2] D00322
D01429 💬		  -  -  [2] 96, 225 💬
 8  Hydrochlorothiazide [2] Hydrochlorothiazide; Hydrochlorothiazide/amiloride;  [1] D00340 💬  -  -  [4] 13, 67, 225, 235 💬
 9  Indomethacin [1] Indomethacin;  [3] D00141
D01565
D02110 💬		 [2] PTGS1, PTGS2 💬 [23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway  [3] 225, 271, 298 💬
 10  Magnesium [19] (s)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate magnesium hydroxide; (s)-4,5-dihydro-2[hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate magnesium hydroxide; Magnesium; Magnesium aspartate; Magnesium aspartate hydrochloride; Magnesium citrate; Magnesium gluconate; Magnesium hydroxide; Magnesium oxide; Magnesium sulfate; Magnesium with ropivacaine; Mineral boost (magnesium); Nexium (esomeprazole magnesium); Omeprazole magnesium; Saroglitazar magnesium 2 mg; Saroglitazar magnesium 4 mg; Sodium picosulfate, magnesium oxide and citric acid; Sodium picosulfate/magnesium citrate laxative; Sulfate, magnesium;  -  -  -  [17]  6 , 11, 13, 46, 51, 64, 70, 93, 97, 166, 225, 235, 284, 291, 296, 297, 298 💬
 11  Metformin [21] 750 mg metformin and 7.5 g l-citrulline daily p.o.; Glucophage (metformin); L-citrulline and metformin & l-citrulline; Metformin; Metformin (generic); Metformin 500mg; Metformin and metformin & l-citrulline; Metformin hcl; Metformin hydrochloride; Metformin treatment; Metformin/cp-690,550; Metformina; Metformina - 500 30 compresse 500 mg; Metformine; Metformine arrow 500mg; Metformine hcl 500 pch; Metformine sandoz 850 mg filmomhulde tabletten; Other: metformin; Pioglitazone or metformin; Sitagliptin and metformin; [metformina];  [2] D00944
D04966 💬		 [2] PRKAA1, PRKAA2 💬 [19] AMPK signaling pathway, Adipocytokine signaling pathway, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway  [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
 12  Omeprazole [19] Bms drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin); Clartihromycin, amoxicillin, and omeprazole; Diclofenac + omeprazole; Dimebon + omeprazole; Esomeprazole; Esomeprazole 20 mg; Naproxen 500 mg tablets (pn 200 minus omeprazole); Nexium (esomeprazole magnesium); Omeprazole; Omeprazole (uk licensed generic product); Omeprazole 20 mg; Omeprazole 20mg; Omeprazole 20mg bid; Omeprazole 40 mg; Omeprazole 40mg capsule; Omeprazole magnesium; Omeprazole rectally 1mg/kg; Pn 200 tablets (500 mg naproxen and 20 mg omeprazole); Rifaximin+omeprazole+miralax;  [4] D00455
D01207
D05259
D05261 💬		 [2] ATP4A, ATP4B 💬 [4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation  [16]  6 ,  8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
 13  Riociguat [14] Adempas (riociguat, bay63-2521); Riociguat; Riociguat (adempas, bay63-2521); Riociguat (bay63-2521); Riociguat coated tablet 0.5 mg; Riociguat coated tablet 1.0 mg; Riociguat coated tablet 1.5 mg; Riociguat coated tablet 2.0 mg; Riociguat coated tablet 2.5 m; Riociguat coated tablet 2.5 mg; Riociguat granules 0.3% for oral application; Riociguat oral product; Riociguat oral tablet; Riociguat pill;  [1] D09572 💬 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 [11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway  [6] 51, 84, 86, 88, 225, 299 💬
 14  Salmon, unspecified - -  -  -  [3] 96, 97, 225 💬
 15  Sildenafil [32] 20 mg sildenafil citrate by mouth; 5% sildenafil cream; Access program - sildenafil citrate, viagra, revatio; Bosentan and sildenafil; Duo-therapy with sildenafil + bosentan; Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan); G04be03- sildenafil - sildenafil (citrato); Mono-therapy with sildenafil; Oral sildenafil; Other: standard of care sildenafil; Sildenafil; Sildenafil (50 mg); Sildenafil (acute-1 hour); Sildenafil (as citrate); Sildenafil (revatio); Sildenafil (revatio) 20 mg tid; Sildenafil (subchronic-4 weeks); Sildenafil 20 mg tablets; Sildenafil 20mg; Sildenafil 20mg and bosentan 62.5mg; Sildenafil 40mg oral capsule; Sildenafil and losartan; Sildenafil by injection; Sildenafil citrate; Sildenafil citrate (uk-92,480); Sildenafil filmtabletten; Sildenafil singly or in association with bosentan; Sildenafil therapy; Sildenafilo; Sitaxsentan and sildenafil; Sodium tanshinone iia sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth; Tadalafil and sildenafil;  [2] D02229
D08514 💬		 [1] PDE5A 💬 [3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway  [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
 16  Spironolactone [5] Ambrisentan plus spironolactone; Spironolactone; Spironolactone (drug); Spironolactone and conivaptan; Spironolactone captopril carvedilol;  [1] D00443 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption  [7] 58, 67, 86, 113, 210, 218, 225 💬
 17  Tolvaptan [22] Jinarc - tolvaptan tablets; Opc-41061 (tolvaptan); Tolvaptan; Tolvaptan (opc-41061); Tolvaptan 15; Tolvaptan 15 mg tablet; Tolvaptan 15 mg tablets; Tolvaptan 15mg; Tolvaptan 30; Tolvaptan 30 mg tablet; Tolvaptan 30 mg tablets; Tolvaptan 30mg; Tolvaptan 45/15; Tolvaptan 60/30; Tolvaptan 7.5 mg tablet; Tolvaptan in euvolemic hyponatremia; Tolvaptan ir; Tolvaptan mr; Tolvaptan oral tablet; [tolvaptan 15]; [tolvaptan 30]; [tolvaptan 45/15];  [1] D01213 💬 [1] AVPR2 💬 [3] Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption  [3] 67, 72, 225 💬