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e.g. Sirolimus, Adalimumab

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26 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Acetaminophen [9] Acetaminophen; Acetaminophen tab 650mg; Acetaminophen tablets; Acetaminophen/paracetamol; Multi-modal pain management [acetaminophen + gabapentin]; Oxycodone/acetaminophen; Paracetamol (acetaminophen); Tramadol /acetaminophen; Tramadol hydrochloride + acetaminophen;  [1] D00217 💬 [2] PTGS1, PTGS2 💬 [23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway  [16]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271 💬
 2  Amifampridine [3] Amifampridine; Amifampridine phosphate; Amifampridine phosphate 10 mg oral tablet;  [1] D10228 💬 [4] KCNA4, KCNC3, KCND2, KCND3 💬 [4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia  [3]  3 , 11, 12 💬
 3  Branaplam [1] Branaplam;  -  -  -  [1]  3  💬
 4  Celecoxib [8] Celebra (celecoxib); Celecoxib; Celecoxib (celebrex); Celecoxib 200 milligrams; Celecoxib 200mg capsule; Celecoxib 400 milligrams; Celecoxib, celebrex®; Fixed dose combination ciprofloxacin/celecoxib;  [1] D00567 💬 [1] PTGS2 💬 [22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway  [9]  2 ,  3 , 34, 46, 70, 89, 161, 171, 271 💬
 5  Dalfampridine [6] Dalfampridine; Dalfampridine er; Dalfampridine-er 10mg; Dalfampridine-er 5mg; Other: withdrawal of dalfampridine-er 10mg; Sustained-release oral dalfampridine;  [1] D04127 💬 [4] KCNA4, KCNC3, KCND2, KCND3 💬 [4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia  [5]  3 ,  4 ,  6 , 13, 14 💬
 6  Hydroxyurea [1] Hydroxyurea;  [1] D00341 💬 [1] RRM2 💬 [6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway  [8]  3 , 13, 19, 20, 65, 85, 86, 284 💬
 7  Itraconazole [2] Itraconazole; Itraconazole/voriconazole;  [1] D00350 💬  -  -  [4]  3 , 65, 227, 299 💬
 8  Leuprolide [11] Depot leuprolide acetate 3.75 mg; Leuprolide; Leuprolide (gnrh agonists); Leuprolide acetate (la); Leuprolide acetate 11.25 mg; Leuprolide acetate 3 month depot; Leuprolide acetate 30 mg; Leuprolide acetate 45 mg; Leuprolide acetate depot; Luphere depot 3.75mg(leuprolide acetate 3.75mg); Lupron (leuprolide acetate);  [2] D00989
D08113 💬		 [1] GNRHR 💬 [2] GnRH signaling pathway, Neuroactive ligand-receptor interaction  [5]  1 ,  2 ,  3 , 51, 76 💬
 9  Levocarnitine [4] Levocarnitine; Levocarnitine propyl hydrochloride; Valproate, levocarnitine; Valproic acid and levocarnitine;  [3] D02030
D02176
D04713 💬		  -  -  [10]  3 ,  5 , 13, 53, 58, 96, 97, 265, 298, 316 💬
 10  Medical air [5] Medical air; Medical air (sham o2); Medical air vs oxygen; Other: medical air; Sham o2 (medical air);  -  -  -  [8]  3 , 51, 58, 85, 86, 97, 193, 299 💬
 11  Midazolam [7] Bms drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin); Midazolam; Midazolam 2 mg; Midazolam 3 mg; Midazolam injection; Montelukast, flurbiprofen, midazolam, digoxin, pravastatin and bms-986142; S-ketamine & midazolam;  [3] D00550
D00696
D05028 💬		 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction  [11]  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 298 💬
 12  Nerve Growth Factor [2] Nerve growth factor; Recombinant human nerve growth factor (rhngf);  -  -  -  [2]  3 , 90 💬
 13  Nusinersen [4] Nusinersen; Nusinersen injectable product; Nusinersen sodium; Nusinersen treatments;  [1] D10881 💬 [1] SMN2 💬 [1] RNA transport  [1]  3  💬
 14  Onasemnogene abeparvovec [2] Onasemnogene abeparvovec; Onasemnogene abeparvovec-xioi;  [1] D11559 💬 [1] SMN1 💬 [1] RNA transport  [1]  3  💬
 15  Phenylbutyric acid - [1] D05868 💬  -  -  [12]  2 ,  3 ,  6 ,  8 , 15, 93, 94, 231, 244, 251, 297, 299 💬
 16  Phosphate ion - -  -  -  [30]  2 ,  3 , 11, 12, 13, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 256, 276, 283, 284, 285, 286, 299 💬
 17  Pyridostigmine [2] Pyridostigmine; Pyridostigmine bromide;  [1] D00487 💬 [1] ACHE 💬 [2] Cholinergic synapse, Glycerophospholipid metabolism  [4]  3 ,  6 , 11, 256 💬
 18  Reldesemtiv [3] Reldesemtiv; Reldesemtiv 150 mg; Reldesemtiv 450 mg;  [1] D11363 💬 [1] TNNC2 💬 [1] Calcium signaling pathway  [2]  2 ,  3  💬
 19  Riluzole [8] Plasma from healthy young people treatment + riluzole; Riluzole; Riluzole (100 mg); Riluzole 50 mg; Riluzole 50 mg (part b); Riluzole oral soluble film; Riluzole oral soluble film (rosf) 50 mg; Riluzole pmcs;  [1] D00775 💬 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 [23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway  [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
 20  Risdiplam [1] Risdiplam;  [1] D11406 💬 [1] SMN2 💬 [1] RNA transport  [1]  3  💬
 21  Salbutamol [9] Nebulized combination ipratropium bromide with salbutamol; Other: salbutamol nebulisation and with cpap; R-salbutamol; R-salbutamol sulphate; Salbutamol; Salbutamol 4mg tablet; Salbutamol sulfate; Salbutamol sulfate ph. eur.; Salbutamol wzf 4 mg;  [1] D02147 💬 [1] ADRB2 💬 [8] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway  [14]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
 22  Sesame oil [2] Sesame oil; Sesame oil, refined;  [1] D03314 💬  -  -  [1]  3  💬
 23  Somatotropin [3] Recombinant human somatotropin; Somatotropin; Somatotropine;  [1] D02691 💬 [1] GHR 💬 [5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway  [20]  2 ,  3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬
 24  Testosterone [13] Androgel 10 grams of gel containing 100 mg of testosterone; Nebido® testosterone undecanoate 1000 mg/4 ml solution for injection; Procedure: testosterone injection; Sustanon (testosterone); Testosterone; Testosterone decanoate; Testosterone enanthate; Testosterone isocaproate; Testosterone phenylpropionate; Testosterone plus somatropin; Testosterone propionate; Testosterone undecanoate; Transdermal testosterone gel;  [6] D00075
D00957
D00958
D00959
D06085
D06087 💬		 [1] AR 💬 [3] Oocyte meiosis, Pathways in cancer, Prostate cancer  [8]  1 ,  2 ,  3 , 13, 60, 78, 113, 265 💬
 25  TRO19622 [2] Olesoxime (tro19622); Tro19622;  -  -  -  [3]  2 ,  3 , 13 💬
 26  Valproic acid [3] Valproic acid; Valproic acid (vpa); Valproic acid and levocarnitine;  [1] D00399 💬 [7] ABAT, ALDH5A1, CACNA1G, CACNA1H, CACNA1I, GAD1, GAD2 💬 [17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism  [16]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬