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e.g. Sirolimus, Adalimumab

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35 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Acetylcysteine [12] Acetylcysteine; Acetylcysteine effervescent tablets; Acetylcysteine sodium; Fluimucil (acetylcysteine); Glatiramer acetate, n-acetylcysteine; Jaktinib dihydrochloride monohydrate 50mg bid and mimic tablets of jakitinib hydrochloride 75mg bid and acetylcysteine effervescent tablets; Jaktinib dihydrochloride monohydrate 75mg bid and mimic tablets of jakitinib hydrochloride 50mg bid and acetylcysteine effervescent tablets; N acetylcysteine; N-acetylcysteine; N-acetylcysteine (nac); N-acetylcysteine capsule; N-acetylcysteine, (nac);  [1] D00221 💬  -  -  [17]  6 , 13, 19, 20, 34, 49, 51, 58, 85, 90, 94, 111, 164, 193, 233, 298, 299 💬
 2  Adenosine [19] 2-cda, 2-chloro-2'-deoxy-beta-d-adenosine; 2-cda, 2-chloro-2'-deoxy-ß-d-adenosine; 2-cda, 2-chloro-2?-deoxy-beta-d-adenosine; 2-cda, 2-chloro-2?-deoxy-ß-d-adenosine; 2-cda, 2-chloro-2’-deoxy-beta-d-adenosine; 2-cda, 2-chloro-2’-deoxy-ß-d-adenosine; 2-chloro-2'-deoxy-beta-d-adenosine (2-cda); 2-chloro-2'-deoxy-ß-d-adenosine (2-cda); 2-chloro-2'-deoxyadenosine (2-cda); 2-chloro-2'-deoxyadenosine, 2cda; 2-chloro-2?-deoxy-beta-d-adenosine; 2-chloro-2?-deoxy-ß-d-adenosine; 2-chloro-2’-deoxy-beta-d-adenosine; 2-chloro-2’-deoxy-beta-d-adenosine (2-cda); 2-chloro-2’-deoxy-ß-d-adenosine; 2-chloro-2’-deoxy-ß-d-adenosine (2-cda); 2-chloro-2’-deoxyadenosine (2-cda); Adenosine; Autologous ex vivo gene therapy products based on the efs lv encoding for the human adenosine deaminase (ada) gene (efs-ada lv);  [1] D00045 💬 [4] ADORA1, ADORA2A, ADORA2B, ADORA3 💬 [12] Alcoholism, Calcium signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [3] 13, 58, 65 💬
 3  Atorvastatin [9] Atorvastatin; Atorvastatin 10mg; Atorvastatin 20mg; Atorvastatin calcium; Atorvastatin tablet 20 mg; Interferon beta treatment to add-on atorvastatin treatment; Interferon beta-1b/atorvastatin group; Lisinopril, losartan, and atorvastatin; Untreated to atorvastatin treatment;  [3] D00258
D00887
D07474 💬		 [1] HMGCR 💬 [4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis  [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
 4  Bluefish [2] Bluefish; Losartan bluefish 50 mg;  -  -  -  [1] 58 💬
 5  Candesartan [3] Candesartan; Candesartan and cilnidipine; Candesartan plus non-ccb agents;  [1] D00522 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway  [2] 58, 67 💬
 6  Cyclosporine [26] Atg+cyclosporine; Atg+rapamune+cyclosporine; Busulfan, fludarabine, & cyclophosphamide with immunosuppression with atg and cyclosporine.; Cyclophosphamide,cyclosporine a; Cyclosporine; Cyclosporine (gengraf ); Cyclosporine (usan); Cyclosporine 5 mg/kg bid days 0-14; Cyclosporine a; Cyclosporine a (csa); Cyclosporine a dry powder inhalation (drug); Cyclosporine combine with mycophenolate mofetil; Cyclosporine inhalation solution; Cyclosporine inhalation solution (cis); Cyclosporine oral product; Cyclosporine pill; Cyclosporine vs infliximab; Cyclosporine-a; Device: cyclosporine a; Liposomal aerosol cyclosporine; Liposomal cyclosporine a; Liposomal cyclosporine a 10 mg; Liposomal cyclosporine a 5 mg; Oral cyclosporine; Rabbit atg, cyclosporine, levamisole; Twice-daily dosage with 0.5% cyclosporine-a eyedrops;  [1] D00184 💬 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 [32] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway  [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
 7  Diltiazem [3] Diltiazem; Diltiazem gel 2%; Diltiazem hydrochloride;  [3] D00616
D03830
D07845 💬		 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 [36] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [3] 51, 58, 86 💬
 8  Dobutamine [2] Dobutamine; Other: dobutamine;  [4] D00632
D03879
D03880
D03881 💬		 [1] ADRB1 💬 [10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway  [3] 57, 58, 215 💬
 9  Eleclazine [1] Eleclazine;  [1] D11155 💬 [5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 [3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction  [1] 58 💬
 10  Ethanol [11] Andrographis paniculata (ethanol extract); Ethanol; Ethanol (96 per cent); Ethanol 96% gel; Ethanol 98% solution; Ethanol bp; Ethanol gel; Ethanolamine; Ethanolamine oleate; Other: physalis angulata ethanol extract; Treprostinil diethanolamine;  [4] D00068
D02798
D04855
D06542 💬		  -  -  [7] 13, 51, 58, 97, 279, 280, 298 💬
 11  Flunarizine - [2] D01303
D07971 💬		 [3] CACNA1G, CACNA1H, CACNA1I 💬 [8] Aldosterone synthesis and secretion, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GnRH secretion, MAPK signaling pathway, Type II diabetes mellitus  [4] 58, 86, 149, 215 💬
 12  Gadolinium [10] Device: magnetic resonance imaging (mri) with gadolinium enhancement; Device: magnetic resonance imaging (mri) without gadolinium enhancement; Diagnostic test: cardiac mri (gadolinium enhanced); Gadolinium; Gadolinium contrast; Gadolinium for abdomen; Gadolinium for lower back; Gadolinium-based contrast; Other: uspio mri - gadolinium mri; Standard gadolinium contrast;  -  -  -  [6] 13, 34, 46, 58, 65, 86 💬
 13  Levocarnitine [4] Levocarnitine; Levocarnitine propyl hydrochloride; Valproate, levocarnitine; Valproic acid and levocarnitine;  [3] D02030
D02176
D04713 💬		  -  -  [10]  3 ,  5 , 13, 53, 58, 96, 97, 265, 298, 316 💬
 14  Losartan [12] Lisinopril, losartan, and atorvastatin; Losartan; Losartan and atenolol or propranolol; Losartan and nebivolol; Losartan and other angiotensin receptor blockers; Losartan bluefish 50 mg; Losartan hexal; Losartan potasico; Losartan potassium; Losartan tablets & qingremoshen granule; Other: losartan; Sildenafil and losartan;  [2] D00357
D08146 💬		 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway  [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
 15  Mangafodipir [3] Mangafodipir; Mangafodipir (teslascan); Other: mangafodipir trisodium;  [1] D08262 💬  -  -  [2] 13, 58 💬
 16  Mavacamten [1] Mavacamten;  -  -  -  [1] 58 💬
 17  Medical air [5] Medical air; Medical air (sham o2); Medical air vs oxygen; Other: medical air; Sham o2 (medical air);  -  -  -  [8]  3 , 51, 58, 85, 86, 97, 193, 299 💬
 18  Methamidophos - -  -  -  [18]  2 , 11, 13, 19, 46, 49, 58, 65, 70, 85, 86, 98, 113, 118, 129, 298, 299, 300 💬
 19  Metoprolol [8] Metoprolol; Metoprolol succinate; Metoprolol succinate + doxazosin; Metoprolol tartrate 50 mg; Metoprolol tartrate oral tablet; Metoprololsuccinat orion 25mg; Metoprololsuccinat ”orion” 25mg; Tesofensine/metoprolol;  [3] D00601
D02358
D05011 💬		 [1] ADRB1 💬 [10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway  [6] 17, 57, 58, 113, 193, 226 💬
 20  Midodrine [2] Midodrine; Midodrine hydrochloride;  [2] D01307
D08220 💬		 [3] ADRA1A, ADRA1B, ADRA1D 💬 [7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway  [3]  6 , 17, 58 💬
 21  Nesiritide - [1] D05147 💬 [1] NPR1 💬 [10] Aldosterone synthesis and secretion, Metabolic pathways, Oxytocin signaling pathway, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [2] 46, 58 💬
 22  Nitrate [11] Gallium nitrate; Isosorbide dinitrate; Isosorbide dinitrate 20 mg; Isosorbide dinitrate 40 mg; Isosorbide dinitrate 60 mg; Isosorbide dinitrate 80 mg; Nitrate; Other: ibuprofen and isosorbide dinitrate combination; Pilocarpine nitrate 5%; Sodium nitrate; Sodium nitrate - double dose;  [1] D02313 💬  -  -  [3] 58, 113, 299 💬
 23  Perhexiline [2] Device: use of bioanalytical assay to monitor plasma levels of perhexiline; Perhexiline;  [2] D05442
D08340 💬		 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CPT1A, CPT1B, CPT1C, CPT2 💬 [45] AMPK signaling pathway, Adipocytokine signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Dilated cardiomyopathy, Dopaminergic synapse, Fatty acid degradation, Fatty acid metabolism, GABAergic synapse, Glucagon signaling pathway, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin resistance, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, PPAR signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Thermogenesis, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [2] 58, 272 💬
 24  Phosphorus [2] Other: 31-phosphorus rmn spectroscopy; Phosphorus;  -  -  -  [2]  8 , 58 💬
 25  Piperazine [2] 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride; Piperazine;  [6] D00807
D01393
D02127
D02145
D05486
D06224 💬		  -  -  [1] 58 💬
 26  Pirfenidone [7] Pirfenidone; Pirfenidone (pfd); Pirfenidone 267 mg [esbriet]; Pirfenidone and nintedanib; Pirfenidone or nintedanib; Pirfenidoneone; Sub-study: pirfenidone;  [1] D01583 💬 [6] CCL2, IL10, IL1A, IL1B, IL6, TNF 💬 [82] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
 27  Pyrazole [2] (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide; Pyrazole;  -  -  -  [4] 28, 46, 58, 75 💬
 28  Ranolazine [7] Ranolazine; Ranolazine 1000 mg; Ranolazine 1000 mg pr tablets; Ranolazine 500 mg; Ranolazine 500 mg pr tablets; Ranolazine 750 mg pr tablets; Ranolazine pr (prolonged-release) 500 mg 1 tablet bis in die and 750 mg 1 tablet bis in die;  [2] D05700
D05701 💬		  -  -  [6]  2 , 58, 86, 96, 113, 114 💬
 29  Regadenoson [1] Regadenoson;  [1] D05711 💬 [1] ADORA2A 💬 [7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway  [1] 58 💬
 30  Sacubitril [3] Sacubitril; Sacubitril valsartan; Sacubitril/valsartan;  [1] D10225 💬 [1] MME 💬 [4] Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system  [1] 58 💬
 31  Sodium nitrate [2] Sodium nitrate; Sodium nitrate - double dose;  -  -  -  [2] 58, 113 💬
 32  Spironolactone [5] Ambrisentan plus spironolactone; Spironolactone; Spironolactone (drug); Spironolactone and conivaptan; Spironolactone captopril carvedilol;  [1] D00443 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption  [7] 58, 67, 86, 113, 210, 218, 225 💬
 33  Triethylenetetramine - -  -  -  [2] 58, 171 💬
 34  Trimetazidine [3] Trimetazidine; Trimetazidine dihydrochloride; Trimetazidine dihydrochloride 20mg;  [2] D01606
D08642 💬		  -  -  [2] 58, 86 💬
 35  Valsartan [5] Benazepril, valsartan and fluvastatin; Enalapril valsartan methylprednisone; Sacubitril valsartan; Sacubitril/valsartan; Valsartan;  [1] D00400 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway  [7] 57, 58, 66, 75, 218, 222, 224 💬