Target Gene/Pathway💬 Info on mouse-over

59 / 286 pathways

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
2 Alcoholism 💬
[1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
3 Alcoholism 💬
[1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
4 Alcoholism 💬
[1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
5 Alzheimer disease 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
6 Amphetamine addiction 💬
[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
7 Amphetamine addiction 💬
[1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
8 Amphetamine addiction 💬
[1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
9 Amphetamine addiction 💬
[1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
10 AMPK signaling pathway 💬
[1] HMGCR 💬 D01915 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
11 AMPK signaling pathway 💬
[1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
12 Amyotrophic lateral sclerosis 💬
[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
13 Bile secretion 💬
[1] HMGCR 💬 D01915 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
14 Bile secretion 💬
[1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
15 Calcium signaling pathway 💬
[4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
16 cAMP signaling pathway 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
17 cAMP signaling pathway 💬
[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
18 Chagas disease 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
19 Cholinergic synapse 💬
[2] CHRNA4, CHRNB2 💬 D08669 💬 Varenicline [2]  6 , 18 💬
20 Circadian entrainment 💬
[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
21 Cocaine addiction 💬
[6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
22 Cocaine addiction 💬
[1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
23 Cocaine addiction 💬
[1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
24 Cocaine addiction 💬
[1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
25 Cytokine-cytokine receptor interaction 💬
[1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
26 Cytokine-cytokine receptor interaction 💬
[1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
27 Cytokine-cytokine receptor interaction 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
28 Dopaminergic synapse 💬
[6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
29 Dopaminergic synapse 💬
[1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
30 Dopaminergic synapse 💬
[1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
31 Dopaminergic synapse 💬
[1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
32 Estrogen signaling pathway 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
33 Fluid shear stress and atherosclerosis 💬
[1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
34 GABAergic synapse 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
35 GABAergic synapse 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
36 Glutamatergic synapse 💬
[14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
37 GnRH secretion 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
38 Hematopoietic cell lineage 💬
[1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
39 Hematopoietic cell lineage 💬
[1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
40 Hepatocellular carcinoma 💬
[1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
41 Herpes simplex virus 1 infection 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
42 HIF-1 signaling pathway 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
43 Huntington disease 💬
[6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
44 Inflammatory bowel disease 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
45 Influenza A 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
46 JAK-STAT signaling pathway 💬
[1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
47 JAK-STAT signaling pathway 💬
[1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
48 JAK-STAT signaling pathway 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
49 Kaposi sarcoma-associated herpesvirus infection 💬
[1] IFNGR1 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
50 Leishmaniasis 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
51 Long-term depression 💬
[3] GRIA1, GRIA2, GRIA3 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
52 Long-term potentiation 💬
[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
53 Metabolic pathways 💬
[1] HMGCR 💬 D01915 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
54 Metabolic pathways 💬
[1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
55 Morphine addiction 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
56 Morphine addiction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
57 Natural killer cell mediated cytotoxicity 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
58 Necroptosis 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
59 Neuroactive ligand-receptor interaction 💬
[2] CHRNA4, CHRNB2 💬 D08669 💬 Varenicline [2]  6 , 18 💬
60 Neuroactive ligand-receptor interaction 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
61 Neuroactive ligand-receptor interaction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
62 Neuroactive ligand-receptor interaction 💬
[14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
63 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D00407 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
64 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D00751 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
65 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D00979 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
66 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D05000 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
67 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D05001 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
68 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D05002 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
69 Nicotine addiction 💬
[2] CHRNA4, CHRNB2 💬 D08669 💬 Varenicline [2]  6 , 18 💬
70 Nicotine addiction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
71 Nicotine addiction 💬
[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
72 Osteoclast differentiation 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
73 Parkinson disease 💬
[1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
74 Parkinson disease 💬
[1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
75 Parkinson disease 💬
[1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
76 Parkinson disease 💬
[1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
77 Pathways in cancer 💬
[1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
78 Pathways in cancer 💬
[1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
79 Pathways in cancer 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
80 Pathways in cancer 💬
[1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
81 Pathways of neurodegeneration - multiple diseases 💬
[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
82 Pathways of neurodegeneration - multiple diseases 💬
[1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
83 Pathways of neurodegeneration - multiple diseases 💬
[1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
84 Pathways of neurodegeneration - multiple diseases 💬
[1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
85 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
86 PI3K-Akt signaling pathway 💬
[1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
87 PI3K-Akt signaling pathway 💬
[1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
88 Prion disease 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
89 Protein processing in endoplasmic reticulum 💬
[1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
90 Rap1 signaling pathway 💬
[3] GRIN1, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
91 Ras signaling pathway 💬
[3] GRIN1, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
92 Retrograde endocannabinoid signaling 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
93 Retrograde endocannabinoid signaling 💬
[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
94 Serotonergic synapse 💬
[3] GABRB1, GABRB2, GABRB3 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
95 Serotonergic synapse 💬
[1] SLC6A4 💬 D00822 💬 Citalopram [6]  6 ,  8 , 13, 18, 46, 127 💬
96 Serotonergic synapse 💬
[1] SLC6A4 💬 D07704 💬 Citalopram [6]  6 ,  8 , 13, 18, 46, 127 💬
97 Spinocerebellar ataxia 💬
[8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
98 Synaptic vesicle cycle 💬
[2] SLC6A2, SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
99 Synaptic vesicle cycle 💬
[2] SLC6A2, SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
100 Synaptic vesicle cycle 💬
[2] SLC6A2, SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
101 Synaptic vesicle cycle 💬
[1] SLC6A4 💬 D00822 💬 Citalopram [6]  6 ,  8 , 13, 18, 46, 127 💬
102 Synaptic vesicle cycle 💬
[1] SLC6A4 💬 D07704 💬 Citalopram [6]  6 ,  8 , 13, 18, 46, 127 💬
103 Systemic lupus erythematosus 💬
[2] GRIN2A, GRIN2B 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
104 Taste transduction 💬
[2] GABBR1, GABBR2 💬 D00241 💬 Baclofen [5]  2 , 10, 13, 18, 149 💬
105 Taste transduction 💬
[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D00697 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
106 Terpenoid backbone biosynthesis 💬
[1] HMGCR 💬 D01915 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
107 Terpenoid backbone biosynthesis 💬
[1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
108 Th1 and Th2 cell differentiation 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
109 Th17 cell differentiation 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
110 Toxoplasmosis 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
111 Transcriptional misregulation in cancer 💬
[1] GRIA3 💬 D00775 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
112 Tuberculosis 💬
[2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬