DDrare: Database of Drug Development for Rare Diseases

291. ヒルシュスプルング病（全結腸型又は小腸型）
［臨床試験数：13，薬物数：32（DrugBank：15），標的遺伝子数：0，標的パスウェイ数：0］

Searched query = "Hirschsprung disease, entire colon type", "Hirschsprung disease, small intestine type", "Hirschsprung disease", "Hirschprung disease", "Hirschsprung disease associated entercolitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = Behavioral: anal dilation; Behavioral: colonic lavage; Behavioral: conservative treatment; Bifico; Butyrate; Butyrate enemas + routine management; Cefazolin; Citric acid; Device: SPY imaging; Erythromycin; Gold; High dose lactulose; Indocyanine Green; Indocyanine green; Kanamycin; Lactulose; Magnesium; Magnesium oxide; Metronidazole; Oral probiotic; Other: Nil per os; Other: routine management; Paraffin Oil; Paraffin oil; Picosulfate; Probiotics; Procedure: surgery treatment; Racol; Senna; Sodium Picosulfate, Magnesium Oxide and Citric Acid; Supplement nutritional supporting; VSL#3

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000024993	2016/12/01	15/12/2016	Study for efficacy of usage of enteral nutrient with immuno-balance modulation action in perioperative management of pediatric patients		Hirschsprung's disease, Atresia ani, Congenital biliary dilatation, GERD	In the control group, the following enteral nutrient will be administered (breast milk or artificial milk for infants, Racol for infants). Dose and duration: Before surgery, the patient will take enteral nutrients at 60 to 100 kcal / kg per day for 3 days. After the surgery, enteral nutrition will restart within 2 to 3 days after surgery, and continue until 6th postoperative day. In contrast, immunomodulatory nutrition is administered in the test group. Dose and duration: Before surgery, the patient will take enteral nutrients at 60 to 100 kcal / kg per day for 3 days. After the surgery, enteral nutrition will restart within 2 to 3 days after surgery, and continue until 6th postoperative day. The study period is from December 1, 2016 to March 31, 2018.	University of Tsukuba Hospital	NULL	Pending	6months-old	48months-old	Male and Female	10	Not applicable	Japan

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

JPRN-UMIN000024993

2016/12/01

15/12/2016

Study for efficacy of usage of enteral nutrient with immuno-balance modulation action in perioperative management of pediatric patients

Hirschsprung's disease, Atresia ani, Congenital biliary dilatation, GERD

In the control group, the following enteral nutrient will be administered (breast milk or artificial milk for infants, Racol for infants).
Dose and duration: Before surgery, the patient will take enteral nutrients at 60 to 100 kcal / kg per day for 3 days. After the surgery, enteral nutrition will restart within 2 to 3 days after surgery, and continue until 6th postoperative day.
In contrast, immunomodulatory nutrition is administered in the test group.
Dose and duration: Before surgery, the patient will take enteral nutrients at 60 to 100 kcal / kg per day for 3 days. After the surgery, enteral nutrition will restart within 2 to 3 days after surgery, and continue until 6th postoperative day.

The study period is from December 1, 2016 to March 31, 2018.

University of Tsukuba Hospital

NULL

Pending

6months-old

48months-old

Male and Female

Not applicable

Japan