299. 嚢胞性線維症
［臨床試験数：1,592，薬物数：1,539（DrugBank：255），標的遺伝子数：81，標的パスウェイ数：162］
Searched query = "Cystic fibrosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04039087 (ClinicalTrials.gov) | September 5, 2019 | 28/7/2019 | Sildenafil Exercise: Role of PDE5 Inhibition | Mechanisms of Exercise Intolerance in Cystic Fibrosis: Role of PDE5 Inhibition | Cystic Fibrosis | Drug: Sildenafil 40mg oral capsule;Drug: Placebo Oral capsule | National Jewish Health | Augusta University;Cystic Fibrosis Foundation | Recruiting | 9 Years | N/A | All | 40 | Phase 2;Phase 3 | United States |
| 2 | NCT02626182 (ClinicalTrials.gov) | December 2015 | 3/12/2015 | Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe CF | Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe Cystic Fibrosis Lung Disease | Cystic Fibrosis | Drug: sildenafil;Drug: placebo | National Jewish Health | NULL | Completed | 18 Years | N/A | All | 14 | Phase 1;Phase 2 | United States |
| 3 | NCT01132482 (ClinicalTrials.gov) | October 2015 | 16/4/2010 | Effects of Sildenafil on CFTR-dependent Ion Transport Activity | Phase II Study of the Effects of Sildenafil on CFTR-dependent Ion Transport Activity | Cystic Fibrosis | Drug: Sildenafil;Drug: Placebo | National Jewish Health | NULL | Completed | 18 Years | N/A | All | 19 | Phase 2 | United States |
| 4 | NCT02057458 (ClinicalTrials.gov) | April 2014 | 4/2/2014 | Blood Flow and Vascular Function in Cystic Fibrosis | Role of Blood Flow and Vascular Function on Exercise Capacity in Cystic Fibrosis | Cystic Fibrosis | Drug: Sildenafil (Acute-1 hour);Drug: Sildenafil (Subchronic-4 weeks);Drug: Placebo | Augusta University | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | 18 Years | N/A | All | 19 | Phase 2 | United States |
| 5 | NCT01194232 (ClinicalTrials.gov) | August 2012 | 1/9/2010 | Sildenafil Trial in Children and Young Adults With CF | Randomized Controlled Study of Sildenafil in Children and Young Adults With Mild to Moderate Cystic Fibrosis Lung Disease | Cystic Fibrosis With Mild to Moderate Lung Disease;CMRI of Lung Perfusion;Lung Perfusion;Lung Vascularization | Drug: Sildenafil | Children's Hospital Medical Center, Cincinnati | NULL | Withdrawn | 8 Years | 21 Years | Both | 0 | Phase 1;Phase 2 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT00659529 (ClinicalTrials.gov) | August 2008 | 14/4/2008 | Safety and Efficacy of Sildenafil in Cystic Fibrosis (CF) Lung Disease | The Role of Phosphodiesterase Inhibitors in CF Lung Disease | Cystic Fibrosis | Drug: sildenafil | National Jewish Health | Cystic Fibrosis Foundation | Completed | 14 Years | N/A | All | 36 | Phase 1;Phase 2 | United States |