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46. 悪性関節リウマチ
［臨床試験数：4,183，薬物数：2,538（DrugBank：401），標的遺伝子数：183，標的パスウェイ数：219］

Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
19 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT04472481
(ClinicalTrials.gov)		September 6, 20197/7/2020Vitamin D Effect in Rheumatoid Arthritis.Vitamin D: Does It Help Tregs in Active Rheumatoid Arthritis Patients.Active Rheumatoid ArthritisDrug: Ergocalciferol 1.25 mg tabletTanta UniversityNULLCompleted33 Years60 YearsAll20Phase 4Egypt
2NCT04344405
(ClinicalTrials.gov)		June 1, 20199/4/2020Vitamin D as a Key Player in Rheumatoid ArthritisVitamin D as a Key Player in Rheumatoid Arthritis Immune Responsethe Immunomodulatory EffectDrug: Vitamin D;Drug: PlaceboAssiut UniversityNULLRecruiting20 Years70 YearsAll60Phase 3Egypt
3JPRN-UMIN000030828
2018/01/1515/01/2018The preventive effect for new vertebral fractures of zoledronic acid and denosumab combined with vitamin D in patients with rheumatoid arthritis. Rheumatoid ArthritisOsteoporosiszoledronic acid
denosumab		Osaka City University Graduate School of MedicineNULLRecruiting20years-oldNot applicableMale and Female500Not selectedJapan
4JPRN-UMIN000022364
2016/05/1020/05/2016Treatment strategy of minodronate in osteoporotic patients with rheumatoid arthritisTreatment strategy of minodronate in osteoporotic patients with rheumatoid arthritis - Effectiveness of minodronate in osteoporotic patients with rheumatoid arthritis Osteoprotic patients with rheumatoid arthritisThe selection criteria is based on which treatment each patient wants to take
Minodronate group: oral intake 50mg per month
Minodronate plus active vitamin D group: oral intake 50mg minodronate per month and eldecalcitol 0.75ug per day after breakfast		Department of Orthopaedic Surgery Shinshu University School of MedicineNULLComplete: follow-up complete50years-old100years-oldMale and Female140Not applicableJapan
5NCT02944799
(ClinicalTrials.gov)		December 201527/6/2016Alendronate Treatment of Osteoporosis in Rheumatoid ArthritisAlendronate Treatment of Osteoporosis in Rheumatoid Arthritis - Indication and Duration: A Randomized, Double-blind, Placebocontrolled Study to Evaluate the Effects of Discontinuation of Alendronate in Patients With Both Rheumatoid Arthritis and Low Bone MassRheumatoid Arthritis;OsteoporosisDrug: Placebo;Drug: Alendronate;Drug: Calcium;Drug: Vitamin DUniversity of AarhusNULLActive, not recruiting18 YearsN/AAll69Phase 2Denmark
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
6NCT02633332
(ClinicalTrials.gov)		February 201530/11/2015Use of Well Known Drugs for New Destination - RA Improvement (RANT)Observational Retrospective Study About the Use of Well Known Drugs in Combination to Obtain a New Drug to Improve Quality of Life/Health in Patient With Diagnosed Rheumatoid Arthritis Not Responding to Commonly Used TreatmentsRheumatoid Arthritis;Autoimmune Diseases;Disorder of Synovium;Sjogren's Syndrome;Acute and Chronic Inflammation;Disorder of Pleura and Pleural Cavity;Felty's Syndrome;Rheumatoid NodulesDrug: Vitamin D3;Drug: Lipitor®;Drug: Acycloguanosine;Drug: Tetracycline;Drug: methotrexate;Drug: etanerceptUniversità Popolare Homo & NaturaNULLCompleted18 Years75 YearsBoth15Phase 1Italy
7JPRN-UMIN000014737
2014/08/0101/08/2014The effects of denosumab compared with oral bisphosphonates (BP) in patients with RA complicated with osteoporosis on the progression of structural damage, BMD and disease activity. rheumatoid arthritisDenosumab group: Denosumab 60mg is administered by subcutaneous injections every 6 months (at baseline, at 6 months and at 12 months). All patients are to take vitamin D.
BP group: Patients take BP continuously. All patients are to take vitamin D.		Yokohama City University Medical CenterNULLComplete: follow-up complete50years-old90years-oldMale and Female286Not selectedJapan
8NCT02243800
(ClinicalTrials.gov)		November 201116/9/2014Study of the Efficacy and Safety of Cholecalciferol Supplementation on the Activity of Rheumatoid Arthritis in Patients With Vitamin D DeficiencyStudy of the Efficacy and Safety of Cholecalciferol Supplementation on the Activity of Rheumatoid Arthritis in Patients With Vitamin D DeficiencyRheumatoid Arthritis;Vitamin D DeficiencyOther: cholecalciferol versus placeboUniversity Hospital, Clermont-FerrandCRINEX Laboratory;BP 337 - 3 rue de Gentilly;92541 MONTROUGE Cedex FRANCERecruiting18 YearsN/ABoth164Phase 3France
9NCT01400516
(ClinicalTrials.gov)		August 201121/7/2011Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA TrialTeriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA TrialRheumatoid ArthritisDrug: Teriparatide;Drug: calcium citrate;Drug: Vitamin D;Drug: TNF antagonistBrigham and Women's HospitalEli Lilly and CompanyCompleted45 YearsN/AAll26Phase 4United States
10EUCTR2009-012615-18-FR
(EUCTR)		16/02/201105/11/2010Efficacy and safety of cholecalciferol on rheumatoid arthritis activity in patients with vitamin D deficiency - SCORPIONEfficacy and safety of cholecalciferol on rheumatoid arthritis activity in patients with vitamin D deficiency - SCORPION Rheumatoid arthritis (RA)
MedDRA version: 12.1;Level: HLT;Classification code 10039075;Term: Rheumatoid arthritis and associated conditions		Trade Name: UVEDOSE
INN or Proposed INN: COLECALCIFEROL		CHU de Clermont-FerrandNULLNot RecruitingFemale: yes
Male: yes		France
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
11NCT01351805
(ClinicalTrials.gov)		January 20114/5/2011Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee PainVitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee PainAutoimmune Diseases;Systemic Inflammatory Process;Knee Pain Chronic;Osteoarthritis;Rheumatoid ArthritisDrug: Fish Oil;Dietary Supplement: Vitamin D;Other: placebo pillBrigham and Women's HospitalNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Active, not recruiting50 YearsN/AAll25876N/AUnited States
12EUCTR2009-015835-34-IT
(EUCTR)		09/04/201029/03/2010VITAMIN D EFFECT ON T LYMPHOCYTES AND OSTEOCLASTOGENESIS IN RHEUMAOID ARTHRITIS - NDVITAMIN D EFFECT ON T LYMPHOCYTES AND OSTEOCLASTOGENESIS IN RHEUMAOID ARTHRITIS - ND Rheumatoid Arthritis
MedDRA version: 12.1;Level: LLT;Classification code 10003268;Term: Arthritis rheumatoid		Trade Name: DIBASE*IM OS 2F 1ML 300000UI/M
INN or Proposed INN: Colecalciferol		AZIENDA OSPEDALIERA ORDINE MAURIZIANONULLNot RecruitingFemale: yes
Male: no		Phase 3Italy
13NCT00279461
(ClinicalTrials.gov)		May 200917/1/2006Vitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid ArthritisVitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid Arthritis: Clinical Trial and Investigations on Dendritic CellsArthritis, Rheumatoid;Vitamin D DeficiencyDrug: Placebo in arm A and Vitamin D in arm B;Drug: vitamin D 3 for arm A ,and matching placebo for arm BIndiana UniversityNULLWithdrawn18 YearsN/ABoth0Phase 2United States
14NCT01426347
(ClinicalTrials.gov)		January 200929/8/2011Treatment of Vitamin D Deficiency in Patients With Rheumatoid ArthritisVitamin Therapy in Rheumatoid ArthritisRheumatoid Arthritis;Vitamin D DeficiencyDrug: Placebo sugar pill;Drug: ErgocalciferolJohns Hopkins UniversityNULLCompleted18 Years75 YearsAll139N/AUnited States
15NCT00427804
(ClinicalTrials.gov)		January 200725/1/2007Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium AbsorptionTumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium AbsorptionRheumatoid Arthritis;Crohn's DiseaseDrug: calcitriolAtlanta VA Medical CenterEmory UniversityCompleted18 Years50 YearsMale9N/AUnited States
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
16NCT00423358
(ClinicalTrials.gov)		February 200517/1/2007Treatment of Hypovitaminosis D in Rheumatoid ArthritisTreatment of Hypovitaminosis D in Rheumatoid ArthritisRheumatoid Arthritis;Hypovitaminosis DDietary Supplement: Vitamin D;Dietary Supplement: placeboUniversity of Wisconsin, MadisonNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed18 Years90 YearsAll22N/AUnited States
17NCT00138983
(ClinicalTrials.gov)		May 200029/8/2005Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Study: a Randomized Placebo Controlled Trial With Alendronate Versus Alfacalcidol.Rheumatoid Arthritis;Polymyalgia Rheumatica;Giant Cell Arteritis;Polymyositis;Wegener’s GranulomatosisDrug: Alendronate versus alfacalcidol (1-alpha OH vitamin D)UMC UtrechtDutch Health Care Insurance BoardCompleted18 Years90 YearsBoth200Phase 3Netherlands
18NCT02932644
(ClinicalTrials.gov)		October 199912/10/2016Vitamin D and Cardiovascular Events in Rheumatoid ArthritisAssociation Between Baseline Vitamin D Metabolite Levels and Risk of Cardiovascular Events in Rheumatoid Arthritis Patients. A Cohort Study With Patient-record Evaluated Outcomes.Rheumatoid Arthritis;Cardiovascular DiseaseOther: Baseline serum vitamin D level below 50 nmol/l;Other: Baseline serum vitamin D level at or above 50 nmol/lOdense University HospitalThe Danish Rheumatism Association;University of Southern Denmark;Region of Southern Denmark;Pfizer;Odense Patient Explorative data Network (OPEN);The Danish Rheumatism Association;University of Southern Denmark;Region of Southern Denmark;Pfizer;Odense Patient Explorative data Network (OPEN)Completed18 Years75 YearsBoth160N/ANULL
19NCT00570934
(ClinicalTrials.gov)		March 19957/12/2007Supplementation With Vitamin D, Calcium or Both on Calcium Absorption and Bone Mineral Content in Children With JRAEffect of Supplementation With 2000 International Units (IU) Vitamin D, 1gm Calcium or Both on Calcium Absorption and Bone Mineralization in Children With Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisDietary Supplement: Cholecalciferol;Dietary Supplement: Calcium;Dietary Supplement: Calcium and cholecalciferol;Drug: PlaceboUniversity of Missouri-ColumbiaNULLCompleted3 Years15 YearsBoth24Phase 3United States

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