DDrare: Database of Drug Development for Rare Diseases

70. 広範脊柱管狭窄症
［臨床試験数：91，薬物数：195（DrugBank：54），標的遺伝子数：60，標的パスウェイ数：85］

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 0.5% marcaine; 0.9% Saline; 0002-8971; 1mg/kg/hr TXA intravenous infusion till the last suture; AK1320 MS; Acetaminophen; Acetate; Adjunctive analgesics; Adjunctive anti-depressants; AlloGen-LI; Alprostadil; Amino acids; Aminocaproic acid; Amniotic Fluid Allograft; Apple; Bilateral transforaminal epidural steroid injections; Bone Marrow Concentrate; Botulinum toxin type A; Botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle; Bupivacaine; Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml; Buprenorphine; CO; Caudal Epidural Injection with Celestone; Caudal Epidural Injection with DepoMedrol; Caudal Epidural Injection with generic Celestone; Caudal epidural injection; Celebrex 200Mg Capsule; Celecoxib; Cilostazol; Combination Product: Goldic serum; Control group; Creatinine; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE; Darvocet; Decadron Phosphate, Injectable; Deksmedetomidiini; Demineralized Bone Matrix; DepoMedrol; Depomedrol; Device: Apple Watch and App; Device: Bioactive Glass-Ceramic Spacer; Device: Cervical Orthosis (CO); Device: Interbody cage (PEEK); Device: Interbody cage (titanium); Device: MILD® (Minimally Invasive Lumbar Decompression); Device: MRI; Device: MasterGraft Granules; Device: No Orthosis; Device: Philips Intelivue MP70 monitor; Device: Pleth Variability Index (PVI); Device: Therm-AppTM TH, thermographic camera; Device: Titanium cage; Dexamethasone; Dexamethasone sodium phosphate; Dexdor; Dexmedetomidine; Dexmedetomidine group; Dexmedetomidine with ropivacaine; Dextrose; Diphenhydramine; EACA; ESKETAMINE HYDROCHLORIDE; Epidural Steroid Injection; Epidural injection; Epidural local anesthetic injection; Epidural steroid injection; Epsilon-Aminocaproic Acid (EACA); Erector spinae plane block (Group E); Erythropoietin; Esketamine; Fentanyl; Forsteo; Forteo; Gabapentin; Heparin; Herbal medicine; Hyaluronic Acid; Hyaluronic acid; Hydromorphone; I-FACTOR; KETAMINE; Kenalog Injectable Product; Ketamine; Ketanest; Ketanest-S; Ketorolac; Limaprost; Liposomal bupivacaine; Lumbar Interbody Fusion with Autograft; Lumbar Interbody Fusion with NeoFuse; MONITOR; Magnesium; Magnesium with ropivacaine; Midazolam; Mirogabalin; Misoprostol; Modal; Modified-thoracolumbar interfascial plane block; Morphine; Morphine PCA; Multi-modal pain management [Acetaminophen + Gabapentin]; Multi-modal pain management [Fentanyl]; Multi-modal pain management [Intravenous Ketamine]; Multi-modal pain management [Valium + Gabapentin]; NS-304; NS-304 Placebo; NSAIDs; NeoFuse; Nicardipine; Normal saline; NuCel; OXYCODONE; OXYCODONE HYDROCHLORIDE; Oksikodoni; Opana; Other: Control; Other: Conventional PCA mode; Other: Epiduroscopy; Other: Group Exercise: community setting; Other: Individualized exercises: clinical setting; Other: Joint Mobilizations (spine, sacroiliac, hip); Other: Optimizing basal infusion (B.I); Other: Other intervention(s); Other: no intervention; Other: physical therapy; Oxanest; Oxycodone; Oxycodone Orion; Oxygen; PCA; PLF with NeoFuse; Parathyroid hormone; Phosphate; Polydeoxyribonucleotides; Predinose oral; Pregabalin; Pregabalin 75mg; Procedure: Acupuncture; Procedure: Allograft; Procedure: Bee venom pharmacopuncture; Procedure: Chuna manipulation; Procedure: Chuna manual medicine; Procedure: Cupping; Procedure: Electroacupuncture; Procedure: Epidural Steroid Injection; Procedure: Epidural local anesthetic injection; Procedure: Epidural steroid with local anesthetic injection; Procedure: Lumbar epidural injection; Procedure: MILD Procedure; Procedure: Manual therapy; Procedure: Other intervention(s); Procedure: PLF with autograft; Procedure: Percutaneous Lumbar Decompression; Procedure: Pharmacopuncture; Procedure: epidural steroid (dexamethasone) injection; Procedure: lumbar interlaminar epidural steroid injection; Procedure: posterolateral spinal fusion with instrumentation; Prolotherapy solution of 20% dextrose; Remifentanil; RhPTH; RhPTH (1-34); Ropivacaine; Ropivacaine plus normal saline; S-ketamine; S-ketamine & midazolam; Selexipag; Standard analgesia use [Fentanyl]; Standard analgesia use [Hydromorphone]; Standard analgesia use [Oxygen]; Standard analgesia use [Volatile Anesthesia]; Steroid injections; Sufentanil; Sugar Pill; Teicoplanin; Teriparatide; Teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34); Titanium; Tramadol; Tramadol with ropivacaine; Tranexamic Acid; Tranexamic Acid 100 MG/ML; Tranexamic acid; Transdermal fentanyl matrix, gabapentin; Transforaminal Epidural Injection; Triamcinolone; Triamcinolone Acetonide and normal saline solution; Tylenol; Vancomycin; ViviGen Cellular Bone Matrix; With U-VANCO (vancomycin hydrochloride); Without U-VANCO (vancomycin hydrochloride); Wound topically irrigated with 500mg TXA; Xylocaine

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04492774 (ClinicalTrials.gov)	July 1, 2020	20/7/2020	Degenerative Lumbar Stenosis Conservative Treatment	GOLDIC Therapy in Lumbar Degenerative Spinal Stenosis - Randomized Controlled Trial	Spinal Stenosis Lumbar;Spinal Canal Stenosis	Combination Product: Goldic serum;Drug: Steroid injections;Procedure: Manual therapy	Sutherland Medical Center	NULL	Recruiting	18 Years	N/A	All	90	Phase 4	Poland
2	NCT03245671 (ClinicalTrials.gov)	December 2017	7/8/2017	Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis	Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study	Lumbar Spinal Stenosis	Drug: Kenalog Injectable Product;Drug: Decadron Phosphate, Injectable;Procedure: Epidural Steroid Injection	Hospital for Special Surgery, New York	NULL	Withdrawn	18 Years	90 Years	All	0	Phase 4	United States
3	NCT02093520 (ClinicalTrials.gov)	May 2014	18/3/2014	The MiDAS ENCORE Study	MILD® Percutaneous Image-Guided Lumbar Decompression Versus Epidural Steroid Injections in Patients With Lumbar Spinal Stenosis Exhibiting Neurogenic Claudication	Spinal Stenosis, Lumbar Region, With Neurogenic Claudication	Procedure: MILD Procedure;Drug: Epidural Steroid Injection	Vertos Medical, Inc.	NULL	Completed	65 Years	N/A	All	302	N/A	United States
4	NCT01934868 (ClinicalTrials.gov)	December 1, 2013	30/8/2013	Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg	A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg	Sciatica;Spinal Stenosis of Lumbar Region;Degeneration of Lumbar or Lumbosacral Intervertebral Disc	Drug: prolotherapy solution of 20% dextrose;Drug: Epidural Steroid Injection	Hadassah Medical Organization	Reuth Rehabilitation Hospital	Active, not recruiting	18 Years	90 Years	All	110	Phase 4	Israel
5	NCT01995461 (ClinicalTrials.gov)	May 2013	18/11/2013	Bilateral Transforaminal Epidural Steroid Injections for Degenerative Lumbar Spinal Stenosis	Effectiveness of Bilateral Transforaminal Epidural Steroid Injections in Degenerative Lumbar Spinal Stenosis Patients With Neurogenic Claudication: A Prospective Outcome Study	Spinal Stenosis, Lumbar Region, With Neurogenic Claudication	Drug: bilateral transforaminal epidural steroid injections	Marshfield Clinic Research Foundation	NULL	Terminated	40 Years	90 Years	All	26	N/A	United States
No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
6	NCT01238536 (ClinicalTrials.gov)	April 2011	8/11/2010	Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)	Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older	Spinal Stenosis;Low Back Pain	Procedure: Epidural steroid with local anesthetic injection;Procedure: Epidural local anesthetic injection;Drug: Epidural steroid injection;Drug: Epidural local anesthetic injection	University of Washington	Kaiser Permanente;University of California, San Francisco;Henry Ford Hospital;Harvard Pilgrim Health Care;Harvard Vanguard Medical Associates;University of Colorado, Denver;Mayo Clinic;Stanford University;Massachusetts General Hospital;Virginia Spine Research Institute;Oregon Health and Science University;Dallas VA Medical Center	Completed	50 Years	N/A	All	400	Phase 4	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT04492774
(ClinicalTrials.gov)

July 1, 2020

20/7/2020

Degenerative Lumbar Stenosis Conservative Treatment

GOLDIC Therapy in Lumbar Degenerative Spinal Stenosis - Randomized Controlled Trial

Spinal Stenosis Lumbar;Spinal Canal Stenosis

Combination Product: Goldic serum;Drug: Steroid injections;Procedure: Manual therapy

Sutherland Medical Center

NULL

Recruiting

18 Years

N/A

All

Phase 4

Poland

NCT03245671
(ClinicalTrials.gov)

December 2017

7/8/2017

Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis

Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study

Lumbar Spinal Stenosis

Drug: Kenalog Injectable Product;Drug: Decadron Phosphate, Injectable;Procedure: Epidural Steroid Injection

Hospital for Special Surgery, New York

NULL

Withdrawn

18 Years

90 Years

All

Phase 4

United States

NCT02093520
(ClinicalTrials.gov)

May 2014

18/3/2014

The MiDAS ENCORE Study

MILD® Percutaneous Image-Guided Lumbar Decompression Versus Epidural Steroid Injections in Patients With Lumbar Spinal Stenosis Exhibiting Neurogenic Claudication

Spinal Stenosis, Lumbar Region, With Neurogenic Claudication

Procedure: MILD Procedure;Drug: Epidural Steroid Injection

Vertos Medical, Inc.

NULL

Completed

65 Years

N/A

All

302

N/A

United States

NCT01934868
(ClinicalTrials.gov)

December 1, 2013

30/8/2013

Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg

A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg

Sciatica;Spinal Stenosis of Lumbar Region;Degeneration of Lumbar or Lumbosacral Intervertebral Disc

Drug: prolotherapy solution of 20% dextrose;Drug: Epidural Steroid Injection

Hadassah Medical Organization

Reuth Rehabilitation Hospital

Active, not recruiting

18 Years

90 Years

All

110

Phase 4

Israel

NCT01995461
(ClinicalTrials.gov)

May 2013

18/11/2013

Bilateral Transforaminal Epidural Steroid Injections for Degenerative Lumbar Spinal Stenosis

Effectiveness of Bilateral Transforaminal Epidural Steroid Injections in Degenerative Lumbar Spinal Stenosis Patients With Neurogenic Claudication: A Prospective Outcome Study

Spinal Stenosis, Lumbar Region, With Neurogenic Claudication

Drug: bilateral transforaminal epidural steroid injections

Marshfield Clinic Research Foundation

NULL

Terminated

40 Years

90 Years

All

N/A

United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT01238536
(ClinicalTrials.gov)

April 2011

8/11/2010

Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)

Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older

Spinal Stenosis;Low Back Pain

Procedure: Epidural steroid with local anesthetic injection;Procedure: Epidural local anesthetic injection;Drug: Epidural steroid injection;Drug: Epidural local anesthetic injection

University of Washington

Kaiser Permanente;University of California, San Francisco;Henry Ford Hospital;Harvard Pilgrim Health Care;Harvard Vanguard Medical Associates;University of Colorado, Denver;Mayo Clinic;Stanford University;Massachusetts General Hospital;Virginia Spine Research Institute;Oregon Health and Science University;Dallas VA Medical Center

Completed

50 Years

N/A

All

400

Phase 4

United States