13. Multiple sclerosis/Neuromyelitis optica
3,050 clinical trials, 2,147 drugs (DrugBank: 348 drugs), 244 drug target genes, 228 drug target pathways
Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04528121 (ClinicalTrials.gov) | September 15, 2020 | 22/8/2020 | Effect of CoDuSe Balance Training and Step Square Exercises on Risk of Fall in Multiple Sclerosis | Effect of CoDuSe Balance Training and Step Square Exercises on Risk of Fall in Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting | Other: CoDuSe balance training and step square exercises;Other: conventional balance training | Lama Saad El-Din Mahmoud | NULL | Recruiting | 20 Years | 40 Years | All | 52 | N/A | Egypt |
| 2 | NCT04391023 (ClinicalTrials.gov) | May 15, 2020 | 12/5/2020 | Cerebellar tDCS and Balance Training in PwMS | The Effects of 2 mA and 4 mA Cerebellar Transcranial Direct Current Stimulation and Balance Training to Reduce Fall Risk in People With Multiple Sclerosis | Multiple Sclerosis | Device: Sham Transcranial Direct Current Stimulation (tDCS);Behavioral: Balance Training;Device: 2 mA Transcranial Direct Current Stimulation;Device: 4 mA Transcranial Direct Current Stimulation | University of Iowa | NULL | Not yet recruiting | 18 Years | 70 Years | All | 30 | N/A | United States |
| 3 | NCT03404388 (ClinicalTrials.gov) | April 1, 2020 | 11/1/2018 | Brain and Behavioral Influences on Motor Skill Learning in Multiple Sclerosis | Brain and Behavioral Influences on Motor Skill Learning in Multiple Sclerosis | Multiple Sclerosis | Behavioral: Balance Training | Wayne State University | NULL | Enrolling by invitation | 18 Years | 65 Years | All | 150 | N/A | United States |
| 4 | NCT04171310 (ClinicalTrials.gov) | November 13, 2019 | 19/11/2019 | Study of Excretion Balance and Pharmacokinetics of [14C]-SAR442168 in Healthy Male Subjects | An Open-label Study of Excretion Balance and Pharmacokinetics Following a Single Oral Dose of [14C]-SAR442168 (Not More Than 3.7 MBq) in Healthy Male Subjects | Multiple Sclerosis | Drug: SAR442168 | Sanofi | NULL | Completed | 30 Years | 65 Years | Male | 6 | Phase 1 | United Kingdom |
| 5 | NCT04408742 (ClinicalTrials.gov) | April 15, 2019 | 26/5/2020 | Relationship Between Pain, Anxiety and Fatigue and Knee Position Sense, Balance and Dual Task Performance During Menstrual Cycle in Females With Multiple Sclerosis | The Relationship Between Pain, Anxiety and Fatigue and Knee Position Sense, Balance and Dual Task Performance During Menstrual Cycle in Females With Multiple Sclerosis | Multiple Sclerosis;Menstrual Pain;Anxiety;Fatigue;Neurologic Symptoms | Other: pain;Other: fatigue;Other: anxiety;Other: position sense;Other: balance;Other: dual task performance | Ankara Yildirim Beyazit University | NULL | Completed | 26 Years | 49 Years | Female | 14 | Turkey | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT03945006 (ClinicalTrials.gov) | March 25, 2019 | 8/5/2019 | Balance, Trunk Impairment and Fear of Falling in Multiple Sclerosis Patients With Incontinence | An Investigation of Balance, Trunk Impairment, and Fear of Falling in Multiple Sclerosis Patients With Incontinence | Multiple Sclerosis;Physical Therapy;Incontinence | Other: Incontinence Severity;Other: Balance;Other: Trunk impairment;Other: Fear of falling | Ankara Yildirim Beyazit University | NULL | Completed | 24 Years | 58 Years | All | 36 | Turkey | |
| 7 | NCT04286828 (ClinicalTrials.gov) | March 25, 2019 | 23/2/2020 | Position Sense, Balance, and Dual Task Performance at the Menstrual Cycle in Females With Multiple Sclerosis | An Investigation of Knee Position Sense, Balance, and Dual Task Performance in Different Phases of Menstrual Cycle in Females With Multiple Sclerosis | Multiple Sclerosis;Neurologic Symptoms;Menstrual Cycle | Other: Position Sense;Other: Balance;Other: Dual Task Performance | Ankara Yildirim Beyazit University | NULL | Completed | 26 Years | 49 Years | Female | 27 | Turkey | |
| 8 | NCT03584672 (ClinicalTrials.gov) | August 5, 2018 | 30/6/2018 | The Reliability, Validity, and Responsiveness of the Static Balance Test in Patients With Multiple Sclerosis. | The Reliability, Validity, and Responsiveness of the Static Balance Test in Patients With Multiple Sclerosis. | Multiple Sclerosis | Other: Static Balance Test;Other: Berg Balance Scale;Other: Timed Up an Go Test;Other: Four Square Step Test;Other: Functional Reach Test;Other: One-leg Stance Test | Gazi University | NULL | Unknown status | 18 Years | N/A | All | 30 | NULL | |
| 9 | NCT03501342 (ClinicalTrials.gov) | April 9, 2018 | 10/4/2018 | Effects of Immersive Virtual Reality on Balance, Mobility, and Fatigue in Patients With Multiple Sclerosis | Effects of Immersive Virtual Reality on Balance, Mobility, and Fatigue in Patients With Multiple Sclerosis | Multiple Sclerosis | Other: Virtual reality group;Other: Dynamic Balance Training | Gazi University | NULL | Completed | 18 Years | 65 Years | All | 39 | N/A | Turkey |
| 10 | NCT04550650 (ClinicalTrials.gov) | April 6, 2018 | 10/9/2020 | Follow-up Study of the Effectiveness of Virtual Reality Therapy in MS Patients | Follow-up Study of the Effectiveness of Virtual Reality Therapy in MS Patients | Multiple Sclerosis, Chronic Progressive;Multiple Sclerosis, Primary Progressive | Other: Training groupe;Other: PNF;Other: Spinning grp;Other: Balance | Somogy Megyei Kaposi Mór Teaching Hospital | NULL | Completed | 35 Years | 60 Years | All | 4 | N/A | Hungary |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 11 | NCT03670459 (ClinicalTrials.gov) | December 31, 2017 | 7/9/2018 | Forty Five Patients With Multiple Sclerosis Recieved Vestibular Rehabilitation and Balance Training | Cawthorne Cooksey Versus Vestibular Habituation Exercises on Trunk Kinetics and Velocity of Gait in Patients With Multiple Sclerosis | Neurologic Disorder | Other: Cawthorne Cooksey exercises;Other: Vestibular habituation exercises;Other: Balance exercises | October 6 University | NULL | Completed | 35 Years | 55 Years | All | 45 | N/A | Egypt |
| 12 | NCT03353974 (ClinicalTrials.gov) | December 1, 2017 | 16/11/2017 | Video Games Therapy on Balance and Cognitive Functions in Mild to Moderate Impaired Multiple Sclerosis Patients. | The Role of Video Games Therapy on Balance and Cognitive Functions in Mild to Moderate Impaired Multiple Sclerosis Patients. A Pilot Randomized Controlled Trial. | Multiple Sclerosis | Device: Video game therapy;Device: Balance platform therapy | University Hospital of Ferrara | NULL | Recruiting | 18 Years | 80 Years | All | 40 | N/A | Italy |
| 13 | EUCTR2016-003073-18-GB (EUCTR) | 29/09/2016 | 16/09/2016 | A study designed to investigate how radiolabelled RPC1063 is taken up, broken down and removed from the body | A Phase I, Single-Centre, Single Dose Oral Excretion Balance Study of [14C]-RPC1063 in Healthy Male Adults - ADME study of [14C]-RPC1063 in healthy male subjects (QCL117686) | The drug is a potential treatment for adult patients with relapsing multiple sclerosis (RMS) and for adult patients with moderately to severely active inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). MedDRA version: 19.0;Level: PT;Classification code 10028245;Term: Multiple sclerosis;System Organ Class: 10029205 - Nervous system disorders MedDRA version: 19.0;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856 MedDRA version: 19.0;Classification code 10013099;Term: Disease Crohns;System Organ Class: 100000004856 ;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Celgene International II Sàrl | NULL | Not Recruiting | Female: no Male: yes | 6 | Phase 1 | United Kingdom | |||
| 14 | NCT03436927 (ClinicalTrials.gov) | July 15, 2016 | 11/12/2017 | Comparison of Two Different Virtual Reality Methods in Patients With Multiple Sclerosis | Comparison of the Effects of Two Different Virtual Reality Treatment Methods in Patients With Multiple Sclerosis: A Randomized Controlled Trial | Multiple Sclerosis | Other: Nintendo Wii Fit Balance exercises;Other: Balance Trainer Balance Exercises | Biruni University | Istanbul University | Completed | 25 Years | 60 Years | All | 51 | N/A | NULL |
| 15 | NCT02870023 (ClinicalTrials.gov) | June 2016 | 9/8/2016 | How Does Strength Training and Balance Training Affect Gait Function and Fatigue in Patients With Multiple Sclerosis? | How Does Strength Training and Balance Training Affect Gait Function and Fatigue in Patients With Multiple Sclerosis? | Multiple Sclerosis | Other: Balance training;Other: Strength training | University of Aarhus | VIA University College;TrygFonden, Denmark;Fondazione Don Carlo Gnocchi Onlus | Completed | 18 Years | N/A | All | 71 | N/A | Denmark |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 16 | NCT03566251 (ClinicalTrials.gov) | May 1, 2016 | 11/6/2018 | Core Stability, Trunk Position Sense, Balance and Functional Mobility in Patients With Multiple Sclerosis | The Investigation of the Relationship Between Core Stability and Trunk Position Sense With Balance and Functional Mobility in Patients With Multiple Sclerosis | Physical Therapy | Other: Balance;Other: Functional mobility;Other: Core stability;Other: Trunk position sense | Ankara Yildirim Beyazit University | NULL | Completed | 18 Years | 65 Years | All | 74 | N/A | Turkey |
| 17 | NCT02293967 (ClinicalTrials.gov) | September 2014 | 14/11/2014 | Mass Balance Study of MT-1303 | An Open-label, Mass Balance Study to Investigate the Absorption, Metabolism and Excretion of [14C] MT-1303 After a Single Oral Dose to Healthy Male Subjects. | Relapsing-remitting Multiple Sclerosis | Drug: MT-1303 | Mitsubishi Tanabe Pharma Corporation | NULL | Completed | 30 Years | 65 Years | Male | 8 | Phase 1 | United Kingdom |
| 18 | NCT02777060 (ClinicalTrials.gov) | September 2014 | 8/6/2015 | Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures | Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures | Diabetes;Cancer;Multiple Sclerosis;Arthritis;Parkinson's Disease;Cognitive Disorders;Brain Injury;Stroke | Procedure: Exergame;Procedure: Home based balance training | University of Arizona | NULL | Recruiting | 18 Years | N/A | Both | 200 | N/A | United States |
| 19 | NCT02287948 (ClinicalTrials.gov) | September 2014 | 6/11/2014 | Wii FIT Balance Board to Recording Balance Parameters in Multiple Sclerosis Subjects | Validation Study for Using Wii FIT Balance Board to Recording Balance Parameters in Healthy Subjects and Multiple Sclerosis Subjects | Postural Balance;Multiple Sclerosis | Device: Nintendo Wii Fit Balance Board | University Hospital of Ferrara | NULL | Completed | 18 Years | 80 Years | Both | 40 | N/A | Italy |
| 20 | NCT02209467 (ClinicalTrials.gov) | August 2014 | 4/8/2014 | Balance and Falls in Multiple Sclerosis | Balance and Falls in Multiple Sclerosis: Intervention and Perceptions From Patients and Next of Kins | Multiple Sclerosis | Other: Group balance training | Örebro County Council | NULL | Completed | 18 Years | N/A | Both | 52 | N/A | Sweden |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 21 | NCT01896700 (ClinicalTrials.gov) | July 2013 | 8/7/2013 | Methylphenidate to Improve Balance and Walking in MS | Methylphenidate to Improve Balance and Walking in MS | Multiple Sclerosis | Drug: Methylphenidate;Drug: Placebo | Oregon Health and Science University | Portland VA Medical Center | Completed | 20 Years | 65 Years | All | 24 | Phase 2;Phase 3 | United States |
| 22 | NCT01816100 (ClinicalTrials.gov) | April 2013 | 25/2/2013 | The Effect of Exercise on Strength and Mobility and Corresponding CNS Plasticity in Multiple Sclerosis Patients | The Effect of Exercise on Strength and Mobility and Corresponding CNS Plasticity in Multiple Sclerosis Patients: A Multimodal Neuroimaging Investigation | Multiple Sclerosis | Other: specifically design 6 month resistance training program;Behavioral: 6 months weight resistance and balance program | University of Nebraska | Biogen | Completed | 19 Years | 65 Years | Both | 6 | N/A | United States |
| 23 | EUCTR2012-000368-90-NL (EUCTR) | 02/10/2012 | 06/08/2012 | Prolonged-Release Fampridine Effect on Walking Ability and Balance in Multiple Sclerosis | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Exploratory Study to Assess the Effect of Treatment With Prolonged-Release Fampridine (BIIB041) 10 mg Twice Daily on Walking Ability and Balance in Subjects with Multiple Sclerosis (MOBILE) | Multiple Sclerosis MedDRA version: 15.0;Level: PT;Classification code 10028245;Term: Multiple sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Fampyra Product Name: Fampridine Product Code: BIIB041 INN or Proposed INN: FAMPRIDINE | Biogen Idec Research Limited | NULL | Not Recruiting | Female: yes Male: yes | 120 | Canada;Belgium;Netherlands;United Kingdom;Italy;Sweden | |||
| 24 | NCT01698086 (ClinicalTrials.gov) | October 2012 | 25/9/2012 | Vestibular Rehabilitation for Persons With Multiple Sclerosis: Who Benefits the Most? (MSVR3trial) | Vestibular Rehabilitation for Persons With Multiple Sclerosis: Who Benefits the Most? | Multiple Sclerosis;Balance;Fatigue;Eye Movement | Other: Vestibular rehabilitation: balance and eye movement exercises | University of Colorado, Denver | National Multiple Sclerosis Society | Completed | 18 Years | 60 Years | All | 88 | N/A | United States |
| 25 | EUCTR2012-000368-90-BE (EUCTR) | 08/08/2012 | 11/06/2012 | Prolonged-Release Fampridine Effect on Walking Ability and Balance in Multiple Sclerosis | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Exploratory Study to Assess the Effect of Treatment With Prolonged-Release Fampridine (BIIB041) 10 mg Twice Daily on Walking Ability and Balance in Subjects with Multiple Sclerosis (MOBILE) | Multiple Sclerosis MedDRA version: 15.1;Level: PT;Classification code 10028245;Term: Multiple sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Fampyra Product Name: Fampridine Product Code: BIIB041 INN or Proposed INN: FAMPRIDINE | Biogen Idec Research Limited | NULL | Not Recruiting | Female: yes Male: yes | 120 | Phase 2 | Canada;Belgium;Netherlands;Italy;United Kingdom;Sweden | ||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 26 | NCT01597297 (ClinicalTrials.gov) | August 2012 | 10/5/2012 | Exploratory Study to Assess the Effect of Fampridine (BIIB041) on Walking Ability and Balance in Participants With Multiple Sclerosis. | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Exploratory Study to Assess the Effect of Treatment With Prolonged-Release Fampridine (BIIB041) 10 mg Twice Daily on Walking Ability and Balance in Subjects With Multiple Sclerosis | Multiple Sclerosis | Drug: BIIB041 (PR Fampridine);Other: Placebo | Biogen | NULL | Completed | 18 Years | 70 Years | All | 132 | Phase 2 | Belgium;Canada;Italy;Netherlands;Sweden;United Kingdom |
| 27 | NCT01582126 (ClinicalTrials.gov) | August 2012 | 16/4/2012 | Group Balance Training for People With Multiple Sclerosis | Group Balance Training for People With Multiple Sclerosis | Multiple Sclerosis | Other: Group balance training | Örebro County Council | Uppsala-Örebro Regional Research Council;Norrbacka-Eugenia Foundation | Completed | 18 Years | N/A | Both | 87 | N/A | Sweden |
| 28 | EUCTR2012-000368-90-IT (EUCTR) | 30/07/2012 | 12/09/2012 | Prolonged-Release Fampridine Effect on Walking Ability and Balance in Multiple Sclerosis | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Exploratory Study to Assess the Effect of Treatment With Prolonged-Release Fampridine (BIIB041) 10 mg Twice Daily on Walking Ability and Balance in Subjects with Multiple Sclerosis (MOBILE) | Multiple Sclerosis MedDRA version: 15.0;Level: PT;Classification code 10028245;Term: Multiple sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Fampyra INN or Proposed INN: FAMPRIDINE | BIOGEN IDEC RESEARCH LTD | NULL | Not Recruiting | Female: yes Male: yes | 120 | Canada;Belgium;Netherlands;United Kingdom;Switzerland;Italy | |||
| 29 | EUCTR2012-000368-90-GB (EUCTR) | 27/06/2012 | 10/07/2012 | Prolonged-Release Fampridine Effect on Walking Ability and Balance in Multiple Sclerosis | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Exploratory Study to Assess the Effect of Treatment With Prolonged-Release Fampridine (BIIB041) 10 mg Twice Daily on Walking Ability and Balance in Subjects with Multiple Sclerosis (MOBILE) | Multiple Sclerosis MedDRA version: 14.1;Level: PT;Classification code 10028245;Term: Multiple sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Fampyra Product Name: Fampridine Product Code: BIIB041 INN or Proposed INN: FAMPRIDINE | Biogen Idec Research Limited | NULL | Not Recruiting | Female: yes Male: yes | 120 | Canada;Belgium;Netherlands;Italy;United Kingdom;Sweden | |||
| 30 | NCT01535664 (ClinicalTrials.gov) | January 2012 | 7/2/2012 | An Open Label, Proof of Concept Study to Evaluate the Effects of Dalfampridine Withdrawal on Gait and Balance Parameters in Subjects With Multiple Sclerosis (MS) | An Open-label, Proof of Concept Study to Evaluate Multiple Gait and Balance Parameters After Withdrawal of Dalfampridine-ER 10mg in Subjects With MS | Multiple Sclerosis | Other: Withdrawal of dalfampridine-ER 10mg | Acorda Therapeutics | Prometrika, LLC;BCS Consulting, Inc. | Completed | 18 Years | 70 Years | All | 20 | United States | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 31 | NCT01453868 (ClinicalTrials.gov) | October 2011 | 13/10/2011 | The Effects of Aerobics Training on Balance in Patients With Multiple Sclerosis | The Effects of Neuromuscular Training on Balance in Patients With Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting | Other: Non Impact Aerobics;Other: Passive : lecture series | Nelson Mandela Metropolitan University | NULL | Recruiting | 20 Years | 60 Years | Both | 60 | Phase 0 | United States |
| 32 | NCT01225289 (ClinicalTrials.gov) | October 2009 | 6/9/2010 | Impact of Vitamin A Supplementation on Immune System in Multiple Sclerosis Patients | The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Multiple Sclerosis | Relapsing Remitting Multiple Sclerosis | Dietary Supplement: Vitamin A;Drug: Placebo | Tehran University of Medical Sciences | NULL | Completed | 20 Years | 45 Years | All | 36 | Phase 4 | Iran, Islamic Republic of |