167. Marfan syndrome
19 clinical trials, 38 drugs (DrugBank: 10 drugs), 10 drug target genes, 49 drug target pathways
Searched query = "Marfan syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2007-005862-10-BE (EUCTR) | 29/05/2009 | 07/01/2009 | Randomized, double-blind study for the evaluation of the effect of losartan versus placebo on aortic root dilatation in patients with Marfan syndrome under treatment with beta-blockers. | Randomized, double-blind study for the evaluation of the effect of losartan versus placebo on aortic root dilatation in patients with Marfan syndrome under treatment with beta-blockers. | Marfan syndrome MedDRA version: 9.1;Level: LLT;Classification code 10026829;Term: Marfan's syndrome | Trade Name: Cozaar Product Name: Losartan INN or Proposed INN: Losartan potassium Trade Name: Coozar Product Name: Losartan INN or Proposed INN: Losartan potassium Trade Name: Coozar Product Name: Losartan INN or Proposed INN: Losartan potassium | University Hospital Ghent | NULL | Not Recruiting | Female: yes Male: yes | Belgium | ||||
| 2 | EUCTR2007-001125-97-ES (EUCTR) | 20/05/2008 | 03/12/2007 | Eficacia y Seguridad de Losartán vs Atenolol en la prevención de la dilatación progresiva de la aorta en la población de pacientes con Síndrome de Marfan (Losartan vs atenolol efficacy and security in aortic dilatation prevention in Marfan syndrome) | Eficacia y Seguridad de Losartán vs Atenolol en la prevención de la dilatación progresiva de la aorta en la población de pacientes con Síndrome de Marfan (Losartan vs atenolol efficacy and security in aortic dilatation prevention in Marfan syndrome) | The aortic dilatation in Marfan syndrome with two different treatments: losartan vs atenolol MedDRA version: 9.1;Level: LLT;Classification code 10026829;Term: Marfan's syndrome | Trade Name: cozaar 50 INN or Proposed INN: LOSARTAN POTASSIUM Trade Name: blokium 50 INN or Proposed INN: ATENOLOL Trade Name: COZAAR INICIO 12,5 mg comprimidos recubiertos con pelicula INN or Proposed INN: LOSARTAN POTASSIUM Trade Name: BLOKIUM 50 mg comprimidos INN or Proposed INN: ATENOLOL | alberto forteza | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Spain | ||||
| 3 | NCT00429364 (ClinicalTrials.gov) | January 2007 | 29/1/2007 | Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome--Pediatric Heart Network | Trial of Beta Blocker Therapy (Atenolol) Versus Angiotensin II Receptor Blocker Therapy (Losartan) in Individuals With Marfan Syndrome (A Trial Conducted by the Pediatric Heart Network) | Marfan Syndrome | Drug: Losartan Potassium;Drug: Atenolol | New England Research Institutes | National Heart, Lung, and Blood Institute (NHLBI);FDA Office of Orphan Products Development;National Marfan Foundation | Completed | 6 Months | 25 Years | All | 608 | Phase 3 | United States;Belgium;Canada |
| 4 | EUCTR2006-003991-37-BE (EUCTR) | 13/12/2006 | 06/12/2006 | Trial of beta blocker therapy (atenolol) vs. angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome - Marfan Trial | Trial of beta blocker therapy (atenolol) vs. angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome - Marfan Trial | Marfan syndrome MedDRA version: 8.1;Level: LLT;Classification code 10026829;Term: Marfan's syndrome | Product Name: losartan INN or Proposed INN: Losartan potassium Product Name: losartan INN or Proposed INN: Losartan potassium Product Name: losartan INN or Proposed INN: Losartan potassium Product Name: Atenolol INN or Proposed INN: Atenolol Product Name: Atenolol INN or Proposed INN: Atenolol Product Name: Atenolol INN or Proposed INN: Atenolol | University Hospital Gent | NULL | Not Recruiting | Female: yes Male: yes | 600 | Belgium |