299. Cystic fibrosis
1,592 clinical trials,   1,539 drugs   (DrugBank: 255 drugs),   81 drug target genes,   162 drug target pathways

Searched query = "Cystic fibrosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
45 trials found
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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1NCT03931252
(ClinicalTrials.gov)
February 202125/4/2019Thermic Effect of Feeding in Cystic FibrosisThermic Effect of Feeding in Cystic FibrosisCystic FibrosisDietary Supplement: Boost VHC;Dietary Supplement: Ensure High ProteinVirginia Commonwealth UniversityNULLEnrolling by invitation18 YearsN/AAll10N/AUnited States
2NCT04531410
(ClinicalTrials.gov)
September 1, 202018/8/2020NETwork of Linoleic Acid Supplementation in Cystic FibrosisDouble-blind Randomized Controlled Study of Linoleic Acid Supplementation for 1 Year in Patients With Cystic Fibrosis - Influence on Clinical Status and MetabolismCystic FibrosisDietary Supplement: linoleic acid supplementation;Dietary Supplement: oleic acid supplementationKarolinska InstitutetEuropean Society of Pediatric Gastroenterology, Hepatology and NutritionEnrolling by invitation5 Years15 YearsAll90N/AItaly;Norway;Poland
3NCT04496921
(ClinicalTrials.gov)
September 202021/7/2020Vitamin K Supplementation to Reduce Deficiencies in Adults With Cystic FibrosisVitamin K Supplementation to Reduce Deficiencies in Adults With Cystic Fibrosis : A Pilot StudyCystic FibrosisDietary Supplement: Vitamin K supplementation, dose #1;Dietary Supplement: Vitamin K supplementation, dose #2Institut de Recherches Cliniques de MontrealUniversité de MontréalNot yet recruiting18 YearsN/AAll40N/ACanada
4NCT04166396
(ClinicalTrials.gov)
February 17, 202014/11/2019Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic FibrosisNon-pulmonary Contributors of Exercise Intolerance in Patients With Cystic FibrosisCystic FibrosisDietary Supplement: Resveratrol;Dietary Supplement: NR;Dietary Supplement: PlaceboVirginia Commonwealth UniversityNULLActive, not recruiting18 YearsN/AAll36N/AUnited States
5NCT04058340
(ClinicalTrials.gov)
July 30, 201912/8/2019Taste Receptors Regulation in CF PatientsThe Effects of Taste Receptors Regulation in Upper Airway Innate Immunity of CF PatientsCystic FibrosisDietary Supplement: lactizole nebulization;Other: PlaceboMedical Universtity of LodzNULLRecruiting6 YearsN/AAll30N/APoland
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
6NCT03734744
(ClinicalTrials.gov)
June 17, 20196/11/2018PK/PD of Vitamin D3 in Adults With CFA Pilot Study Evaluating Single, High-dose Pharmacokinetics/Pharmacodynamics of Vitamin D3 in CFVitamin D Deficiency;Cystic FibrosisDietary Supplement: Vitamin D3University of Southern CaliforniaNULLRecruiting18 YearsN/AAll12N/AUnited States
7NCT03710538
(ClinicalTrials.gov)
April 1, 201920/6/2018The Effect of a Pre-meal Snack and/or Exercise on Post-prandial Glycemic Excursions in Adults With Cystic FibrosisThe Effect of a Pre-meal Snack and/or Exercise on Post-prandial Glycemic Excursions in Adults With Cystic FibrosisCystic FibrosisDietary Supplement: Snack beverage;Behavioral: ExerciseInstitut de Recherches Cliniques de MontrealNULLRecruiting18 YearsN/AAll14N/ACanada
8NCT03462056
(ClinicalTrials.gov)
May 17, 20185/3/2018Ready to Use Therapeutic Food (RUTF) to Promote Growth in Cystic FibrosisPilot Study of Ready to Use Therapeutic Food to Promote Weight Gain in Cystic FibrosisCystic FibrosisDietary Supplement: Cystic Fibrosis Ready to Use Supplemental FoodWashington University School of MedicineCystic Fibrosis FoundationCompleted2 Years12 YearsAll16Phase 1;Phase 2United States
9NCT03205904
(ClinicalTrials.gov)
December 12, 201615/6/2017Nutritional Intervention and Glycemic Improvement in Patients With Pre-diabetic Cystic Fibrosis.Nutritional Intervention and Glycemic Improvement in Patients With Pre-diabetic Cystic Fibrosis.Cystic Fibrosis-related Diabetes;Cystic FibrosisDietary Supplement: DietHospital de Clinicas de Porto AlegreNULLUnknown status10 YearsN/AAll38N/ABrazil
10NCT02810691
(ClinicalTrials.gov)
July 201614/6/2016The Effect of Soluble Fiber to Reduce Post-prandial Glycemic Excursion in Adults With Cystic FibrosisThe Effect of Soluble Fiber to Reduce Post-prandial Glycemic Excursion in Adults With Cystic FibrosisCystic Fibrosis-related Diabetes;Cystic FibrosisDietary Supplement: Soluble fiber supplementation;Dietary Supplement: Placebo (for fiber supplementation)Institut de Recherches Cliniques de MontrealCanadian Cystic Fibrosis Foundation;Université de MontréalCompleted18 YearsN/AAll14N/ACanada
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
11NCT02646995
(ClinicalTrials.gov)
January 201622/12/2015Lipid Formulation to Increase the Bioavailability of Fatty Acids in Cystic Fibrosis (CF) PatientsCystic FibrosisDietary Supplement: modified lipid formulation;Dietary Supplement: Fish oilNestléNULLCompleted5 Years18 YearsAll16N/ASwitzerland
12NCT02589444
(ClinicalTrials.gov)
December 201520/10/2015Vitamin D and Microbiota in Cystic FibrosisPilot Study Evaluating the Role of Vitamin D Repletion on Gut and Lung Microbiota in Cystic FibrosisVitamin D Deficiency;Cystic FibrosisDietary Supplement: High-Dose Vitamin D3;Other: Stool Sample;Other: Sputum Sample;Other: Sham Comparator;Procedure: Blood drawEmory UniversityNULLCompleted18 YearsN/AAll41N/AUnited States
13NCT02518672
(ClinicalTrials.gov)
October 20153/8/2015Pro-resolving Effect of MAG-DHA in Cystic Fibrosis (PREMDIC)Role of DHA Monoglyceride (MAG-DHA) in the Resolution of Pulmonary Inflammation of Patients With Cystic Fibrosis.Cystic FibrosisDietary Supplement: MAG-DHA;Dietary Supplement: PlaceboSCF PharmaCentre de recherche du Centre hospitalier universitaire de Sherbrooke;Solutex (Spain)Terminated18 YearsN/AAll11Phase 2Canada
14NCT02690064
(ClinicalTrials.gov)
April 201519/2/2016Mechanisms for Vascular Dysfunction and Exercise Tolerance in CFMechanisms for Vascular Dysfunction and Exercise Tolerance in CFCystic FibrosisDietary Supplement: Acute Antioxidant;Dietary Supplement: Chronic Antioxidant;Other: PlaceboAugusta UniversityNULLRecruiting7 YearsN/AAll80N/AUnited States
15NCT02043717
(ClinicalTrials.gov)
January 201412/1/2014Increased Vitamin D Reduces Pulmonary Exacerbations in CFIncreasing Vitamin D Serum Levels Reduces Pulmonary Exacerbations in Patients With Cystic FibrosisCystic FibrosisDietary Supplement: Vitamin DHadassah Medical OrganizationNULLCompleted4 YearsN/AAll90N/AIsrael
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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16NCT00924547
(ClinicalTrials.gov)
November 201317/6/2009Oral Docosahexanoic Acid Supplementation in Cystic FibrosisOral Docosahexanoic Acid Supplementation in Cystic Fibrosis: Effects on Exhaled Pro-inflammatory Isoprostanes and Analysis of Its Esterification Sites in PlasmaCystic FibrosisDietary Supplement: Docosahexanoic Acid Supplement;Dietary Supplement: PlaceboVanderbilt UniversityNULLCompleted6 YearsN/ABoth17Phase 2United States
17NCT01880346
(ClinicalTrials.gov)
October 201312/6/2013Comparison of Absorption of Vitamin D in Cystic FibrosisVehicles for the Absorption of Vitamin D in Cystic Fibrosis: Comparison of Powder vs OilCystic FibrosisDietary Supplement: Vitamin D Powder;Dietary Supplement: Vitamin D OilEmory UniversityNULLCompleted18 Years59 YearsBoth17Phase 4United States
18NCT02048592
(ClinicalTrials.gov)
September 201316/12/2013Impact of Immunonutrition on the Patients With Cystic FibrosisImpact of Immunonutrition on the Patients With Cystic FibrosisCystic Fibrosis;Malnutrition;Oxidative StressDietary Supplement: Impact-Nutridrink;Dietary Supplement: Nutridrink-ImpactUniversity Hospital, MotolNULLRecruiting18 Years40 YearsBoth30Phase 4Czech Republic
19NCT01837355
(ClinicalTrials.gov)
March 201310/4/2013Modulation of Intestinal and Pulmonary Inflammation by Lactobacillus Diet Supplementation in Pediatric Cystic FibrosisModulation of Intestinal and Pulmonary Inflammation by Lactobacillus Rhamnosus Diet Supplementation in Pediatric Cystic Fibrosis (MoHuM-1)Pulmonary Inflammation;Cystic Fibrosis;MicrobiotaDietary Supplement: Lactobacillus rhamnosus;Dietary Supplement: PlaceboCantonal Hospital of St. GallenSwiss Federal Institute of Technology;University Hospital Inselspital, BerneUnknown status6 Years20 YearsAll68N/ASwitzerland
20NCT02014181
(ClinicalTrials.gov)
July 201227/11/2013Flaxseed Modulates Inflammation and Oxidative Stress in CFFlaxseed Modulates Oxidative Stress and Inflammatory Biomarkers in Stable Patients With Cystic Fibrosis and Healthy ControlsCystic Fibrosis;Oxidative Stress;InflammationDietary Supplement: finely ground flaxseed powderUniversity of PennsylvaniaNULLCompleted18 Years64 YearsBoth10Phase 1United States
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
21NCT01417481
(ClinicalTrials.gov)
March 201215/8/2011Effect of Glycine in Cystic FibrosisEvaluation of the Capability of a Glycine Oral Supplement for Diminishing Bronchial Inflammation in Children With Cystic FibrosisCystic FibrosisDietary Supplement: Glycine;Dietary Supplement: PlaceboInstituto Nacional de Enfermedades RespiratoriasHospital Infantil de Mexico Federico Gomez;Instituto Mexicano del Seguro SocialTerminated5 Years15 YearsAll13Phase 2Mexico
22NCT02128984
(ClinicalTrials.gov)
January 201228/3/2014Clinical Study With an Enteral Formula With Symbiotic and DHA for Malnourished ChildrenClinical Study With an Enteral Formula With Symbiotic and DHA for Malnourished ChildrenCystic Fibrosis;Failure to Thrive;MalnutritionDietary Supplement: Symbiotic Formula with DHA and antioxidants;Dietary Supplement: Standard FormulaLaboratorios OrdesaQuantum Experimental;Peruvian Clinical ResearchCompleted1 YearN/AAll109N/APeru;Spain
23NCT00889434
(ClinicalTrials.gov)
November 1, 201120/4/2009Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)Single-site, Open-label, Dose-ranging, Efficacy, and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated CFCystic FibrosisDietary Supplement: ECGC;Dietary Supplement: Tocotrienol;Dietary Supplement: EGCG + TocotrienolHadassah Medical OrganizationNULLCompleted18 YearsN/AAll7N/AIsrael
24NCT01783613
(ClinicalTrials.gov)
October 201131/1/2013Eficacy of Long-term Suplementation With Docosahexaenoic Acid in Patients With Cystic FibrosisStudy of the Eficacy of Long-term Suplementation With Docosahexaenoic Acid on Pulmonary, Sistemic and Intestinal Inflammation in Patients With Cystic FibrosisCystic FibrosisDietary Supplement: Docosahexaenoic acid administration: 50 mg/kg/day during 12 months;Dietary Supplement: Placebo: 50 mg/kg/day during 12 monthsFundacion para la Investigacion Biomedica del Hospital Universitario Ramon y CajalNULLCompleted2 Months100 YearsAll96N/ASpain
25NCT01426256
(ClinicalTrials.gov)
October 201129/8/2011Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC Study)Vitamin D for Enhancing the Immune System in Cystic FibrosisCystic Fibrosis;Respiratory Tract InfectionsDietary Supplement: CholecalciferolEmory UniversityCystic Fibrosis Foundation TherapeuticsCompleted16 YearsN/AAll91Phase 3United States
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
26NCT01315665
(ClinicalTrials.gov)
April 201114/3/2011Effect of Sulforaphane in Broccoli Sprouts on Nrf2 ActivationEvaluation of the Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation, Measures of Oxidative Stress, and Neutrophil Migration to Mucosal Surfaces in Healthy and CF SubjectsCystic FibrosisDietary Supplement: Broccoli sproutsUniversity Hospitals Cleveland Medical CenterCystic Fibrosis FoundationCompleted18 Years49 YearsAll15N/AUnited States
27NCT02029521
(ClinicalTrials.gov)
March 201130/12/2013Supplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis PatientsSupplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis for Growth FailureCystic FibrosisDietary Supplement: Oral reduced l-glutathione;Dietary Supplement: PlaceboClark BishopNULLCompleted18 Months10 YearsAll47N/AItaly
28NCT01494909
(ClinicalTrials.gov)
January 201115/12/2011Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and FunctionDevelopment Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and FunctionCystic FibrosisDietary Supplement: Ensure plusTexas A&M UniversityArkansas Children's Hospital Research Institute;University of ArkansasActive, not recruiting10 YearsN/AAll31N/AUnited States
29NCT01201434
(ClinicalTrials.gov)
October 201031/8/2010Effect of Probiotics on Sputum Inflammation and Pulmonary Infections in Patients With Cystic FibrosisThe Effect of Probiotics on Sputum Bacteria, Sputum Inflammation, and Pulmonary Infections in Patients With Cystic Fibrosis: A Double-blind Placebo-controlled TrialCystic FibrosisDietary Supplement: Bio-25 probioticSheba Medical CenterNULLTerminated5 Years40 YearsBoth12N/ANULL
30NCT01956916
(ClinicalTrials.gov)
October 201023/9/2013Probiotics in Cystic FibrosisEffects of LGG Administration in Children With Cystic Fibrosis: A Randomized Controlled TrialCystic FibrosisDietary Supplement: Lactobacillus rhamnosus GG;Dietary Supplement: placeboFederico II UniversityNULLCompleted2 Years18 YearsBoth110Phase 3Italy
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
31NCT01222273
(ClinicalTrials.gov)
September 201014/10/2010Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary AspergillosisOpen-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary AspergillosisCystic Fibrosis;Allergic Bronchopulmonary AspergillosisDietary Supplement: cholecalciferol (Vitamin D3)University of PittsburghNational Heart, Lung, and Blood Institute (NHLBI)Completed12 YearsN/AAll7N/AUnited States
32NCT01321905
(ClinicalTrials.gov)
April 201023/3/2011Prospective Intervention Study on Vitamin D in Patients With Cystic Fibrosis5-month Pilot Intervention Study on Vitamin D in Patients With Cystic FibrosisCystic FibrosisDietary Supplement: Supplementation with vitamin D2/D3Karolinska InstitutetStockholm County Council, Sweden;Swedish Cystic Fibrosis AssociationRecruiting6 YearsN/ABoth15Phase 2Sweden
33NCT01051999
(ClinicalTrials.gov)
February 201015/1/2010Glutamine Supplementation in Cystic FibrosisGlutamine Supplementation and Immunity in Adults With Cystic FibrosisCystic Fibrosis;Immune FunctionDietary Supplement: Glutamine;Dietary Supplement: L-alanineEmory UniversityEmmaus Medical, Inc.Completed18 YearsN/ABoth17Phase 2United States
34NCT01961661
(ClinicalTrials.gov)
September 20099/10/2013Probiotics on Intestinal Inflammation in Cystic FibrosisEffect of Probiotics on Intestinal Inflammation and Microflora in Cystic Fibrosis: a Pilot StudyCystic FibrosisDietary Supplement: Lactobacillus rhamnosus GG;Dietary Supplement: placeboFederico II UniversityNULLCompleted2 Years18 YearsBoth22Phase 3Italy
35NCT01737983
(ClinicalTrials.gov)
May 200912/7/2012Effect of Lactobacillus Reuteri in Cystic FibrosisLactobacillus Reuteri Reduces Pulmonary Exacerbations and Upper Respiratory Tract Infections in CF Patients With Mild-to-moderate Lung Disease. LR Administration Might Have a Beneficial Effect on the Disease Course of Cystic Fibrosis.CYSTIC FIBROSISDietary Supplement: Lactobacillus reuteri;Dietary Supplement: placeboAzienda Policlinico Umberto INULLCompleted6 Years42 YearsBoth61Phase 4Italy
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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PhaseCountries
36NCT00685971
(ClinicalTrials.gov)
December 200827/5/2008Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) PatientsRandomized Placebo-Controlled Trial of Cholecalciferol for Vitamin D Deficiency in Adults With Cystic FibrosisCystic Fibrosis;Vitamin D DeficiencyDietary Supplement: 5000 IU of cholecalciferol;Dietary Supplement: placeboSt. Michael's Hospital, TorontoNULLCompleted18 YearsN/ABoth200N/ACanada
37NCT00788138
(ClinicalTrials.gov)
October 20087/11/2008Effects of Vitamin D Supplementation on Lung Function in an Acute Pulmonary Exacerbation of Cystic FibrosisCystic FibrosisDietary Supplement: Vitamin D3;Dietary Supplement: PlaceboEmory UniversityNULLCompleted18 Years70 YearsBoth30N/AUnited States
38NCT00959010
(ClinicalTrials.gov)
October 200813/8/2009Omega 3 Supplementation in Cystic Fibrosis PatientsBiochemical Effects of a Long-term Supplementation With Omega-3 Polyunsaturated Fatty Acids in Cystic FibrosisCystic FibrosisDietary Supplement: omega-3 triglycerides;Dietary Supplement: PlaceboQueen Fabiola Children's University HospitalNULLCompleted6 Years60 YearsBoth15Phase 3Belgium
39NCT01172301
(ClinicalTrials.gov)
July 200827/7/2010Leucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic FibrosisLeucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic FibrosisCystic FibrosisDietary Supplement: Essential amino acid intake + Leucine vs total AA supplementTexas A&M UniversityArkansas Children's Hospital Research InstituteCompleted10 Years21 YearsBoth14N/AUnited States
40NCT00762918
(ClinicalTrials.gov)
March 200826/9/2008Vitamin D3 for the Treatment of Low Vitamin D in Cystic FibrosisVitamin D and Its Non-Classic Roles in Cystic FibrosisCystic Fibrosis;Vitamin D DeficiencyDietary Supplement: cholecalciferolChildren's Hospital of PhiladelphiaNULLWithdrawn10 Years25 YearsBoth0Phase 3United States
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
41NCT01070446
(ClinicalTrials.gov)
October 200710/2/2010Choline Nutrition in Children With Cystic FibrosisCholine Nutrition in Children With Cystic FibrosisCystic FibrosisDietary Supplement: Vitamin: Choline Bitartrate (2-hydroxyethyl) trimethylammonium salt 1:1University of British ColumbiaCystic Fibrosis Foundation (US)Completed5 Years17 YearsBoth34N/ACanada
42NCT01018303
(ClinicalTrials.gov)
August 200719/11/2009Safety and Efficacy of an Antioxidant-rich Multivitamin Supplement in Cystic FibrosisSafety and Efficacy of a Novel Antioxidant-rich Multivitamin Supplement for Persons With Cystic FibrosisCystic FibrosisDietary Supplement: AquADEKUniversity of Colorado, DenverCystic Fibrosis Foundation Therapeutics;Yasoo Health;National Institutes of Health (NIH)Completed10 Years40 YearsBoth17Phase 1;Phase 2United States
43NCT00406536
(ClinicalTrials.gov)
January 200729/11/2006Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PIPhase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CFCystic Fibrosis;Pancreatic InsufficiencyDietary Supplement: Lym-X-Sorb powder;Dietary Supplement: Placebo powderAvanti Polar Lipids, Inc.National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Completed6 Years17 YearsBoth110Phase 2United States
44NCT00730509
(ClinicalTrials.gov)
April 20044/8/2008Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic FibrosisPreliminary Evidences of Active Form of Folic Acid and Vitamin B12 Supplementation to Ameliorate Cell Membrane in Children With Cystic FibrosisCystic FibrosisDietary Supplement: 5-methyltetrahydrofolate and vitamin B12Universita di VeronaNULLCompleted3 Years8 YearsBoth31N/AItaly
45NCT00530244
(ClinicalTrials.gov)
March 200313/9/2007Use of Formula Fortified With DHA in Infants With Cystic FibrosisThe Effect of Formula Fortified With Docosahexaenoic Acid (DHA) on Infants With Cystic Fibrosis (CF)Cystic FibrosisDietary Supplement: Docosahexaenoic acid (DHA);Dietary Supplement: Standard formula (Enfamil)University of Massachusetts, WorcesterCystic Fibrosis FoundationCompletedN/A56 DaysAll76N/AUnited States