Creatine (DrugBank: Creatine)
12 diseases| 告示番号 | 疾患名（ページ内リンク） | 臨床試験数 |
|---|---|---|
| 1 | 球脊髄性筋萎縮症 | 1 |
| 2 | 筋萎縮性側索硬化症 | 6 |
| 5 | 進行性核上性麻痺 | 1 |
| 6 | パーキンソン病 | 2 |
| 8 | ハンチントン病 | 6 |
| 13 | 多発性硬化症／視神経脊髄炎 | 1 |
| 46 | 悪性関節リウマチ | 1 |
| 49 | 全身性エリテマトーデス | 1 |
| 50 | 皮膚筋炎／多発性筋炎 | 2 |
| 113 | 筋ジストロフィー | 3 |
| 156 | レット症候群 | 1 |
| 201 | アンジェルマン症候群 | 1 |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | JPRN-UMIN000012503 | 2014/06/01 | 25/12/2013 | Effect of creatine in SBMA patients: A double-blind, placebo-controlled clinical study | Spinal and Bulbar Muscular Atrophy | Creatine monohydrate 10 g, daily for 8 weeks Creatine monohydrate 15 g, daily for 8 weeks placebo for 8 weeks | Department of Neurology, Nagoya University Graduate School of Medicine | NULL | Complete: follow-up continuing | 20years-old | 80years-old | Male | 45 | Not applicable | Japan |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01257581 (ClinicalTrials.gov) | March 2011 | 8/12/2010 | Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS) | Phase 2 Selection Trial of High Dosage Creatine and Two Dosages of Tamoxifen in Amyotrophic Lateral Sclerosis (ALS) | Amyotrophic Lateral Sclerosis | Drug: creatine;Drug: tamoxifen | Nazem Atassi | ALS Therapy Alliance;State University of New York - Upstate Medical University | Completed | 18 Years | N/A | All | 60 | Phase 2 | United States |
| 2 | NCT00355576 (ClinicalTrials.gov) | July 2006 | 21/7/2006 | Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis | Phase II Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis | Drug: Celecoxib;Drug: Creatine;Drug: Minocycline | Columbia University | ALS Association;Pfizer | Completed | 21 Years | 85 Years | Both | 86 | Phase 2 | United States |
| 3 | NCT00069186 (ClinicalTrials.gov) | June 2003 | 17/9/2003 | Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis | A Phase III, Multi-Center, Double-Blind, Placebo Controlled, Randomized Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis (ALS) | Drug: Creatine Monohydrate | The Avicena Group | NULL | Active, not recruiting | 21 Years | 80 Years | Both | 107 | Phase 3 | United States |
| 4 | NCT00070993 (ClinicalTrials.gov) | December 2002 | 9/10/2003 | Creatine for the Treatment of Amyotrophic Lateral Sclerosis | Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis | Drug: creatine monohydrate | National Center for Complementary and Integrative Health (NCCIH) | Office of Dietary Supplements (ODS) | Completed | 21 Years | 80 Years | Both | 110 | Phase 2 | United States |
| 5 | NCT00005766 (ClinicalTrials.gov) | May 2000 | 1/6/2000 | Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis | Drug: Creatinine | National Center for Research Resources (NCRR) | NULL | Completed | 18 Years | 80 Years | Both | Phase 2 | United States | ||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT00005674 (ClinicalTrials.gov) | May 2000 | 26/5/2000 | Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS] | Amyotrophic Lateral Sclerosis | Drug: Creatine | National Center for Research Resources (NCRR) | Muscular Dystrophy Association | Completed | 18 Years | 80 Years | Both | Phase 2 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT00605930 (ClinicalTrials.gov) | April 2004 | 14/1/2008 | A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy. | Energy Metabolism in Neurodegenerative Diseases: A Randomized, Double Blind, Placebo-Controlled Clinical Pilot Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy. | Progressive Supranuclear Palsy | Dietary Supplement: Pyruvate, creatine, niacinamide;Dietary Supplement: Placebo | University of Louisville | NULL | Completed | N/A | N/A | All | 20 | N/A | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT00449865 (ClinicalTrials.gov) | March 2007 | 20/3/2007 | NET-PD LS-1 Creatine in Parkinson's Disease | A Multicenter, Double-Blind, Parallel Group, Placebo Controlled Study of Creatine in Subjects With Treated Parkinson's Disease (PD) Long Term Study (LS-1) | Parkinson's Disease | Drug: creatine;Other: placebo | University of Rochester | National Institute of Neurological Disorders and Stroke (NINDS) | Terminated | N/A | N/A | All | 1741 | Phase 3 | United States;Canada |
| 2 | NCT00063193 (ClinicalTrials.gov) | May 2003 | 23/6/2003 | National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial | A Multi-center, Double-blind, Pilot Study of Minocycline and Creatine in Subjects With Early Untreated Parkinson's Disease | Parkinson's Disease | Drug: minocycline;Drug: creatine | University of Rochester | National Institute of Neurological Disorders and Stroke (NINDS) | Completed | 30 Years | N/A | Both | 195 | Phase 2 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01411163 (ClinicalTrials.gov) | April 2010 | 4/8/2011 | Premanifest Huntington's Disease Extension Study II: Creatine Safety & Tolerability | Premanifest Huntington's Disease Extension Study II: Creatine Safety & Tolerability | Huntington's Disease | Drug: Creatine monohydrate | Massachusetts General Hospital | National Institutes of Health (NIH) | Completed | 26 Years | N/A | Both | 24 | Phase 2 | United States |
| 2 | NCT00712426 (ClinicalTrials.gov) | September 2009 | 8/7/2008 | Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E) | Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E) | Huntington's Disease | Drug: Creatine Monohydrate;Drug: Placebo | Massachusetts General Hospital | University of Rochester;National Center for Complementary and Integrative Health (NCCIH) | Terminated | 18 Years | N/A | Both | 553 | Phase 3 | United States;Australia;Canada;New Zealand |
| 3 | NCT01411150 (ClinicalTrials.gov) | May 2009 | 4/8/2011 | Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension Study | Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension Study | Huntington's Disease | Drug: Creatine Monohydrate | Massachusetts General Hospital | National Institutes of Health (NIH) | Completed | 26 Years | N/A | Both | 38 | Phase 2 | United States |
| 4 | NCT00592995 (ClinicalTrials.gov) | December 2007 | 28/12/2007 | Creatine Safety and Tolerability in Premanifest HD: PRECREST | Creatine Safety and Tolerability in Premanifest HD: PRECREST | Huntington Disease | Drug: Creatine monohydrate;Drug: Placebo | Massachusetts General Hospital | NULL | Completed | 26 Years | N/A | Both | 64 | Phase 2 | United States |
| 5 | NCT01412151 (ClinicalTrials.gov) | April 2005 | 5/8/2011 | Creatine Safety & Tolerability in Huntington's Disease | Creatine Safety & Tolerability in Huntington's Disease (CREST-X): A Single-Center, Open-Label, Long-Term Safety & Tolerability Extension Study of Creatine in Subjects With HD | Huntington's Disease (HD) | Drug: Creatine monohydrate | Massachusetts General Hospital | NULL | Completed | 18 Years | N/A | All | 10 | Phase 2 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT00026988 (ClinicalTrials.gov) | October 2001 | 15/11/2001 | Creatine Therapy for Huntington's Disease | Creatine Therapy for Huntington's Disease | Huntington's Disease | Drug: Creatine | National Center for Complementary and Integrative Health (NCCIH) | NULL | Completed | 18 Years | N/A | Both | 64 | Phase 1;Phase 2 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01381354 (ClinicalTrials.gov) | October 2010 | 26/5/2011 | Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) | Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) | Multiple Sclerosis | Other: Progressive exercise;Device: Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV;Other: Modified paleolithic diet;Dietary Supplement: Omega 3 fatty acids;Dietary Supplement: Full Spectrum vitamin;Dietary Supplement: Essential - hydroxytyrosol;Dietary Supplement: Maltodextrin fiber supplement;Dietary Supplement: Mineral boost (magnesium);Dietary Supplement: Niacinamide;Dietary Supplement: Methyl B12;Dietary Supplement: Taurine;Dietary Supplement: creatine;Dietary Supplement: thiamine;Dietary Supplement: riboflavin;Dietary Supplement: N acetylcysteine;Dietary Supplement: alpha lipoic acid;Dietary Supplement: L acetyl carnitine;Dietary Supplement: methyl folate;Dietary Supplement: coenzyme Q;Behavioral: meditation;Behavioral: self massage;Behavioral: learning;Dietary Supplement: Coconut oil | University of Iowa | Direct MS Canada;DJO Incorporated;Pinnaclife Inc.;TZ Press, LLC | Completed | 18 Years | 65 Years | All | 38 | Phase 1 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01767844 (ClinicalTrials.gov) | January 2013 | 8/1/2013 | Can Creatine Supplementation Improve Body Composition and Physical Function in Rheumatoid Arthritis Patients? | Can Creatine Supplementation Improve Body Composition and Physical Function in Rheumatoid Arthritis Patients? A Randomised Controlled Pilot Trial | Rheumatoid Arthritis | Dietary Supplement: Creatine;Dietary Supplement: Placebo | Bangor University | NULL | Active, not recruiting | 18 Years | N/A | Both | 43 | N/A | United Kingdom |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01217320 (ClinicalTrials.gov) | January 2011 | 6/10/2010 | Creatine Supplementation in Pediatric Rheumatology | Efficacy and Safety of Creatine Supplementation in Patients With Juvenile Systemic Lupus Erythematosus and Juvenile Dermatomyositis | Juvenile Systemic Lupus Erythematosus;Juvenile Dermatomyositis | Dietary Supplement: creatine;Dietary Supplement: placebo (dextrose) | University of Sao Paulo | NULL | Recruiting | 6 Years | 18 Years | Both | 40 | N/A | Brazil |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT02267005 (ClinicalTrials.gov) | March 2015 | 1/10/2014 | The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis | The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis | Juvenile Dermatomyositis | Dietary Supplement: Creapure;Dietary Supplement: Glucose Tablet | The Hospital for Sick Children | NULL | Completed | 7 Years | 18 Years | All | 13 | N/A | Canada |
| 2 | NCT01217320 (ClinicalTrials.gov) | January 2011 | 6/10/2010 | Creatine Supplementation in Pediatric Rheumatology | Efficacy and Safety of Creatine Supplementation in Patients With Juvenile Systemic Lupus Erythematosus and Juvenile Dermatomyositis | Juvenile Systemic Lupus Erythematosus;Juvenile Dermatomyositis | Dietary Supplement: creatine;Dietary Supplement: placebo (dextrose) | University of Sao Paulo | NULL | Recruiting | 6 Years | 18 Years | Both | 40 | N/A | Brazil |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2006-006776-37-NL (EUCTR) | 14/05/2007 | 22/12/2006 | Towards the assessment of metabolic biomarkers and creatine uptake and turnover in skeletal muscles of patients with Facioscapulohumeral muscular dystrophy using MR spectroscopy - Assessment of biomarkers in FSHD | Towards the assessment of metabolic biomarkers and creatine uptake and turnover in skeletal muscles of patients with Facioscapulohumeral muscular dystrophy using MR spectroscopy - Assessment of biomarkers in FSHD | Healthy volunteers. Later the protocol will be applied to Facioscapular humeral dystrophy and/or other muscular dystrophies in general. MedDRA version: 8.1;Level: LLT;Classification code 10011328;Term: Creatine | Product Name: creatine-13C Product Code: Cr13C | Radboud University Nijmegen Medical Center | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Netherlands | ||||
| 2 | NCT00018109 (ClinicalTrials.gov) | June 2001 | 3/7/2001 | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | Muscular Dystrophy, Duchenne | Drug: glutamine;Drug: creatine monohydrate | National Center for Research Resources (NCRR) | Children's Research Institute | Completed | 5 Years | 10 Years | Male | Phase 3 | United States | |
| 3 | NCT00016653 (ClinicalTrials.gov) | June 2000 | 21/5/2001 | Creatine and Glutamine in Steroid-Naive Duchenne Muscular Dystrophy | A Multicenter Randomized Placebo-controlled Double-blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy | Muscular Dystrophy, Duchenne | Drug: Creatine Monohydrate;Drug: Glutamine | Cooperative International Neuromuscular Research Group | NULL | Completed | 5 Years | 9 Years | Male | 48 | Phase 2;Phase 3 | United States;Belgium;Israel;Puerto Rico |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01147575 (ClinicalTrials.gov) | January 2005 | 17/6/2010 | Effects of Creatine Supplementation in Rett Syndrome | Effects of Creatine Supplementation in Rett Syndrome: A Randomized, Placebo-controlled Trial | Rett Syndrome | Dietary Supplement: Creatine monohydrate;Dietary Supplement: Placebo | Medical University of Vienna | NULL | Completed | 3 Years | 24 Years | Female | 21 | N/A | Austria |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT00348933 (ClinicalTrials.gov) | July 2006 | 3/7/2006 | Dietary Supplements for the Treatment of Angelman Syndrome | Efficacy of a Therapeutic Treatment Trial in Angelman Syndrome | Angelman Syndrome;Nervous System Diseases | Drug: Betaine;Drug: Creatine;Drug: Metafolin;Drug: Vitamin B12 | University of California, San Diego | Baylor College of Medicine;Rady Children's Hospital, San Diego;Boston Children’s Hospital;Greenwood Genetic Center;Rare Diseases Clinical Research Network | Completed | N/A | 5 Years | All | 90 | N/A | United States |