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Calcitriol    (DrugBank: Calcitriol)

8 diseases
告示番号疾患名（ページ内リンク）臨床試験数
37膿疱性乾癬（汎発型）1
46悪性関節リウマチ2
49全身性エリテマトーデス2
66IgA腎症3
96クローン病2
158結節性硬化症1
235副甲状腺機能低下症2
326大理石骨病1

37. 膿疱性乾癬（汎発型）　［臨床試験数：58，薬物数：50（DrugBank：18），標的遺伝子数：17，標的パスウェイ数：96］
Searched query = "Generalised pustular psoriasis", "Pustular psoriasis", "Herpetic impetigo", "Generalization of acrodermatitis continua", "Generalization of dermatitis continua of the extremities"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 58 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1EUCTR2006-005344-83-DE
(EUCTR)		09/02/200707/11/2006A Randomized, Double-blind, Placebo and Active Treatment-Controlled Study in Psoriatic Patients to Assess the Tolerability, Pharmacokinetics and Efficacy of a Cream Formulation Containing 3% of P32/98A Randomized, Double-blind, Placebo and Active Treatment-Controlled Study in Psoriatic Patients to Assess the Tolerability, Pharmacokinetics and Efficacy of a Cream Formulation Containing 3% of P32/98 Psoriasis is a common inherited autoimmune disease that affects 2-3% of the world-wide population. There are several recognized forms of psoriasis, such as plaque psoriasis, which is also known as psoriasis vulgaris and guttate, inverse, erythrodermic and pustular psoriasis, which can coexist within the same patient. The most common form is the plaque psoriasis.
MedDRA version: 8.1;Level: LLT;Classification code 10037153;Term: Psoriasis		Product Name: P32/98 3%
Product Code: P32/98
Trade Name: Silikis 3µg/g Salbe
INN or Proposed INN: Calcitriol		Probiodrug AGNULLNot RecruitingFemale: yes
Male: yes		Germany

46. 悪性関節リウマチ　［臨床試験数：4,183，薬物数：2,538（DrugBank：401），標的遺伝子数：183，標的パスウェイ数：219］
Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 4,183 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1ChiCTR-IPR-16009029
2016-11-012016-08-15Clinical Study of the Bone Protection Effect of Biqi Capsule for Treatment of Rheumatoid ArthritisClinical Study of the Bone Protection Effect of Biqi Capsule for Treatment of Rheumatoid Arthritis Rheumatoid arthritisRA:the experimental group:MTX 10-15mg po qw+BiQi Capsule, 1.2g po bid;RA:the control group:MTX 10-15mg po qw+LEF, 10mg, po, bid;OA:The traditional Chinese group:BiQi Capsule, 1.2g po bid+Celecoxib capsules 0.2g po take as needed;OA:The western medicine control group:Calcitriol Soft Capsules 0.25ug, po, bid+Celecoxib capsules 0.2g po take as needed;Guangdong Provincial Hospital of Chinese MedicineNULLPending1865BothRA:the experimental group:60;RA:the control group:60;OA:The traditional Chinese group:60;OA:The western medicine control group:60;China
2NCT00427804
(ClinicalTrials.gov)		January 200725/1/2007Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium AbsorptionTumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium AbsorptionRheumatoid Arthritis;Crohn's DiseaseDrug: calcitriolAtlanta VA Medical CenterEmory UniversityCompleted18 Years50 YearsMale9N/AUnited States

49. 全身性エリテマトーデス　［臨床試験数：827，薬物数：638（DrugBank：168），標的遺伝子数：108，標的パスウェイ数：191］
Searched query = "Systemic lupus erythematosus", "SLE"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 827 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01863641
(ClinicalTrials.gov)		April 201317/5/2013The Effect of Calcitriol on Progress and Activity of Lupus NephritisThe Effect of Calcitriol on Progress and Activity of Lupus NephritisSystemic Lupus ErythematosusDrug: calcitriol;Drug: placeboGuilan University of Medical SciencesNULLRecruiting18 Years65 YearsBoth50Phase 2Iran, Islamic Republic of
2NCT00508898
(ClinicalTrials.gov)		May 200827/7/2007The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent ProteinuriaThe Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent ProteinuriaSystemic Lupus Erythematosus;Nephritis;ProteinuriaDrug: Calcitriol;Drug: MultivitaminChinese University of Hong KongNULLWithdrawn18 Years65 YearsBoth0Phase 4Hong Kong

66. IgA腎症　［臨床試験数：199，薬物数：214（DrugBank：57），標的遺伝子数：32，標的パスウェイ数：128］
Searched query = "IgA nephropathy", "IgA nephritis", "Berger disease", "IgA-IgG nephropathy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
3 / 199 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01237028
(ClinicalTrials.gov)		March 20118/11/2010Additive Renoprotective Effects of Oral Calcitriol in IgA Nephropathy Patients Taking Renin-Angiotensin System BlockersAdditive Renoprotective Effects of Oral Calcitriol in IgA Nephropathy Patients Taking Renin-Angiotensin System BlockersIgA NephropathyDrug: CalcitriolYonsei UniversityNULLCompleted20 Years70 YearsBoth168N/AKorea, Republic of
2JPRN-UMIN000002474
2007/01/0101/10/2009Preventive effect of vit K, vit D and, risedronate on 3-dimensional trabecular microstructure in patients with IgA nephropathy on glucocorticoid treatment Glucocorticoid induced osteoporosis in patients with IgA nephropathyMenatetrenone 45mg/day for 6 months
Calcitriol 0.5 microgram/day for 6 months
Risedronate 17.5mg/week for 6 months		Osaka University HospitalDepartment of nephrologyNULLComplete: follow-up complete18years-oldNot applicableMale and Female30Not applicableJapan
3NCT00319761
(ClinicalTrials.gov)		May 200627/4/2006Calcitriol in the Treatment of Immunoglobulin A (IgA) NephropathyThe Safety and Short-Term Efficacy of Calcitriol in the Treatment of Immunoglobulin A NephropathyIGA NephropathyDrug: CalcitriolChinese University of Hong KongNULLCompleted18 Years65 YearsBoth10Phase 4Hong Kong

96. クローン病　［臨床試験数：2,209，薬物数：1,276（DrugBank：240），標的遺伝子数：166，標的パスウェイ数：210］
Searched query = "Crohn disease", "Terminal ileitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 2,209 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT00427804
(ClinicalTrials.gov)		January 200725/1/2007Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium AbsorptionTumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium AbsorptionRheumatoid Arthritis;Crohn's DiseaseDrug: calcitriolAtlanta VA Medical CenterEmory UniversityCompleted18 Years50 YearsMale9N/AUnited States
2NCT00287170
(ClinicalTrials.gov)		July 20062/2/2006Efficacy Study of Targeted, Local Delivery of Drugs to Treat Crohn's DiseasePilot, Open-Label, Randomized, Parallel Group Study to Evaluate Clinical/ and Immunological Efficacy/Safety of Locally Delivered 6-MP or Calcitriol vs Purinethol in Non-Steroid Dependent Patients With Active CDCrohn's DiseaseDrug: Delayed Release 6MP or Calcitriol vs. PurinetholTeva GTCNULLCompleted18 Years75 YearsBoth15Phase 1;Phase 2Israel

158. 結節性硬化症　［臨床試験数：100，薬物数：62（DrugBank：16），標的遺伝子数：35，標的パスウェイ数：115］
Searched query = "Tuberous sclerosis", "Tuberous sclerosis complex"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 100 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT03140449
(ClinicalTrials.gov)		September 5, 201326/4/2017Topical Rapamycin and Calcitriol for Angiofibroma of Tuberous SclerosisStudy of Combination Therapy With Topical Rapamycin and Calcitriol for Cutaneous Lesions of Tuberous Sclerosis: A Double-blind Randomized Controlled TrialFacial AngiofibromaDrug: Rapamycin;Drug: Calcitriol;Drug: Rapamycin-calcitriol combinationNational Taiwan University HospitalNULLCompleted7 Years65 YearsAll52Phase 3NULL

235. 副甲状腺機能低下症　［臨床試験数：67，薬物数：112（DrugBank：24），標的遺伝子数：4，標的パスウェイ数：5］
Searched query = "Hypoparathyroidism", "Accessory thyroid hypergasia disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 67 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT03249012
(ClinicalTrials.gov)		September 1, 20179/8/2017Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy HypoparathyroidismComparing the Quality of Life Associated With Empiric Calcium Repletion and Parathormone (PTH) Based Calcium Repletion for Post Thyroidectomy HypoparathyroidismHypoparathyroidism Postprocedural;Quality of LifeOther: Empiric use of Calcium Carbonate and Calcitriol;Other: PTH based Calcium Carbonate and Calcitriol repletionCHU de Quebec-Universite LavalNULLRecruiting18 YearsN/AAll120N/ACanada
2NCT00001304
(ClinicalTrials.gov)		October 19913/11/1999Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34HypoparathyroidismDrug: Synthetic Human Parathyroid Hormone 1-34;Drug: Calcitriol & CalciumEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NULLCompleted17 Years69 YearsAll27Phase 2United States

326. 大理石骨病　［臨床試験数：20，薬物数：52（DrugBank：14），標的遺伝子数：16，標的パスウェイ数：78］
Searched query = "Osteopetrosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 20 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT00004402
(ClinicalTrials.gov)		November 199918/10/1999Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital OsteopetrosisOsteopetrosisDrug: calcitriol;Drug: interferon gammaFDA Office of Orphan Products DevelopmentMedical University of South CarolinaCompletedN/A10 YearsBoth30Phase 3NULL

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