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Bupivacaine    (DrugBank: Bupivacaine)

8 diseases
告示番号疾患名（ページ内リンク）臨床試験数
46悪性関節リウマチ2
51全身性強皮症1
53シェーグレン症候群2
70広範脊柱管狭窄症3
96クローン病2
168エーラス・ダンロス症候群1
226間質性膀胱炎（ハンナ型）1
298遺伝性膵炎1

46. 悪性関節リウマチ　［臨床試験数：4,183，薬物数：2,538（DrugBank：401），標的遺伝子数：183，標的パスウェイ数：219］
Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 4,183 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT04361513
(ClinicalTrials.gov)		April 15, 202022/4/2020Genicular Nerve Block in Rheuamtoid ArthritisGenicular Nerve Block in Rheumatoid Arthritis: a Prospective Randomized Clinical TrialPain;Joint Function Disorder;InflammationDrug: Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer);Drug: triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip)Sohag UniversityNULLCompleted18 YearsN/AAll64Phase 4Egypt
2EUCTR2016-002035-15-FI
(EUCTR)		20/05/201612/05/2016Outcome after total knee endoprosthesis under general or regional anesthesia, a randomized studyOutcome after total knee arthroplasty under general or spinal anesthesia, a randomized study - Outcome after total knee arthroplasty under general or spinal anesthesia Patients undego total knee arthroplasty operation in general or spinal anaesthesia because of osteoarthritis, rheumatoid arthritis or other degenerative condition of the knee
MedDRA version: 19.0;Level: LLT;Classification code 10031174;Term: Osteoarthrosis;System Organ Class: 100000004859
MedDRA version: 19.0;Classification code 10031158;Term: Osteo arthritis knees;System Organ Class: 100000004859;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]		Trade Name: Bicain spinal
INN or Proposed INN: bupivacaine hydrochloride
Other descriptive name: BUPIVACAINE HYDROCHLORIDE
Trade Name: Propolipid
INN or Proposed INN: propofol
Other descriptive name: PROPOFOL		Helsinki University Central HospitalNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes		Phase 4Finland

51. 全身性強皮症　［臨床試験数：466，薬物数：536（DrugBank：142），標的遺伝子数：110，標的パスウェイ数：210］
Searched query = "Scleroderma", "Systemic sclerosis", "SSc", "dcSSc", "lcSSc"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 466 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT02374320
(ClinicalTrials.gov)		November 201423/2/2015Exparel as a Nerve Block for Severe Hand PainChemical Sympathectomy Following Peripheral Nerve Block With Liposomal BupivacaineCREST Syndrome;Peripheral Vascular Disease;Raynaud Disease;Scleroderma, DiffuseDrug: liposomal bupivacaineJose Soberon, MDNULLTerminated18 YearsN/AAll14Phase 2;Phase 3United States

53. シェーグレン症候群　［臨床試験数：234，薬物数：270（DrugBank：85），標的遺伝子数：49，標的パスウェイ数：174］
Searched query = "Sjogren syndrome", "Sjögren syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 234 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01584947
(ClinicalTrials.gov)		April 201223/4/2012Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral PainClinical Trials With a Local Anesthetic Lozenge for the Treatment of Oral Mucosal Pain in Burning Mouth Syndrome, Sjögrens Syndrome and Lichen Planus.Chronic PainDrug: Bupivacaine;Drug: PlaceboHvidovre University HospitalOracain II ApsTerminated18 Years75 YearsBoth31Phase 2Denmark
2EUCTR2011-006196-19-DK
(EUCTR)		28/02/201230/01/2012Clinical Trials with lozenge as local anaesthesia as treatment for oral pain of patients with burning mouth syndrome and Sjögrens syndromClinical Trials with lozenge as local anaesthesia as treatment of oral pain in burning mouth syndrome and Sjögrens syndrome - SB Lozenge Oral pain caused by the illnesses burning mouth syndrome, Sjögren's syndrome and lichen planus;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]Product Name: Bupizenge
Product Code: BUPI5
INN or Proposed INN: BUPIVACAINE HYDROCHLORIDE		Clinical Research Centre, Hvidovre University HospitalNULLNot RecruitingFemale: yes
Male: yes		60Phase 2Denmark

70. 広範脊柱管狭窄症　［臨床試験数：91，薬物数：195（DrugBank：54），標的遺伝子数：60，標的パスウェイ数：85］
Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
3 / 91 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT04066296
(ClinicalTrials.gov)		September 20203/7/2019Outcomes for Lumbar Decompressions With Use of Liposomal BupivicaineA Double Blinded Randomized Control Trial in Outcomes for Lumbar Decompressions With Use of Liposomal BupivicaineLumbar Spinal StenosisDrug: Liposomal bupivacaineUniversity of Colorado, DenverNULLNot yet recruiting18 YearsN/AAll100Phase 2NULL
2EUCTR2019-003590-25-NL
(EUCTR)		15/06/202015/06/2020Epidural analgesia after back surgerya Randomized controlled trial for epidural Analgesia for Pain relief after lumbar Interlaminar Decompressive spine surgery - RAPID - RAPID Lumbar spinal stenosis
MedDRA version: 21.0;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 100000004859;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]		Trade Name: Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml
Product Name: Bupivacaine
Product Code: Sufentanil		NULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes		34Phase 4Netherlands
3NCT03745040
(ClinicalTrials.gov)		January 26, 20195/11/2018Liposomal Bupivacaine in One-level Instrumented Posterior Spinal FusionDoes Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With InstrumentationLumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Disc Disease;Lumbar SpondylolisthesisDrug: Liposomal bupivacaineAllina Health SystemTwin Cities Spine CenterRecruiting18 YearsN/AAll60Phase 4United States

96. クローン病　［臨床試験数：2,209，薬物数：1,276（DrugBank：240），標的遺伝子数：166，標的パスウェイ数：210］
Searched query = "Crohn disease", "Terminal ileitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 2,209 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT03723447
(ClinicalTrials.gov)		October 23, 201826/10/2018Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)A Prospective Randomized Trial of Transversus Abdominis Plane (TAP) INtraoperative Block With Bupivacaine/Dexamethasone aGainst Liposomal Bupivacaine (Exparel®): the TINGLE TrialPain, Postoperative;Crohn Disease;Inflammatory Bowel Diseases;Colorectal Cancer;Gastrointestinal Cancer;Gastrointestinal Disease;Digestive System Disease;Pain;Pain, Neuropathic;Intestinal DiseaseDrug: Liposomal bupivacaine;Drug: Bupivacaine/epinephrine/dexamethasoneCedars-Sinai Medical CenterNULLActive, not recruiting18 Years90 YearsAll100Phase 4United States
2NCT02538679
(ClinicalTrials.gov)		August 7, 201520/8/2015A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block TechniquesA Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Technique Versus Laparoscopic Transversus Abdominis Plane Nerve Block Technique Versus No Block on Postoperative Opioid Consumption After Major Colorectal SurgeryCrohn's Disease;Inflammatory Bowel Disease;Postoperative PainOther: Placebo;Drug: US TAP Bupivacaine/Epinephrine;Drug: Lap TAP Bupivacaine/EpinephrineCedars-Sinai Medical CenterNULLCompleted18 Years90 YearsAll127N/ANULL

168. エーラス・ダンロス症候群　［臨床試験数：7，薬物数：16（DrugBank：8），標的遺伝子数：9，標的パスウェイ数：54］
Searched query = "Ehlers-Danlos syndrome", "EDS", "cEDS", "hEDS", "clEDS", "vEDS", "kEDS", "aEDS", "dEDS", "DDEDS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 7 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT04036305
(ClinicalTrials.gov)		July 26, 201925/7/2019Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy VolunteersLocal Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy VolunteersEhlers-Danlos Syndrome;Anesthesia, LocalDrug: 0.9% Sodium Chloride Injection;Drug: Lidocaine Injection 2%;Drug: Bupivacaine Injection 0.5%Vanderbilt University Medical CenterUniversity of CalgaryEnrolling by invitation18 YearsN/AAll230United States

226. 間質性膀胱炎（ハンナ型）　［臨床試験数：133，薬物数：151（DrugBank：46），標的遺伝子数：48，標的パスウェイ数：137］
Searched query = "Interstitial cystitis with Hunners ulcer", "Interstitial cystitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 133 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01616992
(ClinicalTrials.gov)		September 20098/6/2012Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic Characteristics (ICEPAC) StudyInterstitial Cystitis: Elucidation of the Psychophysiologic and AutonomicInterstitial Cystitis/Painful Bladder Syndrome;Myofascial Pelvic PainDrug: BupivacaineCase Western Reserve UniversityNULLCompleted18 Years80 YearsFemale200N/AUnited States

298. 遺伝性膵炎　［臨床試験数：93，薬物数：168（DrugBank：51），標的遺伝子数：48，標的パスウェイ数：134］
Searched query = "Hereditary pancreatitis", "Chronic pancreatitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 93 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT04611958
(ClinicalTrials.gov)		December 1, 202027/10/2020Intraductal Liposomal Bupivacaine for Chronic PancreatitisIntraductal Liposomal Bupivacaine as a Therapeutic Trial to Determine the Contribution of Peripheral Versus Central Sensitization in the Pathogenesis of Pain in Chronic Pancreatitis- a Pilot and Feasibility StudyChronic PancreatitisDrug: ERCP with Bupivacaine infusionJohns Hopkins UniversityNULLNot yet recruiting18 Years80 YearsAll8Early Phase 1United States

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