No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | African trypanosomiasis 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
2 | AGE-RAGE signaling pathway in diabetic complications 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
3 | Alzheimer disease 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
4 | Amoebiasis 3 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
2件: IL1R1, IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
5 | Antifolate resistance 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
6 | C-type lectin receptor signaling pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
7 | Cellular senescence 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: IL1A |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
8 | Chagas disease (American trypanosomiasis) 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
9 | Cytokine-cytokine receptor interaction 5 genes, 4 drugs (DrugBank) and 28 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
2件: IL1R1, IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
10 | Cytosolic DNA-sensing pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
11 | EGFR tyrosine kinase inhibitor resistance 1 gene, 1 drug (DrugBank) and 16 diseases shown |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
12 | Fluid shear stress and atherosclerosis 4 genes, 3 drugs (DrugBank) and 21 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
2件: IL1R1, IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
13 | Gap junction 9 genes, 1 drug (DrugBank) and 5 diseases shown |
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 |
D00570 |
Colchicine |
5件: 2, 42, 56, 93, 266 |
14 | Graft-versus-host disease 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
15 | Hematopoietic cell lineage 5 genes, 4 drugs (DrugBank) and 28 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
2件: IL1R1, IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
16 | Herpes simplex virus 1 infection 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
17 | HIF-1 signaling pathway 1 gene, 1 drug (DrugBank) and 16 diseases shown |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
18 | Human cytomegalovirus infection 3 genes, 4 drugs (DrugBank) and 28 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
19 | Human T-cell leukemia virus 1 infection 2 genes, 1 drug (DrugBank) and 17 diseases shown |
2件: IL1R1, IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
20 | IL-17 signaling pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
21 | Inflammatory bowel disease (IBD) 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
22 | Inflammatory mediator regulation of TRP channels 2 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
23 | Influenza A 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
24 | JAK-STAT signaling pathway 1 gene, 1 drug (DrugBank) and 16 diseases shown |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
25 | Legionellosis 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
26 | Leishmaniasis 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
27 | Malaria 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
28 | MAPK signaling pathway 3 genes, 3 drugs (DrugBank) and 21 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
29 | Measles 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
30 | Necroptosis 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
31 | NF-kappa B signaling pathway 2 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
32 | NOD-like receptor signaling pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
33 | Non-alcoholic fatty liver disease (NAFLD) 3 genes, 3 drugs (DrugBank) and 22 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
34 | Osteoclast differentiation 3 genes, 3 drugs (DrugBank) and 21 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
35 | Pathogenic Escherichia coli infection 11 genes, 4 drugs (DrugBank) and 23 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 |
D00570 |
Colchicine |
5件: 2, 42, 56, 93, 266 |
36 | Pathways in cancer 1 gene, 1 drug (DrugBank) and 16 diseases shown |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
37 | Pertussis 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
38 | Phagosome 9 genes, 1 drug (DrugBank) and 5 diseases shown |
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 |
D00570 |
Colchicine |
5件: 2, 42, 56, 93, 266 |
39 | PI3K-Akt signaling pathway 1 gene, 1 drug (DrugBank) and 16 diseases shown |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
40 | Prion diseases 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
41 | Prostate cancer 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
42 | Rheumatoid arthritis 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
43 | Salmonella infection 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
44 | Shigellosis 2 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
45 | Th17 cell differentiation 3 genes, 4 drugs (DrugBank) and 28 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1R1 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
46 | TNF signaling pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
47 | Toll-like receptor signaling pathway 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
48 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank) and 17 diseases shown |
1件: IL1R2 |
D02934 |
Anakinra |
17件: 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 |
49 | Tuberculosis 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
50 | Type I diabetes mellitus 2 genes, 2 drugs (DrugBank) and 10 diseases shown |
2件: IL1A, IL1B |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
51 | Viral protein interaction with cytokine and cytokine receptor 1 gene, 1 drug (DrugBank) and 16 diseases shown |
1件: IL6R |
D02596 |
Tocilizumab |
16件: 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 |
52 | Yersinia infection 1 gene, 2 drugs (DrugBank) and 10 diseases shown |
1件: IL1B |
D09315 |
Canakinumab |
9件: 46, 56, 84, 106, 107, 108, 113, 266, 269 |
D06635 |
Rilonacept |
4件: 51, 106, 107, 266 |