No. |
Drug (Description in trials) |
DrugBank |
KEGG DRUG * |
KEGG GENES * [Number of genes] |
KEGG PATHWAY [Number of pathways] |
Disease ID * [Number of diseases] |
1 |
Ataluren |
Ataluren |
D09323 |
- |
- |
[6] 19, 113, 140, 246, 299, 329 |
2 |
Cannabidiol |
Cannabidiol |
D10915 |
[2] CNR1, CNR2 |
[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis |
[13] 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
3 |
Cannabidiol (cbd) |
Cannabidiol |
D10915 |
[2] CNR1, CNR2 |
[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis |
[2] 140, 158 |
4 |
Cannabidiol oral solution |
Cannabidiol |
D10915 |
[2] CNR1, CNR2 |
[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis |
[4] 140, 144, 145, 193 |
5 |
Clobazam |
Clobazam |
D01253 |
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction |
[2] 140, 144 |
6 |
Diacomit |
Stiripentol |
D05928 |
- |
- |
[1] 140 |
7 |
Epx-100 (clemizole hydrochloride) |
- |
- |
- |
- |
[1] 140 |
8 |
Fenfluramine |
Fenfluramine |
D04148, D07945 |
[4] HTR2A, HTR2B, HTR2C, SLC6A4 |
[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
[2] 140, 144 |
9 |
Fenfluramine hydrochloride |
Fenfluramine |
D04148, D07945 |
[4] HTR2A, HTR2B, HTR2C, SLC6A4 |
[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
[2] 140, 144 |
10 |
Frisium*30cps 10mg |
- |
- |
- |
- |
[1] 140 |
11 |
Gwp42003-p |
- |
- |
- |
- |
[5] 140, 144, 145, 156, 158 |
12 |
Me2080 (stiripentol) |
Stiripentol |
D05928 |
- |
- |
[1] 140 |
13 |
Other antiepileptics |
- |
- |
- |
- |
[1] 140 |
14 |
Stiripentol |
Stiripentol |
D05928 |
- |
- |
[1] 140 |
15 |
Stiripentolo |
- |
- |
- |
- |
[1] 140 |
16 |
Tak-935 |
- |
- |
- |
- |
[2] 140, 144 |
17 |
Topamax |
Topiramate |
D00537 |
[36] CA2, CA4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
[48] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy (DCM), Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy (HCM), Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[1] 140 |
18 |
Topiramate |
Topiramate |
D00537 |
[36] CA2, CA4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
[48] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy (DCM), Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy (HCM), Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[5] 6, 140, 144, 156, 193 |
19 |
Turmeric |
Turmeric |
- |
- |
- |
[4] 140, 144, 158, 299 |
20 |
Verapamil |
Verapamil |
D00619, D02356 |
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S |
[34] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy (DCM), Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy (HCM), Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway |
[4] 96, 130, 140, 167 |
21 |
Zx008 |
- |
- |
- |
- |
[1] 140 |
22 |
Zx008 (fenfluramine hydrochloride) |
Fenfluramine |
D04148, D07945 |
[4] HTR2A, HTR2B, HTR2C, SLC6A4 |
[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle |
[2] 140, 144 |
23 |
Zx008 - 0.2 mg/kg/day |
- |
- |
- |
- |
[1] 140 |
24 |
Zx008 - 0.4 mg/kg/day |
- |
- |
- |
- |
[1] 140 |
25 |
Zx008 - 0.8 mg/kg/day |
- |
- |
- |
- |
[1] 140 |
26 |
Zx008 - 20 mg/day maximum dose |
- |
- |
- |
- |
[1] 140 |
27 |
Zx008 0.2 and 0.8 mg/kg/day |
- |
- |
- |
- |
[2] 140, 144 |