No. |
Drug (Description in trials) |
DrugBank |
KEGG DRUG * |
KEGG GENES * [Number of genes] |
KEGG PATHWAY [Number of pathways] |
Disease ID * [Number of diseases] |
1 |
124i-labeled monoclonal antibody mu 11-1f4 |
- |
- |
- |
- |
[1] 28 |
2 |
124i-p5+14 injection |
- |
- |
- |
- |
[1] 28 |
3 |
2-(3,5-dichloro-phenyl)-benzoxazole-6-carboxylate |
- |
- |
- |
- |
[1] 28 |
4 |
4'-iodo-4'-deoxydoxorubicin |
Iodine |
D00108 |
- |
- |
[1] 28 |
5 |
[d-glucitol, 1-deoxy-1-(methylamino)-, 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate (1:1)] |
Sorbitol |
D00096 |
- |
- |
[1] 28 |
6 |
Acyclovir |
Acyclovir |
D00222 |
- |
- |
[2] 13, 28 |
7 |
Alkeran |
Melphalan |
D00369 |
- |
- |
[2] 28, 60 |
8 |
Amifostine |
Amifostine |
D00226 |
- |
- |
[1] 28 |
9 |
Amifostine trihydrate |
Amifostine |
D00226 |
- |
- |
[1] 28 |
10 |
Amiodarone |
Amiodarone |
D00636, D02910 |
[15] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ11, KCNJ12, KCNJ3, KCNJ5, KCNJ8, KCNQ1, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
[30] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy (DCM), Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway |
[2] 28, 127 |
11 |
Aprotinin |
Aprotinin |
D02971 |
- |
- |
[1] 28 |
12 |
Bendamustine |
Bendamustine |
D07085, D07501 |
- |
- |
[2] 28, 61 |
13 |
Bortezomib |
Bortezomib |
D03150 |
[1] PSMB5 |
[1] Proteasome |
[13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 |
14 |
Bortezomib/dexamethasone (bd), followed by autologous stc & maintenance bortezomib/dexamethasone |
Dexamethasone |
D00292, D00975, D01510, D01615, D01632, D01948, D02174, D02591, D02592 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 28 |
15 |
Busulfan |
Busulfan |
D00248 |
- |
- |
[13] 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 |
16 |
Carboplatin |
Carboplatin |
D01363 |
- |
- |
[4] 28, 34, 60, 85 |
17 |
Carfilzomib |
Carfilzomib |
D08880 |
[1] PSMB5 |
[1] Proteasome |
[1] 28 |
18 |
Carmustine |
Carmustine |
D00254 |
- |
- |
[5] 11, 13, 14, 28, 60 |
19 |
Cc-5013 |
Lenalidomide |
D04687 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[2] 28, 96 |
20 |
Chemotherapy |
- |
- |
- |
- |
[3] 28, 60, 285 |
21 |
Chimeric fibril-reactive monoclonal anti-body 11-1f4 |
- |
- |
- |
- |
[1] 28 |
22 |
Chx a-dtpa anti-cd66 antibody |
Pentetic acid |
D05422 |
- |
- |
[1] 28 |
23 |
Chx-a-dtpa-anti-cd66 |
Pentetic acid |
D05422 |
- |
- |
[1] 28 |
24 |
Cisplatin |
Cisplatin |
D00275 |
- |
- |
[1] 28 |
25 |
Cphc (carboxy pyrrolidine hexanoyl pyrrolidone carboxylate) |
- |
- |
- |
- |
[1] 28 |
26 |
Cyclophosphamide |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[43] 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 61, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 222, 224, 265, 274, 283, 284, 285, 288, 326, 331 |
27 |
Cyclophosphamide, bortezomib, dexamethasone |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[1] 28 |
28 |
Cyclophosphamide, bortezomib, dexamethasone plus daratumumab |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[1] 28 |
29 |
Cyclosporine |
Ciclosporin |
D00184 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
[30] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
[33] 11, 14, 19, 20, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 62, 64, 65, 90, 95, 97, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302 |
30 |
D-glucitol |
Sorbitol |
D00096 |
- |
- |
[2] 28, 299 |
31 |
Daratumumab |
Daratumumab |
D10777 |
[1] CD38 |
[7] Calcium signaling pathway, Hematopoietic cell lineage, Metabolic pathways, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion |
[2] 28, 222 |
32 |
Daratumumab co-formulated with recombinant human hyaluronidase (rhuph20) |
Hyaluronidase |
D04455, D04456, D06604 |
- |
- |
[1] 28 |
33 |
Deaxamethasone |
- |
- |
- |
- |
[1] 28 |
34 |
Dexamethasone |
Dexamethasone |
D00292, D00975, D01510, D01615, D01632, D01948, D02174, D02591, D02592 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 |
35 |
Dexamethasone, 40 mg |
Dexamethasone |
D00292, D00975, D01510, D01615, D01632, D01948, D02174, D02591, D02592 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 28 |
36 |
Dezamizumab |
Dezamizumab |
D11471 |
- |
- |
[1] 28 |
37 |
Diflunisal |
Diflunisal |
D00130 |
[1] PTGS2 |
[20] Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway |
[1] 28 |
38 |
Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhithmias) |
Amiodarone |
D00636, D02910 |
[15] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ11, KCNJ12, KCNJ3, KCNJ5, KCNJ8, KCNQ1, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
[30] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy (DCM), Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway |
[1] 28 |
39 |
Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhythmias) plus egcg |
Amiodarone |
D00636, D02910 |
[15] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ11, KCNJ12, KCNJ3, KCNJ5, KCNJ8, KCNQ1, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A |
[30] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy (DCM), Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway |
[1] 28 |
40 |
Donor lymphocytes |
- |
- |
- |
- |
[1] 28 |
41 |
Doxorubicin |
Doxorubicin |
D03899 |
[2] TOP2A, TOP2B |
[1] Platinum drug resistance |
[5] 26, 28, 34, 61, 331 |
42 |
Doxycycline |
Doxycycline |
D00307, D02129, D03903, D03904, D07876 |
- |
- |
[15] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 162, 167, 227, 280, 299 |
43 |
Dtpa |
Pentetic acid |
D05422 |
- |
- |
[3] 13, 28, 299 |
44 |
Egcg |
Epigallocatechin gallate |
- |
- |
- |
[8] 6, 13, 17, 28, 85, 113, 206, 299 |
45 |
Elotuzumab |
Elotuzumab |
D09337 |
- |
- |
[1] 28 |
46 |
Enbrel |
Etanercept |
D00742 |
[2] LTA, TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[3] 28, 46, 271 |
47 |
Endoxan |
- |
- |
- |
- |
[2] 13, 28 |
48 |
Epigallocatechin |
Epigallocatechin |
- |
- |
- |
[4] 13, 28, 85, 113 |
49 |
Epigallocatechin-3-gallate (egcg) |
Epigallocatechin |
- |
- |
- |
[2] 28, 85 |
50 |
Etoposide |
Etoposide |
D00125, D04107 |
[2] TOP2A, TOP2B |
[1] Platinum drug resistance |
[11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 |
51 |
Filgrastim |
Filgrastim |
D03235 |
[1] CSF3R |
[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer |
[25] 2, 6, 13, 25, 26, 28, 34, 35, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 96, 113, 164, 283, 284, 285, 331 |
52 |
Fludarabine |
Fludarabine |
D01907, D07966 |
[1] RRM1 |
[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism |
[17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 |
53 |
Fludarabine phosphate |
Fludarabine |
D01907, D07966 |
[1] RRM1 |
[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism |
[11] 28, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285 |
54 |
Fortecortin |
- |
- |
- |
- |
[1] 28 |
55 |
Foscarnet |
Foscarnet |
D00579, D02267 |
- |
- |
[2] 28, 60 |
56 |
Foscarnet sodium |
Foscarnet |
D00579, D02267 |
- |
- |
[2] 28, 60 |
57 |
Fx-1006a |
- |
- |
- |
- |
[1] 28 |
58 |
Ganciclovir |
Ganciclovir |
D00333, D04301 |
- |
- |
[3] 28, 60, 97 |
59 |
Green tea |
Green tea leaf |
D06903 |
- |
- |
[5] 6, 17, 28, 46, 96 |
60 |
Green tea extract |
Green tea leaf |
D06903 |
- |
- |
[1] 28 |
61 |
Gsk2315698 |
- |
- |
- |
- |
[1] 28 |
62 |
Gsk2398852 |
- |
- |
- |
- |
[1] 28 |
63 |
Gsk3039294 |
- |
- |
- |
- |
[1] 28 |
64 |
Human transthyretin antisense oligonucleotide |
- |
- |
- |
- |
[1] 28 |
65 |
Humanized igg1, kappa anti-serum amyloid a and anti-al amyloid antibody |
- |
- |
- |
- |
[1] 28 |
66 |
Humax-cd38 |
- |
- |
- |
- |
[1] 28 |
67 |
Hyaluronidase |
Hyaluronidase |
D04455, D04456, D06604 |
- |
- |
[3] 28, 65, 331 |
68 |
Ibrutinib |
Ibrutinib |
D10223 |
[1] BTK |
[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency |
[2] 28, 61 |
69 |
Imatinib |
Imatinib |
D01441, D08066 |
[3] ABL1, KIT, PDGFRA |
[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Viral myocarditis |
[11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 |
70 |
Imatinib mesylate |
Imatinib |
D01441, D08066 |
[3] ABL1, KIT, PDGFRA |
[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Viral myocarditis |
[5] 13, 28, 34, 51, 86 |
71 |
Indium |
Indium |
- |
- |
- |
[3] 28, 84, 299 |
72 |
Indium 111-radiolabelled anti-cd66 |
Indium |
- |
- |
- |
[1] 28 |
73 |
Indium 111 labelled anti-cd66 |
Indium |
- |
- |
- |
[1] 28 |
74 |
Inotersen |
Inotersen |
D10940 |
[1] TTR |
[1] Thyroid hormone synthesis |
[1] 28 |
75 |
Interferon alfa |
Interferon alfa |
D03305 |
[2] IFNAR1, IFNAR2 |
[17] Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway |
[5] 25, 26, 28, 56, 96 |
76 |
Iodo |
Iodine |
D00108 |
- |
- |
[1] 28 |
77 |
Ionis-ttr rx |
- |
- |
- |
- |
[1] 28 |
78 |
Isatuximab |
Isatuximab |
D11050 |
- |
- |
[1] 28 |
79 |
Isis 420915 |
- |
- |
- |
- |
[1] 28 |
80 |
Isis 420915/gsk 299872 |
- |
- |
- |
- |
[1] 28 |
81 |
Ixazomib |
Ixazomib |
D10130 |
[1] PSMB5 |
[1] Proteasome |
[3] 13, 16, 28 |
82 |
Jnj 54767414 |
- |
- |
- |
- |
[1] 28 |
83 |
L01aa03 |
- |
- |
- |
- |
[1] 28 |
84 |
Lenalidomide |
Lenalidomide |
D04687 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[7] 16, 26, 28, 34, 49, 284, 300 |
85 |
Lenalidomide, dexamethasone and cyclophosphamide |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[1] 28 |
86 |
Melflufen |
- |
- |
- |
- |
[1] 28 |
87 |
Melphalan |
Melphalan |
D00369 |
- |
- |
[14] 11, 13, 14, 19, 20, 28, 60, 62, 65, 96, 164, 234, 284, 285 |
88 |
Melphalan, thalidomide and dexamethasone |
Dexamethasone |
D00292, D00975, D01510, D01615, D01632, D01948, D02174, D02591, D02592 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 28 |
89 |
Miridesap |
Miridesap |
D11464 |
- |
- |
[1] 28 |
90 |
Mycophenolate |
Mycophenolic acid |
D05096 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[33] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
91 |
Mycophenolate mofetil |
Mycophenolate mofetil |
D00752, D05094, D05095 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
92 |
N-methyl d-(2,3,4,5,6-pentahydroxy-hexyl)-ammonium |
- |
- |
- |
- |
[1] 28 |
93 |
Neod001 |
- |
- |
- |
- |
[1] 28 |
94 |
Neupogen |
Filgrastim |
D03235 |
[1] CSF3R |
[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer |
[4] 13, 28, 51, 285 |
95 |
Null |
- |
- |
- |
- |
[17] 6, 13, 14, 15, 28, 37, 46, 49, 51, 63, 86, 90, 96, 97, 107, 145, 271 |
96 |
Phosphate |
Phosphate ion |
- |
- |
- |
[29] 2, 3, 11, 12, 13, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 256, 283, 284, 285, 286, 299 |
97 |
Pomalidomide |
Pomalidomide |
D08976 |
[2] IL6, TNF |
[76] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy (DCM), EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pertussis, Prion diseases, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[6] 28, 34, 51, 85, 227, 331 |
98 |
Pomalidomide and dexamethasone |
Dexamethasone |
D00292, D00975, D01510, D01615, D01632, D01948, D02174, D02591, D02592 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 28 |
99 |
Propylene glycol |
Propylene glycol |
D00078 |
- |
- |
[1] 28 |
100 |
Propylene glycol-free melphalan hydrochloride |
Propylene glycol |
D00078 |
- |
- |
[1] 28 |
101 |
Recombinant human hyaluronidase |
Hyaluronidase |
D04455, D04456, D06604 |
- |
- |
[2] 28, 65 |
102 |
Recombinant interferon alfa |
Interferon alfa |
D03305 |
[2] IFNAR1, IFNAR2 |
[17] Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway |
[2] 26, 28 |
103 |
Revlimid |
Lenalidomide |
D04687 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[1] 28 |
104 |
Sargramostim |
Sargramostim |
D05803 |
[1] CSF2RA |
[4] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer |
[6] 6, 28, 60, 62, 96, 229 |
105 |
Siltuximab |
Siltuximab |
D09669 |
[1] IL6 |
[46] AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Amoebiasis, Antifolate resistance, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Malaria, Measles, NOD-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pertussis, Prion diseases, Rheumatoid arthritis, Salmonella infection, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection |
[2] 28, 331 |
106 |
Single infusion of 124i-labeled anti-amyloid mab 11-1f4: 2 mci (1 mg) |
- |
- |
- |
- |
[1] 28 |
107 |
Standard of care therapy |
- |
- |
- |
- |
[1] 28 |
108 |
Sunitinib |
Sunitinib |
D06402, D08552 |
[9] CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB, RET |
[36] Acute myeloid leukemia, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, Gap junction, Glioma, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, TNF signaling pathway, Thyroid cancer, Transcriptional misregulation in cancer, VEGF signaling pathway, Viral protein interaction with cytokine and cytokine receptor |
[2] 28, 34 |
109 |
Sunitinib malate |
Sunitinib |
D06402, D08552 |
[9] CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB, RET |
[36] Acute myeloid leukemia, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, Gap junction, Glioma, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, TNF signaling pathway, Thyroid cancer, Transcriptional misregulation in cancer, VEGF signaling pathway, Viral protein interaction with cytokine and cytokine receptor |
[1] 28 |
110 |
Tafamidis |
Tafamidis |
D09673 |
[1] TTR |
[1] Thyroid hormone synthesis |
[1] 28 |
111 |
Tafamidis meglumine |
Tafamidis |
D09673 |
[1] TTR |
[1] Thyroid hormone synthesis |
[1] 28 |
112 |
Tasmar |
Tolcapone |
D00786 |
[1] COMT |
[4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism |
[2] 6, 28 |
113 |
Tea extract |
Green tea leaf |
D06903 |
- |
- |
[1] 28 |
114 |
Thalidomide |
Thalidomide |
D00754 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 |
115 |
Thiotepa |
Thiotepa |
D00583 |
- |
- |
[11] 13, 19, 20, 28, 51, 60, 65, 85, 96, 164, 284 |
116 |
Tolcapone |
Tolcapone |
D00786 |
[1] COMT |
[4] Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism |
[3] 6, 28, 127 |
117 |
Valganciclovir |
Valganciclovir |
D02495 |
- |
- |
[6] 28, 60, 85, 97, 299, 331 |
118 |
Velcade |
Bortezomib |
D03150 |
[1] PSMB5 |
[1] Proteasome |
[1] 28 |
119 |
Velcade*1fl 3,5mg |
Bortezomib |
D03150 |
[1] PSMB5 |
[1] Proteasome |
[1] 28 |
120 |
Venetoclax |
Venetoclax |
D10679 |
[1] BCL2 |
[39] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Amyotrophic lateral sclerosis (ALS), Apoptosis, Apoptosis - multiple species, Autophagy - animal, Cholinergic synapse, Colorectal cancer, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Epstein-Barr virus infection, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, Gastric cancer, HIF-1 signaling pathway, Hedgehog signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Measles, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Necroptosis, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Platinum drug resistance, Prostate cancer, Protein processing in endoplasmic reticulum, Shigellosis, Small cell lung cancer, Sphingolipid signaling pathway, Toxoplasmosis, Tuberculosis, p53 signaling pathway |
[1] 28 |
121 |
Yttrium-90 |
Yttrium y-90 |
- |
- |
- |
[1] 28 |
122 |
Yttrium-90 radiolabelled anti-cd66 antibody |
Yttrium y-90 |
- |
- |
- |
[1] 28 |
123 |
Yttrium90 radiolabelled anticd66 |
Yttrium y-90 |
- |
- |
- |
[1] 28 |