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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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106 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adipocytokine signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 3  Adrenergic signaling in cardiomyocytes 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ADRB1, ADRB2   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 4  Alanine, aspartate and glutamate metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 5  Alzheimer disease 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 6  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 7  AMPK signaling pathway 
 4 genes, 4 drugs (DrugBank), 53 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 8  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 9  Apelin signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 10  Arachidonic acid metabolism 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 11  Autophagy - animal 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 12  Autophagy - other 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 13  Axon guidance 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 14  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 15  beta-Alanine metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 16  Bile secretion 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 17  Breast cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 18  Butanoate metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 19  C-type lectin receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 33 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 20  Calcium signaling pathway 
 8 genes, 2 drugs (DrugBank), 34 diseases shown 		  [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 21  cAMP signaling pathway 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ADRB1, ADRB2   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 22  Cellular senescence 
 6 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 23  Central carbon metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 24  cGMP-PKG signaling pathway 
 8 genes, 2 drugs (DrugBank), 34 diseases shown 		  [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 25  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 26  Choline metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 27  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 28  Colorectal cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 29  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADRB1   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 30  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 30 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 31  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 32  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 33  Endocrine resistance 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 34  ErbB signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 35  Fluid shear stress and atherosclerosis 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 36  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 37  GABAergic synapse 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 38  Gap junction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADRB1   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 39  Gastric cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 40  Glioma 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 41  Glucagon signaling pathway 
 7 genes, 2 drugs (DrugBank), 40 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 42  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 43  Growth hormone synthesis, secretion and action 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 44  Hepatocellular carcinoma 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 45  Herpes simplex virus 1 infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 46  HIF-1 signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 47  Human cytomegalovirus infection 
 7 genes, 4 drugs (DrugBank), 51 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 48  Human immunodeficiency virus 1 infection 
 6 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 49  Human papillomavirus infection 
 2 genes, 3 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 50  Human T-cell leukemia virus 1 infection 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 51  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 52  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 53  Insulin resistance 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 54  Insulin signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 55  JAK-STAT signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 56  Kaposi sarcoma-associated herpesvirus infection 
 7 genes, 4 drugs (DrugBank), 51 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 57  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 58  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 59  Longevity regulating pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 60  Longevity regulating pathway - multiple species 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 61  MAPK signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 62  Metabolic pathways 
 4 genes, 3 drugs (DrugBank), 23 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 63  MicroRNAs in cancer 
 2 genes, 3 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 64  Mineral absorption 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 65  mTOR signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 66  Natural killer cell mediated cytotoxicity 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 67  Neuroactive ligand-receptor interaction 
 5 genes, 2 drugs (DrugBank), 17 diseases shown 		  [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 68  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 69  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 70  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 71  Osteoclast differentiation 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 72  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 73  Oxytocin signaling pathway 
 8 genes, 3 drugs (DrugBank), 43 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 74  Pancreatic cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 75  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SLC12A2   D00247   Bumetanide   [2] 6, 158 
 76  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 77  Pathways in cancer 
 2 genes, 3 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 78  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 6 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 79  Phospholipase D signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 80  PI3K-Akt signaling pathway 
 3 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 81  Platelet activation 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS1   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 82  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 83  Prostate cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 84  Proteoglycans in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 85  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 86  Regulation of lipolysis in adipocytes 
 5 genes, 2 drugs (DrugBank), 14 diseases shown 		  [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 87  Renin secretion 
 8 genes, 2 drugs (DrugBank), 34 diseases shown 		  [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 88  Retrograde endocannabinoid signaling 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 89  Salivary secretion 
 4 genes, 2 drugs (DrugBank), 5 diseases shown 		  [3] ADRB1, ADRB2, ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] SLC12A2   D00247   Bumetanide   [2] 6, 158 
 90  Serotonergic synapse 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] PTGS1, PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 91  Shigellosis 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 92  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 93  T cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 94  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 95  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 96  Th17 cell differentiation 
 6 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 97  Thermogenesis 
 5 genes, 5 drugs (DrugBank), 56 diseases shown 		  [1] ADRB3   D00483   Propranolol   [5] 6, 158, 167, 227, 278 
 D08443 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 98  Thyroid hormone signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 99  Tight junction 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 100  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 101  Tuberculosis 
 6 genes, 2 drugs (DrugBank), 33 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] VDR   D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 102  Type II diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 103  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABAT   D00535   Vigabatrin   [2] 145, 158 
 104  VEGF signaling pathway 
 6 genes, 2 drugs (DrugBank), 33 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 105  Vibrio cholerae infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SLC12A2   D00247   Bumetanide   [2] 6, 158 
 106  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 

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