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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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39 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adrenergic signaling in cardiomyocytes 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 2  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 3  Alcoholism 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 4  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 5  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NR3C2   D01115   Eplerenone   [3] 75, 113, 215 
 6  Alzheimer disease 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 7  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 8  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 9  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 10  Calcium signaling pathway 
 6 genes, 3 drugs (DrugBank), 22 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 11  cAMP signaling pathway 
 6 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 12  cGMP-PKG signaling pathway 
 5 genes, 3 drugs (DrugBank), 28 diseases shown 		  [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 13  Circadian entrainment 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 14  Cocaine addiction 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 15  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 16  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 17  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 18  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 19  Dopaminergic synapse 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 20  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] OPRM1   D00320   Fentanyl   [5] 46, 70, 85, 215, 231 
 D01399 
 21  Gap junction 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 22  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 23  Huntington disease 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] GRIN1, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 24  Influenza A 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 25  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 26  Morphine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] OPRM1   D00320   Fentanyl   [5] 46, 70, 85, 215, 231 
 D01399 
 27  Neuroactive ligand-receptor interaction 
 12 genes, 6 drugs (DrugBank), 32 diseases shown 		  [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 [1] OPRM1   D00320   Fentanyl   [5] 46, 70, 85, 215, 231 
 D01399 
 [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 28  Nicotine addiction 
 5 genes, 1 drug (DrugBank), 6 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 29  Pathways in cancer 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 30  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 31  Rap1 signaling pathway 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 32  Ras signaling pathway 
 3 genes, 1 drug (DrugBank), 6 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 33  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 34  Renin secretion 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 35  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 36  Salivary secretion 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 37  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PLG   D01136   Tranexamic acid   [5] 46, 70, 215, 227, 288 
 38  Systemic lupus erythematosus 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] GRIN2A, GRIN2B   D00711   Ketamine   [6] 6, 13, 70, 113, 156, 215 
 D08098 
 39  Vascular smooth muscle contraction 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 

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