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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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34 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 2  Cell adhesion molecules (CAMs) 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 [1] PDCD1   D10574   Pembrolizumab   [1] 25 
 3  Cytokine-cytokine receptor interaction 
 3 genes, 3 drugs (DrugBank), 30 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 4  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 5  ECM-receptor interaction 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 6  Epstein-Barr virus infection 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 7  Focal adhesion 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 8  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 30 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 9  Hepatitis B 
 1 gene, 2 drugs (DrugBank), 7 diseases shown 		  [1] IFNAR1   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 10  Hepatitis C 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 11  Herpes simplex virus 1 infection 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 12  Human papillomavirus infection 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 13  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 14  Influenza A 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 15  Intestinal immune network for IgA production 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 16  JAK-STAT signaling pathway 
 3 genes, 3 drugs (DrugBank), 30 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 17  Kaposi sarcoma-associated herpesvirus infection 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 18  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 19  Leukocyte transendothelial migration 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 20  Measles 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 21  Metabolic pathways 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] DHODH   D10172   Teriflunomide   [2] 13, 25 
 22  Natural killer cell mediated cytotoxicity 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 23  Necroptosis 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 24  Neuroactive ligand-receptor interaction 
 1 gene, 2 drugs (DrugBank), 49 diseases shown 		  [1] NR3C1   D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 25  NOD-like receptor signaling pathway 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 26  Osteoclast differentiation 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 27  Pathways in cancer 
 3 genes, 3 drugs (DrugBank), 30 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 28  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PDCD1   D10574   Pembrolizumab   [1] 25 
 29  PI3K-Akt signaling pathway 
 4 genes, 4 drugs (DrugBank), 32 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 30  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] DHODH   D10172   Teriflunomide   [2] 13, 25 
 31  Regulation of actin cytoskeleton 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 
 32  T cell receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] PDCD1   D10574   Pembrolizumab   [1] 25 
 33  Toll-like receptor signaling pathway 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D02745   Interferon alfa-2b   [3] 25, 34, 227 
 34  Yersinia infection 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] ITGA4   D06886   Natalizumab   [6] 13, 15, 25, 46, 63, 96 

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