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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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140 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 2  Adherens junction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 3  Adipocytokine signaling pathway 
 2 genes, 4 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  African trypanosomiasis 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  AGE-RAGE signaling pathway in diabetic complications 
 3 genes, 4 drugs (DrugBank), 23 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 6  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 7  Aldosterone synthesis and secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 8  Allograft rejection 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Alzheimer disease 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amoebiasis 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  AMPK signaling pathway 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 12  Amyotrophic lateral sclerosis (ALS) 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Antifolate resistance 
 4 genes, 4 drugs (DrugBank), 42 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Apelin signaling pathway 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 16  Apoptosis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Asthma 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Autophagy - animal 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 19  Autophagy - other 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 20  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 21  Bladder cancer 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 22  Breast cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 23  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 24  C-type lectin receptor signaling pathway 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 25  Calcium signaling pathway 
 4 genes, 2 drugs (DrugBank), 16 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 26  Cellular senescence 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 27  Central carbon metabolism in cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 28  Chagas disease (American trypanosomiasis) 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 29  Choline metabolism in cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 30  Circadian entrainment 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 31  Colorectal cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 32  Cortisol synthesis and secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 33  Cushing syndrome 
 4 genes, 2 drugs (DrugBank), 16 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 34  Cytokine-cytokine receptor interaction 
 4 genes, 5 drugs (DrugBank), 44 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 35  Cytosolic DNA-sensing pathway 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 36  Dilated cardiomyopathy (DCM) 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 37  EGFR tyrosine kinase inhibitor resistance 
 5 genes, 7 drugs (DrugBank), 49 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 38  Endocrine resistance 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 39  Endocytosis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 40  Endometrial cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 41  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 42  Epstein-Barr virus infection 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 43  ErbB signaling pathway 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 44  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 45  Fc epsilon RI signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 46  Fluid shear stress and atherosclerosis 
 2 genes, 3 drugs (DrugBank), 23 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 47  Focal adhesion 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 48  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 49  FoxO signaling pathway 
 2 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 50  GABAergic synapse 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 51  Gap junction 
 10 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 52  Gastric cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 53  Glioma 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 54  GnRH secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 55  GnRH signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 56  Graft-versus-host disease 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 57  Growth hormone synthesis, secretion and action 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 58  Hematopoietic cell lineage 
 5 genes, 6 drugs (DrugBank), 63 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 59  Hepatitis B 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 60  Hepatitis C 
 2 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 61  Hepatocellular carcinoma 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 62  Herpes simplex virus 1 infection 
 3 genes, 5 drugs (DrugBank), 46 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  HIF-1 signaling pathway 
 5 genes, 7 drugs (DrugBank), 49 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 64  Human cytomegalovirus infection 
 6 genes, 8 drugs (DrugBank), 55 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 65  Human immunodeficiency virus 1 infection 
 2 genes, 4 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 66  Human papillomavirus infection 
 4 genes, 6 drugs (DrugBank), 47 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 67  Human T-cell leukemia virus 1 infection 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  IL-17 signaling pathway 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 70  Inflammatory bowel disease (IBD) 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 71  Influenza A 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 72  Insulin resistance 
 3 genes, 5 drugs (DrugBank), 46 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 73  Insulin signaling pathway 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 74  Intestinal immune network for IgA production 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 75  JAK-STAT signaling pathway 
 5 genes, 7 drugs (DrugBank), 57 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 76  Kaposi sarcoma-associated herpesvirus infection 
 3 genes, 5 drugs (DrugBank), 39 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 77  Legionellosis 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 78  Leishmaniasis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 79  Longevity regulating pathway 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 80  Longevity regulating pathway - multiple species 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 81  Malaria 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 82  MAPK signaling pathway 
 6 genes, 5 drugs (DrugBank), 32 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 83  Measles 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 84  Melanoma 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 85  Metabolic pathways 
 6 genes, 2 drugs (DrugBank), 43 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 86  MicroRNAs in cancer 
 3 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 87  mTOR signaling pathway 
 2 genes, 4 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 88  Natural killer cell mediated cytotoxicity 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  Necroptosis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  Neuroactive ligand-receptor interaction 
 1 gene, 1 drug (DrugBank), 44 diseases shown 		  [1] NR3C1   D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 91  NF-kappa B signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  NOD-like receptor signaling pathway 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  Non-alcoholic fatty liver disease (NAFLD) 
 3 genes, 4 drugs (DrugBank), 30 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 95  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 96  Osteoclast differentiation 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 97  Oxytocin signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 98  Pancreatic cancer 
 3 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 99  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 100  Pathogenic Escherichia coli infection 
 11 genes, 4 drugs (DrugBank), 21 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 101  Pathways in cancer 
 6 genes, 8 drugs (DrugBank), 58 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 102  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 103  Pertussis 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 104  Phagosome 
 9 genes, 1 drug (DrugBank), 4 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 105  Phospholipase D signaling pathway 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 106  PI3K-Akt signaling pathway 
 6 genes, 8 drugs (DrugBank), 58 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 107  Platinum drug resistance 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [2] TOP2A, TOP2B   D03899   Doxorubicin   [6] 26, 28, 34, 61, 63, 331 
 D00125   Etoposide   [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 108  Prion diseases 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 109  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 110  Prostate cancer 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 111  Proteasome 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 112  Proteoglycans in cancer 
 4 genes, 6 drugs (DrugBank), 47 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 113  Rap1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 114  Ras signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 115  Regulation of actin cytoskeleton 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 116  Relaxin signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 117  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 118  Rheumatoid arthritis 
 3 genes, 4 drugs (DrugBank), 23 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 119  RIG-I-like receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 120  Salmonella infection 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 121  Shigellosis 
 3 genes, 5 drugs (DrugBank), 46 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 122  Sphingolipid signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 123  Systemic lupus erythematosus 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 124  T cell receptor signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 125  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 126  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 127  Th17 cell differentiation 
 3 genes, 5 drugs (DrugBank), 48 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 128  Thermogenesis 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 129  Thyroid hormone signaling pathway 
 1 gene, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 130  TNF signaling pathway 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 131  Toll-like receptor signaling pathway 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 132  Toxoplasmosis 
 1 gene, 2 drugs (DrugBank), 19 diseases shown 		  [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 133  Transcriptional misregulation in cancer 
 1 gene, 2 drugs (DrugBank), 6 diseases shown 		  [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D09669   Siltuximab   [2] 28, 331 
 134  Tuberculosis 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 135  Type I diabetes mellitus 
 3 genes, 3 drugs (DrugBank), 29 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 136  Type II diabetes mellitus 
 3 genes, 5 drugs (DrugBank), 53 diseases shown 		  [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 137  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 138  VEGF signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 139  Viral protein interaction with cytokine and cytokine receptor 
 3 genes, 4 drugs (DrugBank), 30 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 140  Yersinia infection 
 2 genes, 3 drugs (DrugBank), 19 diseases shown 		  [1] IL6   D09669   Siltuximab   [2] 28, 331 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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