Home    Back

 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

A    B    C    D    E    F    G    H     I     J    K    L    M    N    O    P    Q    R    S    T    U    V    W    X    Y    Z    other

118 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 2 genes, 3 drugs (DrugBank), 32 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 2  African trypanosomiasis 
 5 genes, 5 drugs (DrugBank), 31 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 3  AGE-RAGE signaling pathway in diabetic complications 
 4 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 4  Allograft rejection 
 5 genes, 4 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 5  Alzheimer disease 
 7 genes, 4 drugs (DrugBank), 54 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 6  Amoebiasis 
 7 genes, 6 drugs (DrugBank), 38 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 7  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 8  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 3 drugs (DrugBank), 54 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 9  Antifolate resistance 
 5 genes, 5 drugs (DrugBank), 45 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 10  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 11  Apoptosis 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 12  Asthma 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 13  Autoimmune thyroid disease 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 14  Axon guidance 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 15  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 16  C-type lectin receptor signaling pathway 
 11 genes, 6 drugs (DrugBank), 56 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 17  Calcium signaling pathway 
 7 genes, 2 drugs (DrugBank), 53 diseases shown 		  [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 18  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRA   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 19  Cell adhesion molecules (CAMs) 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 20  Cellular senescence 
 6 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 21  cGMP-PKG signaling pathway 
 8 genes, 3 drugs (DrugBank), 58 diseases shown 		  [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] OPRD1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 22  Chagas disease (American trypanosomiasis) 
 5 genes, 5 drugs (DrugBank), 31 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 23  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 24  Cholinergic synapse 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 25  Cytokine-cytokine receptor interaction 
 12 genes, 11 drugs (DrugBank), 56 diseases shown 		  [1] CSF2RA   D09930   Mavrilimumab   [2] 41, 46 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 26  Cytosolic DNA-sensing pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 27  Dilated cardiomyopathy (DCM) 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 28  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 44 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 29  EGFR tyrosine kinase inhibitor resistance 
 4 genes, 5 drugs (DrugBank), 23 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 30  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 31  Epstein-Barr virus infection 
 3 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 32  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 33  Fc epsilon RI signaling pathway 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 34  Fluid shear stress and atherosclerosis 
 4 genes, 4 drugs (DrugBank), 36 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 35  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 36  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 37  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 38  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 39  Graft-versus-host disease 
 5 genes, 5 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 40  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 41  Hematopoietic cell lineage 
 8 genes, 9 drugs (DrugBank), 55 diseases shown 		  [1] CSF2RA   D09930   Mavrilimumab   [2] 41, 46 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 42  Hepatitis B 
 4 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 43  Hepatitis C 
 2 genes, 4 drugs (DrugBank), 32 diseases shown 		  [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 44  Herpes simplex virus 1 infection 
 7 genes, 7 drugs (DrugBank), 34 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 45  HIF-1 signaling pathway 
 2 genes, 3 drugs (DrugBank), 17 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 46  Human cytomegalovirus infection 
 11 genes, 10 drugs (DrugBank), 68 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 47  Human immunodeficiency virus 1 infection 
 6 genes, 3 drugs (DrugBank), 54 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 48  Human papillomavirus infection 
 2 genes, 4 drugs (DrugBank), 32 diseases shown 		  [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 49  Human T-cell leukemia virus 1 infection 
 11 genes, 8 drugs (DrugBank), 65 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 50  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 51  IL-17 signaling pathway 
 4 genes, 5 drugs (DrugBank), 29 diseases shown 		  [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 52  Inflammatory bowel disease (IBD) 
 7 genes, 6 drugs (DrugBank), 31 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 53  Inflammatory mediator regulation of TRP channels 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 54  Influenza A 
 8 genes, 8 drugs (DrugBank), 36 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 55  Insulin resistance 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 56  Intestinal immune network for IgA production 
 3 genes, 2 drugs (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 57  JAK-STAT signaling pathway 
 9 genes, 8 drugs (DrugBank), 46 diseases shown 		  [1] CSF2RA   D09930   Mavrilimumab   [2] 41, 46 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 58  Kaposi sarcoma-associated herpesvirus infection 
 9 genes, 5 drugs (DrugBank), 55 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 59  Legionellosis 
 5 genes, 5 drugs (DrugBank), 31 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 60  Leishmaniasis 
 6 genes, 6 drugs (DrugBank), 34 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 61  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 62  Malaria 
 4 genes, 5 drugs (DrugBank), 31 diseases shown 		  [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 63  MAPK signaling pathway 
 8 genes, 5 drugs (DrugBank), 62 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 64  Measles 
 5 genes, 5 drugs (DrugBank), 19 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 65  Melanogenesis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 66  Metabolic pathways 
 3 genes, 2 drugs (DrugBank), 35 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 67  Mineral absorption 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 68  Morphine addiction 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 69  mTOR signaling pathway 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 70  Natural killer cell mediated cytotoxicity 
 6 genes, 3 drugs (DrugBank), 54 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 71  Necroptosis 
 4 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 72  Neuroactive ligand-receptor interaction 
 6 genes, 7 drugs (DrugBank), 65 diseases shown 		  [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] NR3C1   D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D08416   Prednisone acetate   [6] 35, 40, 41, 49, 162, 224 
 D00385   Triamcinolone   [18] 6, 10, 13, 35, 40, 41, 42, 43, 44, 45, 46, 56, 70, 90, 96, 97, 226, 298 
 D00983 
 D00984 
 D00985 
 D06216 
 [3] OPRD1, OPRK1, OPRM1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 73  NF-kappa B signaling pathway 
 3 genes, 4 drugs (DrugBank), 36 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 74  NOD-like receptor signaling pathway 
 4 genes, 6 drugs (DrugBank), 32 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 75  Non-alcoholic fatty liver disease (NAFLD) 
 4 genes, 6 drugs (DrugBank), 38 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 76  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 77  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 78  Osteoclast differentiation 
 9 genes, 7 drugs (DrugBank), 65 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 79  Oxytocin signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 80  Pancreatic cancer 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 81  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 82  Pathogenic Escherichia coli infection 
 4 genes, 5 drugs (DrugBank), 36 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 83  Pathways in cancer 
 11 genes, 9 drugs (DrugBank), 50 diseases shown 		  [1] CSF2RA   D09930   Mavrilimumab   [2] 41, 46 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 84  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 8 genes, 4 drugs (DrugBank), 52 diseases shown 		  [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 85  Pertussis 
 6 genes, 5 drugs (DrugBank), 31 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 86  PI3K-Akt signaling pathway 
 5 genes, 6 drugs (DrugBank), 42 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 87  Prion diseases 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 88  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 89  Prostate cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 90  Proteoglycans in cancer 
 2 genes, 3 drugs (DrugBank), 31 diseases shown 		  [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 91  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 92  Renin secretion 
 6 genes, 2 drugs (DrugBank), 53 diseases shown 		  [1] EDNRA   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 93  Rheumatoid arthritis 
 7 genes, 7 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 94  RIG-I-like receptor signaling pathway 
 3 genes, 3 drugs (DrugBank), 31 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 95  Salmonella infection 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 96  Shigellosis 
 3 genes, 4 drugs (DrugBank), 36 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 97  Signaling pathways regulating pluripotency of stem cells 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 98  Sphingolipid signaling pathway 
 2 genes, 3 drugs (DrugBank), 33 diseases shown 		  [1] OPRD1   D02095   Naltrexone   [11] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97 
 D05113 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 99  Systemic lupus erythematosus 
 3 genes, 3 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 100  T cell receptor signaling pathway 
 7 genes, 4 drugs (DrugBank), 56 diseases shown 		  [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 101  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] FDPS   D00939   Alendronic acid   [7] 19, 41, 46, 50, 271, 274, 299 
 D07119 
 102  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 103  Th1 and Th2 cell differentiation 
 9 genes, 4 drugs (DrugBank), 53 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 104  Th17 cell differentiation 
 13 genes, 10 drugs (DrugBank), 64 diseases shown 		  [1] IL17A   D09967   Secukinumab   [7] 13, 37, 41, 46, 160, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 105  TNF signaling pathway 
 3 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 106  Toll-like receptor signaling pathway 
 7 genes, 6 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 107  Toxoplasmosis 
 5 genes, 5 drugs (DrugBank), 34 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 108  Transcriptional misregulation in cancer 
 3 genes, 3 drugs (DrugBank), 32 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 109  Tuberculosis 
 14 genes, 9 drugs (DrugBank), 60 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 110  Type I diabetes mellitus 
 6 genes, 5 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 111  Type II diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 112  Vascular smooth muscle contraction 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRA   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 113  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 114  Viral carcinogenesis 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 115  Viral myocarditis 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 116  Viral protein interaction with cytokine and cytokine receptor 
 3 genes, 5 drugs (DrugBank), 38 diseases shown 		  [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] IL6R   D10161   Sarilumab   [5] 41, 46, 84, 107, 271 
 D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 117  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 118  Yersinia infection 
 3 genes, 4 drugs (DrugBank), 28 diseases shown 		  [1] IL1B   D09911   Gevokizumab   [4] 41, 50, 56, 269 
 [1] IL6   D10080   Sirukumab   [2] 41, 46 
 [1] TNF   D02597   Adalimumab   [15] 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 

Back to top