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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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170 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 2  Adipocytokine signaling pathway 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 3  Adrenergic signaling in cardiomyocytes 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] SCN5A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 4  African trypanosomiasis 
 3 genes, 3 drugs (DrugBank), 34 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  AGE-RAGE signaling pathway in diabetic complications 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  Alcoholism 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 7  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 8  Allograft rejection 
 5 genes, 4 drugs (DrugBank), 43 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Alzheimer disease 
 6 genes, 4 drugs (DrugBank), 65 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amoebiasis 
 5 genes, 5 drugs (DrugBank), 35 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Amphetamine addiction 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 12  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 13  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 4 drugs (DrugBank), 65 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antifolate resistance 
 4 genes, 4 drugs (DrugBank), 46 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Apoptosis 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Asthma 
 2 genes, 3 drugs (DrugBank), 32 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Autoimmune thyroid disease 
 2 genes, 1 drug (DrugBank), 24 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 19  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 20  Axon guidance 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 21  B cell receptor signaling pathway 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 22  Bacterial invasion of epithelial cells 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 23  Breast cancer 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [2] ESR1, ESR2   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 24  C-type lectin receptor signaling pathway 
 11 genes, 7 drugs (DrugBank), 67 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 25  Calcium signaling pathway 
 9 genes, 5 drugs (DrugBank), 56 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [2] CHRM2, CHRM3   D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 26  cAMP signaling pathway 
 5 genes, 4 drugs (DrugBank), 10 diseases shown 		  [2] ADORA1, ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] CHRM2   D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 27  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 28  Cell adhesion molecules (CAMs) 
 4 genes, 3 drugs (DrugBank), 28 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 29  Cellular senescence 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 30  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 31  cGMP-PKG signaling pathway 
 7 genes, 3 drugs (DrugBank), 55 diseases shown 		  [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 32  Chagas disease (American trypanosomiasis) 
 5 genes, 5 drugs (DrugBank), 35 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 33  Chemokine signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 34  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 35  Cholinergic synapse 
 3 genes, 3 drugs (DrugBank), 5 diseases shown 		  [2] CHRM2, CHRM3   D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 36  Chronic myeloid leukemia 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 37  Cocaine addiction 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 38  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 39  Cytokine-cytokine receptor interaction 
 8 genes, 6 drugs (DrugBank), 44 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 40  Cytosolic DNA-sensing pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 41  Dilated cardiomyopathy (DCM) 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 42  Dopaminergic synapse 
 4 genes, 3 drugs (DrugBank), 58 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 43  Drug metabolism - other enzymes 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 44  EGFR tyrosine kinase inhibitor resistance 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 45  Endocrine and other factor-regulated calcium reabsorption 
 2 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] ESR1   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 46  Endocrine resistance 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [2] ESR1, ESR2   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 47  Endometrial cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 48  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 49  Epstein-Barr virus infection 
 5 genes, 6 drugs (DrugBank), 34 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 51  Estrogen signaling pathway 
 4 genes, 4 drugs (DrugBank), 10 diseases shown 		  [2] ESR1, ESR2   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 52  Fc epsilon RI signaling pathway 
 3 genes, 4 drugs (DrugBank), 33 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 53  Fc gamma R-mediated phagocytosis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 54  Fluid shear stress and atherosclerosis 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 55  Focal adhesion 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 56  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 57  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 58  Gastric acid secretion 
 1 gene, 2 drugs (DrugBank), 3 diseases shown 		  [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 59  Gastric cancer 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 60  Glioma 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 61  Glucagon signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 62  Glutamatergic synapse 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 63  GnRH secretion 
 2 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] ESR2   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 64  Graft-versus-host disease 
 3 genes, 3 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 65  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 66  Hematopoietic cell lineage 
 3 genes, 4 drugs (DrugBank), 59 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 67  Hepatitis B 
 4 genes, 5 drugs (DrugBank), 30 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Hepatitis C 
 4 genes, 5 drugs (DrugBank), 30 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 70  Herpes simplex virus 1 infection 
 7 genes, 6 drugs (DrugBank), 36 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 71  HIF-1 signaling pathway 
 3 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 72  Human cytomegalovirus infection 
 10 genes, 8 drugs (DrugBank), 69 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 73  Human immunodeficiency virus 1 infection 
 8 genes, 6 drugs (DrugBank), 65 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 74  Human papillomavirus infection 
 4 genes, 5 drugs (DrugBank), 30 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 75  Human T-cell leukemia virus 1 infection 
 11 genes, 8 drugs (DrugBank), 66 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 76  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 77  IL-17 signaling pathway 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 78  Inflammatory bowel disease (IBD) 
 5 genes, 4 drugs (DrugBank), 34 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 79  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 80  Influenza A 
 6 genes, 6 drugs (DrugBank), 36 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 81  Inositol phosphate metabolism 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 82  Insulin resistance 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  Insulin secretion 
 1 gene, 2 drugs (DrugBank), 3 diseases shown 		  [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 84  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 85  Intestinal immune network for IgA production 
 3 genes, 2 drugs (DrugBank), 25 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 86  JAK-STAT signaling pathway 
 6 genes, 4 drugs (DrugBank), 29 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 87  Kaposi sarcoma-associated herpesvirus infection 
 9 genes, 6 drugs (DrugBank), 62 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 88  Legionellosis 
 4 genes, 4 drugs (DrugBank), 34 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  Leishmaniasis 
 5 genes, 5 drugs (DrugBank), 35 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  Leukocyte transendothelial migration 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 91  Long-term potentiation 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 92  Longevity regulating pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 93  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 94  Malaria 
 3 genes, 4 drugs (DrugBank), 37 diseases shown 		  [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 95  MAPK signaling pathway 
 7 genes, 5 drugs (DrugBank), 65 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 96  Measles 
 5 genes, 4 drugs (DrugBank), 19 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 97  Melanoma 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 98  Metabolic pathways 
 6 genes, 6 drugs (DrugBank), 51 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 99  MicroRNAs in cancer 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 100  Mineral absorption 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 101  Morphine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 102  mTOR signaling pathway 
 2 genes, 3 drugs (DrugBank), 29 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 103  Natural killer cell mediated cytotoxicity 
 8 genes, 6 drugs (DrugBank), 66 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 104  Necroptosis 
 2 genes, 3 drugs (DrugBank), 29 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 105  Neuroactive ligand-receptor interaction 
 7 genes, 7 drugs (DrugBank), 55 diseases shown 		  [4] ADORA1, ADORA2A, ADORA2B, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [2] CHRM2, CHRM3   D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 [1] NR3C1   D00292   Dexamethasone   [20] 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00088   Hydrocortisone   [8] 6, 53, 75, 78, 81, 83, 97, 299 
 D00165   Hydrocortisone acetate   [8] 6, 53, 75, 78, 81, 83, 97, 299 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 106  Neurotrophin signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 107  NF-kappa B signaling pathway 
 5 genes, 5 drugs (DrugBank), 33 diseases shown 		  [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 108  NOD-like receptor signaling pathway 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 109  Non-alcoholic fatty liver disease (NAFLD) 
 4 genes, 5 drugs (DrugBank), 38 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 110  Non-small cell lung cancer 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 111  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 112  Oocyte meiosis 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 113  Osteoclast differentiation 
 9 genes, 7 drugs (DrugBank), 65 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 114  Oxytocin signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 115  Pancreatic cancer 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 116  Pancreatic secretion 
 1 gene, 2 drugs (DrugBank), 3 diseases shown 		  [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 117  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 15 diseases shown 		  [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 118  Parkinson disease 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 119  Pathogenic Escherichia coli infection 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 120  Pathways in cancer 
 12 genes, 8 drugs (DrugBank), 32 diseases shown 		  [3] AR, ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [2] ESR1, ESR2   D11513   Estetrol   [1] 53 
 D11514 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [2] RARA, RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 121  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 9 genes, 6 drugs (DrugBank), 57 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 122  Pertussis 
 5 genes, 4 drugs (DrugBank), 34 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 123  Phosphatidylinositol signaling system 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 124  Phospholipase D signaling pathway 
 2 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 125  PI3K-Akt signaling pathway 
 5 genes, 5 drugs (DrugBank), 23 diseases shown 		  [1] CHRM2   D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 126  Platelet activation 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 127  Platinum drug resistance 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 128  Progesterone-mediated oocyte maturation 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 129  Prolactin signaling pathway 
 4 genes, 4 drugs (DrugBank), 10 diseases shown 		  [2] ESR1, ESR2   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 130  Prostate cancer 
 3 genes, 3 drugs (DrugBank), 10 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 131  Proteoglycans in cancer 
 4 genes, 6 drugs (DrugBank), 38 diseases shown 		  [1] ESR1   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 132  Purine metabolism 
 2 genes, 3 drugs (DrugBank), 36 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 133  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 134  Rap1 signaling pathway 
 4 genes, 3 drugs (DrugBank), 12 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 135  Ras signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 136  Regulation of actin cytoskeleton 
 4 genes, 4 drugs (DrugBank), 12 diseases shown 		  [2] CHRM2, CHRM3   D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 137  Regulation of lipolysis in adipocytes 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 138  Relaxin signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 139  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 140  Renin secretion 
 6 genes, 3 drugs (DrugBank), 55 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 141  Rheumatoid arthritis 
 7 genes, 7 drugs (DrugBank), 46 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] LTB   D08866   Baminercept   [4] 13, 46, 53, 97 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 142  RIG-I-like receptor signaling pathway 
 4 genes, 4 drugs (DrugBank), 34 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 143  Salivary secretion 
 1 gene, 2 drugs (DrugBank), 3 diseases shown 		  [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 144  Salmonella infection 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 145  Shigellosis 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 146  Signaling pathways regulating pluripotency of stem cells 
 2 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 147  Small cell lung cancer 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 148  Sphingolipid signaling pathway 
 6 genes, 6 drugs (DrugBank), 35 diseases shown 		  [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] FCER1A   D05251   Omalizumab   [6] 53, 65, 98, 162, 226, 299 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 149  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 150  Systemic lupus erythematosus 
 3 genes, 3 drugs (DrugBank), 40 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 151  T cell receptor signaling pathway 
 9 genes, 7 drugs (DrugBank), 65 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 152  Taste transduction 
 4 genes, 3 drugs (DrugBank), 9 diseases shown 		  [1] CHRM3   D00661   Cevimeline   [1] 53 
 D07667 
 D00525   Pilocarpine   [3] 6, 53, 299 
 D02200 
 D05478 
 [3] SCN2A, SCN3A, SCN9A   D01450   Bupivacaine   [7] 46, 53, 70, 96, 168, 226, 298 
 D07552 
 153  TGF-beta signaling pathway 
 1 gene, 2 drugs (DrugBank), 28 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 154  Th1 and Th2 cell differentiation 
 9 genes, 5 drugs (DrugBank), 59 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 155  Th17 cell differentiation 
 10 genes, 7 drugs (DrugBank), 64 diseases shown 		  [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 156  Thyroid hormone signaling pathway 
 2 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] ESR1   D11513   Estetrol   [1] 53 
 D11514 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 157  TNF signaling pathway 
 4 genes, 4 drugs (DrugBank), 29 diseases shown 		  [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 158  Toll-like receptor signaling pathway 
 7 genes, 6 drugs (DrugBank), 44 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 159  Toxoplasmosis 
 5 genes, 5 drugs (DrugBank), 35 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 160  Transcriptional misregulation in cancer 
 3 genes, 3 drugs (DrugBank), 25 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 161  Tuberculosis 
 12 genes, 8 drugs (DrugBank), 69 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VDR   D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 162  Type I diabetes mellitus 
 6 genes, 4 drugs (DrugBank), 43 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 163  Type II diabetes mellitus 
 2 genes, 3 drugs (DrugBank), 29 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 164  Vascular smooth muscle contraction 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 165  VEGF signaling pathway 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 166  Viral carcinogenesis 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] JAK1   D10871   Filgotinib   [6] 46, 53, 96, 97, 222, 271 
 [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 167  Viral myocarditis 
 3 genes, 2 drugs (DrugBank), 27 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 168  Viral protein interaction with cytokine and cytokine receptor 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 169  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 170  Yersinia infection 
 3 genes, 4 drugs (DrugBank), 29 diseases shown 		  [1] NFKB1   D01146   Iguratimod   [3] 46, 53, 271 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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