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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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137 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 2  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 4  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 5  Alzheimer disease 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 6  Amoebiasis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 7  Amphetamine addiction 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 8  AMPK signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 9  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 10  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 11  Apoptosis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 12  Autophagy - animal 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 13  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 14  Axon guidance 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 15  B cell receptor signaling pathway 
 8 genes, 5 drugs (DrugBank), 56 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 16  Bacterial invasion of epithelial cells 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 17  Breast cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 18  C-type lectin receptor signaling pathway 
 7 genes, 4 drugs (DrugBank), 56 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 19  Calcium signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 20  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 21  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 22  Cell adhesion molecules (CAMs) 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 23  Cellular senescence 
 7 genes, 4 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 24  Central carbon metabolism in cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 25  cGMP-PKG signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 26  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 27  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 28  Choline metabolism in cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 29  Cholinergic synapse 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 30  Chronic myeloid leukemia 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 31  Colorectal cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 32  Complement and coagulation cascades 
 3 genes, 2 drugs (DrugBank), 1 disease shown 		  [3] C1R, C1S, KLKB1   D10845   Conestat alfa   [1] 61 
 [1] C1S   D11530   Sutimlimab   [1] 61 
 33  Dopaminergic synapse 
 3 genes, 2 drugs (DrugBank), 55 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 34  Drug metabolism - other enzymes 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 35  EGFR tyrosine kinase inhibitor resistance 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 36  Endocrine resistance 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 37  Endometrial cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 38  Epstein-Barr virus infection 
 4 genes, 4 drugs (DrugBank), 12 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 39  ErbB signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 40  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 41  Fc epsilon RI signaling pathway 
 3 genes, 3 drugs (DrugBank), 7 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 42  Fc gamma R-mediated phagocytosis 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 43  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 44  Focal adhesion 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 45  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 46  Gap junction 
 9 genes, 1 drug (DrugBank), 4 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 47  Gastric cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 48  Glioma 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 49  Glucagon signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 50  Glutamatergic synapse 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 51  Glutathione metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 52  GnRH secretion 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 53  Growth hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 54  Hematopoietic cell lineage 
 1 gene, 1 drug (DrugBank), 42 diseases shown 		  [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 55  Hepatitis B 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 56  Hepatitis C 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 57  Hepatocellular carcinoma 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 58  Herpes simplex virus 1 infection 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 59  HIF-1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 60  Human cytomegalovirus infection 
 7 genes, 4 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 61  Human immunodeficiency virus 1 infection 
 7 genes, 4 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 62  Human papillomavirus infection 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 63  Human T-cell leukemia virus 1 infection 
 7 genes, 4 drugs (DrugBank), 57 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 64  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 65  Influenza A 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 66  Inositol phosphate metabolism 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 67  Insulin resistance 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 68  Insulin signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 69  JAK-STAT signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 70  Kaposi sarcoma-associated herpesvirus infection 
 8 genes, 5 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 71  Leukocyte transendothelial migration 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 72  Long-term potentiation 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 73  Longevity regulating pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 74  Longevity regulating pathway - multiple species 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 75  Malaria 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 76  MAPK signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 77  Measles 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 78  Melanoma 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 79  Metabolic pathways 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 80  MicroRNAs in cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 81  mTOR signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 82  Natural killer cell mediated cytotoxicity 
 8 genes, 5 drugs (DrugBank), 57 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 83  Neuroactive ligand-receptor interaction 
 1 gene, 2 drugs (DrugBank), 53 diseases shown 		  [1] NR3C1   D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 84  Neurotrophin signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 85  NF-kappa B signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 86  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 87  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 88  Oocyte meiosis 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 89  Osteoclast differentiation 
 8 genes, 5 drugs (DrugBank), 56 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 90  Oxytocin signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 91  Pancreatic cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 92  Pathogenic Escherichia coli infection 
 9 genes, 1 drug (DrugBank), 4 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 93  Pathways in cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 94  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 7 genes, 4 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 95  Pertussis 
 2 genes, 2 drugs (DrugBank), 1 disease shown 		  [2] C1R, C1S   D10845   Conestat alfa   [1] 61 
 [1] C1S   D11530   Sutimlimab   [1] 61 
 96  Phagosome 
 10 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] C1R   D10845   Conestat alfa   [1] 61 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 97  Phosphatidylinositol signaling system 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 98  Phospholipase D signaling pathway 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 99  PI3K-Akt signaling pathway 
 3 genes, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 100  Platelet activation 
 3 genes, 3 drugs (DrugBank), 7 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 101  Platinum drug resistance 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [2] TOP2A, TOP2B   D03899   Doxorubicin   [6] 26, 28, 34, 61, 63, 331 
 102  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] BTK   D10223   Ibrutinib   [2] 28, 61 
 103  Progesterone-mediated oocyte maturation 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 104  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 105  Prostate cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 106  Proteasome 
 1 gene, 2 drugs (DrugBank), 15 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 D10130   Ixazomib   [4] 13, 16, 28, 61 
 107  Proteoglycans in cancer 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 108  Purine metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 109  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 110  Rap1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 111  Ras signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 112  Regulation of actin cytoskeleton 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 113  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 114  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 115  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 116  Renin secretion 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 117  Rheumatoid arthritis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 118  Shigellosis 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 119  Signaling pathways regulating pluripotency of stem cells 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 120  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 121  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 122  Staphylococcus aureus infection 
 3 genes, 3 drugs (DrugBank), 9 diseases shown 		  [2] C1R, C1S   D10845   Conestat alfa   [1] 61 
 [1] C1S   D11530   Sutimlimab   [1] 61 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 123  Systemic lupus erythematosus 
 2 genes, 2 drugs (DrugBank), 1 disease shown 		  [2] C1R, C1S   D10845   Conestat alfa   [1] 61 
 [1] C1S   D11530   Sutimlimab   [1] 61 
 124  T cell receptor signaling pathway 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 125  Th1 and Th2 cell differentiation 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 126  Th17 cell differentiation 
 6 genes, 3 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 127  Thermogenesis 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 128  Thyroid hormone signaling pathway 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 129  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 130  Toll-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 131  Tuberculosis 
 6 genes, 3 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 132  Type II diabetes mellitus 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 133  VEGF signaling pathway 
 6 genes, 3 drugs (DrugBank), 56 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 134  Viral carcinogenesis 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 135  Viral myocarditis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 136  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 137  Yersinia infection 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] PIK3CD   D11437   Parsaclisib   [3] 35, 53, 61 

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