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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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182 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 3 drugs (DrugBank), 39 diseases shown 		  [1] KIT   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adherens junction 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [3] FYN, SRC, YES1   D03658   Dasatinib   [1] 85 
 D06414 
 3  Adipocytokine signaling pathway 
 2 genes, 6 drugs (DrugBank), 61 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  Adrenergic signaling in cardiomyocytes 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 5  African trypanosomiasis 
 4 genes, 5 drugs (DrugBank), 41 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  AGE-RAGE signaling pathway in diabetic complications 
 10 genes, 8 drugs (DrugBank), 55 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 7  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 8  Allograft rejection 
 2 genes, 5 drugs (DrugBank), 41 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Alzheimer disease 
 7 genes, 6 drugs (DrugBank), 56 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amoebiasis 
 7 genes, 6 drugs (DrugBank), 42 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 12  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 13  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 6 drugs (DrugBank), 56 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antifolate resistance 
 3 genes, 5 drugs (DrugBank), 41 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Antigen processing and presentation 
 1 gene, 5 drugs (DrugBank), 41 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Apelin signaling pathway 
 3 genes, 3 drugs (DrugBank), 45 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CCN2   D10969   Pamrevlumab   [2] 85, 113 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 17  Apoptosis 
 1 gene, 5 drugs (DrugBank), 41 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Arachidonic acid metabolism 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ALOX5   D00414   Zileuton   [3] 85, 160, 164 
 19  Asthma 
 3 genes, 7 drugs (DrugBank), 41 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 20  Autoimmune thyroid disease 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 21  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 22  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 23  Axon guidance 
 10 genes, 4 drugs (DrugBank), 36 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [4] ABL1, EPHA2, FYN, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SMO   D09992   Vismodegib   [1] 85 
 24  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 25  Bacterial invasion of epithelial cells 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 26  Basal cell carcinoma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SMO   D09992   Vismodegib   [1] 85 
 27  Bladder cancer 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 28  Breast cancer 
 4 genes, 4 drugs (DrugBank), 40 diseases shown 		  [2] FGFR1, FLT4   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] KIT   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 29  C-type lectin receptor signaling pathway 
 10 genes, 7 drugs (DrugBank), 56 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 30  Calcium signaling pathway 
 13 genes, 13 drugs (DrugBank), 55 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CYSLTR1   D00529   Montelukast   [5] 13, 46, 85, 98, 228 
 D08229 
 D06659   Tipelukast   [1] 85 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] P2RX3   D11349   Gefapixant   [2] 85, 226 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 31  cAMP signaling pathway 
 3 genes, 6 drugs (DrugBank), 26 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 32  Cell adhesion molecules (CAMs) 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CD274   D10773   Atezolizumab   [1] 85 
 33  Cell cycle 
 4 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] ABL1   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 34  Cellular senescence 
 11 genes, 5 drugs (DrugBank), 54 diseases shown 		  [2] IL1A, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 35  Central carbon metabolism in cancer 
 7 genes, 4 drugs (DrugBank), 40 diseases shown 		  [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] KIT, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 36  cGMP-PKG signaling pathway 
 11 genes, 9 drugs (DrugBank), 55 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] OPRD1   D00843   Nalbuphine   [1] 85 
 D08246 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 37  Chagas disease (American trypanosomiasis) 
 10 genes, 7 drugs (DrugBank), 46 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 38  Chemokine signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] CCL2   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 39  Choline metabolism in cancer 
 3 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 40  Cholinergic synapse 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] FYN   D03658   Dasatinib   [1] 85 
 D06414 
 41  Chronic myeloid leukemia 
 4 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] ABL1   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 42  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 43  Colorectal cancer 
 4 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 44  Complement and coagulation cascades 
 1 gene, 2 drugs (DrugBank), 2 diseases shown 		  [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 45  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 46  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 47  Cytokine-cytokine receptor interaction 
 14 genes, 10 drugs (DrugBank), 56 diseases shown 		  [6] CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 48  Cytosolic DNA-sensing pathway 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 49  Dilated cardiomyopathy (DCM) 
 4 genes, 6 drugs (DrugBank), 42 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 30 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 51  Drug metabolism - other enzymes 
 4 genes, 4 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 52  EGFR tyrosine kinase inhibitor resistance 
 9 genes, 7 drugs (DrugBank), 45 diseases shown 		  [5] FGFR2, FGFR3, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRB, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 53  Endocrine resistance 
 2 genes, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 54  Endocytosis 
 4 genes, 3 drugs (DrugBank), 12 diseases shown 		  [3] FGFR2, FGFR3, PDGFRA   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 55  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 56  Epstein-Barr virus infection 
 2 genes, 5 drugs (DrugBank), 41 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 57  ErbB signaling pathway 
 3 genes, 3 drugs (DrugBank), 39 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 58  Estrogen signaling pathway 
 2 genes, 3 drugs (DrugBank), 5 diseases shown 		  [1] OPRM1   D00320   Fentanyl   [5] 46, 70, 85, 215, 231 
 D01399 
 D00843   Nalbuphine   [1] 85 
 D08246 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 59  Fc epsilon RI signaling pathway 
 4 genes, 9 drugs (DrugBank), 42 diseases shown 		  [1] ALOX5   D00414   Zileuton   [3] 85, 160, 164 
 [1] FYN   D03658   Dasatinib   [1] 85 
 D06414 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 60  Fluid shear stress and atherosclerosis 
 8 genes, 9 drugs (DrugBank), 50 diseases shown 		  [4] CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 61  Focal adhesion 
 8 genes, 4 drugs (DrugBank), 15 diseases shown 		  [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [3] FYN, PDGFRB, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 62  FoxO signaling pathway 
 5 genes, 3 drugs (DrugBank), 14 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 63  GABAergic synapse 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 64  Gap junction 
 12 genes, 4 drugs (DrugBank), 12 diseases shown 		  [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] PDGFRB, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00491   Paclitaxel   [2] 46, 85 
 D05333 
 65  Gastric acid secretion 
 3 genes, 2 drugs (DrugBank), 21 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 66  Gastric cancer 
 5 genes, 3 drugs (DrugBank), 38 diseases shown 		  [1] FGFR2   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 67  Glioma 
 3 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 68  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 69  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 70  Glutathione metabolism 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 71  GnRH signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 72  Graft-versus-host disease 
 4 genes, 5 drugs (DrugBank), 41 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 73  Growth hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 40 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 74  Hedgehog signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SMO   D09992   Vismodegib   [1] 85 
 75  Hematopoietic cell lineage 
 7 genes, 9 drugs (DrugBank), 70 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] KIT   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 76  Hepatitis B 
 6 genes, 7 drugs (DrugBank), 42 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 77  Hepatitis C 
 1 gene, 5 drugs (DrugBank), 41 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 78  Hepatocellular carcinoma 
 5 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 79  Herpes simplex virus 1 infection 
 9 genes, 8 drugs (DrugBank), 65 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 80  HIF-1 signaling pathway 
 6 genes, 6 drugs (DrugBank), 48 diseases shown 		  [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 81  Hippo signaling pathway 
 4 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] CCN2   D10969   Pamrevlumab   [2] 85, 113 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 82  Human cytomegalovirus infection 
 13 genes, 11 drugs (DrugBank), 69 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 83  Human immunodeficiency virus 1 infection 
 7 genes, 7 drugs (DrugBank), 68 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 84  Human papillomavirus infection 
 4 genes, 9 drugs (DrugBank), 62 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 85  Human T-cell leukemia virus 1 infection 
 12 genes, 8 drugs (DrugBank), 57 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Hypertrophic cardiomyopathy (HCM) 
 5 genes, 6 drugs (DrugBank), 42 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  IL-17 signaling pathway 
 5 genes, 7 drugs (DrugBank), 41 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 88  Inflammatory bowel disease (IBD) 
 11 genes, 9 drugs (DrugBank), 46 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  Inflammatory mediator regulation of TRP channels 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] IL1B   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 90  Influenza A 
 7 genes, 6 drugs (DrugBank), 45 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 91  Insulin resistance 
 3 genes, 6 drugs (DrugBank), 61 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 93  Intestinal immune network for IgA production 
 3 genes, 3 drugs (DrugBank), 14 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 94  JAK-STAT signaling pathway 
 9 genes, 10 drugs (DrugBank), 60 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 95  Kaposi sarcoma-associated herpesvirus infection 
 10 genes, 7 drugs (DrugBank), 57 diseases shown 		  [1] IFNGR1   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 96  Legionellosis 
 3 genes, 5 drugs (DrugBank), 41 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 97  Leishmaniasis 
 9 genes, 7 drugs (DrugBank), 46 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [4] IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 98  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 99  Longevity regulating pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 100  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 101  Malaria 
 8 genes, 6 drugs (DrugBank), 42 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  MAPK signaling pathway 
 22 genes, 11 drugs (DrugBank), 59 diseases shown 		  [3] EPHA2, KIT, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 103  Measles 
 3 genes, 2 drugs (DrugBank), 13 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 104  Melanogenesis 
 2 genes, 4 drugs (DrugBank), 17 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] KIT   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 105  Melanoma 
 3 genes, 3 drugs (DrugBank), 12 diseases shown 		  [3] FGFR1, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 106  Metabolic pathways 
 10 genes, 8 drugs (DrugBank), 57 diseases shown 		  [1] ALOX5   D00414   Zileuton   [3] 85, 160, 164 
 [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 107  MicroRNAs in cancer 
 7 genes, 6 drugs (DrugBank), 42 diseases shown 		  [2] ABL1, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [3] FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 108  Mitophagy - animal 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 109  Morphine addiction 
 1 gene, 2 drugs (DrugBank), 5 diseases shown 		  [1] OPRM1   D00320   Fentanyl   [5] 46, 70, 85, 215, 231 
 D01399 
 D00843   Nalbuphine   [1] 85 
 D08246 
 110  mTOR signaling pathway 
 2 genes, 6 drugs (DrugBank), 61 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 111  Natural killer cell mediated cytotoxicity 
 10 genes, 8 drugs (DrugBank), 59 diseases shown 		  [2] FYN, LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 112  Necroptosis 
 5 genes, 6 drugs (DrugBank), 45 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 113  Neuroactive ligand-receptor interaction 
 13 genes, 19 drugs (DrugBank), 78 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] CYSLTR1   D00529   Montelukast   [5] 13, 46, 85, 98, 228 
 D08229 
 D06659   Tipelukast   [1] 85 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 [1] NR3C1   D00246   Budesonide   [10] 66, 85, 93, 94, 95, 96, 97, 98, 228, 299 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 [3] OPRD1, OPRK1, OPRM1   D00843   Nalbuphine   [1] 85 
 D08246 
 [1] OPRM1   D00320   Fentanyl   [5] 46, 70, 85, 215, 231 
 D01399 
 [1] P2RX3   D11349   Gefapixant   [2] 85, 226 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 114  Neurotrophin signaling pathway 
 1 gene, 2 drugs (DrugBank), 11 diseases shown 		  [1] ABL1   D03658   Dasatinib   [1] 85 
 D06414 
 D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 115  NF-kappa B signaling pathway 
 4 genes, 6 drugs (DrugBank), 41 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 116  NOD-like receptor signaling pathway 
 4 genes, 5 drugs (DrugBank), 41 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 117  Non-alcoholic fatty liver disease (NAFLD) 
 5 genes, 6 drugs (DrugBank), 42 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 118  Oocyte meiosis 
 6 genes, 3 drugs (DrugBank), 30 diseases shown 		  [1] AR   D08250   Nandrolone   [2] 60, 85 
 D00955   Nandrolone decanoate   [2] 60, 85 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 119  Osteoclast differentiation 
 14 genes, 9 drugs (DrugBank), 60 diseases shown 		  [2] FYN, LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 120  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ALOX5   D00414   Zileuton   [3] 85, 160, 164 
 121  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 15 diseases shown 		  [2] ATP4A, ATP4B   D00455   Omeprazole   [15] 6, 8, 13, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 
 D01207 
 D05259 
 D05261 
 122  Oxytocin signaling pathway 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 123  p53 signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 124  Pancreatic cancer 
 5 genes, 3 drugs (DrugBank), 39 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 125  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 126  Pathogenic Escherichia coli infection 
 15 genes, 10 drugs (DrugBank), 46 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, FYN   D03658   Dasatinib   [1] 85 
 D06414 
 [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00491   Paclitaxel   [2] 46, 85 
 D05333 
 127  Pathways in cancer 
 25 genes, 22 drugs (DrugBank), 71 diseases shown 		  [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [3] ABL1, KIT, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] AR   D08250   Nandrolone   [2] 60, 85 
 D00955   Nandrolone decanoate   [2] 60, 85 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 [6] FGFR1, FGFR2, FGFR3, FLT4, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] SMO   D09992   Vismodegib   [1] 85 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 128  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 10 genes, 5 drugs (DrugBank), 52 diseases shown 		  [1] CD274   D10773   Atezolizumab   [1] 85 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 129  Pertussis 
 5 genes, 5 drugs (DrugBank), 41 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 130  Phagosome 
 9 genes, 1 drug (DrugBank), 2 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00491   Paclitaxel   [2] 46, 85 
 D05333 
 131  Phospholipase D signaling pathway 
 7 genes, 7 drugs (DrugBank), 50 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 [3] FYN, KIT, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 132  PI3K-Akt signaling pathway 
 14 genes, 8 drugs (DrugBank), 55 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [3] EPHA2, KIT, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 133  Platelet activation 
 4 genes, 5 drugs (DrugBank), 6 diseases shown 		  [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 [2] FYN, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 134  Platinum drug resistance 
 2 genes, 1 drug (DrugBank), 11 diseases shown 		  [2] TOP2A, TOP2B   D00125   Etoposide   [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 135  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] LCK   D03658   Dasatinib   [1] 85 
 D06414 
 136  Prion diseases 
 4 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] FYN   D03658   Dasatinib   [1] 85 
 D06414 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 137  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 138  Prostate cancer 
 6 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] AR   D08250   Nandrolone   [2] 60, 85 
 D00955   Nandrolone decanoate   [2] 60, 85 
 [4] FGFR1, FGFR2, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 139  Proteoglycans in cancer 
 9 genes, 11 drugs (DrugBank), 63 diseases shown 		  [2] FGFR1, KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SMO   D09992   Vismodegib   [1] 85 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [2] TGFB1, TGFB2   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 140  Purine metabolism 
 5 genes, 5 drugs (DrugBank), 49 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 141  Pyrimidine metabolism 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] RRM1   D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 [1] RRM2   D00341   Hydroxyurea   [8] 3, 13, 19, 20, 65, 85, 86, 284 
 142  Rap1 signaling pathway 
 12 genes, 4 drugs (DrugBank), 15 diseases shown 		  [4] EPHA2, KIT, PDGFRB, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 143  Ras signaling pathway 
 12 genes, 4 drugs (DrugBank), 15 diseases shown 		  [4] ABL1, EPHA2, KIT, PDGFRB   D03658   Dasatinib   [1] 85 
 D06414 
 [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 144  Regulation of actin cytoskeleton 
 7 genes, 5 drugs (DrugBank), 13 diseases shown 		  [1] F2   D09707   Dabigatran   [2] 85, 91 
 D06410   Thrombomodulin Alfa   [1] 85 
 [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRB, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 145  Regulation of lipolysis in adipocytes 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 146  Relaxin signaling pathway 
 4 genes, 5 drugs (DrugBank), 18 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 147  Renal cell carcinoma 
 4 genes, 2 drugs (DrugBank), 12 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 148  Renin secretion 
 8 genes, 7 drugs (DrugBank), 50 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 149  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 150  Rheumatoid arthritis 
 10 genes, 8 drugs (DrugBank), 46 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 151  RIG-I-like receptor signaling pathway 
 1 gene, 5 drugs (DrugBank), 41 diseases shown 		  [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 152  Salivary secretion 
 1 gene, 2 drugs (DrugBank), 14 diseases shown 		  [1] ADRB2   D01373   Formoterol   [4] 85, 228, 299, 306 
 D05277 
 D07990 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 153  Salmonella infection 
 5 genes, 3 drugs (DrugBank), 18 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 154  Serotonergic synapse 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] ALOX5   D00414   Zileuton   [3] 85, 160, 164 
 155  Shigellosis 
 5 genes, 8 drugs (DrugBank), 62 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 156  Signaling pathways regulating pluripotency of stem cells 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] FGFR1, FGFR2, FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 157  Sphingolipid signaling pathway 
 3 genes, 7 drugs (DrugBank), 41 diseases shown 		  [1] FYN   D03658   Dasatinib   [1] 85 
 D06414 
 [1] OPRD1   D00843   Nalbuphine   [1] 85 
 D08246 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 158  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 159  Systemic lupus erythematosus 
 3 genes, 6 drugs (DrugBank), 42 diseases shown 		  [1] ELANE   D03788   Sivelestat   [3] 13, 85, 96 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 160  T cell receptor signaling pathway 
 9 genes, 7 drugs (DrugBank), 56 diseases shown 		  [2] FYN, LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 161  Taste transduction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] P2RX3   D11349   Gefapixant   [2] 85, 226 
 162  TGF-beta signaling pathway 
 4 genes, 6 drugs (DrugBank), 42 diseases shown 		  [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 163  Th1 and Th2 cell differentiation 
 9 genes, 5 drugs (DrugBank), 33 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [1] IL13   D09633   Lebrikizumab   [1] 85 
 D09979   Tralokinumab   [2] 85, 97 
 [1] LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 164  Th17 cell differentiation 
 12 genes, 7 drugs (DrugBank), 57 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] IL6   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] LCK   D03658   Dasatinib   [1] 85 
 D06414 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TGFB1   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 165  Thermogenesis 
 2 genes, 2 drugs (DrugBank), 37 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 166  Thyroid hormone signaling pathway 
 2 genes, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 167  Tight junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 168  TNF signaling pathway 
 5 genes, 5 drugs (DrugBank), 41 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 169  Toll-like receptor signaling pathway 
 3 genes, 5 drugs (DrugBank), 41 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 170  Toxoplasmosis 
 8 genes, 8 drugs (DrugBank), 47 diseases shown 		  [1] ALOX5   D00414   Zileuton   [3] 85, 160, 164 
 [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 171  Transcriptional misregulation in cancer 
 3 genes, 4 drugs (DrugBank), 16 diseases shown 		  [1] ELANE   D03788   Sivelestat   [3] 13, 85, 96 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 172  Tuberculosis 
 16 genes, 9 drugs (DrugBank), 60 diseases shown 		  [2] IFNGR1, IFNGR2   D00747   Interferon gamma-1b   [7] 65, 85, 90, 228, 299, 301, 326 
 [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [3] TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   [4] 51, 85, 222, 274 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 173  Type I diabetes mellitus 
 4 genes, 5 drugs (DrugBank), 41 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 174  Type II diabetes mellitus 
 2 genes, 6 drugs (DrugBank), 61 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 175  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 176  Vascular smooth muscle contraction 
 3 genes, 6 drugs (DrugBank), 26 diseases shown 		  [1] AGTR1   D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 D10135   Macitentan   [5] 51, 85, 86, 88, 210 
 [1] PTGIR   D02721   Iloprost   [4] 51, 84, 85, 86 
 D06213   Treprostinil   [5] 51, 84, 85, 86, 88 
 177  VEGF signaling pathway 
 8 genes, 4 drugs (DrugBank), 36 diseases shown 		  [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 178  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] SRC   D03658   Dasatinib   [1] 85 
 D06414 
 179  Viral myocarditis 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, FYN   D03658   Dasatinib   [1] 85 
 D06414 
 180  Viral protein interaction with cytokine and cytokine receptor 
 5 genes, 5 drugs (DrugBank), 41 diseases shown 		  [4] CCL2, IL10, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LTA, TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 181  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 182  Yersinia infection 
 7 genes, 6 drugs (DrugBank), 41 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [2] IL6, TNF   D08976   Pomalidomide   [6] 28, 34, 51, 85, 227, 331 
 [2] LCK, SRC   D03658   Dasatinib   [1] 85 
 D06414 
 [1] TNF   D00742   Etanercept   [15] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 
 D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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