[
Japanese
/ English ]
Data ver.
Nov2019
- Update: Mar 30, 2021
curr ver.
Disease
Sitemap
Drug
Sitemap
Target Gene/Pathway
Sitemap
News
Mar 30, 2021: This version became obsolete and available for a limited time (Close date: TBA).
Sep 25, 2020:
DDrare - Database of developing drugs, target genes and pathways for rare diseases -
is added to
References
.
Sep 25, 2020: Sitemaps for the three entrances (
Disease
,
Drug
and
Target Gene/Pathway
) are equipped.
Sep 9, 2020: A few drug names were corrected (12,172 drugs -> 12,170 drugs).
Jun 29, 2020: Drugs and target genes shown in Target Gene/Pathway for each disease are now limited to those for the diesase (i.e. Drugs and target genes only for other diseases in a pathway are not shown.). (e.g.
Spinal and bulbar muscular atrophy
)
Jun 22, 2020: English version has opened.
About
DDrare
(
Database of
D
rug
D
evelopment for
Rare
Diseases
)
is a database that provides information on drugs developed in clinical trials, and their target genes and pathways, targeting the intractable diseases (mostly rare diseases) designated by the Ministry of Health, Labour and Welfare (MHLW), Japan. A list of disease names in English, including synonyms and subclass names, was created for the diseases of MHLW (333 diseases on Nov 2019). Using the list as a query, data of clinical trials with drug information (DrugBank) was extracted from four major clinical trial registries: JPRN (Japan), ClinicalTrials.gov (US), EU-CTR (Europe), and ChiCTR (China), through WHO-ICTRP website. Information of drug target genes and pathways (KEGG) is associated with the extracted drug information. This enables cross-reference of disease, drug, and target gene/pathway information, to be utilized for drug discovery research, especially for drug repositioning.
- External link
Intractable diseases designated by the MHLW
(in Japanese)
Downloaded in Nov 2019
Japan Intractable Disease Information Center
(in Japanese)
Referred in Nov 2019
WHO International Clinical Trials Registry Platform (WHO ICTRP)
Downloaded in Nov 2019
- Disease names were searched in "Public title", "Scientific title" and "Condition."
- Recruitment status: ALL
-
Japan Primary Registries Network (JPRN)
,
ClinicalTrials.gov
,
EU Clinical Trials Register (EU-CTR)
and
Chinese Clinical Trial Register (ChiCTR)
, all with drug information in "Intervention."
DrugBank
Release Version 5.1.4 (The latest on Nov 2019)
- Name and synonyms were searched in "Intervention."
KEGG
Downloaded in Nov 2019
References
Research Paper
Trends of Clinical Trials for Drug Development in Rare Diseases.
Curr Clin Pharmacol.
2018
Office of Pharmaceutical Industry Research (OPIR) News Views and Actions
(in Japanese)
Trends in clinical trials for the designated intractable diseases in Japan - Drug combination -
No.57 (Jul 2019)
Introducation of DDrare: Database of drug development for the designated intractable diseases in Japan.
No.54 (Jul 2018)
Trends in clinical trials for the designated intractable diseases in Japan, from the point of view of drug modality.
No.53 (Mar 2018)
Modality analysis of the drugs used in clinical trials for the designated intractable diseases in Japan.
No.52 (Nov 2017)
Marketed drugs used in clinical trials for the designated intractable diseases in Japan.
No.50 (Mar 2017)
Connecting information of the designated intractable diseases in Japan to other databases.
No.49 (Nov 2016)
Sponsors of clinical trials for the designated intractable diseases.
No.49 (Nov 2016)
Trends of clinical trials on the designated intractable diseases in Japan.
No.48 (Jul 2016)
Symposium of Togo (Integration)
(in Japanese)
DDrare - Database of developing drugs, target genes and pathways for rare diseases -
2020
DDrare: Database of drug development for rare diseases providing information of drug target genes and pathways.
2019
DDrare: Database of drug development for rare and intractable diseases.
2018
Looking for global trends of drug development for rare and intractable diseases by investigating clinical trial data
2017
Information analysis for drug development and disease research ~ from basic research to clinical application ~
2016
Disclaimer
The information on this website is provided for research purposes only and does not replace the advice or consultation of a doctor. In principle, all rights relating to the information on this website belong to the National Institutes of Biomedical Innovation, Health and Nutrition. Please contact us in advance if you would like to use the information on this website. Information on this website is subject to change without notice. In any case, we will not be liable for any damages arising from the use of the information on this website.
Contact us
Laboratory of Rare Disease Resource Library
Center for Rare Disease Research
National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
7-6-8 Saito-Asagi, Ibaraki-shi, Osaka 567-0085, Japan