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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
113 valent conjugated pneumococcal vaccine----1件: 265
2150 mg GSK1265744B----1件: 265
3300mg Gemcabene1件: Gemcabene---1件: 265
43TC----2件: 256, 265
5600mg Gemcabene1件: Gemcabene---1件: 265
6Abacavir1件: Abacavir1件: D07057 --4件: 2, 135, 265, 325
7Abacavir 300mg twice daily1件: Abacavir1件: D07057 --1件: 265
8Abacavir sulfate2件: Abacavir,
Sulfate ion		1件: D07057 --1件: 265
9Abacavir sulfate, Lamivudine and Zidovudine4件: Abacavir,
Lamivudine,
Sulfate ion,
Zidovudine		3件: D00353 ,
D00413 ,
D07057 		--1件: 265
10ABC----2件: 256, 265
11Acetate1件: Acetate---41件: 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
12ACETYL- L- CARNITINE1件: Levocarnitine1件: D02176 --1件: 265
13Acetylcarnitine1件: Acetylcarnitine---2件: 2, 265
14Acipimox1件: Acipimox1件: D07190 --2件: 78, 265
15AKCEA-ANGPTL3-LRX----2件: 79, 265
16Amplification by PCR and direct sequencing on the entire coding sequence and intron-exons boundaries of the candidate gene----1件: 265
17Amprenavir1件: Amprenavir1件: D00894 --1件: 265
18Antiretroviral/Anti HIV----1件: 265
19Aramchol1件: Aramchol---1件: 265
20Atazanavir1件: Atazanavir1件: D07471 --1件: 265
21Atazanavir (ATV) + ritonavir (RTV), continuation of backbone 2 nucleoside reverse transcriptase inhibitor (NRTIs)2件: Atazanavir,
Ritonavir		2件: D00427 ,
D07471 		--1件: 265
22Atazanavir (Reyataz)1件: Atazanavir1件: D07471 --1件: 265
23Atazanavir/Ritonavir2件: Atazanavir,
Ritonavir		2件: D00427 ,
D07471 		--1件: 265
24Atorvastatin1件: Atorvastatin1件: D07474 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
25Atorvastatin Calcium2件: Atorvastatin,
Calcium		1件: D07474 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬2件: 97, 265
26ATV----1件: 265
27Avandia administration for 6-12 weeks----1件: 265
28AZT----2件: 94, 265
29AZT/3TC----1件: 265
30Baricitinib1件: Baricitinib1件: D10308 2件: JAK1,
JAK2 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
31Berberine1件: Berberine---2件: 97, 265
32BMS-232632----1件: 265
33Caffeine1件: Caffeine2件: D00528 ,
D01453 		11件: ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		22件: Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 2, 6, 21, 46, 78, 96, 97, 265
34Calcium1件: Calcium---27件: 6, 13, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 156, 214, 215, 222, 224, 235, 265, 274, 298, 299
35Carnitine1件: Levocarnitine1件: D02176 --9件: 5, 13, 58, 86, 96, 97, 265, 298, 316
36CD----8件: 6, 13, 46, 51, 63, 96, 97, 265
37CD-4 guided therapy interruption----1件: 265
38Cholic Acid1件: Cholic Acid1件: D10699 1件: NR1H4 💬1件: Bile secretion 💬4件: 20, 234, 265, 310
39CoFactor----2件: 265, 288
40Cofactor supplementation (thiamine, riboflavin, L-carnitine)3件: Levocarnitine,
Riboflavin,
Thiamine		3件: D00050 ,
D02176 ,
D08580 		--1件: 265
41COMBIVIR1件: Zidovudine1件: D00413 --1件: 265
42Combivir (zidovudine [AZT] / lamivudine [3TC])2件: Lamivudine,
Zidovudine		2件: D00353 ,
D00413 		--1件: 265
43Continuation of current HAART (boosted protease inhibitor [PI] combination + 2 NRTIs)----1件: 265
44Didanosine1件: Didanosine1件: D00296 --2件: 25, 265
45Different HAART regimens----1件: 265
46Diosmin1件: Diosmin1件: D07858 --3件: 46, 97, 265
47Diosminex, 500 mg, tabletki powlekane----1件: 265
48Dolutegravir1件: Dolutegravir1件: D10066 --2件: 2, 265
49Dolutegravir / Lamivudine Oral Tablet2件: Dolutegravir,
Lamivudine		2件: D00353 ,
D10066 		--1件: 265
50Dolutegravir 50 MG1件: Dolutegravir1件: D10066 --1件: 265
51Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO]2件: Dolutegravir,
Lamivudine		2件: D00353 ,
D10066 		--1件: 265
52Doravirine1件: Doravirine1件: D10624 --1件: 265
53Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate 100 MG-300 MG-300 MG Oral Tablet [DELSTRIGO]3件: Doravirine,
Lamivudine,
Tenofovir disoproxil		2件: D00353 ,
D10624 		--1件: 265
54Efavirenz1件: Efavirenz1件: D00896 --1件: 265
55Efavirenz (EFV)1件: Efavirenz1件: D00896 --1件: 265
56Emtricitabine1件: Emtricitabine1件: D01199 --4件: 25, 93, 265, 325
57Emtricitabine/tenofovir2件: Emtricitabine,
Tenofovir		2件: D01199 ,
D06074 		--1件: 265
58Enfuvirtide1件: Enfuvirtide1件: D02499 --2件: 25, 265
59Enfuvirtide (T20)1件: Enfuvirtide1件: D02499 --1件: 265
60Fenofibrate1件: Fenofibrate1件: D00565 1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬6件: 8, 79, 93, 94, 97, 265
61Gemcabene1件: Gemcabene---2件: 79, 265
62Genotropin (human recombinant Growth hormone)1件: Somatotropin---1件: 265
63Growth hormone1件: Somatotropin---14件: 2, 13, 19, 46, 78, 96, 107, 187, 191, 193, 195, 265, 276, 299
64Growth Hormone Releasing Hormone1件: Somatotropin---1件: 265
65GSK1265744B (sodium salt) containing 14C-GSK1265744B----1件: 265
66High-carbohdyrate breakfast----1件: 265
67High-dose REGN4461----1件: 265
68HIV Anti-retroviral Background Therapy----1件: 265
69Hu Leptin (A-100)1件: Leptin---1件: 265
70Human Growth Hormone1件: Somatotropin---5件: 78, 187, 193, 265, 276
71Human recombinant leptin (metreleptin)2件: Leptin,
Metreleptin		1件: D05014 1件: LEPR 💬6件: AMPK signaling pathway, Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease 💬1件: 265
72Indinavir1件: Indinavir1件: D03833 --1件: 265
73ISIS 304801----1件: 265
74Kaletra (lopinavir [LPVr])1件: Lopinavir1件: D01425 --1件: 265
75L-Carnitine1件: Levocarnitine1件: D02176 --7件: 13, 86, 96, 97, 265, 298, 316
76Lamivudine1件: Lamivudine1件: D00353 --7件: 2, 26, 42, 46, 135, 265, 325
77Lamivudine/Zidovudine2件: Lamivudine,
Zidovudine		2件: D00353 ,
D00413 		--1件: 265
78Leptin1件: Leptin---2件: 6, 265
79Lopinavir1件: Lopinavir1件: D01425 --1件: 265
80Lopinavir/Ritonavir2件: Lopinavir,
Ritonavir		2件: D00427 ,
D01425 		--1件: 265
81Lopinavir/ritonavir + nevirapine3件: Lopinavir,
Nevirapine,
Ritonavir		3件: D00427 ,
D00435 ,
D01425 		--1件: 265
82Lopinavir/ritonavir + zidovudine + lamivudine4件: Lamivudine,
Lopinavir,
Ritonavir,
Zidovudine		4件: D00353 ,
D00413 ,
D00427 ,
D01425 		--1件: 265
83Low-Dose REGN4461----1件: 265
84Mecasermin1件: Mecasermin1件: D03297 2件: GHR,
IGF1R 💬		33件: AMPK signaling pathway, Adherens junction, Autophagy - animal, Breast cancer, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Focal adhesion, FoxO signaling pathway, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, JAK-STAT signaling pathway, Long-term depression, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Melanoma, Neuroactive ligand-receptor interaction, Oocyte meiosis, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, mTOR signaling pathway 💬5件: 78, 96, 168, 265, 299
85Metformin1件: Metformin1件: D04966 2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
86METFORMIN HYDROCHLORIDE1件: Metformin1件: D04966 2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬5件: 81, 158, 265, 299, 301
87METRELEPTIN1件: Metreleptin1件: D05014 1件: LEPR 💬6件: AMPK signaling pathway, Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease 💬1件: 265
88Metrelpetin----1件: 265
89Monotherapy (Lopinavir/ritonavir)2件: Lopinavir,
Ritonavir		2件: D00427 ,
D01425 		--1件: 265
90Monotherapy (Lopinavir/ritonavir) + ABC/3TC2件: Lopinavir,
Ritonavir		2件: D00427 ,
D01425 		--1件: 265
91Myalept1件: Metreleptin1件: D05014 1件: LEPR 💬6件: AMPK signaling pathway, Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease 💬1件: 265
92N-trans-3-Hexenoyl] Human Growth Hormone Releasing Factor (1-44) Acetate2件: Acetate,
Somatotropin		---1件: 265
93Nelfinavir1件: Nelfinavir1件: D08259 --3件: 49, 265, 331
94Nelfinavir mesylate1件: Nelfinavir1件: D08259 --1件: 265
95Nevirapine1件: Nevirapine1件: D00435 --1件: 265
96Non-nucleoside reverse transcriptase inhibitors----1件: 265
97Norvir1件: Ritonavir1件: D00427 --2件: 265, 299
98NucleomaxX----1件: 265
99Nucleoside analogue sparing HAART regimen----1件: 265
100Nucleoside reverse transcriptase inhibitors----1件: 265
101Obeticholic Acid1件: Obeticholic acid1件: D09360 1件: NR1H4 💬1件: Bile secretion 💬3件: 93, 265, 296
102Pegvisomant1件: Pegvisomant1件: D05394 1件: GHR 💬5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬2件: 78, 265
103Perform blood cells and fibroblasts biochemical and immuno-labeled investigations----1件: 265
104Pioglitazone1件: Pioglitazone1件: D08378 1件: PPARG 💬11件: AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
105Pioglitazone or metformin2件: Metformin,
Pioglitazone		2件: D04966 ,
D08378 		3件: PPARG,
PRKAA1,
PRKAA2 💬		27件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Huntington disease, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Lipid and atherosclerosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Osteoclast differentiation, Oxytocin signaling pathway, PI3K-Akt signaling pathway, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Tight junction, Transcriptional misregulation in cancer, mTOR signaling pathway 💬1件: 265
106Pneumococcal polysaccharide vaccine 23 valent----1件: 265
107Pravastatin1件: Pravastatin1件: D08410 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
108Pravastatin sodium1件: Pravastatin1件: D08410 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 265
109Prevenar13----2件: 19, 265
110Protease inhibitor----1件: 265
111Protease inhibitors----1件: 265
112R-metHuLeptin1件: Metreleptin1件: D05014 1件: LEPR 💬6件: AMPK signaling pathway, Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease 💬1件: 265
113Raltegravir1件: Raltegravir1件: D06676 --4件: 13, 26, 93, 265
114RECOMBINANT HUMAN GROWTH HORMONE1件: Somatotropin---4件: 78, 193, 265, 276
115Recombinant human growth hormone + rosiglitazone2件: Rosiglitazone,
Somatotropin		1件: D08491 1件: PPARG 💬11件: AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬1件: 265
116REGN4461----1件: 265
117Reyataz1件: Atazanavir1件: D07471 --1件: 265
118REYATAZ 150MG 60 CPS BL1件: Atazanavir1件: D07471 --1件: 265
119Riboflavin1件: Riboflavin1件: D00050 --7件: 38, 46, 96, 97, 162, 168, 265
120Ritonavir1件: Ritonavir1件: D00427 --3件: 2, 86, 265
121Ritonavir (Norvir)1件: Ritonavir1件: D00427 --1件: 265
122Rosiglitazone1件: Rosiglitazone1件: D08491 1件: PPARG 💬11件: AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬5件: 46, 75, 97, 222, 265
123Rosiglitazone maleate1件: Rosiglitazone1件: D08491 1件: PPARG 💬11件: AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬3件: 46, 75, 265
124RTV----1件: 265
125Saquinavir1件: Saquinavir1件: D00429 --2件: 86, 265
126Serostim®[somatropin (rDNA origin) for injection]1件: Somatotropin---1件: 265
127Setmelanotide1件: Setmelanotide1件: D11927 1件: MC4R 💬1件: Neuroactive ligand-receptor interaction 💬2件: 202, 265
128Simvastatin1件: Simvastatin1件: D00434 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
129Somatropin1件: Somatotropin---19件: 2, 3, 19, 46, 65, 74, 75, 78, 96, 107, 113, 187, 193, 195, 238, 265, 274, 276, 299
130ST200----1件: 265
131Standard continuous antiretroviral therapy----1件: 265
132Stavudine1件: Stavudine1件: D00445 --1件: 265
133Sulfate1件: Sulfate ion---27件: 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299
134SUSTIVA1件: Efavirenz1件: D00896 --1件: 265
135TAT4 Gel concentration A----1件: 265
136TAT4 Gel concentration B----1件: 265
137Tenofovir1件: Tenofovir disoproxil---6件: 2, 13, 25, 93, 265, 325
138Tenofovir DF1件: Tenofovir1件: D06074 --1件: 265
139Tenofovir disoproxil2件: Tenofovir,
Tenofovir disoproxil		1件: D06074 --2件: 93, 265
140Tenofovir Disoproxil Fumarate2件: Tenofovir,
Tenofovir disoproxil		1件: D06074 --1件: 265
141Tesamorelin1件: Tesamorelin1件: D06655 1件: GHRHR 💬2件: Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬2件: 78, 265
142Tesamorelin (Egrifta)1件: Tesamorelin1件: D06655 1件: GHRHR 💬2件: Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬1件: 265
143TH9507----1件: 265
144Thiamine1件: Thiamine1件: D08580 --3件: 8, 93, 265
145Tipranavir1件: Tipranavir1件: D08605 --1件: 265
146Total Dietary Replacement----1件: 265
147TRUVADA1件: Emtricitabine1件: D01199 --1件: 265
148Use of lipid-lowering drugs.----1件: 265
149Viral load driven treatment interruption----1件: 265
150Volanesorsen1件: Volanesorsen1件: D11648 1件: APOC3 💬2件: Cholesterol metabolism, PPAR signaling pathway 💬1件: 265
151VOLANESORSEN SODIUM, ApoC-III Antisense Oligonucleotide1件: Volanesorsen1件: D11648 1件: APOC3 💬2件: Cholesterol metabolism, PPAR signaling pathway 💬1件: 265
152Zidovudine1件: Zidovudine1件: D00413 --6件: 25, 26, 135, 265, 325, 331