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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’-----1件: 79
21,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol)1件: Glycerin1件: D00028 --1件: 79
3AAV directed hLDLR gene therapy----1件: 79
4AAV8.TBG.hLDLR----1件: 79
5Acetate1件: Acetate---41件: 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
6AEGR-733----1件: 79
7AK102----1件: 79
8AKCEA-ANGPTL3-LRX----2件: 79, 265
9ALIROCUMAB1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
10Alirocumab SAR236553 (REGN727)1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
11ALN-60212----1件: 79
12ALN-PCSSC1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
13AMG 145----1件: 79
14AMG145----1件: 79
15ANACETRAPIB1件: Anacetrapib1件: D08855 1件: CETP 💬1件: Cholesterol metabolism 💬1件: 79
16ARO-ANG 3 Injection----1件: 79
17Atorvastatin1件: Atorvastatin1件: D07474 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
18Calcium1件: Calcium---27件: 6, 13, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 156, 214, 215, 222, 224, 235, 265, 274, 298, 299
19Calcium rosuvastatin2件: Calcium,
Rosuvastatin		1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
20CER-001----1件: 79
21Cholestyramine1件: Cholestyramine---2件: 13, 79
22Comparator: ezetimibe1件: Ezetimibe1件: D01966 1件: NPC1L1 💬1件: Fat digestion and absorption 💬2件: 79, 260
23Crestor1件: Rosuvastatin1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬3件: 49, 79, 299
24Crestor Film-Coated Tablet1件: Rosuvastatin1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
25Crestor Tablets (calcium rosuvastatin) Film-Coated tablets2件: Calcium,
Rosuvastatin		1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
26Current lipid-lowering treatment----1件: 79
27DPPG----1件: 79
28EVINACUMAB1件: Evinacumab1件: D11753 1件: ANGPTL3 💬1件: Cholesterol metabolism 💬1件: 79
29Evinacumab (REGN1500)1件: Evinacumab1件: D11753 1件: ANGPTL3 💬1件: Cholesterol metabolism 💬1件: 79
30EVOLOCUMAB1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬2件: 79, 222
31Evolocumab (AMG 145)1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
32Ezetimibe1件: Ezetimibe1件: D01966 1件: NPC1L1 💬1件: Fat digestion and absorption 💬4件: 49, 79, 93, 260
33Fenofibrate1件: Fenofibrate1件: D00565 1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬6件: 8, 79, 93, 94, 97, 265
34Fluvastatin1件: Fluvastatin1件: D07983 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬3件: 79, 218, 222
35Gemcabene1件: Gemcabene---2件: 79, 265
36Gene analysis----1件: 79
37Glycerol1件: Glycerin1件: D00028 --5件: 6, 13, 79, 316, 317
38IBI306----1件: 79
39Implitapide1件: Implitapide---1件: 79
40Inclisiran1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
41Inclisiran Sodium1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
42Inclisiran Sodium for injection1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
43ISIS 301012----1件: 79
44ISIS 301012 phosphorothioate oligonucleotide----1件: 79
45ISIS 703802----1件: 79
46JS002----1件: 79
47KJX839----1件: 79
48Lapaquistat1件: Lapaquistat---1件: 79
49Lapaquistat acetate and current lipid-lowering treatment2件: Acetate,
Lapaquistat		---1件: 79
50Leqvio1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
51Leqvio 284 mg solution for injection in pre-filled syringe1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
52Lerodalcibep----1件: 79
53LIB003----1件: 79
54Lojuxta1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
55Lojuxta 10 mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
56Lojuxta 20 mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
57Lojuxta 5 mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
58LOMITAPIDE1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
59Lomitapide 2mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
60Lovastatin1件: Lovastatin1件: D00359 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
61MBX-8025----3件: 79, 93, 94
62MBX-8025 50 mg (Dose Escalation Period 1)----1件: 79
63MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)----1件: 79
64MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)----1件: 79
65Mipomersen1件: Mipomersen---1件: 79
66MK-0859----1件: 79
67Nicotinic acid1件: Niacin1件: D00049 --1件: 79
68Omega-31件: Omega-3 fatty acids---7件: 13, 46, 49, 66, 79, 96, 299
69Omega-3 fatty acids1件: Omega-3 fatty acids---2件: 13, 79
70Phospholipids1件: Omega-3 fatty acids---1件: 79
71Placebo----28件: 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
72Praluent1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
73Pravastatin1件: Pravastatin1件: D08410 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
74PRD7255830----1件: 79
75PRD7255977----1件: 79
76PRD7256003----1件: 79
77Prednisone1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬45件: 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331
78R727----1件: 79
79Recombinant Human Apolipoprotein----1件: 79
80Recombinant Human Apolipoprotein A-I----1件: 79
81Recombinant Human Apolipoprotein A-I/Phospholipids Complex1件: Omega-3 fatty acids---1件: 79
82Recombinant human apolipoprotein a1----1件: 79
83REGN1500----1件: 79
84REGN1500 250 mg SC/15 mg/kg IV/450 mg SC----1件: 79
85REGN7272----1件: 79
86Repatha1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
87Repatha (evolocumab)1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
88Repatha 140 mg Solution for Injection in Pre-filled Pen1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
89Repatha 140 mg soluzione per iniezione in penna preriempita.1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
90Repatha 420 mg solution for injection in cartridge1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
91Repatha 420 mg soluzione per iniezione in cartuccia1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
92Rosuvastatin1件: Rosuvastatin1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
93Rosuvastatin 20mg1件: Rosuvastatin1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
94ROSUVASTATIN CALCIUM2件: Calcium,
Rosuvastatin		1件: D08492 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬4件: 49, 79, 97, 299
95SAR236553----1件: 79
96Sfingomielina----1件: 79
97SHR-1209----1件: 79
98Simvastatin1件: Simvastatin1件: D00434 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
99Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy----1件: 79
100Sphingomyelin----1件: 79
101Standard of Care----8件: 6, 13, 49, 51, 63, 64, 79, 171
102Statins----2件: 46, 79
103TAK-4751件: TAK-475---1件: 79
104Whole genome sequencing----3件: 6, 79, 172
105ZD4522----1件: 79