Drug Description in Trials / DrugBank / KEGG DRUG

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No.	薬物名（臨床試験情報から抽出）	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	指定難病告示番号
1	Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)	2件: Abatacept, Methotrexate	2件: D00142 (Name: Methotrexate), D03203	4件: CD80, CD86, DHFR, DHFR2 💬	18件: Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofacto ...	1件: 46
2	Abatacept + Methotrexate	2件: Abatacept, Methotrexate	2件: D00142 (Name: Methotrexate), D03203	4件: CD80, CD86, DHFR, DHFR2 💬	18件: Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofacto ...	1件: 46
3	Adalimumab with methotrexate	2件: Adalimumab, Methotrexate	2件: D00142 (Name: Methotrexate), D02597	3件: DHFR, DHFR2, TNF 💬	71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African ...	1件: 46
4	AZATHIOPRINE or METHOTREXATE	2件: Azathioprine, Methotrexate	2件: D00142 (Name: Methotrexate), D00238	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One c ...	1件: 96
5	BMS-582949 and Methotrexate	2件: BMS-582949, Methotrexate	1件: D00142 (Name: Methotrexate)	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One c ...	1件: 46
6	Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF	6件: Busulfan, Filgrastim, Fludarabine, Methotrexate, Phosphate ion, Tacrolimus	6件: D00107 , D00142 (Name: Methotrexate), D00248 , D03235 , D07966 , D08556	9件: CSF3R, DHFR, DHFR2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, RRM1 💬	48件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, ...	1件: 60
7	Certolizumab Pegol + Methotrexate (MTX)	2件: Certolizumab pegol, Methotrexate	2件: D00142 (Name: Methotrexate), D03441	3件: DHFR, DHFR2, TNF 💬	71件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African ...	1件: 46
8	Clobetasol propionate + Methotrexate	3件: Clobetasol, Clobetasol propionate, Methotrexate	3件: D00142 (Name: Methotrexate), D01272 , D07715	3件: DHFR, DHFR2, NR3C1 💬	6件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuro ...	1件: 162
9	Combination Product: Exercise, and methotrexate	1件: Methotrexate	1件: D00142 (Name: Methotrexate)	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One c ...	1件: 46
10	Combination Product: Laser, exercise, and methotrexate	1件: Methotrexate	1件: D00142 (Name: Methotrexate)	2件: DHFR, DHFR2 💬	5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One c ...	1件: 46

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