KEGG DRUG

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No.	薬物名（臨床試験情報から抽出）	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	指定難病告示番号
1	Amitriptyline, fluoxetine and tramadol alone (control group) (Synonym: D08623)	3件: Amitriptyline, Fluoxetine, Tramadol	3件: D00326 , D07448 , D08623	3件: OPRM1, SLC6A2, SLC6A4 💬	5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬	1件: 78
2	Sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group) (Synonym: D08623)	4件: Amitriptyline, Fluoxetine, Somatotropin, Tramadol	3件: D00326 , D07448 , D08623	3件: OPRM1, SLC6A2, SLC6A4 💬	5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬	1件: 78
3	Tramadol (Synonym: D08623)	1件: Tramadol	1件: D08623	1件: OPRM1 💬	3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬	5件: 46, 70, 78, 226, 271
4	Tramadol /acetaminophen (Synonym: D08623)	2件: Acetaminophen, Tramadol	2件: D00217 , D08623	3件: OPRM1, PTGS1, PTGS2 💬	26件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Estrogen signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬	1件: 271
5	Tramadol hydrochloride + acetaminophen (Synonym: D08623)	2件: Acetaminophen, Tramadol	2件: D00217 , D08623	3件: OPRM1, PTGS1, PTGS2 💬	26件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Estrogen signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬	1件: 46
6	Tramadol with ropivacaine (Synonym: D08623)	2件: Ropivacaine, Tramadol	2件: D08490 , D08623	6件: OPRM1, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬	6件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction 💬	1件: 70