Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CD52	-	D02802	Alemtuzumab	20件: 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326
2	TPP1	1件: Lysosome	D10813	Cerliponase alfa	1件: 19
3	CSF3R	5件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D03247	Lenograstim	7件: 2, 13, 16, 18, 19, 57, 65
4	ACE	6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D00362	Lisinopril	7件: 19, 46, 49, 66, 67, 113, 222
5	ACE	6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D03752	Quinapril	1件: 19
6	ACE	6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D07892	Enalapril	6件: 19, 46, 66, 113, 210, 222
7	ACE	6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D08131	Lisinopril	7件: 19, 46, 49, 66, 67, 113, 222
8	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
9	NQO1	7件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofacto ...	D08682	Warfarin	11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
10	AGTR1	16件: Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuro ...	D00150	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224

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