Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	DPP4	1件: Protein digestion and absorption	D08516	Sitagliptin	2件: 233, 299
2	ABAT	7件: Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Al ...	D00399	Valproic acid	14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
3	GAD1	7件: Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine me ...	D00399	Valproic acid	14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
4	GAD2	7件: Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine me ...	D00399	Valproic acid	14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
5	GIPR	2件: cAMP signaling pathway, Neuroactive ligand-receptor interaction	D11360	Tirzepatide	1件: 233
6	GLP1R	3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion	D04121	Exenatide	6件: 6, 17, 72, 78, 193, 233
7	GLP1R	3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion	D11360	Tirzepatide	1件: 233
8	PRKAA1	20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, ...	D04966	Metformin	25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 28 ...
9	PRKAA2	20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, ...	D04966	Metformin	25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 28 ...
10	ALDH5A1	3件: Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways	D00399	Valproic acid	14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256

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